RE: Extending the vulnerability-stress model of mental disorders: three-dimensional NPSR1 × environment × coping interaction study in anxiety

to more closely approximate a normal distribution. Given the complexity of the analyses and the erratic distribution of the data points, the correct approach to obtaining a robust P-value would be to perform permutation testing, which would be trivial to undertake. According to the GWAS catalogue (https://www.ebi.ac.uk/ gwas/), which includes thousands of publications, rs324981 is not associated with any trait at genome-wide significance. It is a cause for concern that flawed candidate gene studies, such as this one, continue to be published in peer-reviewed journals.