Identification of ABCA7 SNP‐by‐CpG interactions associated with cognition in older African Americans

The ABCA7 gene confers the largest genetic risk for Alzheimer’s Disease (AD) in African Americans (AA) after APOE ε4. However, the relationship between ABCA7 and cognitive function has not been thoroughly examined in AA without dementia. We investigated the effect of genetic variants and epigenetic markers in ABCA7, as well as their interaction, on cognition in older AA without dementia.