Drug Eruptions: A Challenge for Dermatologists and First Contact Physicians

Adverse drug reactions are quite frequent in current medical practice, being the skin manifestations the most commonly observed, and although they generally have a benign and self-limiting evolution, but in exceptional cases they can be serious and even fatal. The priority in the evaluation of toxicoderma is established in the identification and distinction of severe skin adverse reactions, the so-called SCAR, among which include Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome/drug reaction with the presence of eosinophilia and systemic symptoms (DISH-DRESS), to which should be added acute generalized exanthematous pustulosis (AGEP). Unfortunately, however, our current knowledge does not allow us to determine the true incidence of these reactions, to establish the diagnosis and its causal relationship with certainty, or even to be able to anticipate its appearance.