Partly-O-Diamond Solution-Gate Field-Effect Transistor as an Efficient Biosensor of Glucose


 Assessment of glucose concentration is vital for diagnosis and treatment of diabetes mellitus. Because of the electrochemical advantages of diamond for biosensing, we fabricated a partly-oxygen-diamond solution-gate field-effect transistor to detect glucose. Partly-O-diamond was obtained from H-diamond by ultraviolet ozone treatment. Then, 1-pyrenebutyric acid–N-hydroxy succinimide ester and glucose oxidase were modified on the diamond surface. Finally, shifts of transfer characteristics were applied to determine glucose concentration. The as-prepared biosensor exhibited a wide linear response from 10-5 to 10-1 M with high sensitivity of -53 mV/log10 (glucose concentration). In addition, this biosensor showed good repeatability and stability in multiple detections.