Klotho Protein and Diabetes Mellitus

Diabetes mellitus (DM) is considered an epidemic disease by many countries and shown as one of the leading causes of death in western societies. In the development of the disease, the underlying pathophysiological mechanisms are complex and multifactorial. The frequency of DM increases with age, and the severity of events such as oxidative stress and inflammation increases in patients diagnosed with DM. The Klotho (KL) protein, defined as a new anti-aging protein as a result of the studies on aging mechanisms, was named after KL, who was one of the three goddesses of destiny and spun the thread of life according to Greek mythology. In this review study, the information in the literature was compiled, and the relationship between the KL protein and DM was explained.