Hidden intermediate activation: a concept to elucidate the reaction mechanism of the Schmittel cyclization of enyne-allenes.

The mechanistic paradigm in which the Schmittel cyclization transitions from one-step to stepwise has been investigated through the stabilization of a full hidden intermediate in the framework of the Diabatic Model of Intermediate Stabilization. Hidden intermediate activation was studied in silico employing quasi-classical trajectories and the Electron Localization Function. The stabilization of hidden intermediates achieved by substituting enyne-allenes with cyano and nitro groups generates the appearance of a partially hidden and an explicit intermediate, leading to one-step asynchronous biradical and stepwise biradical/zwitterionic mechanisms, respectively. The mechanistic feature associated with the activation level of the hidden intermediate arises from the Thornton effect and non-RRKM dynamics, where in the case of the CN-substituted system, despite having a single transition state, 54% of the effective trajectories remain in the intermediate zone after 540 fs, indicating that a mixture of mechanisms is observed.