Overlap of genetic risk for Lewy body and Alzheimer’s disease pathology

Lewy body (LB) pathology is relatively understudied compared to Alzheimer’s disease (AD) pathology, and the genetic risk overlap between the two remains unclear. Chia et al. (2021) identified five genomic loci significantly associated with LB pathology in a genome‐wide association study (GWAS) of LB dementia cases and controls (N = 6,618), where 69% of cases and 15% of controls were pathologically confirmed. Here we gathered a largely distinct set of individuals (5.1% overlap) with genetic data and postmortem assessment for both AD and LB pathology (N = 6,002) to estimate the odds ratio (OR) for risk of sole AD pathology (AD+LB−), sole LB pathology (AD−LB+), and dual AD‐LB pathology (AD+LB+) for the five variants reported by Chia et al. We compared our results for APOE to ORs reported by Tsuang et al. (2013).