Predictors of Alzheimer’s disease risk in women with bilateral oophorectomy from the UK Biobank

Two‐thirds of individuals with Alzheimer’s disease (AD) are women and at age 45, the lifetime risk for AD is twice as high in women compared to men (Alzheimer’s Association, 2019). Early life events affecting 17β‐estradiol (E2) may be a mechanism behind this sex difference. Bilateral oophorectomy (BO) predicts cognitive decline, and neurodegeneration, and increased risk of AD in later life—adverse outcomes that are mitigated with E2 therapy (Gervais et al., 2020; Kantarci et al., 2018; Rocca et al., 2007; Zeydan et al., 2019). Our aim was to investigate compounding risk factors for AD in women with BO using UK Biobank data.