Evaluation of Hepatoprotective Potential of Chromolaena odorata (L.) R.M. King & H.Rob. Against Methotrexate-induced Hepatic Toxicity in Rats

Objective: Liver, as an organ, is predominantly responsible for the metabolism of drugs, alcohol, (Catalase and Superoxide dismutase); increased liver function enzymes (Alanine aminotransferase and Aspartate aminotransferase), and increased lipid peroxidation (Malondialdehyde). Corroborating biochemical assessment, Histopathological analysis of untreated Methotrexate rats showed liver sections with focal necrosis, dilation and congestion of central vein and portal vein whereas aqueous leaf extract of Ch. odorata reduced the degree of lesions with seen improvement and reduction of hepatocytes degeneration. Conclusion: Thus, Ch. odorata (L.) offered protection to the liver from damage caused by Methotrexate attributable to its active bioactive agents including flavonoids which scavenges free radicals, enhanced the antioxidant status and protected against oxidative damage and oxidative stress.