Immunohistochemical Expression of Fn14 and GP88 as Prognostic Biological Markers in Invasive Human Breast Cancer

Fibroblast growth factor-inducible 14 (Fn14), is a member of the tumor necrosis factor receptor super family that normally expressed in healthy tissues, but its expression is increased in injured tissue where it thought to play role in tissue remodeling. Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. The aim of the present work was to investigate the expression of Fn14 and GP88 as novel prognostic biomarkers in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. Immunohistochemical technique was used to examine the expression of Fn14 and GP88 in normal, benign as well as in IDC. Present results showed higher expression of Fn14 and GP88 in IDC comparing to normal and benign breast tissues.