Modifiable dementia risk factors associated with higher CSF tau and poorer cognition in middle‐aged adults

Modifiable factors in domains such as mood, lifestyle behaviours, cardiovascular health, cognitive/social engagement, and sleep are associated with increased risk for dementia. These modifiable risk factors could promote Alzheimer’s disease (AD) related biological processes, such as beta‐amyloid (Aβ) or tau accumulation, but these associations remain poorly understood. This study aimed to determine associations between modifiable dementia risk factors with Aβ, tau, and cognition in cognitively unimpaired middle‐aged adults.