Limbic Predominant Age‐related TDP‐43 Encephalopathy Neuropathological Change (LATE‐NC) is Associated with Lower Diffusion Anisotropy in Medial Temporal Lobe White Matter

Limbic predominant age‐related TDP‐43 encephalopathy neuropathological change (LATE‐NC) is now recognized as a common neuropathological disorder of the aging brain and is associated with accelerated cognitive decline. However, the MRI signature of LATE‐NC has not been fully determined. In this work, we hypothesized that abnormalities in white matter (WM) structural integrity caused by LATE‐NC may be detected by means of diffusion tensor imaging (DTI).