Evaluation of Longitudinal [18F]GTP1 Tau Burden Metrics in the Tauriel Phase II Study

Conventional measures of tau PET longitudinal change focus on SUVR. However, a small (n=57) observational [18F]GTP1 study including a broad range of Alzheimer’s disease (AD) participants suggested tau Extent and Load could measure disease progression over 12 months with greater precision than SUVR. We assess the performance of these metrics in a larger 73‐week study in prodromal‐to‐mild AD.