Guineesine
# Guineesine

Guineesine (or guineensine) is a compound isolated from long pepper (Piper longum) and black pepper (Piper nigrum).

## Research

Guineensine inhibits the cellular reuptake of anandamide and 2-arachidonoylglycerol in a mouse model $(EC_{50}$ = 290 nM). This causes an increase in the activity of the two neurotransmitters which are classified as endogenous cannabinoids.

Guineesine can dose-dependently produce cannabimimetic effects in a mouse model which are indicated by potent catatonic, analgesic, hypo-locomotive and hypo-thermic effects. In addition, the analgesic and catatonic effects were reversed by the cannabinoid receptor type 1 (CB1) inverse agonist rimonabant.

Guineesine is also a monoamine oxidase inhibitor (MAOI) in vitro $(IC_{50}$ = 139.2 μM).

