Distributions of amino acids in the primary structure of monoamine oxidase family

In a protein primary structure, a type of amino acids is usually clustered together rather than homogenously distributes. What advantage of such distribution and how to measure different distributions are rarely addressed. In the current communication, we apply the distribution probability to investigate the mutations/variants from monoamine oxidases A and B. The results reveal the rationale of clustering distribution of amino acids in the full-length sequence and in functional regions of the monoamine oxidases, and how the mutations/variants affect the distribution probability. Thus, we can quantitatively measure and compare not only the amino-acid distributions across different monoamine oxidases, but also the effect of mutations/variants on the enzymatic function.