EP194/#277 Clinical characteristics of coronavirus infection in cancer patients

ObjectivesCancer patients are considered a very vulnerable group of the population to SARS-CoV-2 infection and the development of more severe COVID-19 symptoms, which may be due to a systemic immunosuppressive condition caused directly by tumor growth and indirectly by the effects of antitumor treatment. The aim of the study was to study the clinical, laboratory characteristics of coronavirus infection in patients with oncogynecological pathology.MethodsThere were analyzed 60 cancer patients and 60 patients with benign lesions. The frequency of clinical, radiological and laboratory characteristics in both groups of patients was studied.ResultsSimilar clinical symptoms were revealed: fever (88.7% in non-cancerous and 78% in cancer patients), cough (67.8% and 76%, respectively), nausea and vomiting (5.1% and 5.7%), diarrhea (3.8% and 12.2%). Symptoms differed in shortness of breath (21.9% in non-oncological and 50% in cancer), and weakness (38.1% and 64.3%, respectively). Radiologically, the symptom of ‘frosted glass’ was determined in both groups (in 65% and 71%), heterogeneous consolidations (50% and 46%), bilateral involvement of the lungs (51% and 86%). In the laboratory, lymphopenia (82%), leukopenia (32%), increased CRP (82%), D-dimer (36%), hypoalbuminemia (89–98%) were detected with approximately the same frequency in both groups, but anemia was more pronounced in cancer patients (75%) versus 51%. And the increase in LDH and ESR was more characteristic of non-cancer patients than cancer patients (76% and 50% and 86% and 57%, respectively).ConclusionsThe obtained results of the study allow us to develop adequate tactics during special treatment, in particular, performing surgical interventions for oncogynecological diseases.