Hexahydrocurcumin protect myelin damage in Alzheimer’s disease ‐like pathology in bilateral common carotid artery occlusion

Age‐related dementia is usually found in the condition of chronic cerebral hypoperfusion (CCH) by altering the regional cerebral blood flow (rCBF) that causes neuronal damage. The white matter and hippocampal areas are the regions sensitive to CBF lowering which can change that local metabolic stress, initiate inflammatory processes and thereby neuronal cell injury that become the cognitive impairment.