Primary Glioblastoma of Trigeminal Root Entry Zone and Internal Auditory Canal: Case Report

Background: Glioblastoma developed from cranial nerves are extremely rare. We report the case of a 71-year-old woman with glioblastoma arising from both trigeminal root entry zones and Internal Auditory Canal (IAC) nerves. Observations: The patient presented with facial numbness and paresthesia in both trigeminal sensory territories with initial Magnetic Resonance Imaging (MRI) at 1-month follow up showing contrast enhancement and thickening of both trigeminal nerves root entry zone and moderate thickening of IAC bundle, suggesting inflammatory disease. Cranial nerves deficit and neuroimaging were rapidly evolving within few months, with appearance of multiples necrotic lesions of pons, midbrain and left cerebellar hemisphere. Histopathological examination on cerebellar biopsy revealed glioblastoma. The patient underwent no further treatment and died one week after biopsy. Lessons: To the author’s knowledge, this is the first case of primary glioblastoma arising simultaneously from multiple cranial nerves.