Data-adaptive efficient estimation strategies for biomarker studies embedded in randomized trials

Biomarker Studies Embedded in Randomized Trials Wei Zhang, Zhiwei Zhang2,∗, James F. Troendle, and Aiyi Liu Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Office of Biostatistics Research, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA ∗zhiwei.zhang@nih.gov