Application of Electrospun Nanofiber in Wound Healing: Trends And Recent Patents Analysis

Abstract: A full-thickness open wound with loss of residual cells for regeneration does not heal spontaneously and takes a long duration for complete healing. Sometimes, this results in scarring of the skin and significant disability. A scaffold that provides a 3D framework for cell signaling, attachment, and proliferation is essential for the rapid closure of a full-thickness wound. Nowadays, the electrospun nanofiber is the most widely employed formulation in wound healing. The current study analyzed a patent trend analysis of electrospun nanofiber's application in tissue regeneration. The patent search was conducted using open-source patent databases like The Lens and Patentscope. Two hundred thirty-one patent records were found with the keywords and exported from the database for January 1, 2010, and December 31, 2021. After the initial screening, 24 patent documents were shortlisted for in-depth analysis. China, the USA, European Countries, Korea, and Australia lead this patent filing field. The top applicants are either private companies or academic institutions. The last ten years of patents were analyzed in terms of Patent-Applicant, Patent- Inventors, Patent-Owners, patent filed, published and granted. In the top ten Assignee, Marine Essence Bioscience Corp (US) topped the list. The most-recorded IPC class is A61L15/44, a subgroup of A61L15, and it is related to the chemical aspects of, or use of materials for, bandages, dressings or absorbent pads. In the end, some relevant patent was analyzed based on their citation by other patents and non-patent literature. From patent trend analysis, it was observed that the electrospun nanofiber would provide an attractive area for research in tissue regeneration. 