The Common LncRNAs of Neuroinflammation-Related Diseases.

Spatio-temporal specific lncRNAs play important regulatory roles not only in the growth and development of the brain but also in the occurrence and development of neurological diseases. Generally, the occurrence of neurological diseases is accompanied by neuroinflammation. Elucidation of the regulatory mechanisms of lncRNAs on neuroinflammation is helpful for the clinical treatment of neurological diseases. This paper focuses on recent findings on the regulatory effect of lncRNAs on neuroinflammatory diseases and selects ten lncRNAs that have been intensively studied to analyze their mechanism of action. The clinical treatment status of lncRNAs as drug targets is also reviewed. Significance Statement Gene therapies such as CRISPR/Cas9 technology, antisense RNA technology and RNAi technology are gradually applied in clinical treatment, and the development of technology is based on a large number of basic research investigations. This paper focuses on the mechanisms of lncRNAs regulation of neuroinflammation, elucidates the beneficial or harmful effects of lncRNAs in neurosystemic diseases, and provides theoretical bases for lncRNAs as drug targets.