Aβ1‐42‐related sodium‐calcium exchanger isoform‐3 downregulation in models of Alzheimer’s disease: Therapeutic significance of Withania somnifera roots extract

Na+‐Ca2+ exchanger isoform‐3 (NCX3) take‐parts in the aberrant Ca2+‐influx seen during neuronal excitotoxicity. However, the NCX3‐Aβ1‐42‐associated cytotoxicity and whether renovation of the aggregated Aβ1‐42‐induced NCX3 downregulation prevents or delays the onset of Alzheimer’s disease (AD) and AD‐related pathology remain unclear. Withania somnifera (W. somnifera), an indigenous traditional medicinal plant, has a long history of uses in preventing aging‐related neurological‐health impairments. However, this plant’s roots extract therapeutic value in neurodegenerative diseases, such as AD, albeit far less well studied.