Associations between ALOX5 and ALOX5AP Genetic Polymorphisms and Cognitive Performance in Patients with Alzheimer’s Dementia and Mild Cognitive Impairment

Leukotriene activity may contribute to cognitive deficits in Alzheimer’s disease (AD). Leukotrienes are synthesized by 5‐lipoxygenase (5‐LOX) and its activating protein (FLAP), encoded by ALOX5 and ALOX5AP, respectively. This cross‐sectional study investigated the associations of ALOX5 and ALOX5AP single nucleotide polymorphisms (SNPs) with cognitive performance in patients with AD or mild cognitive impairment (MCI).