Translational potential of JAX hAPOE AD mouse model: Phenotypic characterization of cognitive function and amyloid beta

APOEe4 is the greatest genetic risk factor for late onset Alzheimer’s Disease (LOAD). The product of this gene, apolipoprotein E isoform ε4, has been characterized as a lipid transporter and many of its receptors and mechanisms have been identified. Studies have shown that APOEe4 exacerbates accumulation of Aβ peptides and correlates with a decline in cognitive function in humans. We investigated the translational feasibility of the humanized APOE3 (JAX #029018) and APOE4 (JAX #027894) mouse model on two hallmark pathologies of LOAD: cognitive decline and b‐amyloid (Aβ) generation in brain.