Pathological consequences of microglial derived exosome (MDEs) cargo in vivo

Exosome cargo proteins may serve as useful biomarkers for AD however very few studies have characterized the pathological consequences of exosome cargo in vivo. We determined that neuronally‐derived exosomes isolated from autopsy‐confirmed demented AD patients induced AD‐like neuropathology in the WT mouse CNS. Here, we extended our previous studies to investigate the neuropathological and behavioral consequences of plasma cargo proteins derived from microglia cells in vivo.