Comorbid Pathology in Clinical Trial Participants: Autopsy Findings and Clinical Features

The presence of multiple comorbid pathologic features in late onset dementia has been well documented across cohort studies that incorporate autopsy evaluation. It is likely that such mixed pathology may also be common in Alzheimer’s disease and related dementias (ADRD) clinical trial participants, potentially confounding the results of interventional trials that are designed to target a solitary pathophysiologic mechanism.