Stress, anxiety and depression in older adults at increased risk for cognitive decline: association with biomarkers and sex/gender differences

Anxious depressive symptomatology and stress are associated with cognitive decline. Recent evidence suggests a relation between these factors and Alzheimer’s disease (AD) pathophysiology early in the continuum. With the current increases in anxiety, depression and stress due to the Covid19 pandemic ‐ notably in women ‐ unrevealing the biological mechanisms underlying these associations with a sex/gender approach appears fundamental.