Metabolite QTL analysis of ROSMAP and ADNI prioritized sequencing data identifies C14:2 genetic locus on Chr 2

Peripheral metabolic disturbance is a known component of Alzheimer’s Disease (AD), however predictive genetic markers, as well as the associated pathways, remain to be determined. Two AD studies, ROSMAP and ADNI, have generated Whole Genome Sequencing (WGS) and ante‐mortem serum metabolic biomarker samples. A previous study utilizing ROSMAP data has identified the metabolite tetradecadienylcarnitine, C14:2, as protective against incident AD in both brain and serum data (Brain and blood metabolome for Alzheimer’s dementia: Findings from a targeted metabolomics analysis; Huo et. al).