Plasma biomarkers contribution to the structural alteration of perivascular spaces in Alzheimer’s disease

Perivascular spaces (PVSs) are fluid‐filled spaces in the brain surrounding blood vessels. Their function is to facilitate the cerebrospinal fluid (CSF) drainage between the interstitial space and the blood vessel space, allowing the outflow of waste soluble proteins in the brain. Aging leads to the increase of PVS number and volume, especially in basal ganglia and centrum semiovale. Stress was found to alter the cerebral flow of metabolites in the brain and to accelerate Aβ accumulation. High level of cortisol causes hypertension, contributing to increase of blood pressure. Angiotensin‐II raises arterial blood pressure quickly, and its production is associated to levels of Angiotensin‐converting enzyme (ACE). This study objective is to investigate the relationship between plasma biomarkers and the PVS volume fraction, and their effect on cognitive impairment process.