Preliminary study on photodynamic effect of intense pulsed light (IPL) excitation of porphyrin photosensitizer

Intense pulsed light (IPL) is an incoherent high-intensity pulsed light and early studies suggest that it might be used in photodynamic therapy (PDT). This study investigated the feasibility of using IPL combined with Hemporfin, a porphyrin-type photosensitizer. The photodynamic effects of two IPL light sources (560-1200 nm and 640-1200 nm) were determined by photobleaching of Hemporfin and Hemporfin-mediated cell killing experiments. Results showed that when combined with Hemoporfin both IPLs could generate photodynamic effects. Therefore, it is feasible to use IPL as PDT light source.