An Electrochemical Sensor for Molnupiravir Based on a Metal‐Organic Framework Composited with Poly(3,4‐ethylene dioxythiophene): Poly(styrene sulfonate)

Herein, a novel composite based on Cu-3(BTC)(2) and poly (3, 4-ethylene dioxythiophene): poly (styrene sulfonate) with ethylene glycol was successfully synthesized and then modified on the glassy carbon electrode (Cu-BTC@EG-PEDOT : PSS/GCE) to detect Molnupiravir (MPV) as an anti-covid drug. The as-prepared electrode effectively enhanced the electron transfer between the electrode and the analyte, leading to a more sensitive response in the MPV oxidation under optimum conditions. Under the optimum conditions, the developed electrochemical sensor has the advantages in terms of a wide linear dynamic range (0.1 up to 63.3 mu M) and a low detection limit (0.0713 mu M) as well as high selectivity in the presence of several interferences. The newly developed sensor was applied to accurately determine MPV in trace amounts in both environmental and pharmaceutical samples, indicating satisfactory recoveries in the range from 98.30 to 101.41 % for capsules and 96.20 to 104.67 % for river water. The developed sensor demonstrated an excellent electrochemical response for MPV determination owing to the synergistic effects between metal-organic frameworks and a conductive polymer. Hence, the present sensor holds great promise for identifying and quantifying antiviral drugs and extends the application of MOF composites in sensing applications.