Prolonged post-vaccination hyperthermia with systemic inﬂammatory response syndrome

Two clinical cases are described. The information about long-term febrile patients who had lymphadenopathy and splenomegaly is given. A large-scale and lengthy diagnostic search was carried out. During examination, hematological and rheumatological diseases were excluded. Diagnosis by exclusion showed that the clinical picture was associated with previous multiple vaccinations. In both cases, a post-vaccination reaction with systemic inflammatory response syndrome was diagnosed.