JWH-149
# JWH-149

JWH-149 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-pentyl analog of JWH-148. It is a potent but only moderately selective ligand for the $CB_2$ receptor, with a binding affinity of $K_i$ = 0.73 ± 0.03 nM at this subtype, and more than six times selectivity over the $CB_1$ subtype.

In the United States, all $CB_1$ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-149 are Schedule I Controlled Substances.

