NEUROPROTECTIVE POTENTIAL OF FINGOLIMOD AGAINST ALUMINIUM CHLORIDE INDUCED EXPERIMENTAL DEMENTIA IN RATS

Alzheimer’s disease (AD) is an age related neurodegenerative disease mainly characterized by progressive cognitive decline, synaptic loss, extracellular amyloid‐beta (Aβ) deposits and intracellular accumulation of neurofibrillary tangles of tau protein. Multiple etiological factors have been linked with AD pathophysiology, oxidative stress, neuroinflammation, neurotransmitter deficit and foremost are the deregulation of lipid metabolism, consistently involve in AD pathology and cognitive deficit. In the present study, we have explored the neuroprotective potential of Fingolimod (FTY720), against Aluminium Chloride (AlCl3) induced experimental dementia in the rats.