Serum metabolites associate with biofluid neurofilament light chain in Alzheimer’s disease

Neurodegeneration is one of the main components of A/T/N (amyloid/ tau/ neurodegeneration) classification. Recently, neurofilament light chain (NFL), a neuronal protein that is expressed in myelinated axons, has been increasingly recognized as a biomarker of neurodegeneration. In this study, we performed large‐scale association analysis of serum metabolites with NFL in Alzheimer’s disease.