Tau PET shows both direct and atrophy‐mediated effects on cognition: 4‐way decomposition of the effects of tau PET and atrophy on cognitive performance

Evidence suggests that tau pathology predicts subsequent neurodegeneration and that atrophy is associated with cognitive impairment. However, in vivo studies have shown that structural measures only partially mediate tau‐cognition relationships, with direct effects of tau on cognition remaining. The objective of current study is to decompose the overall effect of tau on domain‐specific cognitive performance, in the presence of atrophy as a mediator with which tau may interact.