Boosting Hippocampal Neurogenesis Rescues Cognitive Impairments in 3xTgAD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is an irreversible neurodegenerative disease with no treatment to date. Symptoms of AD include emotional disorders and memory impairments mainly resulting from dysfunction of the hippocampus, a brain area involved in learning, memory, navigation and regulation of mood. To attempt a rescue of hippocampal function in the disease, hippocampal neurogenesis was boosted in the Alzheimer’s mouse model.