Hippocampal grading is sensitive to changes in cognition in early MCI

Increased age and cognitive decline are both associated with changes in the hippocampus. These associations are often measured using hippocampal volume measurements and changes in episodic memory. Some studies have also observed a relationship between hippocampal volume and global cognition. However, these studies often only find associations in progressed stages of cognitive decline. This study examined (1) if hippocampal grading is associated with global cognition in cognitively normal controls (NC), early MCI (eMCI), late (lMCI), and Alzheimer’s disease (AD), and (2) whether these associations differ across diagnostic cohorts.