Spatially resolved transcriptomics in the APPSWE [Tg2576] mouse model of Alzheimer’s disease

Alzheimer's and other neurodegenerative diseases remain pervasive, impacting patients and their families as the disease progresses. Despite the continual expansion of our understanding of these conditions, the detailed molecular mechanisms and progression of pathology throughout the brain remain elusive and complex. Using genomic and RNA‐seq approaches, identification of individual cells and their genetic makeup provide an added perspective on their roles in how the central nervous system (CNS) function in both healthy and diseased states. Here we demonstrate the characterization of spatial transcriptomic patterns in the APPSWE [Tg2576] mouse model of familial Alzheimer’s Disease using the Visium Spatial Gene Expression Solution.