Retromer‐dependent mechanisms of tau dysregulation in Down syndrome

Deficiencies in the retromer complex are reported in brains of Down syndrome subjects, and retromer protein levels inversely correlate with amyloidosis. The complex is also proposed to influence tau levels, however, the relationship between tau neuropathology and retromer deficiency in Down syndrome remains unclear. In the current study, we examine the relationship between pathological tau and retromer deficiency and explore potential mechanisms involved.