IMMUNODEFICIENCY SYNDROMES IN ACUTE HEPATITIS B CONVALESCENTS

Background. Chronic hepatitis B (CHB) remains one of the most urgent problems in modern medicine. There are about 296 million people with CHB worldwide, 820 thousand dying annually of liver cirrhosis and hepatocellular carcinoma. Objective. To study the immunodeficiency syndrome peculiarities in acute hepatitis B (AHB) convalescents. Material and methods. We have studied immunodeficiency syndrome (IDS) in 104 AHB convalescents, the control group comprised 78 apparently healthy donors. All examined were between the ages 18-45. IDSs were studied according to the IDS Map developed by Acad. R.V. Petrov (1987). Results. In 17.3% of AHB convalescent patients IDSs were absent, while in 82.7% - at least one of the three IDSs (infectious, atopic and autoimmune) was detected. In 44.2% of cases, clinical variants of one IDS were noted, in 34.9% - those of two syndromes, in 20.9% - those of three syndromes simultaneously in various combinations. Convalescence from AHB with IDS either had a non-smooth course or the disease transformed into a chronic process in 24.4%, while in the control group - in 12.3% of cases. Conclusions. AHB with IDS should be included in the progredient form, i.e. as a high-risk pathology of liver cirrhosis and hepatocarcinoma development, thus determining its appropriate therapeutic strategy.