The etiology of blood‐based biomarkers for Alzheimer’s Disease in a population‐based sample of mid to late‐age males

The amyloid‐tau‐neurodegeneration (ATN) framework has led to an increased focus on Alzheimer’s disease (AD) biomarkers. The costs and invasiveness of methods relying on cerebrospinal fluid or positron emission tomography imaging have led to efforts to develop sensitive blood‐based biomarkers. Although AD is highly heritable, the biometric genetic and environmental etiology of blood‐based biomarkers has never been explored.