Abstract IA027: Recent advances in the study of extracellular vesicles and nanoparticles in colorectal cancer


 Extracellular vesicles (EVs) and nanoparticles (NPs) are increasingly recognized as important mediators of intercellular communication with implications for the diagnosis, monitoring and possibly treatment of colorectal cancer. We recently reviewed this topic in Gastroenterology. EVs are lipid bilayer-enclosed vesicles that can be classified as small (s) some of which are tetraspanin-containing, endosomally-derived exosomes (5-120 nm) and large that include plasma membrane-budding microvescles (150-800 nm). Nanoparticles are more recently discovered smaller amembranous nanoparticles that include exomeres (30-50 nm) and supermeres (25-35 nm). We have performed a comprehensive proteomic and RNA analysis of sEVs, exomeres and supermeres. Highlights from this analysis will be presented with a focus on their clinical relevance and the merits of parsing versus pooling biofluid fractions.
 Citation Format: Robert J. Coffey. Recent advances in the study of extracellular vesicles and nanoparticles in colorectal cancer [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer; 2022 Oct 1-4; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_1):Abstract nr IA027.