Neuroprotective role of Syzygium aromaticum on SIRT1 and oxidative balance in Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disorder manifested by cognitive and memory impairment. The holistic approach can be better option to prevent and treat the pathological consequences of neurodegenerative disorders. Recent studies, suggest that Ayurveda may provide a good holistic care and treatment. The accumulation of Reactive oxygen species (ROS) in the brain increases with ageing ultimately to the oxidative stress. Sirtuin1 (SIRT1) is a potential mediator of oxidative balance. Syzygium aromaticum have antioxidant properties, may help in scavenging free radical generation and prevent the diseases. This study determined the role of Syzygium aromaticum on neuroprotection and oxidative balance in amyloid beta (Aβ) induced neurotoxicity by activating SIRT1 protein.