Hematological Findings Associated with the Use of Licorice and Silymarin in Cisplatin-Treated Rats

The purpose of this study was to assess the effect of licorice and silymarin supplementations on some hematological parameters in cisplatin treated albino rats. A total of 72 normal male albino rats’ weight 150 -200 gm. The rats were allowed for acclimation for one week at the animal shelter. The rats were divided randomly into six groups, each with 12 rats. Group (1): normal control group and fed with commercial balanced diet. Group (2): licorice extract orally treated group for 6 weeks at a rate of 2 gm/kg body weight. Group (3): silymarin orally treated group at a rate of 100mg/kg every day for six weeks. Group (4): served as hepatotoxic group treated by injection of cisplatin (CP) intraperitoneally in a dose of 1.5 mg/kg body weight every two weeks for three weeks starting from the 4 th week of the experiment. Group (5): received licorice extract orally treated group at a rate of 2 gm/kg body weight for 6 weeks. and injected cisplatin intraperitoneally in a dose of 1.5 g/kg body weight repeated twice a week for 6 weeks starting from the 4 th week of the experiment. Group (6): received silymarin orally treated group at a rate of 100mg/kg daily for 6 weeks. and injected cisplatin intraperitoneally in a dose of 1.5 mg/kg body weight every two weeks for six weeks starting from the 4 th week of the experiment. The purpose