Efficacy and Safety of Chinese Herbal Medicines combined with Cyclophosphamide for Connective Tissue Disease-Associated Interstitial Lung Disease: A Meta-Analysis of Randomized Controlled Trials

Review question / Objective: To evaluate the effectiveness and safety of Chinese herbal medicines (CHMs) combined with cyclophosphamide (CTX) for connective tissue disease-associated interstitial lung disease (CTD-ILD) by performing a meta-analysis. Condition being studied: Chinese herbal medicines (CHMs) and cyclophosphamide (CTX) are widely used in the treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD). However, the clinical benefits of CHMs treatment for CTD-ILD are still controversial, and there is no systemic review to summarize and evaluate their efficacy and safety.