Genetic Relationship between Alzheimer’s Disease and Schizophrenia

Large genome‐wide association studies (GWASs) have demonstrated that common genetic variation contributes to the heritability of brain disorders, including Alzheimer’s disease and schizophrenia. Patients with Alzheimer’s disease and schizophrenia often have similar symptoms such as cognitive decline and hallucinations. Excessive synaptic pruning resulting from neuroinflammation and microglial activation are considered to play an important role in the development of both diseases. However, the genetic correlation between Alzheimer’s disease and schizophrenia is unclear.