Perivascular SPP1 modulates microglia‐synapse engulfment in Alzheimer’s disease models.

Microglia and other resident macrophages in the central nervous system (CNS) exhibit heterogeneous phenotypes dependent on spatiotemporal context, allowing them to fulfil various functions in health and disease. Emerging data suggest that microglia mediate synaptic loss in Alzheimer’s disease (AD) (Bartels et al., Science 2020), yet we know little about the underlying mechanisms and potential subsets or cell states involved.