Effect of regular statin intake on the development of cardiovascular events in the acute period of COVID-19 and within three months after discharge from the infectious diseases hospital. Part II. Analysis of patients discharged from the infectious diseases hospital

Introduction. Currently, there is evidence of a beneficial effect of statins among patients in the acute period of COVID-19. Much less is known about the effect of taking statins on the health of patients in the immediate period after recovery from COVID-19, especially in patients with concomitant cardiological pathology.The aim of the study was to evaluate the relationship of regular statin intake with the development of cardiovascular events in discharged patients with cardiovascular pathology during the acute period of COVID-19 and within 3 months after discharge from the infectious diseases hospital.Materials and methods A retrospective, cohort, observational study of patients who have had COVID-19 and have a history (before COVID-19) of cardiovascular pathologies, in which regular intake of hypolipidemic drugs is indicated, was conducted. Telephone and face-to-face visits were conducted with patients discharged from the infectious diseases hospital after 3 months.Results During the first three months after discharge from the infectious diseases hospital, 9 (21,95 %) new cardiovascular events were registered in patients not taking statins. In the subgroup of patients taking statins, 1 (3,03 %) cardiovascular event was registered. The chances of developing cardiovascular events in patients in the subgroup of patients not taking statins were 9 times higher than with regular administration (OR 0,11; 95% CI: 0,01–0,92), p = 0,036.Discussion The positive effect of taking statins observed in discharged patients after COVID-19 may be due to their additional pleiotropic effects.Conclusion The use of statins in patients with cardiovascular pathology was associated with a significant decrease in cardiovascular events within 3 months after discharge from the infectious diseases hospital.