Modules of genotypic variance reflect heterogeneity across TDP‐43 proteinopathies

TAR DNA‐binding protein (TDP‐43) proteinopathies yield a variety of neurodegenerative conditions including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and hippocampal sclerosis of aging (HS‐Aging). However, the contribution of both shared and disparate single nucleotide polymorphisms (SNPs) to phenotypic presentations is unclear. We hypothesize that shared genetic variation may drive susceptibility across diseases while disparate genetic variation may contribute to our understanding of disease‐specific drivers.