 Where did you guys go? Uh, Atomic, uh, Liquors? I did a cool establishing shot, that's video team lingo for a shot of the exterior of a building. So, when you see that I think you're probably going to be pretty psyched. So, we're drunk. In Sin City. In Sin City. Uh, so I apologize if I'm not making a whole lot of sense. But I am theoretically at least a science reporter. And part of the reason that I'm doing this is because I want to talk about the science of hangovers. Uh, I cannot believe it. Wow, you're upside down. You guys are getting me all excited. So, I'm going to this place called Hangover Heaven, which is a really good name. P.S. It's a great name. Uh, fact. Fact. When doctors are hungover, this is what they do. They hook themselves up to an IV to like rehydrate themselves. And like there are also like vitamins and things in there that may potentially help with like processing alcohol and feeling less bad. And how much science do the like Hangover Heaven people, uh, claim? Uh, when they are discussing, I have a little bit of beer come out of me. That was another science type of event that will happen in a man's life. The thing that I was going to say is that there is some evidence for certain kinds of drugs for hangovers. Um, and if you are a big old nerd, you can pull it on PubMed yourself. Um. I'm not. I'm pretty cool. I'm going to have to leave that to your kind. Sorry. So, I'm hoping that they're right. I'm really, really hoping that like it will take 45 minutes for me to feel better when I'm hungover tomorrow. Because Casey is not going to Hangover Heaven. He's just going to have to tough it out. I'm going to Hangover Hell, y'all. Straight to Hell. Oh, Jesus Christ. I look like my own dad, which is always how you want to appear on video. Light is not my friend right now. Well, I think I have it better because I'm going to drink a lot of water and I'm going to take some Aleve. And I'm going to feel like 80% better. So, I can't wait to find out what her experiences look like. Because in a lot of ways, I do think I have it better. I mean, don't get me wrong, I still hurt all over, but they're not going to stick me with needles today. I really am not feeling good. I sincerely hope I do not get car sick. I have done some dumb things in my time, but this is like, I wouldn't say top 10. I have done some dumb things in my time, but this is like, I wouldn't say top 3, but maybe top 5. You know? Oh, yeah, here we are. Bullshit. What's your hangover cure? I mean, I just take a Revlon, etc. Or I take a few more shots. What I would like to know is how you all are feeling right now. I don't know. I feel like a dog shit in my mouth stepped on my head. I just feel like a guy hit my head. Yeah, but I'm not really feeling well. You guys haven't done it yet, right? I did it yesterday to save my day. I got a little bruise right here. Yeah, we did it yesterday. Did it work? Yeah, it felt great. And it's nice that the port of sub is right here. We're going to get a sandwich and then while we're getting our drip, eat our sandwich. And we're going to watch the interview. Yeah, I'm so excited. It's like an anthem song. We've got to get on this. We love you. We love you. Thanks for interviewing us. Hangover heaven. The verge. The verge. The best. I'm glad you like it. So basically this started while I was working in the recovery room. I'm an anesthesiologist. And seeing people in the recovery room with post-operative nausea and vomiting, headache, dizziness and that type of thing. And seeing that these same symptoms in the recovery room are exactly the same ones that people have with a hangover. And I thought these same medications would work well for hangovers. I came up with a protocol, gathered together a few volunteers, and tried it out. It worked great. And it was just a matter of figuring out a plan that worked, a business plan that worked. If somebody could just distract me while this is happening, that would be really great because... You don't like needles? I really do not like needles. I don't like needles either. To the best of our knowledge, a hangover is probably caused by your immune system. What seems to be going on is that your immune system is responding to the alcohol. Inflammation seems to be the major cause of the hangover. You feel bad, you're achy, your stomach hurts. All of the things that happen basically when you have the flu, which have nothing to do with the flu virus and everything to do with your immune system fighting off the flu virus, pretty much. There are things that make it worse. Dehydration is one of those things. Dehydration is not great for you in general. You know what will make your hangover worse is texting your ex-boyfriend at 3am and just trying to figure out where things went wrong between the two of you. Don't text your ex-boyfriend. I strongly, strongly recommend deleting all of your exes from your phone. I just want to hear from you. It was never going to work, Casey. So I'm being rehydrated here. What else is happening? You also have some intravenous alpha lipoic acid going in, which is a very powerful antioxidant. And then there's basically hydration and a little bit of sugar. Well, let me start from the beginning. Hangovers are not dehydration. Right. It's inflammation, isn't it? Yeah, and oxidative stress. And the dehydration makes the symptoms worse from a concentration effect. With a hangover, when you're dehydrated, the concentration of all the nasty stuff in your blood is higher. You rehydrate people, that concentration becomes lower. People feel better, a little bit better just from the rehydration. And in terms of inflammation, is there an anti-inflammatory thing happening here or... okay. Yeah. Have you taken any Advil today? I have not. Okay, yeah, because we basically give you intravenous Advil. Okay, great. A small dose. It doesn't take a whole lot. So my headache has been treated, my nausea has been treated, I have been rehydrated, and I've also gotten some other things going on in my body just to try to catch up from what happened. What happened to it last night and this morning while I was asleep. Overall, what's your hangover now? I would give it maybe a one. Like I am feeling pretty normal and recovered, which is nice. Yeah, you can get back to your vacation, back to what you have to do here. So, Liz, how was Hangover Heaven? Well, the taxi ride to get there was something, but I started feeling better probably after about 15, 20 minutes. And I was feeling pretty good by the end. And I am like obnoxiously perky and like full of energy right now. Maybe, I mean, it might just be like, you know, the placebo effect. That's totally possible. But I feel good. I want to be clear. I searched the literature for IV cures for hangover and I didn't see anything. There's no evidence that this works. That doesn't mean it doesn't work. It just means we don't know that it works. I feel like there's a bias against research on hangovers just because it's felt to be so like superficial or silly. Probably in the last 15 years, there's been less than 50 papers written on hangovers and maybe even less than 15. But a lot of the papers are sort of social science research looking at behavioral issues rather than actual blood levels of inflammatory markers and that type of thing. The kind of joke, kind of like atmosphere about hangovers probably needs to change. This is going to take some hardcore science. I mean, gas chromatographs, liquid columns, animal research. We don't know a lot and that's sort of a problem. So I would like to see more work. I would like to see more studies. I would like to know more about what parts of the immune system are involved, how other things interact. And I feel like once we know those things, we can actually potentially do evidence-based medicine. I'm going to continue to drink because it's fun and so I'll probably continue to be hungover. I'm never driving my ass to a clinic while hungover to have a needle stuck in my arm and be pumped full of God knows what. So let's meet somewhere in the middle and find a way to get me back out on the town to dance the night away. I think we can all drink to that. Cheers. Like it seems so silly that people don't actually really study it even though virtually everybody gets hungover. Can you hear it?
 Where did you guys go?
 Uh, Atomic, uh, Liquors?
 I did a cool establishing shot, that's video team lingo for a shot of the exterior of a building.
 So, when you see that I think you're probably going to be pretty psyched.
 So, we're drunk.
 In Sin City.
 In Sin City.
 Uh, so I apologize if I'm not making a whole lot of sense.
 But I am theoretically at least a science reporter.
 And part of the reason that I'm doing this is because I want to talk about the science of hangovers.
 Uh, I cannot believe it.
 Wow, you're upside down.
 You guys are getting me all excited.
 So, I'm going to this place called Hangover Heaven, which is a really good name.
 P.S.
 It's a great name.
 Uh, fact.
 Fact.
 When doctors are hungover, this is what they do.
 They hook themselves up to an IV to like rehydrate themselves.
 And like there are also like vitamins and things in there that may potentially help with like processing alcohol and feeling less bad.
 And how much science do the like Hangover Heaven people, uh, claim?
 Uh, when they are discussing, I have a little bit of beer come out of me.
 That was another science type of event that will happen in a man's life.
 The thing that I was going to say is that there is some evidence for certain kinds of drugs for hangovers.
 Um, and if you are a big old nerd, you can pull it on PubMed yourself.
 Um.
 I'm not.
 I'm pretty cool.
 I'm going to have to leave that to your kind.
 Sorry.
 So, I'm hoping that they're right.
 I'm really, really hoping that like it will take 45 minutes for me to feel better when I'm hungover tomorrow.
 Because Casey is not going to Hangover Heaven.
 He's just going to have to tough it out.
 I'm going to Hangover Hell, y'all.
 Straight to Hell.
 Oh, Jesus Christ.
 I look like my own dad, which is always how you want to appear on video.
 Light is not my friend right now.
 Well, I think I have it better because I'm going to drink a lot of water and I'm going to take some Aleve.
 And I'm going to feel like 80% better.
 So, I can't wait to find out what her experiences look like.
 Because in a lot of ways, I do think I have it better.
 I mean, don't get me wrong, I still hurt all over, but they're not going to stick me with needles today.
 I really am not feeling good.
 I sincerely hope I do not get car sick.
 I have done some dumb things in my time, but this is like, I wouldn't say top 10.
 I have done some dumb things in my time, but this is like, I wouldn't say top 3, but maybe top 5.
 You know?
 Oh, yeah, here we are.
 Bullshit.
 What's your hangover cure?
 I mean, I just take a Revlon, etc.
 Or I take a few more shots.
 What I would like to know is how you all are feeling right now.
 I don't know.
 I feel like a dog shit in my mouth stepped on my head.
 I just feel like a guy hit my head.
 Yeah, but I'm not really feeling well.
 You guys haven't done it yet, right?
 I did it yesterday to save my day. I got a little bruise right here.
 Yeah, we did it yesterday.
 Did it work?
 Yeah, it felt great.
 And it's nice that the port of sub is right here.
 We're going to get a sandwich and then while we're getting our drip, eat our sandwich.
 And we're going to watch the interview.
 Yeah, I'm so excited.
 It's like an anthem song.
 We've got to get on this. We love you.
 We love you. Thanks for interviewing us.
 Hangover heaven.
 The verge.
 The verge. The best.
 I'm glad you like it.
 So basically this started while I was working in the recovery room.
 I'm an anesthesiologist.
 And seeing people in the recovery room with post-operative nausea and vomiting,
 headache, dizziness and that type of thing.
 And seeing that these same symptoms in the recovery room
 are exactly the same ones that people have with a hangover.
 And I thought these same medications would work well for hangovers.
 I came up with a protocol, gathered together a few volunteers,
 and tried it out. It worked great.
 And it was just a matter of figuring out a plan that worked, a business plan that worked.
 If somebody could just distract me while this is happening, that would be really great because...
 You don't like needles?
 I really do not like needles.
 I don't like needles either.
 To the best of our knowledge, a hangover is probably caused by your immune system.
 What seems to be going on is that your immune system is responding to the alcohol.
 Inflammation seems to be the major cause of the hangover.
 You feel bad, you're achy, your stomach hurts.
 All of the things that happen basically when you have the flu,
 which have nothing to do with the flu virus and everything to do with your immune system fighting off the flu virus, pretty much.
 There are things that make it worse. Dehydration is one of those things.
 Dehydration is not great for you in general.
 You know what will make your hangover worse is texting your ex-boyfriend at 3am
 and just trying to figure out where things went wrong between the two of you.
 Don't text your ex-boyfriend. I strongly, strongly recommend deleting all of your exes from your phone.
 I just want to hear from you. It was never going to work, Casey.
 So I'm being rehydrated here. What else is happening?
 You also have some intravenous alpha lipoic acid going in, which is a very powerful antioxidant.
 And then there's basically hydration and a little bit of sugar.
 Well, let me start from the beginning. Hangovers are not dehydration.
 Right. It's inflammation, isn't it?
 Yeah, and oxidative stress. And the dehydration makes the symptoms worse from a concentration effect.
 With a hangover, when you're dehydrated, the concentration of all the nasty stuff in your blood is higher.
 You rehydrate people, that concentration becomes lower.
 People feel better, a little bit better just from the rehydration.
 And in terms of inflammation, is there an anti-inflammatory thing happening here or... okay.
 Yeah. Have you taken any Advil today?
 I have not.
 Okay, yeah, because we basically give you intravenous Advil.
 Okay, great.
 A small dose. It doesn't take a whole lot.
 So my headache has been treated, my nausea has been treated, I have been rehydrated,
 and I've also gotten some other things going on in my body just to try to catch up from what happened.
 What happened to it last night and this morning while I was asleep.
 Overall, what's your hangover now?
 I would give it maybe a one.
 Like I am feeling pretty normal and recovered, which is nice.
 Yeah, you can get back to your vacation, back to what you have to do here.
 So, Liz, how was Hangover Heaven?
 Well, the taxi ride to get there was something, but I started feeling better probably after about 15, 20 minutes.
 And I was feeling pretty good by the end.
 And I am like obnoxiously perky and like full of energy right now.
 Maybe, I mean, it might just be like, you know, the placebo effect.
 That's totally possible.
 But I feel good.
 I want to be clear.
 I searched the literature for IV cures for hangover and I didn't see anything.
 There's no evidence that this works.
 That doesn't mean it doesn't work.
 It just means we don't know that it works.
 I feel like there's a bias against research on hangovers just because it's felt to be so like superficial or silly.
 Probably in the last 15 years, there's been less than 50 papers written on hangovers and maybe even less than 15.
 But a lot of the papers are sort of social science research looking at behavioral issues rather than actual blood levels of inflammatory markers and that type of thing.
 The kind of joke, kind of like atmosphere about hangovers probably needs to change.
 This is going to take some hardcore science.
 I mean, gas chromatographs, liquid columns, animal research.
 We don't know a lot and that's sort of a problem.
 So I would like to see more work.
 I would like to see more studies.
 I would like to know more about what parts of the immune system are involved, how other things interact.
 And I feel like once we know those things, we can actually potentially do evidence-based medicine.
 I'm going to continue to drink because it's fun and so I'll probably continue to be hungover.
 I'm never driving my ass to a clinic while hungover to have a needle stuck in my arm and be pumped full of God knows what.
 So let's meet somewhere in the middle and find a way to get me back out on the town to dance the night away.
 I think we can all drink to that.
 Cheers.
 Like it seems so silly that people don't actually really study it even though virtually everybody gets hungover.
 Can you hear it?