Advanced diffusion‐weighted MRI sensitively detects age and sex effects in 34,423 adults

Aging and Alzheimer’s disease (AD) are associated with alterations in the brain’s white matter (WM) microstructure. AD also exhibits significant sex differences and, similar to age, sex has also been associated with WM microstructural variability. A comprehensive characterization of how aging and sex impact WM microstructure may thus improve our understanding of processes involved in AD. Here we examined age and sex effects on traditional and advanced measures of WM microstructure in middle‐ to older‐aged adults.