Association between recollection and familiarity‐based memory measures and plasma biomarkers for Alzheimer’s disease

Normal aging and preclinical Alzheimer’s Disease (AD) share common features, such as structural changes to medial temporal lobe regions and declining episodic memory. However, prior work suggests qualitative differences between AD‐related memory changes and those due to aging. Specifically, recollection‐based, or contextual, memory declines with both normal aging and AD. Alternatively, familiarity‐based, or item, memory is more specific to preclinical AD and atrophy in the perirhinal cortex. In the current analysis, we examined the relationship between these forms of memory with plasma biomarkers associated with AD and neurodegeneration.