Alzheimer’s Disease Related Neurodegeneration Partially Mediates Associations Between Air Pollution and Medial Temporal Lobe Atrophy in Older Women

Ambient air pollutants are toxic to the vascular systems, and recent studies have shown the late‐life exposures may result in neurodegeneration and increased risks for AD. It is unclear if cerebrovascular damage and AD‐related neurodegeneration contribute to the atrophies of medial temporal lobe. Here we assessed whether AD related neurodegeneration and cerebrovascular disease mediated adverse effects of air pollution exposure on MTL atrophy.