Associations between plasma Neurofilament Light Chain (NfL), Sleep Quality and Cognition in individuals with autosomal‐dominant Alzheimer's Disease (ADAD): Findings from the Colombia‐Boston (COLBOS) biomarker study

Methods available for in‐vivo diagnosis of Alzheimer's disease (AD) are expensive and invasive. Neurofilament light chain (NfL), a plasma‐based biomarker for neurodegeneration, is a promising marker for early detection in individuals at increased risk. We previously reported that Presenilin1 (PSEN1) E280A carriers have increased levels of plasma NfL relative to non‐carrier family members twenty years before the onset of clinical symptoms. Here, we examined whether baseline levels of plasma NfL predict self‐reported sleep quality and cognition 10 years later in non‐demented PSEN1‐E280A carriers and non‐carriers.