Population effects of chiral snail shell development relate handedness to health and disease

The spiral patterns of snail shells exhibit chirality, or “handedness.” These patterns often heavily favor the dextral (right-handed, or clockwise) over the sinistral (left-handed, clockwise) phenotype. While the developmental pathways resulting in each enantiomorph (non-superimposable mirror image form) have been studied extensively, there has been limited investigation into how the emphasis on one spiral direction over the other may confer survival benefit. This perspective essay proposes that developmental events determining cell cleavage robustness, mating compatibility, and predator evasion can influence the distribution of dextral and sinistral snails. The connection between chirality and survivability has broader implications for exploring the role of handedness in diseases and their treatments.