Characterisation of pupillary responses to alternating blue and orange light exposures in a fMRI protocol

The non‐image forming (NIF) functions of light are diverse and include stimulation of cognition and alertness, sleep regulation and pupil diameter modulation. Previous work indicated that exposure to blue‐enriched light as well as pupil size variations are associated with higher locus coeruleus (LC) activity. Given the central role of LC structure and function in the earliest stages of Alzheimer’s disease neuropathology, light exposure may constitute a promising stimulation technique to delay disease progression. Prior to addressing light impact on the LC, here, we aimed at characterising the pupil responses to light during fMRI protocol, to determine its quality in assessing NIF effects of light.