FORMULATION, DEVELOPMENT AND EVALUATION OF COLON TARGETING MICROSPHERES FOR EFFECTIVE TREATMENT OF COLONTITIS

Inflammatory bowel disease (IBD) is a commonly relapsing and relapsing seditious disease of the small and large intestine. IBD includes ulcerative colitis (UC) and Crohn's disease (CD) and is the leading cause of the spread of colon cancer known as cancer-associated colitis (CAC). A bead-based drug delivery system targeting the oral colon containing metronidazole-loaded chitosan beads coated with eudragit S-100 was prepared, optimized, and characterized. Metronidazole-loaded colon-targeted microspheres were prepared with a simple emulsion system followed by a cross-linking system. The variable drug polymer ratio was optimized for based on particle size, capture efficiency, further optimized F2 composition was coated with Eudragit S-100. The prepared microspheres were stable spherical particles and showed favorable release profiles in the simulated colonic fluid.