The weekly rate of infection in the town is now higher than any other area in the county.
A total of 156 new COVID-19 cases have been confirmed in Crawley, compared to 137 the previous week and the infection rate has risen to 138.8 per 100,000 people, up from 121.9.
Brighton and Hove has previously been Sussex's worst affected area for several weeks with the infection rate in the city far higher than anywhere else until now.
There have been more new cases in Brighton and Hove (387) than in Crawley.
But the city's infection rate, which measures the proportion of the population carrying the virus, is lower at 133.0 and has dropped from 157.1 the week before.
Today (November 5) marks the first full day of a one month national lockdown in England, which sees new stricter rules coming into force.
It was feared that without a collective national effort, hospitals would be overwhelmed and Boris Johnson hopes to get the R rate below 1 by December 2 - the date we are earmarked to come out of the lockdown.
The second national lockdown comes eight months after the country was first plunged into lockdown in March at the start of the pandemic.
Similar measures have been implemented this time around but there are some discrepancies between the two lockdowns with schools, nurseries and universities all set to stay open.
All non-essential services and businesses have been forced to close today, including pubs and restaurants, while essential shops and educational settings remain open.
The government has also returned to its original message of 'stay at home, to protect the NHS and save lives', as people are only permitted to leave home for a limited number of reasons.
Sussex coronavirus infection rates in full
Here is the full list of COVID-19 infection rates across Sussex, in order of highest to lowest.
From left to right, it reads: name of local authority; rate of new cases in the seven days to October 31; number (in brackets) of new cases recorded in the seven days to October 31; rate of new cases in the seven days to October 24; number (in brackets) of new cases recorded in the seven days to October 24.
Crawley: 138.8 (156), 121.9 (137)
Brighton and Hove: 133.0 (387), 157.1 (457)
Chichester: 111.5 (135), 90.0 (109)
Eastbourne: 110.8 (115), 74.2 (77)
Arun: 95.8 (154), 63.4 (102)
Worthing: 86.8 (96), 81.4 (90)
Horsham: 77.9 (112), 70.2 (101)
Adur: 70.0 (45), 60.7 (39)
Lewes: 68.8 (71), 80.4 (83)
Mid Sussex: 68.2 (103), 85.4 (129)
Wealden: 58.2 (94), 71.8 (116)
Rother: 43.7 (42), 39.6 (38)
Hastings: 36.7 (34), 50.7 (47)