Pharmacological preconditioning with mitochondrial dynamic modulators exerted neuroprotection against cardiac ischemia‐reperfusion injury in obese rats via suppressing microglial inflammation

Obesity is widely acknowledged as a major risk factor for brain and heart complications. Brain inflammation and microglial activation can be induced by either cardiac ischemia/reperfusion (I/R) injury or obese condition. While mitochondrial fission inhibitor (Mdivi‐1) and fusion promoter (M1) have already been reported as potential cardioprotective therapies, their protective effects in the brain suffered from cardiac I/R injury under obese condition have not been investigated.