Voxel to voxel validation of brainstem MRI novel sequences to postmortem tissue reconstruction

Neuroimaging of brainstem structures has gained importance in ADRD as these regions degenerate early in AD. In recent years there has been an explosion of novel neuroimaging sequences to image the brainstem. However, most of these methods lack validation against the ground truth, i.e tissue visualization, making these methods less attractive for clinical use. Among the new proposed methods, high‐definition connectome promises to revolutionize BS imaging as it overcomes several limitations of standard structural MRI, including a high level of imaging deformation. In this project we have developed a pipeline to validate BS connectome sequences using a voxel to voxel comparison between 3D histological volumes and connectome signal. To this date we applied this pipeline to 6 human brains.