Amyloid burden is not associated with brain atrophy in the oldest‐old

Alzheimer’s disease (AD) is an important contributor to brain atrophy in older individuals. However, in the oldest‐old (≥85 years), where multiple pathologies are common and contribute to brain atrophy, the relationship between AD and brain atrophy may be attenuated. Here we examined associations between amyloid burden and brain volumes in oldest‐old participants and compared this to younger‐old.