Associations between psychological factors, grey matter volume, and resistance and resilience to tau pathology in cognitively unimpaired older adults

Modifiable factors may influence risk for Alzheimer’s disease (AD) via two distinct, though not mutually exclusive, pathways: resistance and resilience to pathology. Whereas cognitive ‘resilience’ is defined as the maintenance of better‐than‐expected cognitive performance in the face of Aβ and tau pathology, ‘resistance’ refers to an absence or delaying of the pathology itself. We explored the potential influence of psychological factors on resistance and resilience to tau pathology in older adults at risk of AD dementia, and whether grey matter volume mediates these relationships.