Our research activities are focussed on understanding the different mechanical subtypes among patients with heart failure (systolic dysfunction), in order to develop tailored therapies to improve left ventricular performance. We work in a collaborative framework with a multidisciplinary emphasis, spanning biomedical engineering, cardiology, diagnostic imaging, and population based clinical outcomes.
Identidying clinical markers to separate out groups of heart failure patients with markedly different profiles of left ventricular systolic performance.
Using integrative functional imaging (echocardiography, magnetic resonance imaging, perfusion and sympathetic scintigraphy) to explore the mechanics and myocyte milieu in patients.
Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Guo DC, Regalado E, Casteel DE, Santos-Cortez RL, Gong L, Kim JJ, Dyack S, Horne SG, Chang G, Jondeau G, Boileau C, Coselli JS, Li Z, Leal SM, Shendure J, Rieder MJ, Bamshad MJ, Nickerson DA; GenTAC Registry Consortium; National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Kim C, Milewicz DM.Am. J. Hum. Genet. (2013) 93(2):398-404.
Successful outcome in pregnancy with arterial tortuosity syndrome. Allen VM, Horne SG, Penney LS, Rapchuk IL, Brock JA, Thompson DL, Stinson DA. Obstet. Gynecol. (2009) 114(2 Pt 2):494-8.
Identifying opportunities to address the congestive heart failure burden: the Improving Cardiovascular Outcomes in Nova Scotia (ICONS) study. Howlett JG, Johnstone DE, Sketris I, O'Reilly M, Horne GS, Cox JL; Improving Cardiovascular Outcomes in Nova Scotia investigators. Can. J. Cardiol. (2003) 31;19(4):439-44.
Halifax, Nova Scotia, Canada B3H 4R2
Truro, Nova Scotia, Canada B2N 5E3