Towards the development of a reference measurement procedure for the quantification of neurofilament light chain

Neurofilament‐light chain (Nf‐L) is an early marker monitoring axonal damage which occur in many forms of dementia. During neurodegeneration, Nf‐L is released into biological fluid and is quantifiable in cerebrospinal fluid (CSF) and blood. Currently, its quantification is performed by immunoassays. While those ones are sensitive and precise, the development of a reference measurement procedure (RMP) using mass spectrometry (MS) approaches traceable to the International System of Units (SI) is essential to achieve standardisation.