María Domínguez Castellano
# María Domínguez Castellano

María Domínguez Castellano (born 1965, Alcántara, Spain) is a Spanish neuroscientist and director of the Department of Developmental Neurobiology in the Institute of Neurosciences, Alicante, Spain, which is a joint Miguel Hernández University of Elche (UMH) and Spanish National Research Council (CSIC) institution.

## Biography

She has a B.S. in biochemistry from the University of Seville and a Ph.D. in developmental biology from the Autonomous University of Madrid. Her doctoral thesis title was "Función del gen asense del complejo génico achaete-scute en la generación de los órganos sensoriales de Drosophila melanogaster" ("Role of the asense gene of the achaete-scute gene complex in the generation of the sensory organs of Drosophila melanogaster "). She worked at University of Zurich and the University of Cambridge before taking up a post at the Institute of Neurosciences (UMH-CSIC) in 2000. She became a full professor in 2008, and Director of the Department of Developmental Neurobiology in 2016.

In 2008 she won the Alberto Sols prize [es], with the jury citing "the study of the development and formation of the retina as a neural model, a study that in turn has revealed new mechanisms of cancer development" and the Francisco Cobos prize for Biomedical Research.

Since 2007, she has been a member of the European Molecular Biology Organization (EMBO). She is a member of Asociación de Mujeres Investigadoras y Tecnólogas [es] (AMIT), the Association of Women Researchers and Technologists.

## Selected publications

* Gutierrez-Perez, I., Jordan-Rowley, J., Lyu, X., Valadez-Graham, V., Vallejo, D.M., Ballesta-Illan, E., Lopez-Atalaya, J.P., Kremsky, I., Caparros, E., Corce, V.G., Dominguez, M " Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb. " Cell Rep . 28(10), 2715 - 2727.e5 (2019)
* Reiff, T., Antonello, Z.A., Ballesta-Illán, E., Mira, L., Sala, S., Navarro, M., Martinez, L.M., Dominguez, M " Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila. " EMBO J . 4, 38(21) - e101346 (2019)
* Villegas, S.N, Gombos, R., García-López, L., Gutiérrez-Pérez, I., García-Castillo, J., Vallejo, D.M., Da Ros, V., Ballesta-Illán, E., Mihály, J., Dominguez, M. " PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation. " Cell Rep . 22(10), 2541 - 2549 (2018)
* Vallejo DM., Juarez-Carreño S., Bolivar J., Morante J., Dominguez M. " A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. " Science . 350(6262), - aac6767 (2015)
* Garelli, A, Gontijo, A,, Miguela, V,, Caparros, E,, Dominguez, M " Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation time. " Science . 336(6081), 579 - 582 (2012)
