The impact of individual vascular risk factors on longitudinal neurodegeneration in cognitively unimpaired individuals

Vascular risk factors (VRFs) have an important role in the etiology and progression of Alzheimer´s Disease (AD). We recently described that VRF burden interacts with AD pathophysiology increasing plasma neurofilament light (NfL) levels, a biomarker of neuroaxonal damage. However, whether individual VRFs interact with AD pathophysiology to promote longitudinal neurodegeneration remains to be elucidated. Here, we aimed to assess the impact of individual VRFs in the longitudinal trajectory of plasma NfL in cognitively unimpaired (CU) individuals.