Abstract 156: Study of Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio, RDW And Hba1c in Subject with Type 2 Diabetes Mellitus and Their Correlation with Diabetic Nephropathy and Retinopathy

Background: 17% in the world with diabetes is from India. Chronic inflammation plays a central role in the development and progression of diabetes and in the pathogenesis of its complication. NLR should be used as a marker of diabetic control level ln addition to HbA1C ln type 2 diabetic subjects. RDW might be considered as an effective predictive index in the evaluation of diabetic nephropathy or diabetes associated complications. MPV is higher in those who have microvascular complications such as retinopathy or Microalbuminuria. Objective: To study the changes in various haematological parameters in type 2 diabetic mellitus patients. To assess Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume (MPV), HbA1c cand RDW as a predictive inflammatory marker in type 2 diabetic mellitus. To correlate the haematologicalchanges in type 2 diabetes mellitus patients associated with diabetic nephropathy and retinopathy. Material and Method: It's a case control study included 200 sample – 100 case (diabetic) and 100 control (non-diabetic). Results: 200 patients included in study 100 cases (diabetic) in which 57.8% (male) and 42.2% (female) has diabetes. Most of the age group between 55-65 yrs of age (38%) has diabetes NLR raised in diabetic group shows significant value (0.001). MPV raised in diabetic group and is significant (0.0001). PLR raise in diabetic group as compared to control group shows significance (0.0001) and HbA1c raised in patient with microvascular complication. RDW significantly raised in case than control group. Conclusion: In this study with non- diabetic group as control, haematological parameter in diabetic patients in outdoor patient department and during hospital stay analysed found that patient with microvascular complications and with raised HbA1C (>7.5%) has significantly raised NLR, PLR, MPV, RDW. Simple complete blood count can be used as an effective tool to monitor glycemic regulation in type 2 DM.