Synthesis, Characterization, and PASSS Inet Prediction of New Polyesters

The interfacial polycondensation of indazole monomers 3 and 4 with various aromatic and aliphatic acid chlorides, including isophthaloyl-, terephthaloyl-, adipoyl-, and sebacoyl chloride, gave polyesters 5a-d and 6a-d containing an indazole moiety. The generated polyesters were categorized using elemental analysis, IR, H-NMR, and MS spectra; XRD and Thermal Gravimetry analysis (TGA) examinations. Prediction of inflammatory biological behavior of selected polyesters using PASS Inet at Pa < 0.70, giving a high probability of anti-Gluconate 2-dehydrogenase (acceptor) inhibitor.