Characterization of Longitudinal Brain Changes in a Community Cohort in Relation to Aging and Cognitive Impairment

Brain atrophy in aging and Alzheimer’s Disease (AD) involve numerous cortical and subcortical regions. Though there is much overlap in atrophy patterns between aging and AD, there may be regional differences between these two conditions (Fjell et al., 2019). Few studies, however, have explored these patterns in large community samples. This study attempts to investigate longitudinal changes in brain volumes and thickness in relation to aging and cognitive impairment in a well‐characterized community cohort.