Abstract 73: A real-world feasibility study evaluating the improvements in Glycemic Variability and metabolic parameters in people with Diabetes Mellitus driven by a remotely monitored personalized lifestyle program

Objective: To assess the effect of novel, personalized diabetes care program, on glycemic variabilityand other metabolic parametersamong people with Diabetes Mellitus (PwD) Methods: It was a 3-month follow-up study in PwD enrolled in OneCare 12-week virtual remote care program. Patients underwent 14 days of continuous glucose monitoring (CGM) with Abbottfreestyle libre device at the beginning and end of the program. Using 96 daily blood glucosereadings from each patient's CGM, daily glycemic variability values were averaged over first three days of first sensor application and last three days of second sensor application ending at day 90. Glycemic variability was calculated using EasyGV© software, a custom program that calculates various parameters of glycemic variability. Program was supported by health coach who remotely monitored patients through weekly scheduled calls to track progress. The patient's data, including HbA1c, weightwas also used for the analysis. Results: 50 CGM tracings were obtained and 44 evaluable CGM tracings, of 22 patients were included in the study with the mean age of 42.23 (13.2) years. 73% were male, duration ofdiagnosis of Diabetes Mellitus (DM) 3 (0.3-20) years, baseline HbA1c (%) of 8.8 (2.08), weight (kgs) of 75 (12.1). Post intervention, decline in HbA1c (%) was -1.87 (SD 1.85, p <.001). The significant mean improvement in FBS and PPBS (mmol/l) was -2.04 (SD 2.87) and -3.76 (SD 4.12) respectively. Mean weight (kgs) change was -4.22 (SD 3.3, p <.001). On day 1-4 of program participation, the mean (SD) of Coefficient of Variation (%CV) was 30.2% (12.3). This decreased to 22.9% (6.7) during days 87-90 (p = 0.02). Mean standard deviation of blood glucose on the first day of program participation was 2.1 (0.62). This decreased to1.63 (0.62) during days 87 to 90 (p = .01). The Mean Average Glucose (MAG) value on initial days of the program were 4.9 (1.05), which decreased to 4.4 (1.3) at the end of program (p = 0.02). Mean M value reduced from 29.56 (59.6) to 9.6 (21.7) (p = 0.04). Conclusion: Through 3-monthpersonalised lifestyle program, PwD achieved significant improvements in glycaemic variability and other metabolic parameters. A well designed prospective study is warranted to prove these feasibility results obtained.