Tau Pathology in the Entorhinal‐Hippocampal Circuit

The lateral entorhinal cortex (LEC) is the site of tau accumulation in early stages of Alzheimer’s disease and has projections downstream to the dentate gyrus (DG) of the hippocampus. The pathological form of tau has the ability to propagate across synapses, spreading to connected brain regions and correlating with memory deficits and synaptic loss. Downstream to the LEC, the hippocampal DG is the site of ongoing adult neurogenesis, with new granule neurons added showing enhanced plasticity and increased survival compared to older neurons. We are interested in examining the role of neuron age for vulnerability to tau pathology in the LEC‐DG circuit.