Abstract 79: Gender differences in Acromegaly- clinical presentation and outcome study

Objective: To study the impact of gender on clinical presentation and outcome in patients with Acromegaly. Methods: A retrospective study of gender differences in patient with Acromegaly. Statistical analysis was done using SPSS version 26. Chi square test, MannWhitneyUtestand T test were applied to determine the correlation between different parameters under study. Results: A total of 103 patients were included in our study (54 females, 49 males). Headache was more common in females (77% vs 55%; p = 0.02). Females had lower median IGF-1 levels than males (520, IQR: 330.3 vs 713, IQR: 500; p = 0.012). When stratified to age groups below and over 50 years, the gender difference in IGF-I median was significantonly among the younger patients (520 vs752.5; p = 0.017). Median basal and nadir GH levels were comparable between both genders in both age groups. Females had greaterremission rate (31% vs 12%; p = 0.05). Age at presentation and diagnostic delay were not statistically different in both genders. There was no significant difference in terms of prevalence of comorbidities. The tumorvolumeof males and females (both below and over 50 years) showed no statistically significant difference. Conclusion: In our study, women < 50 years had significantly lower IGF-1 level compared with men in the same age group. More females achieved remission suggesting the role of gender in response to therapy although no difference was found in tumor volume andknosp grade.