Abstract 193: Analysis of Kidney Function in Hypothyroid Patients in a Tertiary Care Hospital in North Eastern Part of India

Introduction: Thyroid hormones (TH) are essential for an adequate growth and development of the kidney. Conversely, the kidney is not only an organ for metabolism and elimination of TH, but also a target organ of some of the iodothyronines' actions. Thyroid dysfunction causes remarkable changes in glomerular and tubular functions and electrolyte and water homeostasis. Aim and Objective: To study the kidney function in hypothyroid patients. Materials and Methods: This observational cross-sectional study includes 38 known diagnosed case of primary hypothyroidism admitted in medicine wards and attending OPD in our hospital excluding pregnant woman, T2DM, patient with known renal disease, patients taking any drugs which can alter renal function & patients suffering from any illness that affect renal function. The collected blood and urine samples from the study population have been estimated for the study parameters. eGFR calculated by MDRD equation. Results: With a female preponderance of hypothyroidism, urine ACR <30mg/dl was seen in 58% cases, microalbuminuria in 30% cases while macroalbuminuria in 12% cases. High creatinine values seen in 42% cases, stage 2,3 CKD found in 46%,48% cases. A significant positive correlation between urinary Na, K, ACR, Urea, Creatinine with TSH level while an inverse relationship with eGFR and serum Na level. While Free T3 & T4 showing reverse relationship. eGFR was significantly higher, serum creatinine & blood urea is lower in patients who were on treatment. Conclusion: So in untreated hypothyroid patients, significant alteration in kidney functions occurs. TSH values are negatively correlated with eGFR and positively with microalbuminuria & other kidney functions. Free T3 & T4 have reverse relationship of serum TSH. Hypothyroid patients have higher urinary Na, K loss low eGFR higher serum creatinine, blood urea & albuminuria. It is recommended to check for kidney function in every hypothyroid patient to avoid early derangement of kidney function and to take necessary measure to prevent it.