Abstract 76: Prediction of relapse after antithyroid in newly diagnosed patients with graves disease

Background: Graves' disease most common cause of hyperthyroidism. Despite, presence of multiple treatment options namely thionamides, radioiodine therapy and surgeryneed for an effective and complication free option is still being explored. Different studies have found several clinical, biochemical, or demographic factors for prediction relapse after antithyroid therapy atbaseline and end of treatment. No previous studies have been conducted in Indian patients. Aims and Objectives: To study various clinical, biochemical and imaging features in newly diagnosedpatients with grave's disease on antithyroid drugs at baseline. To predict potential factors of relapse after 1 year follow up. Results: in this interim analysis a total of 96 patients have been recruited. Mean age of patients is 40 years with a female preponderance of 61% with history of smoking and biomass exposure in 12% and 20% respectively. Patients had a coexistent autoimmune disorder in 8% and family h/o thyroid disorder in 16% of the patients. Out of the 26 patients completing 12 months of ATD therapy 6 (21%) had gone into biochemical remission. This population does not differ from baseline parameters of age, goitre size, T4 levels andTRabs. However, all patients entering remission were females (100%) compared to 67% in baseline Conclusions: Interim analysis shows that medical therapy leads to initial remission in about 21% of the patients at 12 months of therapy.