Longitudinal tau accumulation interacts with cortical thinning to predict steeper memory decline in cognitively normal older adults

Cross‐sectional measures of tau pathology, a hallmark of Alzheimer’s disease (AD), have been associated with brain structure and memory performance in cognitively normal older adults (OA). Fewer studies have explored the downstream effects of longitudinal tau accumulation in OA. Here, we investigated relationships between tau accumulation, atrophy, and memory performance change over time.