Modulating T cell inflammation in a mouse model of Alzheimer’s disease

Recent single cell transcriptomic studies using peripheral blood and post‐mortem brain samples from Alzheimer’s disease (AD) patients have suggested a significant role for T cells in modulating AD‐related neuroinflammation. Previous findings from our group and others show that T cells in AD patients and aged individuals are clonally expanded and upregulate genes related to inflammation, cytotoxicity, and senescence. We have found that TSC22D3, a putative anti‐inflammatory transcription factor, is upregulated in brain‐infiltrating CD8+ T cells and found in gene co‐expression modules in peripheral blood from AD patients.