The interplay between functional MRI measures of episodic memory and CSF measures of tau in healthy adults at risk of Alzheimer’s Disease

Neural changes occur early in Alzheimer’s disease (AD). Longitudinal data on the relationship between AD pathology and brain activity, however, are sparse. Using an established cohort of cognitively unimpaired older adults (PREVENT‐AD) at risk of AD (due to familial incidence), we assessed the relationship between functional magnetic resonance imaging (fMRI) activity during episodic memory retrieval and cerebrospinal fluid (CSF) markers of tau and β‐amyloid. We aimed to test whether baseline fMRI signal predicts changes in CSF markers and vice versa.