Sex Differences in Mild Cognitive Impairment Risk by APOE Genotype

Male sex is suggested as a risk factor for mild cognitive impairment (MCI), but this association may be influenced by the female verbal memory advantage, and the use of verbal memory tests has been shown to delay MCI diagnosis in women. Moreover, this association may vary by apolipoprotein E (APOE) genotype. The National Alzheimer’s Coordinating Center (NACC) uniform data set (UDS) contains demographic data and annual standardized neuropsychological (with memory being assessed primarily with verbal tests) and clinical diagnostic data obtained by 41 NIA‐funded Alzheimer’s Disease Centers across the U.S. This large database is a rich resource for evaluating sex effects on MCI/Dementia diagnosis by APOE genotype.