Posterior hippocampal redundancy: A marker of non‐pathological brain aging

Several neural mechanisms underlying brain resilience to Alzheimer’s disease (AD) have been proposed, including redundant neural connections between the posterior hippocampi and all other brain regions (pHipp‐redundancy), and global functional connectivity of the left frontal cortex (gLFC). It remains unclear whether these two mechanisms confer resilience to AD pathologies through similar or distinctive mechanisms. We examined if redundancy, measured through graph theory, underlies the neuroprotective effects of both pHipp‐redundancy and gLFC connectivity in the early stage of AD pathologies.