1922 U.S. National Championships – Men's singles
# 1922 U.S. National Championships – Men's singles

Two-time defending champion Bill Tilden defeated Bill Johnston in the final, 4–6, 3–6, 6–2, 6–3, 6–4 to win the men's singles tennis title at the 1922 U.S. National Championships. It was Tilden's third U.S. Championships singles title and fifth major singles title overall.

## Draw

### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Final eight

| Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final | Final |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Bill Johnston | 6 | 6 | 7 | | | | | | | | | | | |
| Manuel Alonso | 0 | 2 | 5 | | | | | | | | | | | |
| Manuel Alonso | 0 | 2 | 5 | Bill Johnston | 8 | 6 | 6 | | | | | | | |
| | | | | Vincent Richards | 6 | 2 | 1 | | | | | | | |
| Vincent Richards | 6 | 6 | 7 | Vincent Richards | 6 | 2 | 1 | | | | | | | |
| James Anderson | 4 | 2 | 5 | | | | | | | | | | | |
| James Anderson | 4 | 2 | 5 | | | | | | Bill Johnston | 6 | 6 | 2 | 3 | 4 |
| | | | | | | | | | Bill Tilden | 4 | 3 | 6 | 6 | 6 |
| Bill Tilden | 6 | 6 | 6 | | | | | | | | | | | | Bill Tilden | 4 | 3 | 6 | 6 | 6 |
| Zenzo Shimizu | 2 | 3 | 1 | | | | | | | | | | | |
| Zenzo Shimizu | 2 | 3 | 1 | Bill Tilden | 4 | 6 | 6 | 6 | | | | | | |
| | | | | Gerald Patterson | 6 | 4 | 3 | 1 | | | | | | |
| R. Norris Williams | 3 | 3 | 4 | Gerald Patterson | 6 | 4 | 3 | 1 | | | | | | |
| Gerald Patterson | 6 | 6 | 6 | | | | | | | | | | | |
