Gynecomastia associated with methotrexate therapy for psoriatic arthritis

Methotrexate is widely used for treatment rheumatic diseases, including psoriatic arthritis. Adverse reactions could develop during methotrexate therapy, the most common of which are skin lesions, liver dysfunction, diarrhea, nausea, etc. Gynecomastia is a rare complication of low-dose methotrexate therapy. The mechanism of its development is not fully understood. We present a case report of the development of gynecomastia in a patient with psoriatic arthritis during treatment with methotrexate.