Interplay of genetic and epigenetic factors in regulating immune‐related pathways in Alzheimer’s disease

Alzheimer’s disease (AD) is a major cause of dementia and among the most complex of diseases, featuring various heterogeneous molecular mechanisms. Not only genetic but also non‐genetic factors (i.e., epigenetics) contribute to progression in the human brain; dysregulation of gene expression by single nucleotide polymorphisms (SNPs) and altered DNA methylation is often observed in AD patients. Although genetic and epigenetic regulators have each independently received intensive study for their roles in AD progression, their interactive contributions to expression regulation are not yet fully understood. In this study, we aimed to elucidate the interplay of SNPs and DNA methylation in determining transcript‐level expression status in AD.