Sex differences in Actigraph‐estimated versus Self‐reported sleep quality and Alzheimer’s disease neuropathology among cognitively‐unimpaired older adults

Despite implications of sleep disturbances in Alzheimer’s disease (AD) pathophysiology (e.g. cerebral amyloid accumulation, atrophy in AD‐pathology sensitive brain regions); contradictory findings on sleep/neuropathology relationships at preclinical‐AD stage exist, possibly due to sex‐differences and/or methodological disparities and inconsistencies in sleep evaluation. We sought to address this conundrum using self‐reported versus actigraphy‐based data, to explore sex differences associated with amyloid load and MRI whole brain/sub‐regional volumetric indices, among asymptomatic older adults.