Longitudinal analysis of auditory dysfunction in Alzheimer’s disease mice 5xFAD

There is no cure for AD at this moment. All available therapies require accurate diagnosis and staging of AD to ensure proper strategy. Current diagnosis methods rely on high‐cost technologies with radioactive agents, and those are not necessarily included in regular health screenings. Thus, a low‐cost, non‐invasive approach of AD analysis is in great need. The comorbidity between Alzheimer’s disease and hearing loss has been shown to be significant. Beyond hearing loss, AD patients also showed auditory processing disorders. However, it remains unclear if auditory deficits can be a good biomarker for AD analysis, especially for early stages.