Blood plasma profiles of neuropsychiatric symptoms in older people

Neuropsychiatric symptoms (NPS) in older people worsen the patients’ and caregivers’ quality of life and are associated with cognitive decline. A better understanding of the biology underlying NPS may lead to novel ways for early detection and more targeted treatment. This study tested the hypothesis that NPS are associated with altered protein levels in blood plasma and these proteins improve prediction of NPS in a memory clinic setting. Additionally, we explored the association of the protein patterns with persistent NPS and cognitive decline.