Associations between default‐mode functional connectivity and distress, cardiovascular and metabolic risks and cognition in middle aged and older adults

“Stress” and cardiovascular and metabolic (CVM) conditions are frequently related and affect brain function and increase risk for neurocognitive disorders in aging. The mechanisms by which these occur are unclear. This study investigates how indices of psychological distress and CVM relate to functional connectivity (FC) of the default‐mode network (DMN) and cognition in generally healthy middle‐aged and older adults.