Quantitative analysis of 6,150 real‐world amyloid Positron Emission Tomography (PET) scans from the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) study

Amyloid‐PET had been widely used and validated in research settings, using highly selected samples, harmonized acquisition protocols, co‐registration with MRI, and central interpretation by highly experienced experts. In contrast, in clinical settings, more heterogeneous acquisition, reconstruction, and interpretation may compromise the accuracy of the imaging. We quantitatively analyzed real‐world amyloid‐PET scans to assess their validity.