SLCO1B3 T334G polymorphisms and mycophenolate mofetil-related adverse reactions in kidney transplant recipients

Background: The correlation between SLCO1B3 T334G polymorphisms and mycophenolate mofetil (MMF) adverse reactions in kidney recipients is unknown. Methods: A single-center, retrospective study was performed in which 111 patients were divided into four groups according to the type of adverse effect experienced. The clinical data and concentrations of MMF at different months after transplantation were statistically analyzed. Results: The G allele in the gastrointestinal reaction group was significantly higher than that in the no adverse effects group (p < 0.05). Logistic regression model showed that the SLCO1B3 T334G genotype was an independent risk factor for gastrointestinal reactions caused by MMF. Conclusion: Patients with the SLCO1B3 T334G GG genotype were more likely to experience gastrointestinal reactions.