Kidney function is associated to Alzheimer’s related blood biomarkers (NfL, P‐tau181, and GFAP) but not dementia risk in a community‐based cohort followed over 17 years

In order to determine the future of Alzheimer’s disease (AD) related blood biomarkers in the clinical setting, it is crucial to identify factors that could affect the interpretation of biomarker levels. Kidney function has been shown to influence biomarker levels, but has also exhibited associations to dementia risk and it is unclear whether kidney function plays a role in AD pathology or is merely a factor influencing blood biomarker levels. Therefore, the aim of this study was to explore the association of kidney function with risk of incident AD/dementia diagnosis within 17 years and with the blood biomarkers, neurofilament light (NfL), phosphorylated tau (p‐tau181), and glial fibrillary acidic protein (GFAP), in a community‐based cohort study.