789 USEFULNESS OF NEUTROPHIL-TO-LIMPHOCYTE RATIO AS A PROGNOSTIC BIOMARKER FOR IN-HOSPITAL COMPLICATIONS AND LONG-TERM MORTALITY IN OLDEST OLD STEMI PATIENTS


 
 
 the neutrophil to lymphocyte ratio (NLR) is an indicator of systemic inflammation and a prognostic marker in patients undergoing percutaneous coronary intervention (PCI) that has been demonstrated to be related to in-hospital complications and long-term mortality in patients with ST segment elevation myocardial infarction (STEMI).
 
 
 
 to assess the correlation between NLR and in-hospital complications and mortality, as well as long-term mortality in a population of oldest old (i.e. >85 years old) STEMI patients.
 
 
 
 we enrolled every oldest old patient admitted in two Hub hospitals with a diagnosis of STEMI who underwent an invasive strategy (coronary angiography ± percutaneous coronary intervention) between January 2010 and June 2021. Blood samples were performed at the first medical contact (in the emergency room or in the cath-lab according to presentation). Follow-up data were collected with phone calls or with revision of computer registries. In-hospital MACCE was defined as a composite of death, heart failure, in-stent thrombosis, relapsing angina, stroke, BARC 3 to 5 bleedings during hospital stay.
 
 
 
 four hundred fifty-eight patients accessed the Hub hospitals for STEMI during the selected period. Among them, 355 patients were eligible for this analysis. One hundred fifty-five patients (44%) experienced an in-hospital MACCE. Patients with in-hospital MACCE had a significantly higher NLR at baseline (10,2±7,4 vs 7,0±4,7 p<0,001), this was also true when in-hospital mortality was considered per se (11,1±8,3 vs 8,0±5,8 p=0,002).
 
 
 
 in our multicentre registry of oldest old STEMI patients, NLR has demonstrated to be an easy access, useful tool to predict in-hospital MACCE and in-hospital mortality.
