<human>: hello doctor, i have a question for you which my family physician can t explain to me..i am 43 years old asian male i have been into twinrix hepa B vaccination for the 5th dosage now and still comes into negative result for antibodies .my family doctor can t explain why until now i am still negative for antibodies he was suggesting me to continue the vaccine until i will get positive blood result. perhaps one of you can explain to me why twinrix has no effect for me? Thank you! AAAAA
<bot>: Hello and welcome to Chat Doctor, The regime for hepatitis B virus which is followed most commonly is as follows:Doses 0, 1 and 6 and a booster dose within five years after the first dose. The first dose is the 0 dose, 1st dose is taken at first month and 6th dose six months after the first dose. The booster dose has to be taken within five years of the first dose. This regime should be strictly followed and if the compliance is not good, the antibody title may not be as expected. The antibodies start rising after six months. A booster dose potentates the antibody titles. If the booster dose is not taken within five years, the effect of the vaccination starts weaning off. Please confirm whether you have taken the doses at correct time. Thanks and take care Chat Doctor. 