1950 U.S. National Championships – Women's singles
# 1950 U.S. National Championships – Women's singles

First-seeded Margaret Osborne duPont defeated Doris Hart 6–3, 6–3 in the final to win the women's singles tennis title at the 1950 U.S. National Championships.

## Seeds

The six seeded U.S. players are listed below. Margaret Osborne duPont is the champion; others show in brackets the round in which they were eliminated.

* Margaret Osborne duPont (champion)
* Doris Hart (finalist)
* Louise Brough (third round)
* Beverly Baker (semifinals)
* Pat Canning Todd (quarterfinals)
* Shirley Fry (quarterfinals)

## Draw

### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* r = Retired

### Final eight

| Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Finals | Finals | Finals | Finals |
| - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Margaret Osborne duPont | 6 | 6 | | | | | | | | | |
| 5 | Pat Canning Todd | 4 | 1 | | | | | | | | | |
| 5 | Pat Canning Todd | 4 | 1 | 1 | Margaret Osborne duPont | 6 | 1 | 6 | | | | |
| | | | | | Nancy Chaffee | 1 | 6 | 0 | | | | |
| | Nancy Chaffee | 6 | 6 | | Nancy Chaffee | 1 | 6 | 0 | | | | |
| | Barbara Scofield | 2 | 2 | | | | | | | | | |
| | Barbara Scofield | 2 | 2 | | | | | | 1 | Margaret Osborne duPont | 6 | 6 |
| | | | | | | | | | 4 | Doris Hart | 3 | 3 |
| 2 | Doris Hart | 6 | 6 | | | | | | | | | | 4 | Doris Hart | 3 | 3 |
| 6 | Shirley Fry | 4 | 4 | | | | | | | | | |
| 6 | Shirley Fry | 4 | 4 | 2 | Doris Hart | 6 | 6 | | | | | |
| | | | | 4 | Beverly Baker | 4 | 1 | | | | | |
| 4 | Beverly Baker | 6 | 9 | 4 | Beverly Baker | 4 | 1 | | | | | |
| | Betty Rosenquest | 2 | 7 | | | | | | | | | |
