Self‐reported sleep quality interacts with Alzheimer’s disease biomarkers on brain structure and metabolism in cognitively unimpaired adults

Poor sleep quality has been associated with a greater burden of AD pathology and altered brain structure in cognitively unimpaired (CU) individuals. However, there is a lack of studies analysing associations between sleep quality and brain structure and function, while taking into account AD pathology. We aimed to test associations of self‐reported sleep quality with grey matter volume (GMv) and brain glucose metabolism in middle‐aged CU and sought interactions with biomarkers of AD pathology.