Electrochemical detection of CEA and CA153 Lung Cancer Markers Based on ZnO/Porous Graphene Oxide Composite Biosensor

In this work, zinc oxide/porous graphene oxide (ZnO/HGO) composites were prepared by wet chemistry for the construction of electrochemical sensors for the tumor markers carcinoembryonic antigen (CEA) and CA153. The electrochemical behavior of the sensor in the sensing system. The results showed that the electrochemical sensor showed good linearity in the concentration range of 0.1 to 20 ng/mL and 0.5 to 70 U/mL toward CEA and CA 153, respectively. In addition, electrochemical signals were combined for discriminant analysis of different markers. Discriminant analysis can be performed on unknown samples, and if a larger number of samples can be added, the accuracy of model building can be further improved and the identification rate of unknown samples will be greatly increased. This method is fast and convenient, and provides a new method for tumor marker identification.