CRGDyk-targeted PAMAM nanoparticles for synergistic phototherapy/chemotherapy targeting of melanoma

Temozolomide (TMZ) and indocyanine green (ICG) are relatively effective drugs for cancer treatment. TMZ can effectively cross the barrier between blood and brain, while ICG has a high thermal conversion rate, but they also have disadvantages such as easy decomposition in vivo and poor targeting. In order to address the shortcomings of these two drugs and to improve their stability and targeting in vivo, as well as to further enhance their efficacy, I will use PAMAM nanoparticles to encapsulate TMZ and ICG and target the tumour-targeting peptide cRGDyk as a synergistic therapy, and conduct relevant experimental validation.