Effect of Ethanol Extract from Semangkuk Fruits (Scapium affine) on Histological Image of Liver Male Mice

The use of traditional medicine by drinking will go through a digestive process that involves absorption by the intestines, the intestines as a digestive tract supply blood to the liver so that the food and drinks consumed by an individual are closely related to liver histology. The liver as a detoxifier of toxins works by breaking down toxic compounds into several compounds such as urea, ammonia, and uric acid. Damage to liver organs includes necrosis, steatosis, and inflammation. One of the plants that can be used in traditional medicine is a fruit or a semangkuk plant, a semangkuk fruit is a type of plant that is efficacious as a decrease in heat. Testing related to the histological picture of the liver organs on a bowl of fruit has never been carried out so this test aims to find out about the histological picture of animal liver-induced extract at doses of 100 mg / KgBB, 150 mg / KgBB, and 200 mg / KgBB, with positive control given acetaminophen and normal control, in the extraction method carried out by maceration. The test animals used were 30 male white mice and were divided into 5 groups. Mice are surgically taken from the liver organs, then staining is carried out using hemotoksilin eosin and observed using a microscope to see whether or not there is damage to the liver organs. Data analysis using one-way ANOVA. From the results of the study, it was found that there was damage to the liver organs such as damage to necrosis, steatosis, and inflammation with the highest dose of 200 mg / KgBB, so a semangkuk of fruit is not safe to use if at high doses.