Abstract 55: Clinical and biochemical profile of Graves' disease with and without orbitopathy- A comparative study

Background: Graves orbitopathy is an immune mediated inflammation of extraocular muscles and retroorbital tissues that occur in patients with Graves disease. It is not yet clear why only a proportion of patients with Graves disease develop orbitopathy. Objectives: To compare the clinical and biochemical profile of patients of Graves' disease with and without orbitopathy. Methods: This cross-sectional study was carried out from July 2021 to October 2022. Patients of Graves' disease who presented in the Endocrine OPD or IPD were evaluated clinically and biochemically. Graves' orbitopathy was diagnosed based on the criteria suggested by Bartley. Thus 30 patients without orbitopathy and 29 patients with orbitopathy were included. Results: 3/27 (10.3%) patients with orbitopathy had active disease.1 patient had dysthyroid optic neuropathy. The male to female ratio among those patients with and without orbitopathy were 0.6 (11:18) and 0.4 (9:21) respectively. 8 out of 29 (27.5%) patients with orbitopathy and 1 out of 30 (3.3%) patients without orbitopathy were smokers. Among patients with orbitopathy 27.5% had a TRAB value of more than 40 while it was 13.3% among those without orbitopathy. The mean TRAB value of those with and without orbitopathy were 22.3 and 22.1 respectively. Conclusion: Among patients with orbitopathy, more people had a higher TRAB titre when compared to those without orbitopathy. There was no significant difference in the mean TRAB titre between the two groups. The presence of orbitopathy was significantly associated with smoking.