Aspects of the formation of post-vaccination immunity against porcine circovirus infection and its correction

Relevance. Prevention of circovirus diseases in swine management is one of the urgent problems in the industry. The article provides data on the results of the use of two regimens for administering vaccines against circovirus infection to piglets according to immunological, biochemical and zootechnical indicators.Methods. The work was carried out on piglets, which were vaccinated with "Ingelvak CircoFLEX" vaccine (Germany) against circovirus at the age of 21 days, in the experimental group it was administered together with "leukocytic lysate" obtained from donors hyperimmunized with this vaccine. Evaluation of the effectiveness of post-vaccination immunity formation was carried out based on the results of immunological, biochemical, zootechnical and statistical studies.Results. It was established that when the vaccination was combined with the introduction of «leukocytic lysate» from hyperimmunized donors, the number of piglets with a positive test for the presence of viral neutralizing antibodies was 79.30–82.33%, in the control — 67.80–71.60%, as a result of changes in the leukocytic blood pool within the normal limits. In piglets of experimental group blood concentration of total protein and albumins starting from 60-day age exceeds control level by 7.73–8.68 and 17.84–30.27% respectively. In the experimental group, compared with the control group, the co-storage of animals is increased by 9.02%, the live weight of piglets at the end of the nursery period is increased by 12.88 kg, or 31.85%, based on one head and the value of medium increases in live weight — by 90 g, or 26.01%. 