Multi‐Ancestry Genome‐wide Association Analysis of Late‐Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies a Novel Cross‐Ancestry Association in LRRC4C

Increasing diversity in genomic studies is critical for defining the genetic architecture of LOAD by improving power to identify variants more prevalent in or specific to a given ancestry. In this study, we constructed and analyzed a multi‐ancestry collection of GWAS datasets in the Alzheimer’s Disease Genetics Consortium (ADGC) to identify novel LOAD susceptibility loci and characterize shared and unique features of LOAD genomic risk profiles between ancestry groups.