The cross‐sectional association between APOE ε4 and cognition in midlife: Baseline data analysis of the Physical Activity and Alzheimer’s Disease study ‐ II

Carrying at least one ε4 allele of Apolipoprotein E (APOE ε4) is a strong genetic risk factor for cognitive decline in late life. However, how APOE ε4 is associated with cognition in midlife (to what extent and in which domains) remains unspecified. We investigated the association between APOE ε4 carrier status and various domains of memory and executive function in healthy, sedentary adults in midlife.