Identification of Genetic Variants and Serum Metabolites Associated with Blood‐derived Mitochondrial DNA Copy Number

Mitochondrial DNA Copy Number (mtDNA‐CN) can be used to estimate mitochondrial function and it varies across tissues and cell types. Blood‐derived mtDNA‐CN has been studied in aging‐related diseases including Alzheimer’s Disease (AD). However, little is known about the genetic contribution to variation of blood‐derived mtDNA‐CN and how this variation affects the level of serum metabolites.