A transcriptomic signature of late‐life depression

Late‐onset Alzheimer’s disease (AD) is commonly accompanied by symptoms of depression. While genes associated with pathological AD diagnosis and mid‐life depression have been identified, the transcriptomic signature of late‐life depression has not been described. We hypothesized that neocortical gene expression would be associated with symptoms of late‐life depression proximal to death, independent of pathologic AD diagnosis and medication status.