Hippocampal metabolism in preclinical Alzheimer’s disease

Hippocampal metabolism has been variably reported to be decreased in Alzheimer’s disease (AD), and is less well studied during preclinical stages of AD. Since AD is associated with significant hippocampal atrophy, careful segmentation and partial volume correction methods are necessary. Here we performed manual segmentation of the hippocampus coupled with regional partial volume correction to estimate hippocampal glucose (rCMRGlc) and oxygen (rCMRO2) metabolism from positron emission tomography (PET) studies in cognitively normal adults with and without brain amyloid deposition.