ABCA7*V1599M variant in 5xFAD mice mediates differences in amyloid‐beta pathology and reactive gliosis

In several large genome‐wide association studies (GWAS), genetic polymorphisms of ATP‐binding cassette transporter subfamily A member 7 (Abca7) have been identified as a risk factor for late‐onset Alzheimer’s Disease (LOAD). ABCA7 is a member of a family of ATP‐binding cassette (ABC) transporters and functions as a transmembrane protein mediating the release of cholesterols and phospholipids from cellular membranes. Previous studies have also proposed its role in mediating phagocytic clearance of amyloid beta (Aβ) oligomers within macrophages in the brain.