Cardiorespiratory fitness attenuates the deleterious effects of sleep apnea on cerebral structure, perfusion, and risk of Alzheimer’s disease in the Wisconsin Sleep Cohort study

Emerging evidence suggests that age‐related changes in cerebral structure and perfusion—hallmark features of preclinical Alzheimer’s disease (AD)—may be sensitive to vascular risk modifiers such as physical exercise and sleep quality. Here, we examine whether cardiorespiratory fitness modifies the effects of obstructive sleep apnea (OSA) on cerebral structure, perfusion, and AD risk.