Alteration of Fatty Acid Metabolism is Associated with Alzheimer’s Disease in People with Down Syndrome

People with Down syndrome (DS) are at high risk for Alzheimer’s disease (AD) in part because nearly all carry an extra copy of the APP gene which results in overexpression of amyloid. However, other factors are likely to interact with this genetic risk to produce individual pathobiological and clinical trajectories. We sought to examine the impact of diverse physiological pathways on AD risk in people with DS using plasma metabolomics.