Microglia with fatty acid‐binding protein 5 deficiency exhibit proinflammatory phenotype contributing to neuroinflammation

Microglia are the resident immune cells in the brain, which show a broad spectrum of phenotypes ranging from the pro‐inflammatory, potentially cytotoxic to the anti‐inflammatory, scavenging, and regenerative. Fatty‐acid binding protein 5, an intracellular protein that are important for cellular metabolism, have been identified in human and mouse microglia; however, its role in microglia is yet to be defined. Studies from our laboratory and others have shown that FABP5 is downregulated in the brain of Alzheimer’s disease patients and APP/PS1 mice. This study is to explore the impact of FABP5‐deficiency on microglia phenotype.