HIVEP3 variant is associated with increased amyloid deposition and lower hippocampal volume in cognitively unimpaired subjects.

A GWAS performed in a Canadian cohort identified, for the first time, the polymorphism rs10493098 C in the HIVEP3 gene to be associated with increased risk for late‐onset Alzheimer’s disease (AD). HIVEP3 is a transcription factor that regulates inflammatory response, neuroregeneration, cell growth and apoptosis. In this project, we examined three different population cohorts (PREVENT‐AD, ROSMAP and ADNI cohorts) to investigate the role of the rs10493098 C polymorphism in the pathophysiology of AD.