Exploratory evaluation of 18F‐MK‐6240 tau PET positivity in TANGO phase 2 clinical trial of gosuranemab (BIIB092) in Mild Cognitive Impairment and mild Alzheimer’s disease

TANGO was a randomized, placebo‐controlled, phase 2 study evaluating gosuranemab, an investigational anti‐tau antibody, for potential treatment of mild cognitive impairment (MCI) due to Alzheimer’s disease and mild Alzheimer’s disease. We explored the feasibility and validity of assessing 18F‐MK‐6240 tau PET positivity in post hoc exploratory analyses, to inform evaluation of treatment effect in future clinical trials.