Thienotriazolodiazepine
# Thienotriazolodiazepine

A thienotriazolodiazepine is a heterocyclic compound containing a diazepine ring fused to thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:

* α-Hydroxyetizolam
* Brotizolam
* Ciclotizolam
* Clotizolam
* Deschloroclotizolam
* Deschloroetizolam
* Etizolam
* Flubrotizolam
* Fluclotizolam
* Fluetizolam
* Metizolam

Thienotriazolodiazepines interact with the benzodiazepine receptor site, they typically have similar effects as 1,4-benzodiazepines (such as diazepam) and triazolobenzodiazepines (such as alprazolam).

Thienotriazolodiazepines that are not $GABA_A$ receptor positive allosteric modulators include:

* Apafant
* Israpafant
* JQ1
