Cognitive‐behavioral associations of amygdala subregional tau pathology in cognitively unimpaired Presenilin‐1 E280A mutation carriers

Carriers of the Presenilin‐1 (PSEN1) E280A mutation are virtually determined to develop Alzheimer’s disease (AD) dementia by midlife. Tau pathology accumulates in the amygdala of PSEN1 carriers prior to clinical onset. Amygdala dysfunction, particularly in basolateral regions, may contribute to early neuropsychiatric symptoms in sporadic AD and other dementias. We aimed to examine the cognitive‐behavioral associations of subregional amygdala tau pathology in preclinical PSEN1 carriers, focusing on episodic memory and neuropsychiatric symptoms.