MIND diet associated with less hippocampal sclerosis: A Community‐Based Neuropathologic Study

Mediterranean‐DASH Intervention for Neurodegenerative Delay (MIND) diet is associated with slower cognitive decline, reduced Alzheimer’s dementia risk, and greater brain volume. We have also shown MIND diet is associated with less Alzheimer’s disease (AD) pathology. Hippocampal sclerosis (HS, severe neuronal loss and astrogliosis in CA1/subiculum), is increasingly recognized as an important pathologic finding associated with TDP‐43 (“LATE‐NC), AD pathology, and dementia. The pathogenesis of HS is not clear but may be neurodegenerative and/or vascular. This study investigates the association of the MIND diet with hippocampal sclerosis in autopsied brains from a community sample.