Investigating the functional significance of presynaptic tau in ageing and disease

Synaptic dysfunction is an early pathological feature of neurodegenerative disease and is a close correlate of cognitive decline. Modified tau mislocalises to the synaptic compartment in disease, where some forms of tau interact with synaptic proteins and disrupt synapse function. This study seeks to further explore synaptic tau accumulation, and the impact on synaptic health and tau release, during ageing and tauopathy progression.