Unexpected Findings from 8,205 Brain Magnetic Resonance Imaging Examinations of Research Volunteers ≥ 40 years old

Brain MRI is used routinely to study morphology in normal aging and dementia. Expert image review for clinically significant findings varies across sites and best practice is unsettled. We describe unexpected findings from 8,205 research brain MRIs from adults 40 years and older, comparing neuroradiologist presumptive diagnoses versus lesions flagged as concerning by scanning staff.