Capsule endoscopy successfully diagnosed Henoch-Schönlein Purpura in a patient with small intestine involvement

A young woman presented with vomiting after eating shrimp and abdominal pain predominantly around the umbilicus and upper abdomen. Physical examination revealed epigastric and periumbilical tenderness without rebound tenderness. Petechiae, ecchymoses, and palpable rashes were observed in the distal part of both lower limbs (▶Fig. 1). Laboratory tests revealed an increase in CRP (38.1mg/L), ESR (38mm/h), and IgE (872.0 IU/ml), while the other relevant tests and physical examinations were unremarkable. Abdominal computed tomography (CT) showed diffuse thickening and edema in the horizontal part of the duodenum with dilated lumen (▶Fig. 2). Gastroscopy and colonoscopy did not reveal any detailed abnormalities. Capsule endoscopy was performed, which revealed multiple areas of purpuric erythema throughout the small intestine (▶Fig. 3) and notably purpuric lesions fusing with each other to form large hemorrhagic blisters in the proximal small bowel, which had not been reported previously (▶Fig. 4, ▶Video 1). A diagnosis of Henoch-Schönlein purpura was adopted after ruling out other diseases. The patient was treated with methylprednisolone and achieved a good therapeutic outcome. Seven days later, the patient’s abdominal symptoms and palpable rashes fully disappeared. A second examination with abdominal CT and capsule endoscopy performed 8 weeks after the start of treatment showed that the previously identified lesions had completely resolved. Henoch-Schönlein purpura is an IgAmediated systemic vasculitis with clinical manifestations including non-thrombocytopenic palpable purpura, abdominal pain, arthritis, and renal disease [1]. Gastrointestinal symptoms occur in about 50% to 85% of patients and the lesions can involve the entire gastrointestinal tract, with small intestine involvement being the most common [2, 3]. Therefore, capsule endoscopy has a unique value in the diagnosis of small intestine involvement in Henoch-Schönlein purpura, allowing a comprehensive view of E-Videos