Capturing DNA methylation heterogeneity and examining its relationship to somatic mutations in Alzheimer’s disease

One of the barriers to the identification of molecular targets in Alzheimer’s disease (AD) is its biological heterogeneity. However, computational approaches used to quantify heterogeneity in cohorts can be improved to produce more nuanced output. We develop novel and refine existing statistical methods to capture molecular heterogeneity and examine it on multiple ‐omic levels in the context of AD.