Retrospective MRI‐based tracking of hippocampal sclerosis

The hippocampus plays a crucial role in memory encoding and retrieval and is highly vulnerable to age‐related pathologic alterations. Hippocampal sclerosis (HS) is a prominent histologic finding in dementia patients which results in worsening of cognitive symptoms but has been so far understudied. Contrary to HS developed in epilepsy, HS of aging specially affects individuals over 85 years old. It is defined by severe neuronal loss and gliosis in CA1 and subiculum areas, which is disproportionate to the expected damage from other pathologies that commonly coexist with HS, such as AD and TDP‐43 pathology.