Predicting neurodegenerative disease using the unique gut microbiota composition of transgenic mice modeling amyloid‐β plaques and neurofibrillary tangles

The gut microbiota, the aggregates of microbial cells that inhabit the gastrointestinal tract, communicates bidirectionally with the brain via immune, neural, metabolic, and endocrine pathways, known as the gut‐brain axis. The gut‐brain axis is suspected to contribute to the development of Alzheimer’s disease (AD). We hypothesize that altered gut microbiota composition contributes to the development of AD pathologies and neuroinflammation via the gut‐brain axis.