Resistance, brain and cognitive resilience to ATN in a memory clinic population

Brain resistance (R) has been defined as the capacity of the brain to preserve its integrity and to sustain normal cognition despite aging. Resilience has been defined as the capacity to sustain a better‐than‐expected brain integrity (brain resilience,BR) or cognitive performance (cognitive resilience,CR) in presence of pathological burden. There is a high variability in the individuals’ R, BR or CR, and it has been demonstrated that individuals with high BR and CR develop symptoms later than those with low CR. The aim of this study was to investigate the association between demographics, clinical features, and blood measures and individual’s R, BR and CR. Moreover, we investigated the cognitive longitudinal trajectories of individuals with low and high R, BR and CR.