The study of the long-term effects of industrial substances by toxicologists of the I.V. Sanotsky School

One of the areas of scientific research that deeply interested I.V. Sanotsky was the study of the long-term effects of the influence of chemical compounds on the body, which is one of the most urgent problems of modern toxicology. The study aims to analyze and evaluate the results of experimental studies of chemicals with long-term effects, on the basis of which a methodology for hygienic rationing of these substances in preventive toxicology. The researchers have conducted a literature search for the period 1975-2020 according to the data of the scientific electronic library elibrary.ru and the archive of the Izmerov Research Institute of Occupational Health by keywords: preventive toxicology, long-term effects, hygienic standardization. The results of experimental studies of chemicals with long-term effects allowed us to scientifically substantiate the basic principles of establishing MPC during hygienic rationing: - selection of an experimental model, issues of data transfer from animals to humans; - dependence of the studied effects on the dose or concentration of chemicals; - threshold of effects; - dependence of the effect on the time of exposure and observation; - selectivity of the effect of poisons on reproductive function; - sanitary standardization of the content of chemical compounds with a specific effect on reproductive function. As a result of the long-term work of the Department of Industrial Toxicology, specialists have developed methodological approaches, and also have created tested, modernized, unified guidelines for the system of institutions whose task was to obtain data for the toxicological assessment of new substances with long-term effects to determine harm thresholds.