The Role Of Gamma-Interferon And Interleukin12 In The Pathogenesis Of Rheumatoid Arthritis Patients In Iraq

Background: Objectives:  To evaluate the significant importance of   IFN-y and  IL-12 level   in Rheumatoid Arthritis patients. Material and Methods: A serum sample was collected from two groups. The first group was patients with Rheumatoid Arthritis (RA), the Second group was healthy volunteers. serum of this sample used to detect IFN-y and IL12 level was quantified by using ELISA.  Result: The level of serum INF-gamma was significantly lower in patients with rheumatoid arthritis in comparison with control group, 54.01 (14.81) versus 62.55 (28.11), respectively (p = 0.006) . The level of serum IL-12 was significantly lower in patients with rheumatoid arthritis in comparison with control group, 8.47 (2.44) versus 132.82 (56.30), respectively (p < 0.001).  
Conclusion: On the basis of the current study, the level of serum INF-gamma was significantly lower in patients with rheumatoid arthritis it means have no significant effect on disease susceptibility of patients. This study has found that the level of serum IL-12 was significantly lower in patients with rheumatoid arthritis.