Multiple necrotizing skin lesions due to glatiramer asetate injection

Nicolau’s syndrome due to glatiramer acetate (GA) injection has been rarely reported. We report a 35-year-old woman with multiple sclerosis who presented with two necrotizing skin lesions due to consecutive subcutaneous GA injection. The patient was diagnosed with Nicolau’s syndrome and treated with wound care. The lesions regressed slowly with a mild scarring. We discontinued GA treatment because of the recurrence risk of skin lesions. We think the syndrome has a good prognosis with conservative treatment; however, discontinuation of GA may be necessary especially in case of multiple skin lesions.