Factors Associated to Progression of Hippocampal Sclerosis: Contribution of a New Staging System

Hippocampal sclerosis (HS) is a neuropathological condition with 5% to 30% of prevalence in the elderly (Nelson et al., 2013). HS is mostly associated with TDP‐43 proteinopathy, limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) (Nelson et al., 2019), and usually coexists with other neurodegenerative disorders like Alzheimer´s (AD) and Lewy body disease (LBD). LATE is a progressive pathology that may combine with HS (LATE_HS+) in its advanced phases. We have developed a staging scheme for HS with a high correlation with TDP‐43 staging. Here we analyze the contribution of this classification system to understand the progression of HS in the context of focal TDP‐43 pathology in the medial temporal lobe (MTL).