Short antibiotic treatment followed by regular administration of acid suppressant (proton pump inhibitor) reduce AB42 load in the brain and in the gut.

Fecal microbiota transplantation (FMT) from healthy mice, microbiota depletion with antibiotic treatment (ABT) or with germ free mice have been associated with a reduction of cerebral amyloid load in Alzheimer’s disease (AD) mice models, indicating that the gut microbiota can modulate amyloid load in the brain. Interestingly, amyloid can also deposit in the gut, particularly within proximity to vasculature, nerves, and nerve plexuses. Additionally, acid suppressant drug such as proton pump inhibitors (PPI) have been shown to modify the gut microbial population. Here we postulate that ABT+PPI could modulate the gut microbiota and amyloid load in the gut and in the brain.