Cross‐ancestry effect of APOE on cognitive performance

Alzheimer's disease (AD) is more prevalent in populations of non‐European ancestry, with Black and Hispanic adults 1.5 and 2.5 times more likely to develop AD respectively. Health disparities in AD could be explained by race and ancestry, where race captures risk factors due to socio‐economic aspects of health and ancestry captures the biological mechanisms influenced by genetic variation. The APOE ε4 allele is the most significant genetic risk factor for AD; however, the risk conferred by APOE ε4 differs across populations. Here, we investigate the interactive effect of race, ancestry and APOE on episodic memory performance.