Bio‐Hermes: A Validation Study to Assess a Meaningful Relationship Between Blood and Digital Biomarkers with Aβ PET Scans for Alzheimer’s Disease

The Global Alzheimer’s Platform Foundation® (GAP) has developed a biomarker study (Bio‐Hermes) that will compare results of blood and digital biomarker tests with the results of brain amyloid PET scans and traditional cognitive tests. The trial will enroll 1,000 participants across three cohorts: Healthy, MCI, and Mild AD. In addition, Bio‐Hermes has a discrete recruiting endpoint that requires enrollment of a minimum of 200 participants (20%) from traditionally underrepresented populations (Black/African American & Latino). Bio‐Hermes will generate a unique, well‐characterized, diverse sample set that will explore the utility of several leading biomarkers. This study will contribute to reducing the time and variability of therapeutic clinical trials in Alzheimer’s disease. Bio‐Hermes will generate a first of its kind, “head‐to‐head” comparison of a broad set of AD biomarkers.