Clinical Virology and Effect of Vaccination and Monoclonal Antibodies against SARS-CoV-2 Omicron Sub variant BF.7 (BA.5.2.1.7) : A systematic review

Since its identification in late 2019 the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) In Wuhan, China, by the World Health Organization (WHO), which cause the coronavirus disease 2019, it is rapidly spreading, resulting in the global pandemic. As of 19 December 2022, more than 64 million confirmed cases and 6,645,812 deaths have been reported across the world. Over time, the SARS-CoV-2 acquired genetic mutations resulting in multiple types of SARS-CoV-2 variants and subvariants that have been confirmed. The Omicron (B.1.1.529) variant was identified later in November 2021, with enhanced immune escape and was followed with various sublineages due to mutations in the spike protein of the SARS-CoV-2. However, rapid resurge in COVID-19 reports by Omicron subvariant BF.7(BA.2.75.2) in China and other countries, alarming global threat. The present systematic review was conducted using "Omicron" AND "BA.5.2.1.7" OR "BF.7" in Pub Med, Google Scholar and MedRXiv database and grey literature from the authentic database and websites . We have identified a total of 14 published studies. We have reviewed all the eligible available studies to understand the viral mutations, factors associated with increase in the reports of COVID-19 cases in china and across the world and to evaluate the effectiveness of vaccination and monoclonal antibodies against BF.7 variant