MINE (chemotherapy)
# MINE (chemotherapy)

MINE in the context of chemotherapy is an acronym for one of the chemotherapy regimens used for treatment of relapsed or refractory aggressive non-Hodgkin's lymphoma and Hodgkin's lymphoma.

Today this regimen is often combined with monoclonal antibody rituximab. In this case the regimen is called R-MINE or MINE-R.

The [R]-MINE regimen consists of:

* Rituximab - anti-CD20 monoclonal antibody that can kill both normal CD20-expressing B cells and malignant ones;
* Mesna to prevent the development of hemorrhagic cystitis which may otherwise result from ifosfamide administration;
* Ifosfamide - an alkylating antineoplastic agent from oxazafosforine group;
* Mitoxantrone - a synthetic anthracycline analogue (anthraquinone) that is able to intercalate DNA and thus prevent cell division (mitosis);
* Etoposide - a topoisomerase inhibitor.

## Dosing regimen

| Drug | Dose | Mode | Days |
| - | - | - | - |
| Rituximab | 375 $mg/m^2$ | IV infusion | Day 1 |
| Mesna | 1330 $mg/m^2$ | IV infusion over 1h together with ifosfamide, plus 500 mg PO 4h after ifosfamide | Days 1-3 |
| Ifosfamide | 1330 $mg/m^2$ | IV infusion over 1h | Days 1-3 |
| Mitoxantrone | 8 $mg/m^2$ | IV infusion | Day 1 |
| Etoposide | 65 $mg/m^2$ | IV infusion over 1h | Days 1-3 |
