Formulation and Optimization of Liquisolid Compact for Enhancing Dissolution Properties of Polyphenol Stilbenoid- Resveratrol

Resveratrol is a class II drug in the Biopharmaceutics Classification System (BCS) with poor water solubility (0.03 mg/ml) and high permeability. Liquisolid system is an innovative technique used for enhancing dissolution rate and bioavailability of poorly soluble drugs. The present study demonstrated that Resveratrol loaded SNEDDS and Liquisolid compacts were successfully developed. Ten SNEDDS formulation were formulated with different ratio oil, surfactant and co-surfactant. Out of ten formulations four were selected based on dilution and self-emulsification time. Out of four formulations F4 formulation showed smaller particle size than compared with other formulations. Characterization was done for particle size, polydispersity index and zeta potential was found to be 22.03nm, 0.281 and -1.20Mv respectively. Morphology was found to in spherical shape with the size range of 10-40 nm. In-vitro studies showed that formulation F4 has better release of 90.09% compared to drug in solution of 39.62%. F4, F5, F6 and F9 formulations were selected and converted into Liquisolid compacts using adsorbents Neuslin and Fuji calin and total eight formulations were formulated and Liquisolid compacts made of formulation F4 of Neuslin was found to be better release of 93.53% compared to formulation F4 of Fuji calin. Hence from our study it showed that Neuslin showed better drug release than Fuji Calin and Neuslin can be used to improve solubility and dissolution of poorly water soluble drugs. 
Keywords: Resveratrol, Self-nanoemulsifying drug delivery systems, Liquisolid compacts, Characterization, Neuslin, Fuji calin.