Antituberculosis Activity of Active Compound of Ethyl Acetate Extract for Patikan Kebo (Euphorbia hirta L.)

Infectious diseases caused by bacteria are a concern in the world of health. The microbe Mycobacterium tuberculosis which causes tuberculosis (TB) is one of the main disease problems in the world, as evidenced by the existence of 10.4 million sufferers and 1.8 million deaths in the world in 2015. During 5 years (2015 to 2020), the World Health Organization was done some comprehensive programs it can reduce mortality up to 13%. However, since early 2020 were increased the mortality rate again as in 2015. In addition, the increasing incidence of bacterial resistance to antibiotics has triggered various studies to find alternative antibacterial agents. This study is related to the anti-tuberculosis activity (against M. tuberculosis strain H37Rv with the liquid dilution method with Middlebrook 7H9 (MB 7H9) and solid dilution with Lowenstein-Jensen (LJ)) in ethyl acetate patikan kebo (Euphorbia hirta L.) extract. The investigation of antimycobacterial tuberculosis, it was found that a concentration of 800 µg/mL had anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv. The active compound as a result of isolation is the triterpenoid (taraxasterol) group.