NDST3
# NDST3

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

   3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan $sulfate]_{(n)}$ = adenosine 3',5'-bisphosphate + 2 $H^+$ + N-sulfo-α-D-glucosaminyl-[heparan $sulfate]_{(n)}$

This is a step in the production of heparin.

## Clinical significance

Mutations in NDST3 have been linked to schizophrenia.

