Investigation of Cholinesterase Inhibitor Effects of Some Chalcone Substituted Metallophthalocyanines

In this work, previously synthesized tetra-chalcone-substituted metallophthalocyanines (MPcs) containing Ni(II), Zn(II), Co(II), and Cu(II) in the inner core were investigated anticholinergic activities against Alzheimer's disease (AD). The MPcs were evaluated for their inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using the original Ellman's colorimetric procedure. Against these two cholinesterase enzymes, all compounds showed inhibitory effects with IC50 values ranging from 1.243-2.369 μM against AChE and 2.865-3.372 μM against BChE. Among the four MPcs, CuPcs (2) showed the strongest inhibitory activity against AChE. ZnPcs (3) also showed the most effective inhibition for BChE.