Malignancy risk in kidney transplant recipients exposed to immunosuppression pre-transplant for the treatment of glomerulonephritis


 
 
 Kidney transplant patients with glomerulonephritis (GN) as their native disease may receive significant amounts of pre-transplant immunosuppression (PTI), which could increase the risk for development of malignancy post-transplant.
 
 
 
 We conducted a single-center, retrospective study of kidney transplant recipients from January 2005 until May 2020. Patients with GN as their native kidney disease who received PTI for treatment of GN (n = 184) were compared to a control cohort (n = 579) of non-diabetic, non-PTI receiving kidney transplant patients. We calculated hazard ratios (HR) with 95% confidence intervals (95%CI) for outcomes of first occurrence of solid or hematologic malignancy, non-melanoma skin cancer (NMSC) and post-transplant lymphoproliferative disorder (PTLD).
 
 
 
 Over median follow-up of 5.7 years, PTI for GN was associated with significantly increased risk for malignancy compared to controls (13.0% vs 9.7% respectively, adjusted HR 1.82 [95%CI 1.10-3.00]), but not for NMSC (10.3% vs 11.4% respectively, adjusted HR 1.09 [95%CI 0.64-1.83]) nor PTLD (3.3% vs 3.1% respectively, adjusted HR 1.02 [95%CI 0.40-2.61]). The risk for malignancy was significantly increased in those who received cyclophosphamide (HR 2.59 [95%CI 1.48-4.55]) or rituximab (HR 3.82 [95%CI 1.69-8.65]) pre-transplant, and particularly in those who received both cyclophosphamide and rituximab, but not for calcineurin inhibitors nor mycophenolate.
 
 
 
 The use of PTI for treatment of GN, especially cyclophosphamide or even with rituximab, is associated with increased risk for development of solid or hematologic malignancy post-transplant. These data highlight potential risks with treatment of GN and underscore the importance of post-transplant malignancy surveillance in this patient population.
