6-Fluoro-DMT
# 6-Fluoro-DMT

6-Fluoro-N,N-dimethyltryptamine (6-Fluoro-DMT) is a synthetic drug of the tryptamine chemical class.

## Pharmacology

### Binding profile

6-Fluoro-DMT possess affinity for the $5-HT_{1A}$ (392.6 nM), $5-HT_{1B}$ (217.7 nM), $5-HT_{1D}$ (55.4 nM), $5-HT_{1E}$ (460.8 nM), $5-HT_{2A}$ (866 nM), $5-HT_{2B}$ (29.8 nM), $5-HT_{2C}$ (674.2 nM), $5-HT_{5A}$ (960.5 nM), $5-HT_6$ (25.6 nM), $5-HT_7$ (40.8 nM), $D_1$ (547.3 nM), $D_2$ (610.4 nM), $D_3$ (866.8 nM), $D_4$ (1,454 nM), $D_5$ (6,291 nM), $α_{1A}-adrenergic$ (173.3 nM), $α_{2B}-adrenergic$ (295.5 nM), $α_{2C}-adrenergic$ (148.8 nM), $H_1$ (46.6 nM), $H_2$ (925.4 nM), $I_1$ (898.4 nM), $_1$ (6,892 nM), and $_2$ (7,128 nM) receptors, as well as the SERT (144.6 nM). It has low/negligible (> 10,000 nM) affinity for the $5-HT_3,$ $α_{1B}-adrenergic,$ $α_{2A}-adrenergic,$ $β_1-adrenergic,$ $β_2-adrenergic,$ $H_3,$ $H_4,$ and $M_1-M_5$ receptors, as well as the DAT and NET. It has not been screened at $5-HT_{1F},$ $5-HT_4,$ $α_{1D}-adrenergic,$ $β_3-adrenergic,$ or $VMAT_1/VMAT_2.$

