Abstract 7: A cross sectional study on the metabolic and hormonal profile of patients on lithium

Background: Lithium is the gold standard for the treatment of bipolar affective disorder and is associated with a number of biochemical and hormonal changes with use. In the absence of sufficient data from this part of the country, this study was planned. Objectives: Prevalence of biochemical (specially glycemic status and calcium) and hormonal (specially thyroid function) in patients on lithium. Method: This was a cross sectional study planned on adult patients taking lithium for at least 6 months and were not on thiazides, bisphosphonates or had history of prior thyroid or parathyroid disease or surgery. A total of 40 patients were taken. Data was managed in Excel 2016 and exported to SPSS 25 software for statistical analysis. Level of significance was set at p < 0.05. Result: Mean age of patients was 40 ± 13.9 yrs, with 30 females. Most patients were in age gr 30-40 yrs and hypertension present in 30%. Mean serum calcium was 8.6 mg/dl with a prevalence of thyroid dysfunction at 46%. Discussion/Conclusions: Lithium use is associated with hypothyroidism predominantly.