Problems using structural MRIs from the oldest‐old, and some solutions: Lessons learned from The 90+ Study and ADNI

The oldest‐old (≥85 years) have the highest rates of dementia. However, because of pronounced brain atrophy, standard neuroimaging programs face unique challenges in this cohort. Here, using data from both The 90+ Study and Alzheimer’s Disease Neuroimaging Initiative (ADNI), we report the prevalence of errors when processing brain MRIs from oldest‐old participants using standard approaches and present some strategies for ameliorating these issues.