Fingolimod (FTY720) offers neuroprotection against AlCl3 induced Experimental Dementia in Rats

Alzheimer’s disease (AD) is an age related progressive neurodegenerative disorder mainly characterized by cognitive decline, synaptic loss, and other mental functions. Extracellular amyloid beta (Aβ) deposits and intracellular accumulation of neurofibrillary tangles of tau protein are the two major hallmarks of AD. Multiple etiological factors have been linked with AD pathophysiology, oxidative stress, neuroinflammation, neurotransmitter deficit and foremost are the dysregulation of lipid metabolism, consistently involve in AD pathology and cognitive deficit.