Effectiveness And Safety Of Tofacitinib In The Management Of Ulcerative Colitis: A Brazilian Observational Multicentric Study


 
 
 Ulcerative colitis (UC) is a chronic inflammatory bowel disease which affects the colorectal mucosa with a relapsing–remitting pattern. The therapeutic options currently available for the medical management of UC include many options. Tofacitinib is an oral small molecule, JAK inhibitor, more selective for JAK 1 and JAK 3, which reduces the inflammatory process involved in the pathogenesis of UC.
 
 
 
 Retrospective observational multicentric study of patients with ulcerative colitis (UC) who used tofacitinib in any phase of their treatment. Clinical remission and response (according to Mayo Score), mucosal healing, primary and secondary loss of response, discontinuation of the drug with possible causes, and the need for dose optimization or switching to biologicals, need for surgery and adverse events were evaluated.
 
 
 
 From a total of 56 included patients, clinical remission was observed in 43.6% at week 12, 54.5% at week 26, 57.9% at week 52 and 40% at the last follow-up visit. Clinical response was observed in 71.4%, 81.8%, 89.5% and 61.8% at the same time periods, respectively. Mucosal healing rates were 50% and 17,8% needed colectomy.
 
 
 
 Tofacitinib was effective in induction and maintenance of clinical response and remission rates, compatible to other international real-word studies and meta-analyses.
