Loneliness and subjective cognitive impairment in preclinical Alzheimer’s disease and healthy aging

Loneliness is associated with increased dementia risk, and greater amyloid‐β (Aβ) and tau accumulation in cognitively normal older adults. However, the potential for loneliness to influence cognitive dysfunction during the preclinical disease stage has not yet been examined. Subjective cognitive complaints are an early indicator of cognitive dysfunction in Alzheimer’s disease, and may provide a sensitive endpoint to evaluate the influence of loneliness during the preclinical disease stage. This study evaluated the relationships between loneliness, subjective cognition, and Aβ status in cognitively unimpaired older adults.