Evaluating the relationship between endostatin and cognition in mild cognitive impairment (MCI), coronary artery disease (CAD), and Alzheimer’s disease (AD)

Endostatin is an endogenous angiogenesis inhibitor that can regulate pro‐and anti‐angiogenic factors, notably vascular endothelial growth factor. Research shows that endostatin levels in the brain are associated with amyloid plaque formation in Alzheimer’s disease (AD), and may contribute to AD pathogenesis. Hence, endostatin may be relevant to the broad range of cognitive impairments, namely people with mild cognitive impairment (MCI), AD, and/or coronary artery disease (CAD) who are at risk for cognitive impairment. We examine associations between serum endostatin and global cognition.