Abstract IA005: Risk prediction in colorectal cancer screening: Reflections on the current status


 Colorectal cancer screening is an effective means of reducing colorectal cancer incidence and mortality. However, the testing we have, though effective, is costly and inefficient, with the majority of people undergoing an expensive, negative screening examination such as colonoscopy. Risk prediction is a potential means to tailor screening and personalize care to risk. Individuals could be directed to a less invasive test (FIT or blood testing) as opposed to a more invasive test (colonoscopy), or to other adjustments such as modifying the starting age for screening. The polygenic risk score is an objective, reproducible risk assessment tool, that has promise, but its utility and possible application in clinical practice will require considerably more investigation. Other challenges include determining the “threshold“ for assignment to a low risk as opposed to a high risk screening strategy, and ensuring that risk assessment does not deter subsequent screening behavior.
 Citation Format: Robert E. Schoen. Risk prediction in colorectal cancer screening: Reflections on the current status [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer; 2022 Oct 1-4; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_1):Abstract nr IA005.