Quantitative amyloid‐PET measures in a memory clinic population

In clinical practice, visual assessment of amyloid‐PET images results in a binary classification (negative or positive) of amyloid status. While this approach has shown high clinical utility, the expected approval of disease‐modifying treatments warrants the need for objective amyloid burden quantification, to further support a high‐confidence diagnosis of Alzheimer’s disease (AD) and treatment decisions. We investigated two widely available quantification methods, i.e. Centiloid (CL) and z‐scores to optimize clinical use of amyloid‐PET.