Translational potential of JAX humanized APOE mice: trajectories of resilient versus susceptible aging by sex and weight

Aging, chromosomal sex, and genetic risk factors interact to determine the trajectory of an individual’s age‐related biological changes and, in turn, may predispose individual risk or resilience to AD. To advance translational validity of the JAX humanized APOE (hAPOE) mouse model, we investigated whether a well‐documented preclinical AD symptom, inexplicable weight loss, was evident in our hAPOE mouse colony. Further we determined whether this hallmark symptom could be used to detect subpopulations of vulnerable vs resilient.