HISTOLOGICAL EVALUATION OF FDA-APPROVED HYALURONIC ACID BASED SCAFFOLD IN REVASCULARIZATION OF NECROTIC MATURE PERMANENT TEETH WITH APICAL PERIODONTITIS IN DOGS

* Corresponding author INTRODUCTION Hyaluronic Acid (HA) hydrogel scaffolds have shown promising potential in promoting cell viability, mineralization and odontoblastic differentiation in many regenerative pulp investigations in vitro. (1) Commercially available HA dermal fillers have controlled preparations and enhanced mechanical integrity through crosslinking technology. Moreover, they are easy to acquire, handle, and inject into the root canal. Previous studies have shown promising results when FDA-approved Restylane Lyft sterile injectable dermal filler was used as a scaffold for pulp regeneration in vitro and in immature teeth in vivo. (2,3) However, to date, the performance of Restylane Lyft hasn’t been histologically investigated as scaffold in mature teeth.