Quantitative Proteomic Analysis of Non-Tobacco Associated Oral Squamous Cell Carcinoma Reveals Deregulation of Cytoskeletal and Apoptotic Proteins

Oral squamous cell carcinoma (OSCC) constitutes 45% of all cancers occurring in the Indian sub-continent thus leading as the single most commonly encountered cancer of the head and neck region. OSCC contributes to over 80% of malignant head and neck lesions and is well recognized as the most common malignant tumour of oral structures. Every year 300,000 new cases are diagnosed worldwide (Krishnan et al., 2014) The use of the molecular approach in the last few decades has revealed the proteomic picture in the pathogenesis of OSCC. There are powerful search engines to help identify alterations in genetic expression, the Abstract