Incidental Variants Associated with Pathogenesis in Dilated Cardiomyopathy

delay cohort. Of note, this specific subset showed significant overlapping with genes that had been identified from rare variant studies of schizophrenia, which were more likely to be expressed in more mature neuronal cell types during development. “I believe the most immediate implication of these findings is the reinforcement that we need to consider more neuropsychiatric and neurodevelopmental phenotypes jointly in studying genetic architecture,” says Jack M. Fu, PhD, a postdoctoral Fellow at Harvard Medical School/Broad Institute/Massachusetts General Hospital and the study’s lead author. “Clues for each individual condition might be valuable to uncovering the genetic underpinnings of another, whether they be derived from similarities or differences between phenotypes. In time, we hope to see coalescence of signals that converge onto specific cellular pathways and functions, which will be fundamental to developing therapeutic treatments or management strategies.”