Expression of Concern: RyR1 and RyR3 isoforms provide distinct intracellular Ca2+ signals in HEK 293 cells

The authors state that this error does not significantly impact the interpretation of the article, the data reliability or the reader’s understanding of the paper and that the scholarly integrity of the article remains intact. “Data reported in Fig. 6A and B aimed to illustrate variability of spontaneous Ca signals in two RyR3-expressing cells; spontaneous Ca release events are also reported in Fig. 5 and duplication of signal in Fig. 6Ab does not impact on the main interpretation of the article which was that HEK293 cells expressing RyR3 display spontaneous Ca release events and those expressing RyR1 do not. This suggested that, at least in these cells, isoform-specific functional properties may contribute to generation of intracellular Ca signals.”