Building the Research Path for Identifying and Validating Cognition‐related Digital Biomarkers

Cognitive dysfunction is a core feature of dementia spectrum disorders but simple screening tests are less sensitive to detect the deficits, especially in the very early stage of disease course using most standardized test instruments. This results in delayed discovery of disease onset and opportunity for early interventions that might be more effective in delaying or arresting progression. Digital phenotyping using a combination or hardware and software solutions provide potentially much more effective tools for helping clinicians identify subtle signs of cognition deficits and track them in a compressed timeline to confirm the accuracy of decreasing slope indicative of a neurodegenerative etiology.