Application of Prussian blue nanoparticles and paclitaxel encapsulated in melanoma cell membrane in the treatment of melanoma

Melanoma is a type of skin cancer that has a substantial rate of morbidity and mortality and is a worldwide problem. Phototherapy and chemotherapy are the most popular therapies for it today. Phototherapy (PT) is a medical treatment in which natural or artificial light is used to improve a health condition. Chemotherapy is a cancer treatment in which the patient is given harmful medications to stop the cancer cells from growing. Though both therapies show efficiency towards cancer, they also display side effects. Since phototherapy needs directly light to lesion site, this therapy would pale its usefulness against disseminated tumors like liver cancer. Recently nanomaterials are popular among target drug research, this is because nano-drug delivery systems that encapsulate or adsorb pharmaceuticals on the surfaces of natural or synthetic polymer materials have the advantages of decreasing adverse drug reactions, controlling drug release rates, and targeting tumor locations. Consequently, using Chemo-photothermal therapy combination would significantly reduce the risk of side effects. This article talks about a new nanostructure of target drug: Melanoma cell membrane encapsulated with Prussian blue and paclitaxel. Prussian blue (PB) has been employed as a photothermal conversion reagent to produce heat to cause localized tumor destruction and paclitaxel is usually adopted in chemotherapy.