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DREADFUL CoNFLAGRATIoN!---T,oo squares burnt aud thirty houses desroyed-We stop the press to announce the most destructive fire that has ever occurred in this city. It was discovered about l2 o'clock last nigh, in the kitchen of N Drez, Esq on Main street, from which the flames spread with rigtf rapidity, destroying in their course two en- tire squares one on each side of Maine street from Cherry to Locust streets. The wind was blowing a perfect gale and the noble exertions of our gallant iremen were of but little avail, still all was done that strong arms and stout hearts could do to stay the gress of the destroying element.

 At this late hour, wearied and worn down as we are we cannot pretend state the amount oftheoss, but it must be immense. We are unable to give the names of all the sufferers. The principal losers, however, must be W. E. Hant S Co., furniture deal CTS, and the Messrs. Vough of the Union Hotel.- vickburg Whig, 10th inst.