TWO CLINICAL CASES OF GAUCHER DISEASE IN THE REPUBLIC OF NORTH OSSETIA – ALANIA OF RUSSIA: THE PREVALENCE OF THE DISEASE, ITS DIAGNOSTIC ISSUES AND PROSPECTS FOR TREATMENT

Gaucher disease (GD) is a rare hereditary metabolic disorder that leads to death or lifelong disability of patients without treatment. A report of the two GD cases is presented. The issues of early diagnosis and optimization of treatment methods against the background of intolerance to imiglucerase and velaglucerase alfa were described. The prevalence of GD in newborns in the Republic of North Ossetia-Alania of Russia was assessed as 1:82,575.