Cerebrospinal fluid levels of growth associated protein 43 (GAP‐43) are associated with Alzheimer’s disease biomarkers, cognition, and functional changes

Growth‐associated protein 43 (GAP‐43) is a presynaptic protein involved in synaptic plasticity implicated in Alzheimer’s disease (AD). This study investigates cerebrospinal fluid (CSF) levels of GAP‐43 in relation to AD fluid biomarkers and clinical outcomes. To determine how associations change across disease states, interactions with cognitive and amyloid status are examined.