Association of Retinal Nerve Fiber Layer Thickness with Plasma pTau181 and Aβ42/Aβ40 ratio

The eye has been considered a ‘window to the brain’ and to several neurodegenerative brain disorders including Alzheimer’s disease (AD) that display alterations in the eye, especially the retina. Plasma levels of AD biomarkers, including pTau181 and Aβ42/Aβ40 ratio are significantly altered in AD patients. We sought to evaluate the association of peripapillary retinal nerve fiber layer (RNFL) thickness measured using optical coherence tomography (OCT) with plasma levels of pTau181 and the Aβ42/Aβ40 ratio.