RANKL and RANK in Cancer Therapy

Receptor activator of nuclear factor-kB (RANK) and its ligand (RANKL) have been described as key regulators in mammalian physiology such as bone metabolism, immune system, mammary gland biology or cancer. Herein, we explore the multiple functions of the RANKL/RANK pathway in physiology and pathophysiology and discuss the underlying principles and strategies to modulate the RANKL/RANK pathway as a therapeutic target in immune-mediated cancer treatment.