Evaluation of A Direct Regional Reprojection Reconstruction Method to Improve Quantitation of Amyloid and Tau PET Images using 3D Printed Phantoms

Image reconstruction and partial volume correction (PVC) techniques designed to account for the limited spatial resolution of PET are used inconsistently in amyloid and tau PET imaging, likely due to a lack of characterization of the techniques and their unknown effect on reliability. In this study, we aimed to test the accuracy and reliability of a variety of reconstruction and image‐based correction methods using 3D‐printed PET phantoms.