<human>: My mother was given a phenehren injection. Immediately after the injection a white spot with a red and black ring came up. Shortly after the center turned black. Now 2 days later she has a nickle size white spot with a red edge. There is no drainage but seems to be hard under skin. What could this be?
<bot>: Phenergan Injection can cause severe chemical irritation and damage to tissues regardless of the route of administration. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and extraneuronal or perineuronal infiltration. Adverse reactions include burning, pain, thrombophlebitis, tissue necrosis, and gangrene. In some cases, surgical intervention, including fascistoid, skin graft, and/or amputation have been required