Bead‐based electrochemical gap sensors for detection of tau protein in blood to diagnosis and monitoring the tauopathy

Recently, there is a need for a method for detecting biomarkers in blood that can be collected relatively easily for diagnosis and monitoring of dementia symptoms in Alzheimer's disease (AD) patients. Tau protein, a typical hallmark of AD, has six isoforms, and is divided into four repeating microtubule binding domains (4R) and three microtubule binding domains (3R) depending on whether exon 10 is included. According to the balance of 3R‐ and 4R‐tau, tauopathy can be distinguished. It is expected to be able to differentiate normal (NC) from AD and other dementias by measuring the tau protein in the blood.