Association of Mid‐life Discrimination Stress and Coping on Brain Volumes

Chronic stress is related with poor health outcomes including changes in brain structure and function. Stress‐related glucocorticoid and adrenergic receptors are richly expressed in hippocampus, prefrontal cortex, and amygdala, but it is unclear if all forms of stress impact these brain regions. Perceived discrimination is a form of stress, and there is limited research in how perceived discrimination can impact brain volumetrics. Our goal is to assess the association of perceived discrimination in brain regions prone to stress‐related affect.