Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review

Objective: To estimate the acute analgesic efficacy of combined Pregabalin and Celecoxib after operation via a systematic review and meta-analysis. Methods: Studies for inclusion were randomized controlled trials, reporting on relevant outcomes (0–6 hours, 24 hours, 7 days pain scores) with treatment with combined Pregabalin and Celecoxib. Results: The pooled results from meta-analysis demonstrated that compared with placebo, combined Pregabalin and Celecoxib reduced pain scores at 0 to 6 hours in 3 articles, 24 hours in 5 articles, 7 days in 2 articles (standard mean difference [SMD], −3.10 at 0–6 hours, −2.80 at 24 hours, −1.32 at 7 days, respectively). Combined Pregabalin and Celecoxib could significantly reduce the postoperative narcotic consumption in 3 studies (SMD, −1.99 at 36 hour). Discussion: This work suggested that combined Pregabalin and Celecoxib were efficacious in reduction of postoperative pain and narcotic requirements after surgery, whereas more trials are needed to further identify the efficacy of combined Pregabalin and Celecoxib in the management of acute postoperative pain.