Premature aging in co‐occurring Alcohol Use Disorder and Post‐Traumatic Stress Disorder from a functional connectome perspective

Post‐Traumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD) may be associated with premature brain aging which increases the risk for Alzheimer’s Disease and Related Dementias (ADRD). While each disorder alone has been studied as a risk factor for ADRD, few studies have examined premature brain aging in co‐occurring PTSD/AUD. It is important to know whether co‐occurring PTSD/AUD may amplify ADRD risk. Consequently, the present study tested the hypothesis that, relative to healthy controls (HC), PTSD/AUD would show more pronounced premature brain aging than AUD alone.