Distinct Patterns of Brain Atrophy in MCR and amnestic MCI pre‐dementia syndromes

Both amnestic Mild Cognitive Impairment (aMCI) and the Motoric Cognitive Risk (MCR) syndrome are reliable predictors of Alzheimer’s Disease (AD). There is also some evidence for that MCR is a stronger predictor of vascular dementia (VaD) than AD. The current study directly compared cortical and hippocampal atrophy patterns in MCR and aMCI to inform the development of interventions targeted to these pre‐dementia syndromes. We hypothesized that MCR would be associated with a widespread pattern of cortical atrophy while aMCI would be associated with atrophy restricted to hippocampal and neighboring temporal regions.