Blood protein kinase activity regulating genes are associated with brain glucose metabolism

The diagnosis of Alzheimer’s disease (AD) has been greatly improved due to the fundamental role of positron emission tomography (PET) imaging. Also, predicting PET brain imaging alterations using blood‐based biomarkers is of high interest. This way, integrating PET and omics data can provide new insights into AD pathophysiology. Here, we aimed to develop a framework that combines blood transcriptomics with PET data. We hypothesized that integrating omics and PET data will help advance our understanding of AD neurobiology and may reveal relevant new peripheral biomarkers.