Alzheimer’s Disease Proteinopathy and Synaptic Integrity: The Protective Role of Physical Activity

Alzheimer’s disease (AD) proteinopathy levels are associated with greater synaptic dysfunction markers in brain tissue and cerebrospinal fluid (CSF). However, it is less well known how physical activity (PA) affects this relationship. We aimed to examine the moderating role of PA on AD proteinopathy and synaptic marker outcomes in typically aging adults.