Early reocclusion after successful mechanical thrombectomy for large artery occlusion-related stroke

Background and Purpose: Despite initial successful recanalization after mechanical thrombectomy (MT), some patients with large artery occlusion (LAO)-related stroke will experience an early reocclusion of the injured vessel which may worsen their prognosis. We aimed to investigate the prevalence, associated factors and prognosis of early reocclusion after successful MT in a large prospective cohort of stroke patients with LAO. Methods: We included patients from the Lille reperfusion registry with LAO-related stroke involving M1 segment, internal carotid artery terminus or tandem ICA-M1 occlusion, with successful recanalization after MT and available 24-hour imaging follow-up. Early reocclusion was defined as internal carotid artery terminus or M1 occlusion on 24-hour MRI or CT vascular imaging. Multivariable logistic regression models were used to investigate factors associated with early reocclusion and its impact on outcomes. Results: Between 2015 and 2020, 62 of 1015 included patients experienced an early reocclusion (6.1%). Age (OR per 15 years decrease: 1.38 [1.05–1.81]), antiplatelet use (OR: 0.41 [0.19–0.89]), several device passes (OR: 2.13 [1.18–3.83]), atherosclerosis cause (OR: 2.38 [1.19–4.78]) and early clinical worsening (OR: 2.45 [1.18–5.07]) were independently associated with early reocclusion. Early reocclusion was independently associated with poor prognosis (OR: 7.15 [3.49–14.65]) and mortality (OR: 2.05 [1.07–3.91]) at 3 months. Conclusion: Six percent of patients with LAO-related stroke and initial successful recanalization experienced early reocclusion. This event is associated with a seven-fold increased risk of poor functional outcome and a two-fold increased risk of mortality. Further efforts are warranted to refine early detection of patients at risk of reocclusion and to improve their management.