Chronic electrophysiology reveals age related loss of coherence between hippocampus and entorhinal cortex in ThyTau22 mice

Recent studies suggest spatial learning and memory impairment, which is an early clinical sign of Alzheimer’s disease (AD), is caused by dysfunction of neurons that communicate between the hippocampus and entorhinal cortex. Technological limitations have prevented chronic cellular‐level tracking of these interconnected brain regions during the many months or years before onset of age‐related cognitive deficits. This study aims to take advantage of recent progress in chronic electrophysiology probes to explore how cellular and circuit‐level changes progress with aging across these two brain regions in a mouse model of AD.