Characterization of behavioral changes, MRI brain volumetry and brain metabolic profile of 5xFAD mouse model of Alzheimer’s disease

5xFAD mice (B6SJL‐Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax)) express five AD linked mutations in human APP (K670N/M671L, I716V and V717I) and PSEN1 (M146L and L286V) transgenes. APP and PSEN1 mutations cause human like AD pathology by overproducing Aβ42, leading to plaque accumulation in the brain. The objective of this study was to characterize the behavioral changes, brain volumetry and metabolic profile, beta amyloid accumulation and other biomarkers in 5xFAD mice.