Doxorubicin loaded gold nanoparticle for chemo and photothermal combination therapy of melanoma cancer

Cancer is one of the leading causes of incurable death and remains a serious disease worldwide. Of all types of skin cancer, melanoma is the most aggressive malignancy. Adriamycin is one of the most commonly used and important antibiotics among anti-cancer drugs in recent years and has a significant killing effect on melanoma cells when chemotherapy is administered using adriamycin. In PTT treatment, gold nanoparticles are used as photosensitizers with the property of warming up under 808 nm near infrared light to achieve melanoma inhibition. However, neither chemotherapy nor PTT alone is a good solution to this challenge and may result in a range of complications. We have therefore taken the approach of chemically combining adriamycin with gold nanoparticles to form a new nano-drug for treatment to compensate for its shortcomings when acting singly.