The relationship between uric acid and total femur bone mineral density in hypertensive and non-hypertensive populations

Objective This study aimed to explore the association between uric acid (UA) and total femur bone mineral density (BMD) in hypertensive and non-hypertensive groups. Methods We conducted a cross-sectional study of 13,108 participants in the NHANES database, including 4,679 hypertensive and 8,429 non-hypertensive subjects. A weighted multiple linear regression analysis was conducted to explore the association between UA and total femur BMD. Results In the hypertensive group, the relationship between UA and total femur BMD was positive [β, 3.02 (95% CI, -0.44 to 6.48), p = 0.0962). In the non-hypertensive group, the association was significantly positive [β, 5.64 (95% CI, 2.06–9.22), p = 0.0038]. In gender-stratified analysis, UA was analyzed as a continuous variable and a categorical variable (quartile). The significantly positive association was present in both the hypertensive male group [β, 5.10 (95% CI, 0.98–9.21), p for trend = 0.0042] and non-hypertensive male group [β, 10.63 (95% CI, 6.32–14.94), p for trend = 0.0001]. A smooth curve fitting showed that in the hypertensive male group, the relationship between UA and total femur BMD was an inverted U-shaped curve. In the hypertensive female group, the relationship was basically negative. In the non-hypertensive population, the relationship between UA and total femur BMD was an inverted U curve in both men and women. Conclusion In the hypertensive male group, the association between UA and total femur BMD was an inverted U-shaped curve. As to women, the relationship was basically negative. In the non-hypertensive group, the association between UA and total femur BMD was an inverted U-shaped curve in different genders.