Neuroinflammation co‐localizes highly with tau in amnestic mild cognitive impairment

Neuroinflammation, along with beta amyloid and tau brain deposition, is a potential diagnostic biomarker and therapeutic target in patients with Alzheimer’s disease (AD). The role of inflammation at various stages of the AD process needs to be clarified. TSPO PET is useful to image brain inflammation, but some tracers have low affinity for TSPO and “second generation” tracers, with higher affinity, cannot image subjects with a low‐binder TSPO rs6971 genotype. We overcame this problem by using 11C‐ER176, a high‐affinity tracer allowing for imaging of all participants and with a more favorable metabolite profile than other high affinity tracers (Fujita, 2017). Then, we correlated the localization of neuroinflammation tau and amyloid in a subset of the participants.