A Novel Protective locus significantly reduces the ApoEε4 risk for Alzheimer’s Disease in individuals of African Ancestry.

African ancestry populations have a lower risk for developing Alzheimer disease (AD) from ApoEε4 compared to other populations. Understanding this mechanism of protection could lead new therapeutic insights for AD. Our goal is to identify areas of the genome that interact with ApoEε4 in African ancestry that result in the lowered risk for developing AD in this population.