Role of astrogliosis in the relationship between cerebrovascular burden and Alzheimer’s disease pathology

Cerebrovascular disease represents a common co‐pathology of Alzheimer's disease (AD) contributing to cognitive decline. While both vascular injury and AD pathology were previously linked to reactive astrocytes (astrogliosis), the interrelationship between these biomarkers remains unclear in AD. Here, we investigated potential effects of plasma glial fibrillary acidic protein (GFAP), an assumed marker of astrogliosis, on the relationship between vascular burden and AD pathology.