<human>: My wife has stage IV Ewing Sarcoma...been thru 11 chemo cycles and 28 radiation treatments...recently had her lung drained re: fluids/blood clots and also found new tumors...shes currently on I/E and VAC protocol...but that is obviously not working...whats next for her?
<bot>: Hi. I am very sorry for your wife. She has a progressive disease on VAC /IE chemotherapy. If she has a good performance status she needs to undergo second line chemotherapy for refractory disease. Chemotherapy protocol options are:1. Cyclophosphamide and topotecan2. Irinotecan and temozolomide3. Docetaxel and GemcitabineYou can discuss it with your oncologist. I hope I have answered your question. I will be more than happy to answer any further question. Wishing you all the best and thank you for choosing Chat Doctor.