Prognostic value of regional tau PET measures in Alzheimer’s Disease

Recent findings (Ossenkoppele et al, JAMA Neurology, 2021; Pontecorvo et al, Brain, 2019) suggest that tau‐positron emission tomography (PET) may better predict cognitive change in AD compared to amyloid‐PET and MRI‐based cortical thickness. However, the relationship between region‐based standardized uptake value ratio (SUVR) metrics and cognitive change in terms of prognostic value is not clearly understood. In this study, we evaluated the potential utility of region‐based tau‐PET metrics to stratify patients by cognitive decline risk and amyloid status in the brain.