Investigating a new neocortical mask for Centiloid quantification

The Centiloid (CL) project was developed to harmonise the quantification of Amyloid PET scans to a unified scale. The neocortical mask used for quantification was obtained using a private dataset of 19 mild AD patient and 25 older controls imaged using 11C‐PiB. The mean difference SUVR images were smoothed, subtracted and thresholded at 1.05 SUVR. While this threshold was chosen to maximise areas of specific Amyloid binding while avoiding areas of non‐specific binding, it was not evaluated in terms of agreement between different tracers or group separation. In this study, we created a new mask using an independent dataset of 11C‐PiB images, and investigated its impact on inter‐tracer agreement, tracer variability and group separation.