Multifunctional Role of Phyllanthus Acidus L. as a Therapeutic Agent for Management of Diabetes and Associated Complications: A Review

Background: Plant based medicines have been used in traditional system of medicines since time immemorial for the treatment of diabetes due to relatively low prevalence of side effects and ease of access in developing countries. Objective: The review compiles and analyses the scientific data to accentuate the role of Phyllanthus acidus also known as star gooseberry, as a promising treatment for the management of diabetes and related complications. Method: Several electronic databases like Google Scholar, Pub Med, Scopus, Web of Science, Science Direct etc. and other published data in books and dissertations were utilised to compile this review. Result: Both in-vitro and in-vivo research have indicated that the phytoconstituents present in Phyllanthus acidus may affect the various biomarkers of diabetes. The mode of action behind antidiabetic property of the plant and its biologically active components are mainly due to inhibition of 𝛼-glucosidase, suppression of PPAR-𝛾, and elevate production of insulin. Conclusion: The antioxidant and anti-inflammatory studies pertaining to Phyllanthus acidus also strengthen its claim as an effective antidiabetic agent. Therefore, Phyllanthus acidus shows promising therapeutic potential to be used in the treatment of diabetes and its co morbidities.