Prevalence of Dyslipidaemia in Lichen Planus in a Tertiary Level Hospital

Background: Lichen planus (LP) is a chronic inflammatory papulosquamous disorder affecting the skin, mucous membranes, hair, and nails. It is clinically characterized by small, flat-topped, shiny, polygonal violaceous papules that may coalesce into plaques. It is believed that LP represents a T-cell-mediated inflammatory disorder. Chronic inflammation causes disturbances in the lipid metabolism. A link between dermatological disorders and dyslipidemia has been established in the recent past. When this dyslipidemia becomes prolonged it increases the risk of cardiovascular disease, stroke & metabolic syndrome. Proper evaluation & early detection reduced the burden of dyslipidaemia in patients with Lichen planus. Objectives: Purpose of this study was to evaluate the prevalence of dyslipidaemia in patient with lichen planus. Materials & Method: This cross-sectional study was conducted Department of Dermatology and Venereology, Dhaka Medical College Hospital, Dhaka. Total sample size was 100. Patients with lichen planus aged >18 years of age and of both sexes were enrolled for study. Clinical examination and relevant investigation were done meticulously. Serum lipid profile was evaluated based on NCEP/ATP III criteria. Data was processed and analysed with the help of computer program SPSS and Microsoft excel. Quantitative data expressed as mean and standard deviation and qualitative data as frequency and percentage. Comparison was done by tabulation and graphical presentation in the form of tables, pie chart, graphs, bar diagrams, histogram & charts etc. Results: in this study maximum incidence was seen in the 4th decade (e.g., 57.0%), mean age of the patient was 53.42±8.5 years. Male and female ratio was 4.88:1. On evaluation of serum lipid level, 28 patients found borderline to high total cholesterol level (> 200 mg/dl) with mean value 167.57 mg/dl ± 47.84. Abnormal Serum LDL cholesterol was detected in 32 patients with mean value 126.16 mg/dl ± 47.29. Serum HDL ......