4-Bromoanisole
# 4-Bromoanisole

4-Bromoanisole is the organobromine compound with the formula $CH_3OC_6H_4Br.$ It is colorless liquid with a pleasant smell similar to that of anise seed. It is one of three isomers of bromoanisole, the others being 3-bromoanisole and 2-bromoanisole. It is the precursor to many 4-anisyl derivatives.

## Reactions and uses

4-Bromoanisole forms a Grignard reagent, which reacts with phosphorus trichloride to give tris(4-methoxyphenyl)phosphine:

    3 $CH_3OC_6H_4MgBr$ + $PCl_3$ → $(CH_3OC_6H_4)_3P$ + 3 MgBrCl

4-Bromoanisole forms the organozinc derivative $CH_3OC_6H_4ZnBr.$

4-Bromoanisole is compound sometimes used in RNA extraction which serves to further eliminate DNA contamination. It interacts with genomic DNA (gDNA) and through a separation phase, it will be located in the organic layer instead of the aqueous layer (upper layer) containing the RNA extract.

