In vivo biomarkers of arteriolosclerosis are associated with ADRD biomarkers

Brain arteriolosclerosis, which involves thickening of the vessel wall and stenosis of arterioles, is one of the main pathologies of cerebral small vessel disease, and often co‐occurs with other pathology indicative of Alzheimer’s disease and related disorders (ADRD). A novel classifier of arteriolosclerosis, ARTS, was recently developed by the MarkVCID consortium for in vivo studies of arteriolosclerosis. We hypothesized that higher levels of arteriolosclerosis are associated with worse ADRD biomarker levels.