ENVISION: Increasing diversity of a large phase 3b/4 confirmatory trial of aducanumab to better understand the efficacy and safety among historically underrepresented participants of Alzheimer’s disease research and clinical trials.

While Black/African Americans and Latinx/Hispanics have nearly twice the risk of developing Alzheimer’s disease compared to Non‐Hispanic Whites, their involvement in clinical research and trials remains low. Due to the lack of data and underrepresentation in research, it is unknown if there are clinicopathological differences in Alzheimer’s disease or response to therapies. We have established specific recruitment goals for underrepresented groups in the aducanumab Phase 3b/4 confirmatory ENVISION study, which is a multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group study of participants with mild cognitive impairment and mild dementia stages of Alzheimer’s disease (Stages 3 and 4; NCT05310071), designed to better understand the efficacy and safety of aducanumab treatment for these populations.