Hippocampal inflammation is associated with vascular dysfunction in middle aged Non‐Latinx Black APOE‐ε4 carriers

Neuroinflammation may be associated with global vascular dysfunction and damage. APOE‐ε4, a major genetic risk factor for late onset AD, is expressed in neuroinflammatory cells and may lead to increased pro‐inflammatory cytokine and nitric oxide production in response to injury. We examined the relationship of vascular dysfunction and damage with a magnetic resonance spectroscopy (MRS) marker of neuroinflammation in APOE‐ε4 carriers and non‐carriers.