Handmade cloning: a developing alternative to traditional SCNT cloning methods

Handmade Cloning (HMC) is a method of somatic cell nuclear transfer (SCNT) that eliminates the need for micromanipulators, making it a novel revolution in embryology. Not only is it cheaper than its predecessor, traditional cloning that uses micromanipulators, but it is also more efficient in terms of birth rate and economic expenditures. Given that the technology is relatively recent, variations in HMC procedure and method have been explored in different species and experiments; these modifications generally have a positive effect on HMC efficiency in such experiments. In recent years, the increasing number of research in HMC generally fall into two categories: first, the factors that contribute to HMC’s improved efficiency. Two, HMC’s possible usage in genealogy and transgene integration. Hence, this review will highlight and summarize the factors that contribute to HMC efficiency, the issues and setbacks that obstruct HMC development, as well as a glimpse into the future of HMC.