ythdf2(ch200) and its role in development of the early zebrafish embryo

We appreciate the well-presented data and focus on mechanism in the paper titled, “Ythdf m6A Readers Function Redundantly during Zebrafish Development” by Kontur et al. December 29, 20201 [DOI: https://doi.org/10.1016/j.celrep.2020.108598]. However, we would like to suggest several alternative conclusions regarding the role of Ythdf2 in maternal RNA clearance and the phenotypic consequences of the ythdf2(ch200) mutation as described in Zhao et al. 2017, “m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition”2 [DOI: https://doi.org/10.1038/nature21355], along with caveats regarding the interpretation of Ythdf2’s roles in mRNA metabolism in the early embryo.