Acetic Acid-Water Mediated Efficient One-Pot Synthesis of
Functionalized Isoxazolyl Amino Chromeno[4,3-b]pyridine Derivatives

A simple, efficient, economical and environmentally benign method has been developed for one-pot
three component synthesis of isoxazolyl amino chromeno[4,3-b]pyridine derivatives from
4-amino-3-methyl-5-styrylisoxazoles, malononitrile and (E)-3-benzylidenechroman-4-one by using
acetic acid (AcOH) as a promoter and water as a green reaction medium under thermal condition. The
interesting features of this method are environmental friendly, metal-free, less reaction time, wide
substrate scope, operational simplicity, easy purification of products and good yields.