Abstract 101: Correlation between ovarian morphology, biochemical and hormonal parameters in patients with and without pco morphology in Pcos

Background: Studies have reported considerably different rates in terms of the incidence of polycystic ovary (PCO) morphology in patients with PCOS. There are inconsistent results regarding the effects of PCO morphology on clinical and biochemical features in PCOS patients. Understanding the metabolic and biochemical differences between patients with and without polycystic ovary (PCO) morphology can guide better management of the patients. The group found to have a worse metabolic/ biochemical profile can be considered for close follow up with respect to the occurrence of future cardiovascular adverse event. Objective: To determine the biochemical and hormonal differences in polycystic ovary syndrome (PCOS) patients with and without polycystic ovary (PCO) morphology. Methods: Patients with PCOS diagnosed as per Rotterdam Criteria, presenting to Dept. of Endocrinology, SCBMCH between July 2021 to September 2022 were included. Relevant history, anthropometry and peripheral blood samples were taken from patients in the follicular phase spontaneous menstrual cycles / de novo sample in amenorrheic women including total testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), 17-OHP, DHEAS, AMH, Thyroid profile, S. Prolactin, hsCRP. Patients will be segregated into two groups based on USG pelvis, one with PCO morphology fulfilling criteria and one with PCO morphology not fulfilling criteria and biochemical and hormonal parameters will be statistically analysed. Results: Total 68 PCOS patients were recruited as per inclusion criteria. Out of total, 37 patients had PCO morphology on USG as per Rotterdam criteria (Group I) and 31 patients did not fulfill USG criteria of PCOS (Group II). The two groups were similar with respect to age and BMI. Mean serum levels of LH and LH/FSH ratio of Group I were significantly higher than Group II. Serum Testosterone and androstenedione levels were higher in Group II but not statistically significant. Total Cholesterol and S. Triglyceride levels were significantly higher in Group II. Mean HOMA-IR was higher in Group II. Mean AMH levels were higher in Group II. Mean hs CRP level were higher in Group I but not statistically significant. Conclusion: The group of patients without diagnostic PCO morphology had a worse metabolic profile in terms of dyslipidemia and insulin resistance as compared to the group with diagnostic PCO morphology. Hence, a more careful follow up must be considered in terms of cardiovascular risk assessment in this group.