Identification of transcriptional signatures of cognitive resilience using single nucleus RNA sequencing

It is estimated that a third of the elderly population is not diagnosed with Alzheimer’s disease (AD) due to the absence of cognitive impairment despite carrying risk variants of AD or presenting AD pathology post‐mortem. This suggests that at‐risk individuals may carry protective mechanisms that promote resilience to cognitive impairment, however the underlying molecular processes that promote resilience remain unknown.