Prevalence and clinical associations of atrophy subtypes using clinical routine image analysis software in MCI patients from a memory clinic population

Three patterns of brain atrophy have been consistently identified in cases of Alzheimer’s dementia [1]: a limbic‐predominant (LP) phenotype, with atrophy of the hippocampus but relatively spared neocortex; a hippocampal sparing (HS) phenotype, with atrophy in the cortex (especially lateral temporal and parietal lobes) but sparing of the hippocampus; and a typical/diffuse (TD) phenotype that presents with atrophy in both. A recent study extended this concept to a less severely affected memory clinic population (the MEMENTO Study). Here, we assessed atrophy subtypes in that same population using an approach based on the output of QyScore® an FDA‐approved and CE‐marked image analysis software.