Construction of a canine model with acute type B aortic dissection using a self-made pressure water flow device.

A reproducible canine aortic dissection (AD) model is useful for evaluating the performance of novel endovascular treatment devices. Thus, we performed a surgical method for constructing a reproducible Stanford type B AD (TBAD) canine model. Computed tomography angiography was performed 2 h after the modeling procedure to identify the existence of a false lumen, and follow-up imaging was performed 10 d after the procedure using digital subtraction angiography, intravascular ultrasound (IVUS), and color Doppler flow imaging (CDFI) to confirm the stable persistence of the false lumen. The success rate of the modeling operation was 88.8% (16/18). All surviving dogs had distal re-entries (16/16), and the furthest re-entry did not exceed the celiac trunk artery. The number of re-entries in the dogs was 1.50 ± 0.52, and the mean length of the false lumen was 175.37 ± 16.98 mm. IVUS showed that the largest proportion of the false lumen was 84.88 ± 1.27% of the whole lumen. The CDFI showed that the peak systolic velocity in the false lumen (10.89 ± 0.74 cm/s) was significantly slower than that in the true lumen (25.31 ± 1.72 cm/s) (P <0.001). Moreover, the direction of blood flow in the true lumen was consistent, whereas that in the false lumen was disordered. We optimized the traditional surgical method to construct a canine model of TBAD, that improves the success rate of the modeling operation, and designed a novel device to prolong the false lumen. The proposed model have wide implications in evaluating novel endovascular treatment device performance and studying the AD-related hemodynamics.