Impact of area under the curve-based vancomycin dosing combination with anti-pseudomonal beta-lactam antibiotics: a systematic review and meta-analysis

Review question / Objective: Did AUC-based vancomycin dosing reduce acute kidney injury than trough-based dosing when combined with anti-pseudomonal beta-lactam antibiotic? Condition being studied: Patients received Vancomycin combined with anti-pseudomonal beta-lactam antibiotics and monitor with either trough-base dosing or AUC-based dosing vancomycin. Information sources: All study types except case reports, case series, and conference abstracts were considered. PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were searched from inception to November2022.