Dissecting cell‐subtype specific regulatory variants and their target genes underpinning the pathogenesis of late onset Alzheimer’s disease

The genetic architecture of late‐onset Alzheimer’s disease (LOAD) is yet to be fully explored. While GWAS discovered numerous LOAD‐associated loci, the causal variants and their target genes remain largely unknown. We aim to advance our understanding of the genetic architecture of LOAD by systematic interrogation of elements and variants underlying gene dysregulation in LOAD in a cell‐subtype resolution.