Executive functioning and attention in amnestic mild cognitive impairment are related to widespread grey matter integrity

Memory problems that are characteristic of amnestic mild cognitive impairment (aMCI) are often accompanied by difficulties in attention and executive functions (EF). Studies have consistently reported atrophy of the hippocampus and its association with memory decline in aMCI. However, it is less clear whether differences in grey matter volume (GMV) also contribute to difficulties in attention and EF. To that end, we investigated whether GMV is related to performance on a series of cognitive tests in people with aMCI.