A 1.25 MHz, 108 dB Chopped Sampling-Mixer-Based Impedance Spectroscopy SoC in 0.18-μm CMOS

This paper presents an electrochemical impedance spectroscopy (EIS) system-on-chip in 0.18-μm CMOS, achieving a wide scan frequency range of 1.25 MHz. An on-chip direct digital frequency synthesizer generates a digital sine wave as well as in-phase and quadrature-phase clocks that are synchronized to the sinewave. A chopped sampling mixer realizes lock-in detection without requiring quadrature sinewaves while suppressing low-frequency noise and offset. The receive utilizes a 12-bit pipelined SAR ADC operating in 5 MS/s in combination with a digital averaging filter to maximize the dynamic range. The measured performance shows that the prototype EIS chip achieves the highest frequency scan range with a comparable dynamic range of 108 dB and power consumption of 14 mW when compared with the previous state-of-the-art prototypes.