Deep plasma proteomics reveal age‐related molecular pathways modulated by GRF6019 treatment in Alzheimer’s disease patients

Blood has been widely investigated to discover biomarkers and gain insights into the biology of aging and age‐related diseases. Its protein composition provides information about complex biological processes, as proteins are often direct regulators of cellular pathways. Using recent methodological developments allowing the measurement of thousands of proteins with very high sensitivity and specificity, we sought to understand comprehensive proteomic changes in two AD clinical trials.