Orbital and Ocular Adnexal Lymphomas: A Retrospective Single Center Study

Purpose: To evaluate and present the clinical and histopathological features of patients with orbital and adnexal lymphoma. 
Methods: Eight patients that had histologically proven orbital and adnexal lymphoma between 2011 and 2021 were evaluated retrospectively. Clinical appearance, age, gender, imaging, tumor localization, treatment methods, pathological diagnosis and systemic features of patients were obtained from the files. 
Results: The mean age of the patients was 59.1 (range 42-79). While 6 of the patients were male, 2 were female. Painless mass and orbital swelling were the most common first signs and symptoms in patients. The MRI findings demonstrated unilateral involvement in 6 patients and bilateral involvement in 2 patients. Intraorbital location in 3 patients (behind the orbital septum), lid location in 2 patients (eyelids in front of orbital septum), conjunctival involvement in 1 patient and lacrimal gland involvement in 2 patients were detected. All cases were reported as Non-Hodgkin B-cell lymphoma [Primary extranodal marginal lymphoma of the mucosa-associated lymphoid tissue (5 patients), diffuse large B-cell lymphoma (2 patients), follicular lymphoma (1 patient)]. 
Conclusion: Lymphomas are common among orbital tumors and clinical findings change depending on the localization in orbita. Ophthalmologists should be attentive to orbital swellings and consider orbital and ocular adnexal lymphomas among differential diagnoses.