Cholinergic Hub Vulnerability in Typical and Atypical Alzheimer’s Disease Presentations

The nucleus basalis of Meynert (nbM) is a critical hub that supplies cholinergic input throughout the cortex. Prior to even entorhinal cortex involvement, the nbM is observed to be vulnerable to tau pathology. Neuropathologic and neuroimaging studies provide strong evidence suggesting evaluation of nbM volume may be highly informative as an early biomarker of Alzheimer’s disease.