Characteristics and Outcome of Neonates Born from Mother with Confirmed SARS-Cov-2 Infection at Prof. Dr I.G.N.G Ngoerah Hospital and Udayana University Hospital Bali

Introduction: Coronavirus disease 2019 (COVID-19), firstly emerge in Wuhan-China in early December 2019. The virus has rapidly spread causing global pandemic. Infection of SARS-CoV-2 in pregnancy tend to be severe and associated with adverse neonatal outcomes. Investigation the number and evaluate clinical feature also outcome of neonates that born from positive COVID-19 mother especially in Prof. DR I.G.N.G Ngoerah Hospital and Udayana University Hospital is required as baseline data.
Methods: This is descriptive observational study. Data on neonates age 0 days - 28 days old born from mother with confirmed COVID-19 were collected from medical record at Prof. DR I.G.N.G Ngoerah Hospital and Udayana University Hospital, during period of March 2019 until December 2020 registry taken from patients from October 2017 to August 2020. We exclude subject with incomplete data.
Results: Total of 90 infants were included in this study, positive swab results were 6 (6%) and negatives were 84 (93.3%). Of 90 infants as many as 50 (55.5%) were males, and 40 (44.4%) were females. Most babies were born by Cesarean delivery 81 (90%). Of 76 (84.4%) samples had full term gestational age and 75 (83.3%) samples born with birth weight more than 2500 grams. Total 80 (88.8%) born with APGAR score 7-10. Most comorbidities we found were respiratory distress and use of antibiotic each 10 (11.1%). Most of the samples that 64 (71.1%) had length of stay less than eight days. One patient died in the group of infants with positive swabs, while none in the group with negative swab results.
Conclusion: Six of the total 90 samples of babies were confirmed to have COVID-19 infection through the RT PCR swab examination. One patient died in this study. Currently the risk of vertical transmission of COVID-19 infection cannot be excluded, it is important to carry out prevention strategies, to make babies are not exposed by viral exposure (prevent maternal infection and reduce the possibility of neonatal exposure to the virus). We suggest multicenter research to provide a more specific description of the outcomes of babies born from mothers with confirmed COVID-19.

Keywords: COVID-19, SARS-CoV-2, neonatal outcomes.