Abstract IA017: Microbiota drivers of colorectal cancer and their translation to prevention


 Abundant data support that the microbiota, both communities and individual pathogenic bacteria, promote the development of colorectal cancer (CRC). More limited data support that CRC is initiated by specific bacteria or communities. This talk will focus on bacterial contributors to CRC pathogenesis, potential mechanisms, gaps in knowledge and potential approaches to enabling use of the colon microbiota and its members to advance CRC prevention. Improved approaches to prevention are particularly key to identify those at risk for early onset CRC that represents a global change in CRC epidemiology.
 Citation Format: Cynthia L. Sears. Microbiota drivers of colorectal cancer and their translation to prevention [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer; 2022 Oct 1-4; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_1):Abstract nr IA017.