Examining the diagnostic utility of the mnemonic discrimination task for classification of cognition and amyloid‐β burden

Developing non‐invasive diagnostics that can effectively predict amyloid‐β (Aβ) burden is crucial, as this technology could help to identify individuals with increased risk for AD and provide a window for potential treatment or intervention. Mnemonic discrimination tasks (MDTs) are designed to assess the ability to discriminate highly similar episodic memory representations (e.g., objects or spatial locations). The relationship between the MDT performance and Aβ burden, however, has not yet been directly tested. In this study, we investigated whether MDT performance can successfully classify cognitive status or Aβ load in older adults.