Heat Transfer Model and Soft Sensing for Segmented Fluidized Bed Dryer

The aim of this work is to evaluate thermal behaviors and develop a soft sensor for online prediction of LOD (loss-on-drying) in the segmented fluidized bed dryer (Seg-FBD) in the ConsiGma25 line, which is regarded as the intermediate critical quality attribute for the final drug product. Preheating and drying experiments are performed and heat transfers and conductions among the Seg-FBD are evaluated based on the temperature measurements from sensors and an infrared thermal camera. A temperature distribution in dryer cells and high heat conductions in walls are found. Considerable heat transfers between the neighboring dryer cells are determined, which equal approximately 7% of the energy provided from the heated air. The cell-to-cell heat transfers are implemented into the heat transfer and drying models of the Seg-FBD. The models are calibrated successively in gPROMS Formulated Products (gFP) and the temperature and LOD errors are less than 2 °C and 0.5 wt.%, respectively. Subsequently, a soft sensor is established by combining data sources, a real-time data communication method, and the developed drying model, and it shows the capability of predicting real-time LOD, where the error of end-point LOD is within 0.5 wt.%. The work provides detailed steps and applicable tools for developing a soft sensor, and the online deployment of the soft sensor could support continuous production in the Seg-FBD by enabling visualization of process status and determination of process end point.