Laying the groundwork of an in vivo macromolecular crystallography platform at Synchrotron SOLEIL

The identification of protein crystals naturally occurring inside cells and organisms has opened a window for a new type of macromolecular crystallography (MX) and structural biology, referred to as in vivo MX. In the past decade, there have been efforts to obtain deeper insights into the yet uncontrollable events dictating in vivo crystal growth, by further developing sample handling and delivery procedures and applying these techniques to the structure determination and analysis of readily available ivMX systems. To facilitate the use of ivMX by the larger community, milestones for the implementation of a complete pipeline have been set at Synchrotron SOLEIL (France).