Furonazide
# Furonazide

Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C.

## Synthesis

Furonazide was first prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product.

## Applications

Furonazide has shown bacteriostatic action and is tuberculostatic at levels of $10^{−8}$ molar. The in vitro antibacterial activity of furonazide against Bacillus Calmette-Guerin was found to be essentially equal to that of isoniazid on an equimolar basis. In vivo studies in the guinea pig showed furonazide slightly more active than isoniazid as a tuberculostatic agent. The drug has relatively low toxicity. The median lethal dose $(LD_{50},$ rat oral) was reported as 2,600 mg/kg.

