Longitudinal trajectory of microglial activation and astrocyte activation

Neuroinflammation plays a significant role in the pathogenesis of AD. Here, we evaluate neuroinflammation, the interrelationship between neuroinflammation, amyloid and tau pathologies, and the impact of neuroinflammation in disease trajectory. We specifically focus on microglia as a major player in neuroinflammation and spatial and temporal variation of microglial phenotypes and novel methods of evaluation of astroglial activation.