Macrophage Scavenger Receptor 1 in the CSF pre‐symptomatic with a parental history of AD and in the cortex of autopsy‐confirmed Alzheimer’s Disease cases.

The macrophage scavenger receptor 1 (MSR1) also known as SCARA1, is a gene that encodes for a macrophage/microglia cell surface receptor. Its primary function is to mediate the endocytosis of modified (acetylated or oxidized) low density lipoproteins (LDLs)(Frenkel, Wilkinson et al. 2013). Interestingly, MSR1 has been found to bind to soluble β‐amyloid (Aβ) and it is thought that it participates to its clearance via a microglia‐mediated process (PrabhuDas, Baldwin et al. 2017). Using multiple cohorts covering a wide range of brain health stages, MSR1 gene expression and protein level alterations were investigated to map the associations between MSR1 and Alzheimer’s disease (AD) pathophysiology.