Choroid Plexus Calcification Associations with Brain Morphology and Family History of Alzheimer's Disease

The choroid plexus (CP) is the primary source of cerebrospinal fluid (CSF) production and forms the blood‐CSF barrier which regulates nutrients and hormones to the brain. Changes in CSF production are associated with aging and Alzheimer’s disease (Saade 2019, Hubert 2019). CP calcification (CPcal) has been associated with metabolic disorders, cerebrovascular diseases, and tumors (Wu, 2009). Here, we used MRI‐derived quantitative susceptibility mapping (QSM) from the UK Biobank(Miller, 2016) to investigate whether CPcal is associated with morphological brain alterations and family history of Alzheimer's disease or related dementias (ADRD).