Sema6D Promotes TREM2‐dependent Phagocytosis in Human iPSC‐derived Microglia

Microglia mediate key functions in inflammation and phagocytic clearance central to Alzheimer’s disease (AD). Semaphorins and their receptors, plexins and neuropilins, are best known for their role in axon guidance, but emerging roles include the regulation of innate immunity. Semaphorin receptors are highly expressed in microglia, including those encoded by AD risk genes discovered through genome‐wide association studies (e.g. PLXNA4 and PLCγ2). We investigate the function of semaphorin 6D (Sema6D) and interacting receptors in human iPSC‐derived microglia (iMG).