An Old Pathway Learns Two New Tricks: Role of Complement in Postoperative Cognitive Dysfunction, and in Synaptic Damage in APOE4 carriers

Genetic studies in both mice and humans suggest a role for complement in Alzheimer's disease, but exactly how complement contributes to preclinical AD progression is unclear. It is also unclear to what extent complement may play a role in AD risk within APOE4 carriers, or in the pathophysiology of perioperative neurocognitive disorders in older adults.