Pathological tau in cognitively normal older adults predicts prospective neurodegeneration and cognitive decline

Pathological tau burden has been linked to neurodegeneration in AD patients. Although previous studies have linked brain atrophy in people at the preclinical stage of AD to early tau deposition, most evidence is based on cross‐sectional findings or retrospective changes before the tau measurement. This study examines longitudinal atrophy and cognitive decline following the assessment of tau, and specifically the relationship between whole brain tau measures and prospective changes in brain structure and memory.