Apolipoprotein E moderates the association between Non‐APOE Polygenic Risk Score for Alzheimer’s Disease and Aging on Preclinical Cognitive Function

Apolipoprotein E4 (APOE‐ε4) is the strongest known risk factor for late‐onset Alzheimer’s disease (LOAD). Variation in cognitive decline patterns among cognitively unimpaired individuals suggests that additional LOAD‐related genetic factors may interact with APOE‐ε4 to influence cognitive decline during asymptomatic aging. In the present study, we aim to investigate whether any genome‐wide association studies (GWAS) and p‐value threshold (pT)‐informed non‐APOE polygenic risk scores (PRS) moderate associations between APOE‐ε4 and longitudinal cognition.