Whole brain MRI‐free tau and amyloid PET quantification

The growing use of PET imaging in Alzheimer’s research and clinical practice has resulted in the need for PET quantification when an MRI is unavailable or contraindicated. The Desikan‐Killiany (DK) atlas in Freesurfer (FS) is often used in conjunction with a native space MRI to define regions of interest for tau and amyloid PET quantification. Here we developed a template‐space DK atlas for use in MRI‐free amyloid & tau quantification, and validated the performance of the template using MRI‐free florbetapir and flortaucipir SUVrs in relation to our gold standard native space SUVrs.