Higher body mass and fat composition are related to 1‐year cerebral amyloid accumulation in individuals with elevated risk for Alzheimer’ disease

Amyloid‐β is a classical hallmark and risk factor for development of Alzheimer’s disease (AD). Observational data suggest that having higher body mass index (BMI) is associated with lower cerebral amyloid burden in cognitively normal adults. However, the influence of body composition on cerebral amyloid deposition has not been investigated. We investigated whether baseline body composition influences 1‐year change in cerebral amyloid in a sample enriched with older adults with elevated amyloid.