Electrochemical Biosensors with Butyrylcholinesterase. Period 2016-2022. A review

Butyrylcholinesterase (BChE) biosensors are analytical devices with BChE as a biorecognition element for specific interaction with an analyte. They serve to detect various compounds from which group organophosphate and carbamate neurotoxins are probably the most important. The BChE biosensors can be used in a way similar to that of the more widespread acetylcholinesterase (AChE) biosensors. Compared with the AChE, the BChE biosensors are less sensitive to the inhibition of some natural toxins and can work with many enzymatic substrates. In the last few years, new applications of BChE have been described, and advanced materials and analytical methods have been implemented into practice. This review focuses on the comparison of BChE biosensors with the other types of analytical devices applicable for neurotoxic compounds assay, an explanation of the assay principles, and an introduction of relevant papers from recent years.