Epigenome‐wide association study and integrative cross‐omics analyses of cerebral white matter hyperintensities implicate novel gene networks related to Alzheimer’s disease

Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging are markers of cerebral small vessel disease (cSVD), a major risk factor for Alzheimer’s disease and related dementia (ADRD). Despite the successful identification of multiple genetic variants associated with this highly heritable condition, its genetic architecture remains incompletely understood. More specifically, the role of DNA methylation (DNAm) has received little attention.