POLYDIPSIA COMPLICATED TO SEVERE HYPONATREMIA IN SCHIZOPHRENIA. CASE REPORT

Over the years the comprehension of homeostatic regulation of fluid intake became more complex due to the interconnections between psychopathology, neurobiology and endocrinology. Primary polydipsia (PP) is usually defined as a condition with excess consumption of fluids leading to polyuria with diluted urine and hyponatremia. This clinical case concerns a middle-aged woman suffering from simple schizophrenia and demonstrates a diagnostically complicated combination of psychosis, polydipsia with severe hyponatremia, abnormal endocrinological indicators and resistance to antipsychotic treatment. This case highlighted PP management challenges arising from treatment-resistant schizophrenia, underlining the need for more specific PP treatment options, thus further high-quality research.