Neuroprotective Effect of Tannic Acid against Rotenone Induced Rat Model of Parkinson’s Disease

Tannic acid is ubiquitously occurring plant polyphenol which is found in most of the beverages such as wine, beer, black and green tea and several food stuffs such as grapes, bananas, peas, sorghum, chocolates and lentis. It is reported to have antioxidants. Anti-mutagenic, anti-cancer and neuroprotective effects. The present study is designed to evaluate the anti-parkinsonic role of TA against rotenone induced rat model of PD by analysing the levels of dopamine, oxidants and activities of antioxidants. Animals were randomized and divided into 4 groups, control, rotenone treated, rotenone+TA treated and TA alone treated. Rotenone injection, enhanced the levels of DA and TBARS, diminished the levels of GSH and activities of SOD, catalase and GPx. Oral administration of TA attenuated the rotenone induced toxicity by its neuroprotective and antioxidant properties.