MS-245
# MS-245

MS-245 is a tryptamine derivative used in scientific research. It acts as a selective $5-HT_6$ receptor antagonist with a $K_i$ of 2.3 nM, and was derived through structure-activity relationship development of the selective $5-HT_6$ agonist EMDT. It has been used as a lead compound for further development of tryptamine-derived $5-HT_6$ antagonists. In animal studies it has been shown to boost the activity of, but not substitute for, both amphetamine and nicotine.

