<human>: My father s histopathology (medium biopsy specimen, tissue/parafin block)results last week diagnosed the following .He had shooting pain in back & legs.Clinical diagnosis :Extradural mass at D12-L1 . Specimen : Excised Extradural Tumor D12-L1. Gross:Recd. in formalin a single greyish white irregular soft tissue peice measuring 2.4x2.00.8 cms.Cut surface is smooth & firm in consistency.Microscopic Examination:Sections are composed of Diffuse Sheets of large cells containing coarsely clumped nuchlei having prominent nucleoli and is surrounded by a distinct eosinophilic cytoplasm. Also seen are plasmacytoid cells along with granulocytic series of cells . An occasional mitosis is also observed. Interpretation/Diagnosis D/D: ? Extramyeloid Granulocytic Sarcoma ?? Lympoplasmacytic Lymphoma ??? PLasmacytoma Comments: ADV:IHC:MPO,LCA,CK,CD43,CD-38/138,CD-3 I am unable to understand the report. Kindly let me know whether it is cancer ,If yes which type of cancer , which stage, Chances ? My mail id is YYYY@YYYY (in case I lose connection) Thanks & regards
<bot>: Extradural mass at D12-L1 vertebra level means, Spinal cord is covered by aura, Pia and arachnoid covering and mass at this point is absolutely correctly given by histopatho report of biopsy(extra myeloid granulocyte sarcoma??, lymphoplasmacytic lymphoma?, plasmacytoma?)  So but all together cancer treatment is firmly based on final diagnosis you can't treat all three differential diagnosis, so you have to finally conclude one of them by a special test so called Immunohistochemistry which is a currently available weapon to diagnosis of cancer beside H&E Stained biopsy report, Once IOC has given report of biopsy, majority time we have to believe it's finding of it and start treatment as per its report. If its lymphoma then treatment is chemotherapy followed by radiotherapy to local site, if its sarcoma treatment is chemo, if it turns plasmacytoma then radiotherapy after skeletal survey of whole body to rule out possibility of multiple myeloma.