The Association of Sleep Duration and Sleep Efficiency with Amyloid β Accumulation Among Cognitively Healthy Later Life Adults: A Systematic Review

Amyloid β(Aβ) accumulation is a hallmark of the progressive neurodegenerative Alzheimer’s Disease (AD). Disruptions in sleep beyond aging are found to be risk factors of developing AD because sleep may involves in Aβ level regulations, neurotoxin clearance, or inflammation process. Sleep disruptions can be defined by shorter sleep duration and lower sleep efficiency. This systematic review examines how sleep duration and efficiency are associated with amyloid deposition in later life adults.