Multiparity and brain‐age interact with amyloid aggregation to determine cognitive performance in cognitively unimpaired middle‐aged women

How pregnancy influences women's brain aging later in life remains controversial. Whereas multiparity has been associated with decelerated brain aging, it has been also identified as a risk factor for Alzheimer’s disease (AD). However, the impact of of childbirths on cognitive performance in women at higher risk of developing AD is underresearched. We investigated whether the association between multiparity, brain‐age and amyloid (Aβ) aggregation contributes to cognitive performance in cognitively unimpaired (CU) middle‐aged women.