REVIEW ON MOISTURE CONTENT: A STABILITY PROBLEM IN PHARMACEUTICALS

Liquid water is associate in many different manufacturing processes including pharmaceutical processes. Moisture can affect the thixotropy of semi-solid dosage forms as well as the chemical stability, crystal structure, powder flow, compaction lubricity, dissolution rate, and polymer film permeability of solid dosage forms. While water content measures how much water is in a sample, moisture analysis tells us how wet or dry a sample is. Its crucial to measure this because substances other than water can make a sample moist. Additionally, it has an impact on unit operations that naturally depend on the quantity and quality of water present. 
As a result, it is crucial to understand how moisture affects each components unique qualities, including those of the active substances and excipients. In this article, the significance of moisture content in pharmaceuticals is highlighted. Moisture is measured using a variety of techniques, and changes caused by moisture are shown for a number of product and process attributes.
KEYWORDS: Moisture Content, Pharmaceuticals, Determination of Moisture Content, Importance, Moisture Induced Changes.