Research progress of ubiquitination modified natural immune antiviral signaling pathway

Natural immunity is an important way for the human body to resist viral infection. In the process of natural immune antiviral, viral nucleic acids can be recognized by Toll-like Receptors (TLR receptors), RIG-1 Like Receptors (RLRs receptors), cytoplasmic DNA receptors and mitochondrial antiviral-signaling protein receptors (MAVS receptors) within immune cells, and then the information is transmitted to downstream signal molecules, so that immune cells generate IFN- 1 ( type 1 interferon ).In this process, ubiquitination modifications play a wide role in regulating natural immune antiviral processes, thereby maintaining stability in the human body. This paper mainly introduces the four specific receptors of TLR receptor, RLRs receptor, cytoplasmic DNA receptor and MAVS receptor, as well as the natural immune antiviral pathways mediated by these receptors, and further elaborates the role of ubiquitination modification in these pathways, aiming to lay a foundation for the study of natural immune antiviral pathways.