<human>: I am 50 yrs old have been taking zoloft and estrogen replacement.  I have gained 30 pounds and am a small person.   My stomach is so bloated I look pregnant.  I do not eat junk food or soda.  I eat chicken, fish, vegs and salads...I am at my wits end.  I suffer from panic attacks so going off the meds is not an option.  I am also extremely tired all of the time and have no energy to excersice.  Any advice what be welcomed
<bot>: Hi. Thanks for your query. The reasons of your symptoms of bloating, tiredness and no energy to exercise can be due to the following factors:-Estrogen replacement can be the first reason itself as it alters the bodies physiology.-Also has direct effect on Psychology and so on. It is possible that you may need to get altered dosage after talking to your Doctor.-Zoloft- Sertraline also has side effects of weight gain as this is amitriptyline group, and you seriously need to talk to your treating Doctors.-Local causes can be intestinal disturbed flora which can be easily corrected by taking pre and probiotics. -Or if possible you should take another / second opinion of a doctor to have detailed sessions of psychotherapy and change of medicines. -Get some tests :Hormonal levels, thyroid functions, blood sugar, Electrolytes.