Study on glomerular transforming growth factor level on renal fibrosis by Centella asiatica

In this study, 48 rat models were established and randomly divided into experimental group (n=36) and control group (n=12). The experimental group was further divided into low-dose group, middle-dose group and high-dose group (n=12/group). the levels of transforming growth factor (TGF-β) and vascular endothelial growth factor(VEGF) were detected by enzyme-linked immunosorbent assay (ELISA) at 6 weeks,12 weeks and 18 weeks, respectively, which proved that Centella asiatica can inhibit renal tissue cytokines and extracellular matrix (ECM) produced. Compared with the control group, the level of TGF-β and VEGF in the kidney tissue of the rats in the model group was significantly increased. Compared with the model group, the level of TGF-β and VEGF in the kidney tissue of the rats in the Centella asiatica group was significantly decreased. It provides a theoretical basis for the effect of Centella asiatica on inhibiting renal fibrosis.