Pupil and eye tracking measures as a tool for detection and intervention in neurodegeneration

The locus coeruleus–noradrenaline system plays an extensive role in cognition and behaviour. It is among the earliest and most prominent sites of pathology in neurodegenerative diseases of ageing, including Alzheimer’s and Parkinson’s disease. Improving our ability to detect changes in this system in vivo has implications for early diagnosis and for tracking treatment interventions.