The Functional Role of Amyloid Precursor Protein at Mitochondria

Aβ is generated from amyloid precursor protein (APP) via sequential proteolytic processing. While APP processing and its localization are well understood, the functional role of APP is largely unknown. APP is expressed almost ubiquitously but is concentrated in neuronal synapses and localizes to mitochondria. The functional consequence of mitochondrial APP localization is not well understood. We leveraged a mutant APP construct which does not localize to mitochondria to interrogate the functional role of APP at mitochondria.