Prodromal FTD ‐ what do we know about it and what do we still have to learn?

Frontotemporal dementia (FTD) is a complex disease that can initially present with subtle symptoms across several domains including behavior, cognitive/language, psychiatric and motor. This heterogenous prodromal phase is preceded by a slowly progressive presymptomatic accumulation of biological changes. With the emergence of new potential therapeutic agents for genetic forms, there is a need for robust clinical characterization and diagnostic definitions of these disease phases.