Differential associations of amyloid and tau (from PET) with brain volumes (from MRI) by cognitive status

Alzheimer’s disease pathology (AD) is an important cause of neurodegeneration and brain atrophy. Non‐AD mechanisms can also cause neurodegeneration alone or in conjunction with AD. Harboring combination of AD and non‐AD pathologies leads to greater cognitive impairment and dementia. Here, we examined the hypothesis that the association of amyloid and tau burden from positron emission tomography (PET) with brain volumes from magnetic resonance imaging (MRI) is weaker in those with dementia compared to those with mild cognitive impairment (MCI) or normal cognition.