Comparison of lipidomic profiling and spatial distribution in brain of a genetic mouse model of Alzheimer’s disease using DESI Imaging Mass Spectrometry: regional lipid dyshomeostasis in AD.

Alzheimer’s disease (AD) is one of the biggest health challenges worldwide. It is culpable for millions of deaths annually, the annual associated costs reach many billions, and these trends are expected to increase dramatically over the next decades. Yet, the underlying cause of AD is not yet understood and therefore no effective treatment is available to date.