Synthesis and Anticancer Activity of Novel Thiazolo-Coumarin Derivatives

As a starting point for creating new inhibitor scaffolds, a molecular hybridization approach was applied
in designing the novel molecules using coumarin-thiazole hybrids as mPGES-1 enzyme inhibitors.
Thus, in present work, the novel thiazolo coumarin derivatives (8-35) were synthesized and characterized
by 1H NMR, IR and ESI-MS spectra. All the synthesized molecules (8-35) were also investigated for
their anticancer activity on MCF-7 (breast cancer), caco-2 (colon cancer), HeLa (Cervix cancer) cell
lines. Studies revealed that compounds (8-14) and (22-28) showed inhibition (IC50) at different
concentrations of 12.5, 50, 100 μg/mL and more than 100 μg/mL.