Hormonal and metabolic features of puberty in adolescents with ultrasound signs of fatty hepatosis (on the example of Arkhangelsk)

AIM: To establish the nature of hormonal and metabolic disorders and the relationship of atherogenic risk factors in puberty in adolescents with ultrasound signs of fatty hepatosis. 
METHODS: A sample of 120 adolescents aged 1217 years from Arkhangelsk having instrumental signs of fatty hepatosis were examined for indicators of peroxidation, chronic inflammation and insulin resistance. A group of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of examination were used as a comparison group. 
RESULTS: The results showed higher mean values of total C-reactive protein (2.76 mg/ml), lipid peroxidation (531.28 mmol/l), waist circumference (72.15 cm), body mass index (25.70 kg/m2), uric acid (0.29 mmol/l), HOMA index (2.24 IU), insulin (11.92 uIU/ml), triglycerides (0.91 mmol/l), and low-density lipoprotein cholesterol (2.20 mmol/l) in the group of adolescents with fatty hepatosis than in the comparison group (0.77 mg/ml, p 0.001; 371.19 mmol/l, p=0.027; 58.19 cm, p 0.001; 25.70 kg/m2, p 0.001; 0.25 mmol/l, p 0.001; 1.01 IU, p 0.001; 5.90 uIU/ml, p 0.001; 0.69 mmol/l, p 0.001; 2.06 mmol/l, p=0.025, respectively). 
CONCLUSION: These results confirm that the pathogenetic components of non-alcoholic fatty liver disease (insulin resistance, accompanied by hyperinsulinemia against the background of abdominal fat deposition, activation of lipid peroxidation, atherogenic dyslipidemia, hyperuricemia, and chronic inflammation) should be considered in adolescence in the prevention, diagnosis, monitoring, and treatment of non-alcoholic fatty liver disease.