Variability Independent of Mean Blood Pressure as an Electronic health record‐based Measure of Dementia Risk

The risk of developing Alzheimer’s Disease and Related Dementias (ADRD) is associated with visit‐to‐visit blood pressure (BP) variability, including variability independent of the mean (VIM).1,2 The association between ADRD and VIM has primarily been evaluated using standardized BP measurements from clinical trials and cohorts, rather than utilizing measurements from clinical practice, potentially limiting generalizability to the real‐world context. As such, we sought to evaluate the relationship between ADRD and BP VIM utilizing real‐world data collected from the electronic health record (EHR).