Risk of unexpected mortality is increased by evoked seizures in the APP/PSEN1, but not PSEN2‐N141I transgenic, mouse model of Alzheimer’s disease

Patients with early‐onset Alzheimer’s disease (AD) with amyloid precursor protein (APP) duplication are at significantly elevated risk of seizures (Zarea et al, Neurology 2016). Deaths specifically from AD in patients with epilepsy have increased over 200% in the last 20 years (DeGiorgio et al, BMJ Open 2020). The incidence of sudden, unexpected death in epilepsy (SUDEP; Harden et al, Neurology 2017) remains unchanged. The co‐occurrence of epilepsy and AD critically increase risks for mortality yet whether specific AD‐associated risk genes more significantly escalate mortality risk is unclear.