Life’s Simple 7 cardiovascular risk score and rate of cognitive decline in preclinical dementia

We investigated whether vascular risk factors (VRFs), assessed with the Life’s Simple 7 (LS7) score, are associated with rate of cognitive decline in the preclinical dementia phase. We sought to test whether (1) poor LS7 further accelerates rate of cognitive decline in preclinical dementia or (2) the dementia process itself overshadows potential effects of LS7.