Structural Modularity is a Feature of C9orf72 Intrinsic Network Degeneration

Genetic forms of frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) provide an important target for early therapeutic interventions. However, pre‐symptomatic biomarkers to monitor disease progression are lacking. Prior neuroimaging studies suggest disruption of functional and structural networks are an early feature of neurodegenerative disease. Network modularity quantifies the degree of segregation between sub‐networks. We hypothesize that structural network modularity is a marker of neurodegeneration in C9orf72 carriers.