List of Cash Box Best Sellers number-one singles of 1950
# List of Cash Box Best Sellers number-one singles of 1950

These are the songs that reached number one on the Top 40 Best Sellers chart in 1950 as published by Cash Box magazine. Artists were not specified in the charts of this time period so songs may represent more than one version. The artist who most popularized each song is listed.

| Issue date | Song | Artist |
| - | - | - |
| January 7 | "I Can Dream, Can't I?" | The Andrews Sisters |
| January 14 | "I Can Dream, Can't I?" | The Andrews Sisters |
| January 21 | "I Can Dream, Can't I?" | The Andrews Sisters |
| January 28 | "I Can Dream, Can't I?" | The Andrews Sisters |
| February 4 | "I Can Dream, Can't I?" | The Andrews Sisters |
| February 11 | "I Can Dream, Can't I?" | The Andrews Sisters |
| February 18 | "Dear Hearts and Gentle People" | Bing Crosby |
| February 25 | "Chattanoogie Shoe Shine Boy" | Red Foley |
| March 4 | "Chattanoogie Shoe Shine Boy" | Red Foley |
| March 11 | "Chattanoogie Shoe Shine Boy" | Red Foley |
| March 18 | "Chattanoogie Shoe Shine Boy" | Red Foley |
| March 25 | "Music! Music! Music!" | Teresa Brewer |
| April 1 | "Music! Music! Music!" | Teresa Brewer |
| April 8 | "Music! Music! Music!" | Teresa Brewer |
| April 15 | "Music! Music! Music!" | Teresa Brewer |
| April 22 | "The Third Man Theme" | Anton Karas |
| April 29 | "The Third Man Theme" | Anton Karas |
| May 6 | "The Third Man Theme" | Anton Karas |
| May 13 | "The Third Man Theme" | Anton Karas |
| May 20 | "The Third Man Theme" | Anton Karas |
| May 27 | "The Third Man Theme" | Anton Karas |
| June 3 | "The Third Man Theme" | Anton Karas |
| June 10 | "The Third Man Theme" | Anton Karas |
| June 17 | "The Third Man Theme" | Anton Karas |
| June 24 | "The Third Man Theme" | Anton Karas |
| July 1 | "The Third Man Theme" | Anton Karas |
| July 8 | "Bewitched, Bothered and Bewildered" | Vivienne Segal |
| July 15 | "Bewitched, Bothered and Bewildered" | Vivienne Segal |
| July 22 | "Bewitched, Bothered and Bewildered" | Vivienne Segal |
| July 29 | "Bewitched, Bothered and Bewildered" | Vivienne Segal |
| August 5 | "Mona Lisa" | Nat King Cole |
| August 12 | "Mona Lisa" | Nat King Cole |
| August 19 | "Mona Lisa" | Nat King Cole |
| August 26 | "Mona Lisa" | Nat King Cole |
| September 2 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| September 9 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| September 16 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| September 23 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| September 30 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| October 7 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| October 14 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| October 21 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| October 28 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| November 4 | "Goodnight, Irene" | Gordon Jenkins and The Weavers |
| November 11 | "Harbor Lights" | Sammy Kaye |
| November 18 | "Harbor Lights" | Sammy Kaye |
| November 25 | "Harbor Lights" | Sammy Kaye |
| December 2 | "Harbor Lights" | Sammy Kaye |
| December 9 | "Harbor Lights" | Sammy Kaye |
| December 16 | "The Thing" | Phil Harris |
| December 23 | "Harbor Lights" | Sammy Kaye |
| December 30 | "Tennessee Waltz" | Patti Page |
