Spatial proteomics in the hippocampi of resistant and resilient individuals as compared to Alzheimer’s disease (AD) and primary age‐related tauopathy (PART).

An intriguing group of individuals, termed “resilient,” demonstrate neuropathologic changes consistent with Alzheimer disease (AD), yet display no cognitive impairment. In addition, there are older individuals who resist the development of AD neuropathologic change despite their age, termed “resistant.” Herein, we analyzed protein expression in the hippocampi around normal and neurofibrillary tangle (NFT)‐bearing neurons in these resistant and resilient individuals as compared to those with AD and primary age‐related tauopathy (PART) with cognitive decline.