Tau heterogeneity in Aβ positive patients

A substantial proportion of individuals on the AD continuum have tau PET burden that is not elevated, suggesting that they may be in an earlier stage on the AD continuum and/or have other copathologies that account for their impairment. To examine these possibilities, we compared Aβ+, cognitively impaired individuals with lower tau burden to theirAβ+ high tau counterparts across a variety of biomarker and clinical measurements.