Impairment of cerebral CO2 dynamic vasoreactivity in MCI & AD patients: a multi‐center study of cerebral flow regulation

Alzheimer’s Disease Centers in Los Angeles (USC), Dallas (UT‐SWMC) and Kansas City (KUMC) have joined together to study the regulation of cerebral perfusion through analysis of spontaneous time‐series data using a modeling methodology that previously yielded indications of reduced CO2 dynamic vasomotor reactivity (DVR) in amnestic MCI patients. We report initial results from this ongoing multi‐center study that confirm those preliminary findings and, furthermore, elucidate the effects of slow‐paced breathing.