APOE genotype and blood pressure influence global and regional cerebral blood flow in older adults post‐high lipid feeding

Both hypertension and the E4 allele of the APOE gene are known risk factors for Alzheimer’s disease (AD). We investigated the influence of these factors on global cerebral blood flow (CBF) and four prespecified areas (angular gyrus, hippocampus, posterior cingulate, temporal lobe) using arterial spin labeling (ASL) MRI both in fasting state and after ingestion of a high fat drink.