Genetically predicted Telomere Length and its relationship with Alzheimer’s disease and Life Expectancy

Telomere length (TL) is a well‐known hallmark of biological aging, being telomere shortening associated with overall mortality and increased rates of age‐related diseases, such as Alzheimer’s disease (AD). However, observational studies are limited to conclude whether TL is causally associated with those outcomes or with related underlying pathological processes. This study aimed to evaluate whether TL may play a causal role in life expectancy and the risk of neurodegenerative diseases through Mendelian Randomization (MR) analyses.