Diagnostic Accuracy of Plasma Osteopontin in Egyptian Hepatocellular ‎Carcinoma Patients

, p<0.05). Tumors >5cm in diameter resulted in significantly higher plasma OPN compared to tumors <5cm (p<0.05). Child-Pugh score, multiple tumors, or lymph nodes didn’t significantly affect OPN levels in HCC group (p>0.05). Diagnostic sensitivity, specificity, and overall accuracy of OPN for HCC vs Cirrhotic group were superior to AFP (97%, 70%, and 84% at cut-off value 90 ng/mL for OPN vs 90%, 63% and 77% at cut-off value 5.5 ng/ml for AFP). The area under the ROC curve (AUC) value for OPN was higher than AUC value for AFP (0.923 vs. 0.902). Conclusion: Serum OPN had better diagnostic ability for detecting HCC compared to AFP, suggesting OPN as a promising diagnostic marker for HCC at normal AFP levels.