Plasma Biomarkers of Neurodegeneration and Tau in Relation to Longitudinal Depressive Symptoms in Older Adults: Findings from the Harvard Aging Brain Study

Depressive symptoms are common in late life and Alzheimer’s Disease (AD) but the underlying neurobiology of these symptoms and their relationships to AD biomarkers is unclear. Probing these relationships using biomarkers of neurodegeneration and tau that can be measured via plasma can importantly guide AD prognosis and treatment. The current study determined the relationships between baseline measures of neurofilament light (NfL) (a marker of neurodegeneration) and an N‐terminal fragment of tau (NT1, an early and specific marker of AD) and longitudinal depressive symptoms in a cohort of older adults.