RFC4
# RFC4

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.

## Function

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.

## Interactions

RFC4 has been shown to interact with:

* BRD4,
* CHTF18,
* PCNA,
* RFC2,
* RFC3, and
* RFC5.
