Genetic Risk Score for Alzheimer’s Disease Predicts Brain Volume Differences in Mid‐ and Late‐life in UK Biobank Participants

Genetic risk variants for late‐onset Alzheimer’s disease (LOAD) predict brain atrophy, cognitive changes, and dementia onset in late‐life. Little is known about the association between LOAD genetic variants and regional brain volumes in middle aged adults. Further understanding of when associations emerge across mid‐to‐late‐life may point to the earliest manifestations of LOAD.