The value of vaginal wash urea and creatinine concentration for diagnosis of premature rupture of membranes

: Prelabour rupture of fetal membranes (PROM) refers to fetal membrane rupture before the onset of uterine contractions; preterm PROM (PPROM) is the term used when the pregnancy is less than 37 completed weeks of gestation. Purpose: This study aims to assess the accuracy of vaginal fluid urea and creatinine for the diagnosis of premature rupture of membranes and preterm premature rupture of membranes. Patients and Methods: A total of 90 pregnant women were included in the current study, between completed 28 weeks to completed 40 weeks of gestation, divided into two equal groups: 45 pregnant women with PPROM or PROM diagnosed by pooling of fluid in posterior fornix and 45 pregnant women who are attending the outpatient clinic for routine antenatal care, each group had the posterior vaginal fornix irrigated with 5ml saline and aspirated then assessed for urea and creatinine concentration. Results: This study showed that the confirmed PPROM and PROM group had higher levels of vaginal fluid urea and creatinine compared to the control group with a very highly statistically significant difference between the groups. Conclusion: vaginal fluid urea and creatinine determination for the diagnosis of PPROM and PROM is a rapid