Selecting appropriate meaningful change thresholds for trials of early (prodromal‐to‐mild) AD: A caregiver‐rated, anchor‐based analysis based on the Tauriel Study

Clinically meaningful change thresholds for assessments used in Alzheimer’s disease (AD) trials, including the Clinical Dementia Rating Scale – Sum of Boxes (CDR‐SB), may differ by disease stage and are increasingly important to interpret efficacy. However, anchor‐based estimates for the CDR‐SB have largely used clinician‐ rather than caregiver‐rated anchors. We established meaningful change thresholds for the CDR‐SB using a caregiver‐rated anchor of global change in early (prodromal‐to‐mild) AD patients over an 18‐month clinical trial.