Differential vulnerability of hippocampal microstructure in 5xFAD mouse model of Alzheimer’s Disease: A dMRI study

Hippocampal subfields exhibit differential vulnerabilities to Alzheimer’s disease (AD) associated pathologies. These pathological processes extensively attenuate the structural and functional interconnectivities of the subfields. Abnormal accumulation of beta‐amyloid (Aβ) is considered a primary hallmark of AD. Histopathological studies suggest region‐specific accumulation of Aβ in hippocampal subfields. The aim of the current study is to understand the subfield‐specific in‐vivo microstructural changes in hippocampus due to Aβ load in 2.5 months old 5xFAD mouse model of AD.