Cell type specific gene expression profiles of the candidate genes for Alzheimer’s disease

Decades of genetic studies discovered candidate genes for Alzheimer’s disease (AD). Molecular mechanistic insights, however, are available for few candidate genes. This lack of understanding on gene function has been a challenge to translate the role of candidate genes to discovering treatment and diagnostic biomarkers. Recent advances in single cell profiling provide an opportunity to understand functional significance of candidate genes and their products for the cell types implicated in AD.