Functional Interpretation of Alzheimer’s Disease Genetic Risk and Systematic Gene Prioritization

Genome‐wide association studies (GWAS) of Alzheimer’s disease (AD) risk identified over 100 genome‐wide significant susceptibility loci in the past 15 years, but remaining challenges include resolving the mechanism of action of how these associations functionally contribute to AD risk and prioritizing the candidate risk genes in the complex risk loci. To address these, we have recently developed a systematic gene prioritization pipeline that nominated highly likely candidate risk genes within the majority of 42 new loci identified by our recent AD GWAS meta‐analysis. In this subsequent work, we investigated the complete landscape of AD risk‐associated molecular phenotypes and further extended our analyses to known AD risk loci and subthreshold significant loci.