Alprazolam safety in pregnancy

Benzodiazepines are commonly prescribed for the treatment of anxiety disorders, including in pregnant women. There is conflicting information in the research literature, however, regarding benzodiazepines’ safety when used during pregnancy, with concern over both pregnancy and neonatal outcomes. Animal data have suggested potential teratogenic risk associated with alprazolam exposure, including occurrence of cleft lip and palate and limb abnormalities in rat offspring.