Systematic review of studies evaluating the microbiome of periimplantitis using next generation sequencing techniques

Review question / Objective: This systematic review aims to summarize and critically analyse the methodology and findings of studies which have utilized sequencing techniques to elucidate the microbial profiles of peri-implantitis. Condition being studied: Peri-implantitis is defined as an infection of the peri-implant tissues accompanied by suppuration and clinically significant progressing crestal bone loss after the adaptive phase, leading to decreased osseointegration and pocket formation. Eligibility criteria: Original studies investigating the microbiome of peri-implant tissues through next-generation DNA sequencing methods will be included. Culture-based study, conference papers, review articles, studies regarding peri-implantitis associated with other systematic factors (smoking, diabetes mellitus, etc.), articles that examine only specific microorganisms will be excluded from this systematic review. Non-English language articles and research conducted on non-human specimens will be excluded.