ADSP Functional Genomics: from gene, to function to mechanisms and targets

Genetic studies have been highly successful in identifying genetic regions associated with Alzheimer’s disease, and we are now at the exciting juncture of applying this knowledge to understanding disease mechanisms. The ability to generate and mine clinical and omicdata is advancing our understanding of neurodegeneration. The Alzheimer’s Disease Sequencing Project (ADSP) Functional Genomics Consortium (FunGen‐AD; https://adsp‐fgc.niagads.org/) aims to apply cutting‐edge genomics technologies, high‐throughput genetic screening and cutting edge disease modeling to understand the functional consequences of genetic susceptibility and resilience to Alzheimer’s Disease, and to identify genetics‐guided targets for the prevention, diagnosis, and treatment of Alzheimer’s disease and related dementias (AD/ADRD).