Oxidative stress mediated neuroinflammation induced by chronic sleep restriction as triggers for Alzheimer’s disease

Overactivation of brain renin angiotensin system (RAS) has shown to be associated with initiation and progression of Alzheimer’s disease (AD) through increased production of amyloid beta and oxidative stress resulting in cognitive impairment. Further, chronic sleep restriction (CSR) also shown to induce increased production of amyloid beta. Angiotensin converting enzyme inhibitors has been stated to possess beneficial effect against AD. However, the mechanisms still needs to be studied. In the present study we have investigated the effect of CSR on memory and biological functions in mice for better understanding of its effect in initiating AD and also the protective effect of ACEI, Captopril