Default Mode Network failure is associated with increased tau PET uptake

The accumulation of neurofibrillary tangles contributes to a neurodegenerative cascade toward Alzheimer’s disease. Focal tau deposition may impair signal integrity within a broader network of functionally connected brain regions. 18F‐Flortaucipir PET allows visualization of tau pathology in vivo, and functional compensation between Default Mode Network (DMN) subsystems is an fMRI‐based biomarker of network failure. We sought to characterize the relationship between network failure in the DMN and tau burden throughout the brain.