Lipoprotein Lipase Regulates Lipid and Lipoprotein Processing in Microglia

Lipoprotein Lipase (LPL) is the rate‐limiting enzyme in lipoprotein hydrolysis. In the brain, LPL is predominantly expressed in microglia and is a key feature of phagocytic disease‐associated microglia thought to be protective in AD. Indeed, we have previously shown that microglia lacking LPL show impaired phagocytosis, lipid uptake, and cholesterol efflux (Bruce et al., 2018; Loving et al., 2021). Since ApoE4‐containing brain‐derived lipoproteins increase AD risk, we investigated how LPL regulates microglial lipoprotein processing.