Impact of therapeutic plasma exchange on amyloid plaque load and vascular health in APP/PS1 mice

Therapeutic plasma exchange (TPE) has been shown to be a beneficial treatment for Alzheimer’s disease (AD) to both humans and mice; however, little is known about TPEs impact on preserving vascular function. Since AD pathology is usually associated with vascular dysfunction, the current study investigates the therapeutic potential of TPE on preserving vascular reactivity in young APPswe/PS1dE9 AD mouse model.