How flexibility can enhance catalysis

Conformational changes are observed in many enzymes, but their role in catalysis is highly controversial. Here we present a theoretical model that illustrates how rigid catalysts can be fundamentally limited and how a conformational change induced by substrate binding can overcome this limitation, ultimately enabling barrier-free catalysis. The model is deliberately minimal, but the principles it illustrates are general and consistent with many unique features of proteins as well as with previous informal proposals to explain the superiority of enzymes over other classes of catalysts. Imple-menting the discriminative switch suggested by the model could help overcome limitations currently encountered in the design of artiﬁcial catalysts.