sTREM2 affects cytokine expression profiles in THP‐1 cell model.

TREM2 is an innate immune receptor expressed on myeloid cells such as microglia and macrophages and is involved in several crucial cellular response pathways including activation and inflammation. TREM2 is cleaved from cell surface by ADAM10/17 releasing as soluble TREM2 (sTREM2) and is reported to be elevated in CSF of AD patients. The relationship between inflammation and sTREM2 remains largely uncharacterized.