Sex and Race/Ethnic Differences in Risk Factors for Alzheimer’s Disease and Related Dementias: Implications for Prevention

We previously estimated that 1 in 3 cases of Alzheimer’s disease and related dementias (ADRD) in the U.S. may be attributable to modifiable risk factors, the most important being physical inactivity, depression, and smoking. However, these estimates do not account for changes in risk factor prevalence over the past decade and do not consider potential differences based on sex or race/ethnicity. The objective of this study was to update and estimate the proportion of ADRD in the U.S. that are potentially attributable to modifiable risk factors and to assess for differences by sex and race/ethnicity.