STEREOTACTIC RADIOTHERAPY IN EARLY STAGE BREAST CANCER IN NEOADJUVANT AND EXCLUSIVE SETTINGS: A SYSTEMATIC REVIEW

Introduction
Breast cancer (BC) is one of the most common tumours, better screening policies and multidisciplinary approach allow personalised treatment. Radiotherapy (RT) plays a central role in the multimodal approach in BC, and recent evidence have shown the non-inferiority of hypofractionated treatments. The aim of this study is to describe the feasibility and validity of stereotactic RT (SBRT) in BC in neoadjuvant and exclusive setting.
Methods 
A Pubmed/MEDLINE and Embase systematic review was conducted to assess the role of radiomics in BC. The search strategy was “breast [All Fields] AND "stereotactic" [All Fields] AND "radiotherapy" [All Fields])” and only original articles referred to BC in humans in the English language were considered.
Results
A total of 2149 studies were obtained using the mentioned search strategy on Pubmed and Embase. After the complete selection process, a total of 12 papers were considered eligible for the analysis of the results. SBRT in BC was described in 8 studies regarding neoadjuvant approach and 4 papers regarding exclusive approach.
Conclusions
Relative low toxicity rates; the reduced treatment volumes in the neoadjuvant setting and the possibility to replace surgery when not feasible in exclusive setting, resulted to be main advantages for SBRT in BC. Current evidence showed as both the neoadjuvant and the definitive settings seem to be promising clinical scenarios for SBRT especially for EBC.
