Examination of associations between female natural reproductive span and dementia risk

Despite substantial evidence for a greater prevalence of Alzheimer’s disease and related dementias (ADRD) among women, there is a limited understanding of sex‐specific mechanisms which may modify risk. Greater lifetime estrogen exposure (often approximated by the length of the reproductive span) is hypothesized to be protective, however, previous investigations into the relationship between the female reproductive span and ADRD have been mixed.