Synggen: fast and data-driven generation of synthetic heterogeneous NGS cancer data


 
 
 Whole-exome and targeted sequencing are widely utilized both in translational cancer genomics and in the setting of precision medicine. The benchmarking of computational methods and tools that are in continuous development is fundamental for the correct interpretation of somatic genomic profiling results. To this aim we developed synggen, a tool for the fast generation of large-scale realistic and heterogeneous cancer sequencing synthetic datasets which enables the incorporation of phased germline SNPs and complex allele-specific somatic genomic events. Synggen performances and effectiveness in generating synthetic cancer data is shown across different scenarios and considering different platforms with distinct characteristics.
 
 
 
 synggen is freely available at https://bitbucket.org/CibioBCG/synggen/
 
 
 
 Supplementary data are available at Bioinformatics online.
