Protective Effect of 3-Benzoyl-7-Hydroxy Coumarin on Lipid Peroxidation and Minerals on Rat Liver Tissues Induced Oxidative Stress with Lead Acetate

Lead is a toxic substance and damages human metabolism. Coumarin-derived substances have many effects such as antioxidant, anticancer, and antibacterial ones. In this study, the effects of 3-benzoyl-7-hydroxy coumarin on rat liver tissues under oxidative stress with lead acetate were investigated. In the study, rats were divided into 4 groups. Control group (K), Coumarin group (KUM), Lead acetate group (P) and Coumarin+Lead acetate group (KUMP) groups were formed. Malondialdehyde (MDA), lead (Pb), iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) levels were determined in the liver tissues of the rats. MDA level of P group increased compared to the other groups. A decrease was observed in the KUMP group compared to the P group MDA level. While the Pb and Fe levels of the P group increased compared to the K group, the Pb and Fe levels of the KUMP group decreased compared to the P group. As a result, it is concluded that the 3-benzoyl-7-hydroxy coumarin molecule protects the high lipid peroxidation, lead, and iron metabolism caused by lead acetate in the liver.