Polygenic determinants of White Matter Hyperintensities and sex‐specific genetic profiles in the Alzheimer’s continuum

Recent genetic association studies suggested the polygenic contribution to white matter hyperintensities (WMH). The aim of this study was to provide a genetic characterization of WMH in middle‐aged cognitively unimpaired individuals at higher risk of Alzheimer’s disease (AD) by investigating whether the genetic predisposition to specific complex diseases is associated with WMH and whether these effects are sex‐specific and dependent on core AD CSF biomarker levels.