Cardiovascular Risk, Alzheimer’s Disease Biomarkers, and Cognition: The Health and Aging Brain Study

Cardiovascular risk (CVR) factors (hypertension, dyslipidemia, diabetes, and smoking) and emerging plasma biomarkers including β‐amyloid (Aβ) 40/42, tau, and neurofilament light (NfL) are each associated with risk of Alzheimer’s Disease (AD), although whether CVR and AD biomarkers affect cognitive aging independently or synergistically is unclear. As part of the Health and Aging Brain Study, we assessed the association of CVR burden and cognition and if this association is modified by AD biomarkers.