Uncovering Diverse Mechanistic Spreading Pathways in Disease Progression of Alzheimer's Disease

Although the root cause of Alzheimer's disease (AD) is largely elusive, the amyloid hypothesis has been widely used in the AD research framework, where amyloidosis induces (A biomarker) or facilitates the spread of pathologic tau (T biomarker) followed by immediate neurodegeneration ([N] biomarker) and progressive cognitive decline. As the massive heterogeneities manifested in the clinical symptoms, it is critical to understand the pathophysiological mechanism of how whole‐brain AT[N] biomarkers exert a synergistic effect on cognitive decline in the long period of disease progression.