Anterior chamber enhancement – a window into the orbital glymphatic system and beyond?

Recently, an orbital glymphatic system (GS) was described, that serves retinal homeostasis and clearance. In accordance to the brain GS, the orbital GS is supposed to be altered in a variety of disease, first and foremost Alzheimer's Disease (AD). Disturbances of the orbtial GS where suggested to serve as early (imaging) biomarker. Therefore it is highly desirable to visualize orbital GS function in vivo. This study investigated intravenously injected Gadolinium‐based contrast agent (GBCA) to visualize the orbital GS. We used a retrospective patient cohort of children suffering from retinoblastoma (RB) who are supposed to show altered orbital GS function to test the validity of this method.