Derivation and evaluation of signatures using plasma β‐amyloid and pTau‐181 for brain amyloid‐β detection

Detection of brain amyloid‐b (Ab) pathology using blood‐based tests would be considerably more convenient for patients, in addition to being a faster and more cost‐effective method for screening and monitoring patients in clinical trials. Using patient screening data from internal clinical trials, we derive signatures for brain Ab detection using plasma Ab42, Ab40, and pTau‐181, and evaluate their performance accuracy in an independent dataset.