Demographic features and hematological profile in patients of chronic lymphocytic leukemia in southern Punjab Pakistan.

Objective: To generate data regarding clinicohematological findings of CLL in patients of Southern Punjab Pakistan. Study Design: Descriptive Cross-sectional study. Setting: Hematology Section Pathology Department, Nishtar Medical University, Multan. Period: January 2016 to September 2019. Material & Methods: A total of 44 patients of all age groups diagnosed as CLL were enrolled. Diagnosis was made on morphology and immunohistochemistry of bone marrow trephine biopsies and cases without immunohistochemical panel were excluded from the study. Clinical features and baseline tests were evaluated in all cases. The data was analyzed using SPSS Version 23.0. Results: Out of 44 patients, majority were males (70.5%). Mean age was 51±12.6 years. B symptoms were present in 71% patients. Lymph nodes were enlarged in 44%. Splenic and hepatic enlargement was seen in 32% and 15.9% respectively. Anemia was seen in 45.5% and thrombocytopenia in 34.1%. Bone marrow was infiltrated in 100% patients and the most common pattern of infiltration was diffuse (65%). CD20 and CD5 were positive in all of the cases (100%) and CD23 in 96%. Seropositivity for both anti HCV and HBsAg was present in 2.3%. Conclusion: The clinicohematological features of CLL in our patients show some differences to the cited literature with a greater majority presenting at younger age with diffuse bone marrow involvement having lower positivity for HBsAg, anti HCV and less hepatosplenomegaly.