Parental SES buffers the effect of plasma pTau181 on memory among non‐Latinx White, Latinx, and non‐Latinx Black middle‐aged adults

Inclusive ADRD research should consider social and structural forces as potential sources of cognitive reserve and resilience. Characterization of neuropathology is critical for cognitive reserve research, but few cohorts have AD biomarker data in concert with sufficient sample size, population representativeness, and multi‐level, lifecourse measurement of determinants that is necessary to contribute substantial or novel evidence for when and where to intervene. We partnered with participants in a population‐representative intergenerational study in NYC to determine whether parental socioeconomic status (PSES) buffers the association of plasma pTau181 concentrations with memory among middle aged adults, and whether moderation of neuropathology is similar across racialized and ethnic groups.