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 In the most obstinate stages of the disease, they are equally certain, having cured many after every other remedy had failed In short, they have been so universally successful that the proprietor challenges any to produce remedy of equal certainty, under a fnlfei itule of Three Hundred Dollars. .=5.. q

 iahl2 I. C. DUBOSE & CO!, 39 Water st.

 Qse Price, $2 per box, with fllL diree tions. '