Post synaptic density 95 (PSD95)–Actin interaction: A critical regulator of synaptic strength and plasticity in Alzheimer’s disease pathology

PSD95 serves as a scaffolding protein to several neurotransmitter receptors, signal transduction components, and adhesion molecules at the synapse. It is a potential regulator of synaptic strength and plasticity by regulating glutamatergic receptor trafficking, which is impaired in AD. PSD95 interacts directly with NMDA receptors while the interactions with AMPA receptors are through an auxiliary subunit TARPs. Actin cytoskeleton is highly enriched at the synapse. However, the interaction of PSD‐95 – actin and its consequences in synaptic transmission is not understood. Therefore, we investigated the critical role of PSD‐95 association at the synapse with actin and its impact on AMPA and NMDA receptors using AD mice.