Hippocampal subregional thinning related to tau pathology in early stages of Alzheimer’s disease

Subregions in the medial temporal lobe (MTL) are affected early by Alzheimer’s disease (AD) pathology and subject to grey matter atrophy. Measuring the earliest AD‐related atrophy in the hippocampus is challenging as region‐of‐interest (ROI) analyses of hippocampal subregional volumes collapse across voxels within anatomical subregions. PET imaging studies, however, report accumulation of tau pathology between anatomical subregions in the earliest disease stages (Berron et al., 2021) fitting reports from the neuropathological literature (Lace et al., 2019; Ravikumar et al., 2021). Thus, sensitive in vivo methods of point‐wise structural measures are needed in order to detect the earliest hippocampal thinning in AD along the anterior‐posterior as well as the medial‐lateral hippocampal axis.