Examining differences across cognitive trajectory profiles in late middle‐aged adults: Results from the Wisconsin Registry for Alzheimer’s Prevention

Cognitive decline in Alzheimer’s disease (AD) and other dementias may accelerate in preclinical phases as brain pathology increases. Here we: 1) developed cognitive trajectory profiles using longitudinally‐based random slope and change point (CP) parameter estimates from a cognitive composite; and 2) examined how AD‐related biomarkers varied across these cognitive profiles.