List of side effects of doxepin
# List of side effects of doxepin

The antidepressant drug doxepin has been associated with a number of different adverse effects, including the following.

The incidence of these adverse effects is not totally known as the scarcity of well-designed clinical trials involving doxepin prohibits it. Side effects that are common (based on its pharmacology or the frequency of these side effects with related agents) appear with a * superscript whereas the side effects which are serious are in bold. Doxepin is licensed to be used in much smaller doses (viz., 3mg and 6 mg) in some countries, the side-effects profile of which may differ from this list.

* $Nausea^*$
* $Dizziness^*$
* $Drowsiness^*$
* Dry $mouth^*$
* $Constipation^*$
* Blurred $vision^*$
* $Headache^*$
* Urinary $hesitancy^*$
* $Agitation^*$
* Hypotension (low blood pressure)
* Hypertension (high blood pressure)
* Tachycardia (high heart rate)
* Skin rash
* Facial oedema
* Photosensitisation
* Urticaria (hives)
* Pruritus (itching)
* Indigestion
* Bone fractures
* Taste disturbances
* Diarrhoea
* Anorexia (weight loss)
* Aphthous stomatitis (canker sores)
* Gynaecomastia (swelling of the breasts in men)
* Galactorrhoea (lactation that is unassociated with breast feeding or pregnancy)
* Chills
* Fatigue
* Weakness
* Flushing
* Alopecia (hair loss)
* Eosinohpilia
* Blood dyscrasias (abnormalities in the cellular composition of blood)
* Increased liver function tests
* Hyperpyrexia (high fever ≥41.5 °C or 106.7 °F)
* Seizures
* Confusion
* Malaise
* Increased $appetite^*$
* Changes in ECG parameters (e.g. QRS & PR interval)
* Ataxia
* Hallucinations
* Paraesthesias
* Nervousness
* Numbness
* Tinnitus
* Hepatitis (liver swelling)
* Exacerbation of asthma
* Hepatic (liver) abnormalities
* Urinary retention
* Extrapyramidal symptoms
* Testicular swelling
* Hyperglycaemia (high blood sugar)
* Hypoglycaemia (low blood sugar)
* Hyponatraemia (low blood sodium)
* Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
* Closed-angle glaucoma
* Alzheimer's disease or dementia*
