Siege of Mytilene
# Siege of Mytilene

Siege of Mytilene can refer to one of the following sieges of the town of Mytilene, on the Greek island of Lesbos:

* Siege of Mytilene by the Athenians during the Mytilenean revolt (428–427 BC)
* Siege of Mytilene (333 BC) by the Persians under Memnon of Rhodes during the campaign of Alexander the Great
* Siege of Mytilene (81 BC), by the Roman Republic
* Siege of Mytilene (1462), by the Ottoman Empire
