Parametrized quantum-mechanical approaches combined with the fragment molecular orbital method

Fast parametrized methods such as density-functional tight-binding (DFTB) facilitate realistic calculations of large molecular systems, which can be accelerated by the fragment molecular orbital (FMO) method. Fragmentation facilitates interaction analyses between functional parts of molecular systems. In addition to DFTB, other parametrized methods combined with FMO are also described. Applications of FMO methods to biochemical and inorganic systems are reviewed.