Strengthen oversight of risky research on pathogens

Description Policy reset and convergence on governance are needed Life sciences research offers immense benefits and is crucial for advancements in medicine, public health, agriculture, and management of the environment. But a recent guidance framework by the World Health Organization (WHO) reminds us of the continued lack of awareness and governance structures in many countries for life sciences research that may cause harm through accident or misapplication (1). Robust risk management would enable the full realization and equitable distribution of potential benefits from the life sciences and associated technologies, and reassure the public (1). International guidelines and standards of conduct are needed (2), along with effective oversight institutions and leadership (3). The US government (USG) has played a prominent role to date and is now reviewing its biosecurity policies. We identify substantial gaps and suggest approaches to address them so as to improve US policies and usefully influence policies globally.