Oxalamide Based Fe(II)-MOFs as Potential Electrode Modifiers for Glucose Detection

In an attempt to expand the coordination chemistry of N,N’-bis(2,4-dicarboxyphenyl)-oxalamide (H6L) ligand, we isolated and structurally characterized two new Fe(II) Metal-Organic Frameworks (MOFs), namely [Fe2(H2L)(H2O)5] (3D-Fe-MOF) and [Fe(H4L)(H2O)2]∙2H2O, (2D-Fe-MOF) by carefully adjusting the reaction conditions to achieve the optimal degree of deprotonation of the bridging ligand. Both MOFs were found stable in water, as evidenced by powder X-ray diffraction data and their ability to sorb glucose (GLU) from either an aqueous solution or artificial sweat was investigated only to show negligible sorption. Α graphite paste sensor (GPE) using the 3D-Fe-MOF as a modifier was fabricated. Τhe 3D-Fe-MOF modified GPE was assessed for non-enzymatic GLU detection in aqueous solution at pH 6 via differential pulse voltammetry and the preliminary results were discussed.