Association of Optic Disc Hyperfluorescence with Subclinical Macular and Optic Disc Edema in Uveitis Patients

Purpose: To investigate the frequency of optic disc hyperfluorescence (ODH) and their association with macular and optic nerve head thickness in patients with active uveitis.Methods: This retrospective cross-sectional study included 37 eyes of 30 patients with active noninfectious uveitis who underwent spectral domain-optical coherence tomography (OCT) and fluorescein angiography. OCT parameters were compared between baseline and post-treatment according to the ODH.Results: ODH was observed clearly in 22 eyes (64.7%) and equivocally in five eyes (14.7%) at baseline. In subgroup analysis without clinically significant optic disc edema, central subfield thickness, peripapillary retinal nerve fiber layer thickness, disc rim area, and disc area were 262.2 μm, 110.9 μm, 1.49 mm2, and 2.02 mm2 at baseline and significantly decreased after treatment (249.5 μm, 102.1 μm, 1.34 mm2, and 1.95 mm2, respectively) in eyes with ODH (p = 0.044, p < 0.001, p = 0.001, p = 0.024, respectively). However, there was no significant changes in the eyes without ODH (all p > 0.05).Conclusions: There was a difference in the thickness reduction of the macula and optic nerve head according to the ODH. Baseline ODH should be regarded as a sign of ocular inflammation and carefully monitored.