CD21 (CR2, EBV-receptor) is present on mature B cells and follicular dendritic cells (FDCs). This antibody can be used to demonstrate the FDC network in lymphoid tissue. This feature can be useful in examining tissue with germinal centre lesions resulted by disease processes, such as HIV infection, some neoplastic conditions, like 8-cell MALT lymphomas, mantle cell lymphoma, and some T cell lymphomas.
Fixed-embedded human Castleman lymphoma
Cat#: DB 135
CD23 is strongly expressed on EBV transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell CLL and some cases of centroblastic/centrocytic lymphoma.
Fixed-embedded human lymph node