Regulation of T helper 17 to regulatory T cell (Th17/Treg) as mediator of stress‐induced psychological impairment and cognitive deterioration

Chronic stress disrupts immune homeostasis while gut microbiota‐derived metabolites attenuate inflammation, thus promoting resilience to stress‐induced immune and behavioral abnormalities. There are both peripheral and brain region‐specific maladaptations of the immune response to chronic stress that produce interrelated mechanistic considerations required for the design of novel therapeutic strategies for prevention of cognitive deterioration in a mouse model of Alzheimer’s disease (AD) type cognitive deterioration