Inducible microRNA‐34a overexpression impairs cognition and promotes Alzheimer's pathology

Alzheimer’s disease (AD), a chronic neurodegenerative condition resulting from pathological brain aging, is the most common cause of geriatric dementia and is likely polygenic in origin. The discovery of microRNAs (miR), small, endogenous, non‐coding, and highly conserved RNAs that regulate post‐transcriptional expression of potentially hundreds of genes, has revealed new drivers and therapeutic targets of AD pathogenesis. Research from our group and others indicates that miR‐34a may be a promising candidate.