Study of osseointegration properties of multilayer coatings with a biodegradable film of flavonoid nanoaggregates

Characteristics of new implant coating of materials obtained by the method of induction heat treatment and modified by flavonoids nanoaggregates are studied and the prospects for their use in dental animal implantology are presented. It has been established that for a non-toxic biofunctional coating forming on a surface of implantation materials, it is had to apply the following concentrations of substances: propolis - 1.25 mg / 1 ml, polymer - no more than 0.0001%. Research has shown that experimental implants coatings do not inhibit erythropoiesis and leucogenesis. In addition, absence of sharp dispersion in calcium, phosphorus, creatinine and urea level, recovery of primary AST, ALT activity and the minimum values of C-reactive protein in experimental group animals in early term indicate implants have not any toxic effect.