Frailty and Alzheimer’s Disease Related Plasma Biomarkers in Men from Midlife to Early Old Age

About 7 million older American adults are affected by frailty (Bandeen‐Roche et al., 2015). Frailty places older adults at an increased risk of adverse physical and mental health outcomes, including Alzheimer’s Disease (AD). However, prior to old age, frailty or its relationship to AD biomarkers such as beta‐amyloid 40 and 42 (Aβ40, Aβ42), tau, and neurofilament light (NfL) are understudied.