Small-cell neuroendocrine carcinoma of the vagina: A case report.

OBJECTIVE
We present a rare case of small-cell neuroendocrine carcinoma of the vagina.


METHOD
A 79-year-old Caucasian woman presented to the hospital of Leros, a distant Greek island, with a six-month history of "vaginal pressure feeling" and bleeding. Gynecologic examination revealed a 4-5 cm lesion on the lower third of the anterior vaginal wall. The patient declined a transfer to a tertiary hospital in Athens, so no biopsy could be obtained prior to surgery.


RESULTS
The tumor was resected surgically. Histology indicated a small-cell carcinoma of the vagina.


CONCLUSION
There is no consensus on the treatment of small-cell neuroendocrine carcinoma of the vagina. The rarity of the condition should motivate the founding of data-collection registries, in order to obtain a better understanding of the condition and optimize management and treatment.