The potentially protective role of an understudied tau isoform in Alzheimer’s disease

As Alzheimer’s disease (AD) progresses, tau becomes abnormally aggregated and hyperphosphorylated in selective brain regions such as the cortex and hippocampus. Surprisingly, the cerebellum remains spared from tau pathology. Given this observation, we proposed to examine possible differences in the level of various tau isoforms in the cerebellum compared to the forebrain.