Increased pro‐inflammatory plasma markers are associated with a longitudinal decrease in left hippocampal volumes in MCI patients

Apart from amyloid and tau, neuroinflammation plays a significant role in the Alzheimer’s disease (AD) pathogenesis. However, the role of blood bound pro‐inflammatory cytokines on neurodegeneration is still being debated. It is theorised that the activation of inflammation‐associated microglia in the CNS can oscillate through AD’s course, showing elevations in the early stages of AD progression [1]. This study aimed to establish the relationship between the presence of pro‐inflammatory markers and hippocampal volumes, in individuals with an AD diagnosis, late mild cognitive impairment (LMCI) and a cognitively normal control.