Neurofibrillary Tangles Prediction Based On MRI

Neurofibrillary tangles, one of the hallmark pathologies of Alzheimer’s disease, are closely related to brain atrophy and cognitive decline. The purpose of this work was to develop an MRI‐based classifier of neurofibrillary tangles by combining ex‐vivo MRI and neuropathology in brain autopsies from a large number of community‐based older adults.