Abstract 69: Phenotypic, biochemical and radiological correlation of children with growth hormone deficiency in a tertiary care hospital in Eastern India

Background/ Objective: Growth hormone deficiency (GHD) is a non-exceptional cause of short stature. Hormonal evaluation and hypothalamic- pituitary MRI are essential to establish the etiological diagnostic. The objective of our study was to find out the prevalence of MRI abnormalities in patients with GHD. Secondly, to find the correlation between radiological and biochemical and clinical correlates of GHD. Materials and Methods: This isa retrospective longitudinal study of 50 patients with idiopathic GHD who underwent MRI examination at our hospital. The patients were classified into isolated GHD (IGHD) and multiple pituitary hormone deficiency (MPHD) to observe the difference in clinical, biochemical and MRI findings. Results: A total of 50 patients were included in our study of which 16 patients had MPHD while 34 patients had IGHD. Prematurity, breech delivery, neonatal jaundice, micropenis, consanguinity was more common in MPHD group as compared to IGHD group. About 19 patients (38%) had MRI abnormalities of which majority were MPHD. In patients who had severe GHD (peak GH <3 ng/ml), (n = 20) 60% (n = 12) had MRI abnormalities while 7 (23.3%) patients with non-severe GHD had MRI abnormalities. Patients with height SDS <-3SD are more likely to have MRI abnormalities than patients with height SDS >-3SD. Conclusion: About one- third patients with GHD are likely to have MRI abnormalities of which majority patients are MPHD. There is a positive correlation between severity of GHD and presence of MRI findings. Patients with severe short stature are more likely to have MRI findings.