1,2,3-Triazoles containing Thiazole-Piperazine Moieties:
Synthesis, Biological Assessment and Molecular Docking

A novel series of thiazole-triazole-piperazine multi hybrids was designed for antimicrobial activity
and the synthetic method for this series has been developed by copper catalyzed 1,3-dipolar
cycloaddition of thiazole-based azide with Boc-piperidine based alkyne in the presence of CuSO4 and
sodium ascorbate. Boc deprotection followed by alkylation of piperidine moiety in hybrid derivatives
was also carried out. All the target compounds were confirmed using FTIR, 1H NMR, 13C NMR and
LC-MS spectral techniques. These compounds were screened for the antimicrobial activity against
bacteria and fungi. The antimicrobial activities are also comparable to standard drugs ampicillin and
clotrimazole. All the molecules showed good to moderate activity and supported by molecular docking
studies and ADME prediction.