Novel peptide‐driven global proteomics platform to identify unique peptide profiles linked to Alzheimer’s disease

There is a growing need for new biomarker signature(s) to further improve the predictive values of currently used markers for Alzheimer’s disease (AD) staging, monitoring, and prognostic prediction of disease progression. Most AD biomarker discovery studies have not focused on peptide level alterations despite unquestionable importance of abnormal proteolysis in AD. Here we present a peptide‐focused unbiased global proteomics platform to identify unique peptide profiles associated with amyloid pathology in cognitively impaired subjects.