Becoming physically active or maintaining physical activity during midlife is associated with biomarkers of amyloid‐beta, microglia, and temporal lobe integrity

Physical activity (PA) has a beneficial effect on brain health in older age. Whether and how changes in PA during midlife are linked to brain health later in life remains understudied. In adults at risk for Alzheimer’s disease (AD), we investigated the change in PA during midlife in relation to biomarkers of AD pathology, microglia, and brain integrity.