Abstract IA011: Transcriptional dependencies of tuft cell lung tumors


 Using genetic screens performed in cancer cell lines, we previously identified a tuft cell variant of small cell lung cancer. This novel tumor entity is characterized by high expression of, and addiction to, POU2F3, which encodes a POU homeodomain transcription factor. Subsequent work by several laboratories has revealed tuft cell tumors exist in several different anatomical sites (e.g., thymus, prostate, GI tract), indicating a broader relevance of this cell lineage in human cancer. In my presentation, I will present our efforts to reveal transcriptional mechanisms in tuft cell lung tumors, focusing on the identification of OCA-T1 and OCA-T2 as coactivators of POU2F3.
 Citation Format: Christopher R. Vakoc. Transcriptional dependencies of tuft cell lung tumors. [abstract]. In: Proceedings of the AACR Special Conference: Cancer Epigenomics; 2022 Oct 6-8; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_2):Abstract nr IA011.