Late-life depression, allostatic load, and risk of dementia: The AGES-Reykjavik study

The biological underpinnings of the relationship between depression and dementia are currently not completely understood. Previous research has highlighted the role of vascular, metabolic, inflammatory, and stress markers in the role of both depression and dementia. Allostatic load has been an all‐encompassing term to describe these biological factors when investigating subgroups in individuals based on health characteristics. The current study aimed to elucidate if depression subtypes exist based on modifiable allostatic load factors using latent class analysis (LCA), and whether these subtypes have differing risk on incident all‐cause dementia, Alzheimer’s disease (AD), and non‐AD diagnosis using Cox regression analyses.