Associations between FDG metabolism and fMRI connectivity in the default mode network depend on Aβ status in MCI patients

Brain function can be assessed using both resting‐state functional magnetic resonance imaging (rs‐fMRI) and Fluorodeoxyglucose (FDG) PET imaging. The associations between these biomarkers and their evolution with Alzheimer’s disease (AD) are unclear. We aimed to evaluate the associations between the default mode network (DMN) connectivity and glucose metabolism in mild cognitive impairment (MCI) patients with (Aβ+) and without (Aβ‐) AD pathology.