Structural and metabolic brain correlates of excess Aβ accumulation at the earliest AD continuum

The discrepancy between the expected and actual level of cerebral amyloid (Aβ) deposition for any given level of soluble Alzheimer’s disease (AD) core biomarkers, has been proposed as a proxy measure of factors promoting fibrillar Aβ accumulation in the brain. However, the impact of these factors on brain structure and function in cognitively unimpaired (CU) individuals has not been reported. Here, we assessed the impact on brain structure and metabolism of the excess cortical Aβ deposition for a given level of CSF pTau/Aβ42 ratio, a marker of pathophysiological progression along the Alzheimer’s continuum. Furthermore, we analyzed whether this association is modulated by the APOE‐ε4 risk allele.