Trajectories of cognitive performance in late middle‐aged adults: Bayesian random change point mixed model analysis in WRAP

Previous studies indicate that rates of cognitive decline in Alzheimer’s disease (AD) and other dementias may accelerate significantly as brain pathology increases. The objectives of this study included to: 1) characterize changepoints and related slope parameters across four cognitive composites in a longitudinal cohort study; and 2) examine how these parameters varied across predictors of interest.