<human>: My wife aged 46 is having blood urea 58 and increased to 78-80. Creatinine 3.2 reduced to 2.2 and increased to 2.9 and reduced to 2.8 in months time (fluctuation). Sugar levels normal. for 8 years metformin is used.BP fluctuating 120/70, 140/90, now 120/60.  pls advise what to do for treatment.
<bot>: Hello and welcome to Chat Doctor. As a Urologist, I can understand your anxiety. Your wife has chronic renal (kidney) failure(CRF), with diabetes.(DM). She should do the following tests for expert opinion and treatment :1. Urine routine, culture and ACR.2. Blood routine, FBS,HbA1C,LFT, sodium,potassium, uric acid, and platelets.3. Ultrasound scandium, with residual urine. According to the reports, treatment will be advised. You may send a direct question to me, with all reports, for expert opinion. Chat Doctor.  Manga.