Thienorphine
# Thienorphine

Thienorphine is a very potent, extremely long-acting, orally-active opioid analgesic with mixed agonist–antagonist properties which was developed by the Beijing Institute of Pharmacology and Toxicology as a potential treatment for opioid dependence. It is a high-affinity, balanced ligand of the μ- $(K_i$ = 0.22 nM), δ- $(K_i$ = 0.69 nM), and κ-opioid receptors $(K_i$ = 0.14 nM), behaving as a partial agonist of the μ- $(E_{max}$ = 19%–28%) and κ-opioid receptors $(E_{max}$ = 65–75%) and as an antagonist of the δ-opioid receptor. It also possesses relatively low affinity for the nociceptin receptor $(K_i$ = 36.5 nM), where it acts as an antagonist.

