Role of polyelectrolytes in modulating membrane‐templated Aβ40 aggregation

Amyloid fibril formation is associated with protein‐misfolding disorders and is a key pathway for the pathogenesis of Alzheimer’s disease (AD). The fibrillar structure of amyloid beta‐protein (Aβ) is the hallmark of amyloid plaques in the brains of patients with Alzheimer’s disease (AD). The interaction between the cell membrane and the Aβ40 peptide may induce membrane disruption and membrane leakage and may be related to the toxicity in Alzheimer’s disease (AD).