Large‐Scale Network Dysfunction in Dementia with Lewy Bodies: Preliminary Results from an fMRI Connectomic Mapping Study

The diagnosis of dementia with Lewy bodies (DLB) is often delayed in clinical practice. The sensitivity and specificity of structural MRI is suboptimal: a multisite study with autopsy confirmation demonstrated 64% sensitivity and 68% specificity for differentiating DLB from Alzheimer's Disease (AD; Harper et.al, 2016). There is an urgent need to develop additional reliable biomarkers for DLB. We describe resting state functional MRI (rsfMRI) results using an automated connectome mapping program (Infinitome).