White matter associated microglia in Alzheimer’s disease

White matter is composed of mostly myelinated axons that connect neurons from different brain regions into functional circuits. Aging results in both grey and white matter degeneration, but the specific microglial responses to the damage is unknown. Strikingly, in Alzheimer’s disease white matter alterations occur early in the disease course. Here, we analyzed microglia responses in the white matter in aging rodents and models of Alzheimer’s disease.