Brain‐wide spatial analysis reveals cell‐type‐specific genetic modifiers of Alzheimer’s disease progression

There is significant variation in the age at onset and severity of cognitive decline among those with Alzheimer’s disease (AD). Despite strong genetic links to AD loci, the specific variants, target genes and cell types that drive AD‐related deterioration remain elusive. Recent advances in brain‐wide cell type and pathology quantification across our AD mouse genetic reference panel provide new opportunities to identify genetic factors that act in a cell‐type‐specific fashion to modify disease progression in response to causal AD mutations; linking, for the first time, genetics to regional cell composition to characterize susceptibility versus resilience to AD.