PULSATILE DRUG DELIVERY SYSTEM: A REVIEW

Pulsatile Drug Delivery Systems (PDDS) are gaining a lot of interest as the delivery of the drug will be at the right site and at the right time, and the amount of drug that is reaching the site of action will also be so accurate, and therefore it generally improves the patient compliance. These followed a sigmoidal drug release profile and were characterized by a time of no drug release followed by a rapid and complete drug release. This article focuses on the various types of methodologies involved for the existing system and different marketed technologies, including PulsincapTM, OROS, DIFFUCAPS, CODAS®, TIMERx®, and CONTIN®, which follow the above mechanism to render a sigmoidal drug release profile, diseases requiring pulsatile drug delivery system, need for PDDS and evaluation of PDDS.