Amyloid and tau pathologies associate with distinct aspects of the inflammatory cascade

Inflammation has long been pointed out as a key feature in Alzheimer’s disease (AD). However, the heterogeneity of AD pathology might trigger different aspects of the immune response. Here, we aimed to study the association of the newly proposed concept of inflammatory composite indexes with Aβ and tau pathologies across the aging and AD spectra. We hypothesize that distinct inflammatory pathways are associated with the different hallmarks of AD.