Hormone therapy in menopause can increase risk of depression

Opioid overdose in a treatment gap month was more likely with the buprenorphine hydrochloride formulation than with buprenorphine/naloxone film or tablet formulations. Overdose was also more likely in patients taking lower doses of 8 mg/day or less. Treatment gaps were associated with a 13.5% increase in total Medicare spending per month, mainly attributable to an increase in medical spending. “Health care professionals could consider adopting adherence monitoring technologies and engaging with patients about their adherence issues,” the study’s authors wrote. [Gibbons J, et al. JAMA Psychiatry 2022; published online Oct 5; doi: 10.1001/ jamapsychiatry.2022.3118] ▪