Cognitive decline in Autosomal Dominant Alzheimer’s Disease and its relation to TauPET and fMRI Complexity in the Hippocampus

In recent years the neurofibrillary tangle pathology detected with tauPET imaging has been found to be closely related to cognitive decline in Alzheimer’s Disease. However, PET scans are expensive and involve radioactive tracers. We and others have proposed the complexity of rs‐fMRI using MultiScaleEntropy (MSE) as an index for neuronal function. Reduced entropy values have been associated with aging, APOEɛ4 genotype and cognitive function in AD. Here we hypothesize that the BOLD signal complexity is sensitive to tau‐related neuronal injury and cognitive decline in AD.