Lower myelin content is associated with poorer gait variability in older adults with cerebral small vessel disease and mild cognitive impairment

Mobility decline is often observed in individuals with cerebral small vessel disease (cSVD). Loss of myelin in the cerebral white matter is a common feature of cSVD and could be one of the mechanisms contributing to poor mobility; however, this hypothesis remains to be tested. Using myelin water fraction (MWF), we investigated whether myelin content is associated with gait parameters in older adults with cSVD.