Summary of the National Advisory Committee on Immunization (NACI) Rapid Response: Updated interim guidance on Imvamune in the context of ongoing monkeypox outbreaks

on of a Fractional Dose of MVA-BN The safety of intradermal (ID) administration of a fractional dose (1/5 th of the standard dose) of MVA-BN vaccine (containing the same virus type and content as Imvamune ® ) was assessed in a Phase II randomized clinical trial among healthy individuals 18 years and older born after 1971. The study compared 2 doses of MVA-BN administered 28 days apart when using subcutaneous (SC) administration of a standard dose (n=167) and ID administration of a fractional dose (n=191) (31) . ID Although severe individuals ID group local reactions functional Compared SC group, a higher proportion of individuals in the ID group did not receive a second vaccination due persistent local reactogenicity (mild time of the second vaccination (20/192 for ID administration and 3/167 for SC administration). most local symptoms not .