Amyloid independent pathways have an impact on longitudinal tau deposition

Amyloidosis‐driven tau deposition has been a significant focus of imaging research in Alzheimer’s disease (AD). However, the 3R/4R tau seen in AD can be observed in the transentorhinal/entorhinal regions (Braak I/II) in the absence of amyloidosis. The underlying drivers of this phenomenon are not well understood. Our goal was to examine amyloid‐independent pathways of longitudinal Tau‐PET SUVR progression in the entorhinal cortex (ERC) using a broad range of risk and protective factors.