Isoaspartate as a biomarker for early diagnostics of neurodegenerative diseases

The formation of isoAsp via spontaneous asparagine (Asn) deamidation or aspartate (Asp) isomerization has been regarded as a molecular clock of aging that significantly correlates with neurodegenerative diseases (NDDs). Our earlier findings established a strong link between isoAsp and Alzheimer’s disease (AD). In this study, we aimed at validating the diagnostic value of blood isoAsp‐related biomarkers for NDD prediction.