A multimodal atlas of the molecular and cellular changes to cortex driven by Alzheimer’s disease

Alzheimer’s disease (AD) is the most common form of dementia, which can be detected early as mild cognitive impairment but has no broadly effective treatments to halt patients' yearslong decline. Histopathology studies have long noted dramatic, progressive, and stereotyped changes across numerous brain regions, including protein aggregate formation and even selective loss of molecularly defined neuronal populations. But the underlying molecular and cellular mechanisms that cause AD and facilitate its progression remain unknown or are only coarsely understood, hampering efforts to treat or cure the disease.