Different atrophy profiles detected in AD patients who carry APOE4 versus non‐carriers: An ENIGMA‐VBM Multicohort Analysis (N=1,893)

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and apolipoprotein E (APOE) ε4 allele is the greatest common genetic risk factor for late‐onset AD. In one of the largest multi‐cohort VBM analyses to date, we aimed to a) map regional brain cortical volume deficits in people with dementia vs controls (CTL) and b) investigate how atrophy patterns in AD were modulated by carrying the APOE4 genotype.