Synthesis of Multi-Substituted 4,5-Dihydrofurans: Microwave Assisted Reaction of
β-Ketonitriles, Aldehydes and Pyridinium Phenacyl Salts via [1+1+3]
Knoevenagel-Michael-Oxa-Michael Cyclization Triple Cascade Sequence

A microwave assisted protocol for the development of fully substituted dihydrofurans has been explained
as a three component triple cascade reaction between pyridinium ylide, phenacyl nitriles and aldehydes.
This [1+1+3] annulation protocol produced the dihydrofurans having two stereocentres. A total of 14
molecules have been synthesized with high chemical yields.