Menopause age and hormone therapy use moderate PET tau and amyloid association: findings from the Wisconsin Registry for Alzheimer Prevention

Sex differences in tau deposition are apparent in clinically normal older adults. Abnormal β‐amyloid (Aβ) may strengthen this association between sex and tau. Whether hormone therapy (HT) and menopause influence this higher tau retention in women and whether this is contingent upon levels of Aβ burden is unclear. We examined differences in the cross‐sectional association between Aβ and regional tau deposition as a function of sex, HT‐exposure and age‐at‐menopause.