Translational potential of JAX humanized‐APOE mice: sex differences in bioenergetic function in brain

The preclinical phase of late onset Alzheimer’s disease (LOAD), known as the preclinical phase, can start 10 to 20 years prior to onset of clinical symptoms. Hypometabolism and impaired mitochondrial bioenergetics can emerge during prodromal phase as early indicators of AD risk. APOEe4, the greatest genetic risk factor for LOAD, is well documented to induce lipid metabolic dysregulation. We therefore sought to determine the impact of APOEe4. The following study analyzed body composition and mitochondrial functions to elucidate how the presence of APOEe4 in a mouse model contributes to bioenergetic changes, and whether they affect females and males equally.