Effects of continuous renal replacement therapy on Apache-II score, creatinine, and urea nitrogen levels in patients with acute kidney injury

Objective: To analyze the effects of continuous renal replacement therapy (CRRT) on acute physiology and chronic health scoring system II (APACHE-II) score, creatinine, and urea nitrogen levels in patients with acute kidney injury (AKI). 
Methods: Medical records of 79 patients with AKI treated in Shandong Provincial Third Hospital from January 2019 to January 2021 were retrospectively divided into two groups based on the received treatment. Of them 37 patients received intermittent hemodialysis (IHD) treatment (control group) and 42 patients received CRRT (observation group). Clinical efficacy, survival rate, severity of disease, renal function and serum electrolytels and fluid balance were analyzed. 
Results: After the treatment, the total efficacy of the observation group was 95.24%, and the 6-month survival rate was 97.62%, which was higher than 81.08% and 83.78% in the control group, respectively (P<0.05). The Apache-II score of the observation group was (15.76±4.29), which was lower than that of the control group (23.62±5.37). Levels of creatinine, urea nitrogen, and serum levels of potassium (K+), chlorine (Cl-) and sodium (Na+) in the observation group were lower than those in the control group (P<0.05). 
Conclusion: CRRT can achieve significant results in the treatment of patients with AKI, help to improve the curative effect, survival rate, alleviate the severity of the disease, recovery of renal functions, the recovery of serum electrolytels and fluid balance. 
doi: https://doi.org/10.12669/pjms.39.1.6591 
How to cite this: Hou H, Li L. Effects of continuous renal replacement therapy on Apache-II score, creatinine, and urea nitrogen levels in patients with acute kidney injury . Pak J Med Sci. 2023;39(1):50-54. doi: https://doi.org/10.12669/pjms.39.1.6591 
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