Abstract 124: Correlation of serum cortisol withserum adiponectin and biochemical parameters in patients of secondary adrenal insufficiency

Introduction: Recent studies have shown an association between adrenal insufficiency (AI) and increased cardiovascular risk (CVR). However, there is no information on whether secondary adrenal insufficiency (SAI) is associated with the increased risk of cardiovascular disease. Aims and Objective: The aim of the current study was to estimate thecorrelation of serum cortisol with serum adiponectin and metabolic parameters in patients of secondary adrenal insufficiency. Material and Methods: Total 40 patientswere recruited. Patient diagnosed to have Secondary Adrenal Insufficiency (hypocortisolemia) confirmed with ITT will be included and relevant history, baseline clinical data, anthropometry, blood investigations like CBC, FPG, 2 hr PPG, LFT, RFT, HbA1c, fasting lipid profile, thyroid function test, serum adiponectin will be collected. Results: Of total patients, 35% were male, 65% were female with mean age of 45 year, BMI 22.6 kg/m2. 30% Patient had secondary adrenal insufficiency. The relationship between serum cortisol levels during the ITT and each of TG, LDL-C, HDL-C, and serum adiponectin levels was determined by the calculation of the Pearson correlation coefficient Conclusion: Peak cortisol levels correlated significantly with serum adiponectin levels and serum HDL levels. There were no differences in TG and LDL-C levels between the two groups