Associations of AD risk factors with cerebrospinal fluid ATN biomarker profiles in 10,662 persons without dementia from the Amyloid Biomarker Study

The pathophysiology of Alzheimer’s disease (AD) is characterized by amyloid‐β deposition (A), tau tangle formation (T) and neurodegeneration (N). In order to promote the development and implementation of a successful intervention to prevent or delay AD progression, frequency estimates of the evolution of these pathological events across age and its relation with other AD risk factors in the various pre‐dementia stages are essential.