IONIZING RADIATION AND CYTOKINES: THE ROLE IN THE PATHOGENESIS OF PLASMA CELL MYELOMA (LITERATURE REVIEW)

The review presents literature data on the role of ionizing radiation as a negative environmental factor in the occurrence of plasma cell myeloma (PCM). The data of studies of various categories of irradiated persons regarding the incidence of PCM, in particular employees of nuclear enterprises and victims of the accident at the Chornobyl Nuclear Power Plant accident, are given. The effect of cytokines (interleukin-6 and interleukin-10) on PCM substrate cells was analyzed, including under conditions of combined action of IR and cytostatic agents in vitro. Key words: plasma cell myeloma, ionizing radiation, cytokines, interleukin-6, interleukin-10.