Improved biomarker associations using neuropsychological criteria versus ADNI criteria for diagnosis of MCI in Vietnam‐era veterans with head injury histories

Compared to conventional Petersen/Winblad criteria for mild cognitive impairment (MCI), our prior work has shown that neuropsychological or “actuarial” criteria more accurately predicts progression to dementia, and is more strongly associated with Alzheimer’s disease (AD) biomarkers and imaging profiles. However, research to date has been conducted in relatively healthy samples with few comorbidities. Given that history of traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) is common in older veteran populations, and both conditions are well‐documented risk factors for AD, we compared Jak/Bondi neuropsychological and ADNI MCI criteria to examine cross‐sectional cognitive and biomarker profiles in a well‐characterized sample of Vietnam‐era veterans with history of TBI and PTSD.