Rewiring the logic board of IFN signaling

Interferons (IFNs) activate cell-autonomous immunity to combat infection and control inflammation. In this issue of Science Signaling, Boccuni et al. reveal how macrophages incorporate stress signals through the p38 MAPK pathway to enhance IFN-induced responses against intracellular pathogens. Description Integrated cell stress and interferon signaling enable enhanced and customized immune responses (Boccuni et al., in 13 December 2022 issue).