Abstract 78: Dorsal pancreatic agenesis: A single centre experience

Background: Dorsal pancreatic agenesis is a rare developmental anomaly characterised by absence of pancreatic body and tail. Aims and Objectives: Case-series to describe clinical, biochemical characteristics and outcomes among dorsal pancreatic agenesis patients in our institute during the time period Feb 2021-Sept 2022. Results: During this period we found 10 subjects, of which 60% were males. The median age at diagnosis was 23.5 yr (range 16-52 yr). The median duration of diabetesat presentation was 3.5 yrs (range 1-14 yr). The most frequent clinical manifestations were found to be diabetes (100% cases) and non-specific abdominal pain (80%). Steatorrhea was seen in 30% cases. None of the patients presented with DKA. Anti GAD antibody was negative in 4 out of 4 cases tested. Serum amylase and lipase levels were normal in the cases presenting with pain abdomen. All the patients underwent CT abdomen which showed non-visibility of distal body and tail of pancreas. MRCP was done in 2 cases whichrevealed absent dorsal pancreatic duct. Next generation sequencing for MODY panel was done in 7/10 cases and no pathogenic variants were detected. Two patients are on OHA and rest 80% (8/10) cases are on treatment with insulin. Symptoms and signs of micro or macrovascular complications were not found in any of the cases. Conclusion: Dorsal pancreaticagenesis is a rare condition diagnosed during imaging for common abdominal symptoms. It is an important differential diagnosis in young patients presenting with diabetes mellitus and pain abdomen.