Genetic insights of all‐cause and vascular dementia through genome‐wide association studies

Genome‐wide association studies (GWAS) have identified more than 40 genetic loci associated with Alzheimer’s disease (AD). Although vascular dementia (VaD) is the second most common type of dementia after AD, the genetic contribution to VaD is understudied. We hypothesize that common forms of dementia will share genetic risk factors. We conducted the largest trans‐ancestral GWAS of "all‐cause dementia" (ACD), VaD, and examined the underlying biological mechanisms