Variant position: 408 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 708 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PTEKTEESKAAAPAPVSEAV CRTSMCSIQSAPPEPATL-KGT
Mouse PAEKKSNDTSQTPP--GETV PRASMCSIRSAPPKLASL-KG
Rat PAAKIK-------------- -------------------KG
Pig PTEKTKESQATAPTPVGEAV SRTSLCCVQSAPPKPA---TG
Bovine PTEKTEASPAAAPYPVAEDV PRTSMCSLQSAPPTAAPA-KG
Rabbit PTGKTEESKAAVPAPVAEAV PRTSMCSIQPVPPKPASLQKS
Sheep PTEKNRGIPGRCPRACARG- CASDLHVFCAVSSTHSSSSEG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 708 Calpastatin
cDNA cloning of human calpastatin: sequence homology among human, pig, and rabbit calpastatins.
Asada K.; Ishino Y.; Shimada M.; Shimojo T.; Endo M.; Kimizuka F.; Kato I.; Maki M.; Hatanaka M.; Murachi T.;
J. Enzym. Inhib. 3:49-56(1989)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS SER-408 AND GLY-592;
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-479 (ISOFORM 8); VARIANT SER-408;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 153-708 (ISOFORMS 2/3); SEQUENCE REVISION; VARIANT SER-408;
El-Amine M.; Talbot G.; Despres N.; Asselin C.; Boire G.; Menard H.A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-708 (ISOFORMS 1/2/3/4); VARIANT SER-408;
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