Macropinocytosis of APP is controlled by a cascade of regulatory proteins

The internalization of the Amyloid Precursor Protein (APP) is recognized as an important step in beta‐amyloid (Aβ) production. We have discovered that macropinocytosis of cell surface APP leads to rapid transport directly to lysosomes, bypassing early and late endosomes. This process leads to APP cleavage to Aβ and is regulated in part by Arf6.