<human>: I have had an ALP test with elevated levels of 202 and a liver isoenzyme level of 17.  Could these results be related to the simvastatin that I take?  This is a second ALP taken with two days; the first resulted in a value of 195.  This lead to taking the second ALP isoenzyme test, as stated above.
<bot>: Hi, Elevated ALP level in simvastatin treated patient are not so common but may occur in someone due to toxic intermediate of Chat Doctor.  This has a self limiting coarse & Idiosyncratic in nature and persistent liver injury indicate failure of adaptation process. Medication only be stopped when there is 10-fold increase in value then normal/ persistent 5-fold increase/ appearance of symptoms related to liver injury. You should take further step according to your treating physician. Get well soon.