PREVENTION OF PHENYTOIN PRECIPITATION IN INFUSION FLUIDS

Introduction:- Phenytoin sodium only remains in solution when the pH is considerably alkaline (pH 10-12) but there are
reports of loss of clarity when added in intravenous infusion uids . Phenytoin precipitation is reported to occlude
implanted central venous access devices and can cause irritation and tissue necrosis. Phenytoin precipitation can be prevented to avoid
complications with the help of pH adjustment. To prevent phenytoin sodium precipit Objectives:- ation in infusion uids by pH adjustment with
sodium hydroxide. Physical stability of admixtures was tested in case of Phe Materials And Methods :- nytoin sodium in 100 ml 0.9 % w/v
Normal Saline and after addition of different volumes of 5% and 10 % sodium hydroxide. Physical stability was determined with visual inspection
and pH measurement. Clear uid was found on addition of 10% sodium hydroxide. It increases Results:- approximately 3- 4 pH when added to
infusion uid. 1 ml of 10% Sodium hydroxide can be used to prevent phenytoin sodium precipitati Conclusion:- on in infusion uids.