Custom: terminated multimode fibre probe for holographic micro-endoscopy

Using multiphoton microscopy, we can image the tissue with sub-cellular resolution at depths down to 1.5 mm. Beyond this reach, the light must be delivered to the target region by optical relay elements inserted into the tissue – the endoscopes. Focusing light through a step-index multimode optical fibre (MMF) using wave-front control enables minimally-invasive endoscopy. With fibre micro-endoscopes, we can reach any depth with negligible tissue disruption and keep the resolution below 1 micrometre, sufficient for in vivo microscopy. We designed a novel custom-terminated multimode fibre probe. This work will focus on optical fibre probe manufacturing methods (etching, polishing and coating) and their impact on imaging quality.