2022 Guanajuato Open – Singles
# 2022 Guanajuato Open – Singles

Astra Sharma was the defending champion having won the previous edition in 2019, however she chose to participate at the 2022 BNP Paribas Open instead.

Zhu Lin won the title, defeating Rebecca Marino in the final, 6–4, 6–1.

## Seeds

* Zhu Lin (champion)
* Rebecca Marino (final)
* Anastasia Gasanova (withdrew)
* Arianne Hartono (second round)
* Robin Anderson (second round)
* Mirjam Björklund (withdrew)
* Valentini Grammatikopoulou (second round)
* Jamie Loeb (quarterfinals)

## Draw

### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| - | - | - | - | - | - | - | - |
| 1 | Zhu Lin | 6 | 6 | | | | |
| | Anastasia Tikhonova | 2 | 0 | | | | |
| | Anastasia Tikhonova | 2 | 0 | 1 | Zhu Lin | 6 | 6 |
| | | | | 2 | Rebecca Marino | 4 | 1 |
| | Carolina Alves | 5 | 1 | 2 | Rebecca Marino | 4 | 1 |
| 2 | Rebecca Marino | 7 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | L Zhu | 6 | 6 | | | | | | | | | | | | | | | |
| Q | AP Martínez Mora | 0 | 0 | | 1 | L Zhu | 6 | 6 | | | | | | | | | | |
| | D Vismane | 4 | 1 | | | Q Gleason | 1 | 4 | | | | | | | | | | |
| | Q Gleason | 6 | 6 | | | | | | | 1 | L Zhu | $6^5$ | 6 | 6 | | | | |
| Q | E Oosterhout | 3 | $6^5$ | | | | | | | 8 | J Loeb | $7^7$ | 2 | 3 | | | | |
| | K Volodko | 6 | $7^7$ | | | K Volodko | 4 | $7^7$ | 4 | | | | | | | | | |
| | L Glushko | 3 | 3 | | 8 | J Loeb | 6 | $6^4$ | 6 | | | | | | | | | |
| 8 | J Loeb | 6 | 6 | | | | | | | | | | | | 1 | L Zhu | 6 | 6 |
| LL | AM Becerra | 6 | $6^1$ | $6^3$ | | | | | | | | | | | | A Tikhonova | 2 | 0 |
| WC | G Arangio | 4 | $7^7$ | $7^7$ | WC | G Arangio | 1 | 1 | | | | | | | | | | |
| | A Tikhonova | $7^7$ | 1 | 6 | | A Tikhonova | 6 | 6 | | | | | | | | | | |
| | F Contreras | $6^4$ | 6 | 2 | | | | | | | A Tikhonova | 6 | 6 | | | | | |
| Q | D Hewitt | 2 | $7^7$ | 6 | | | | | | Q | D Hewitt | 2 | 3 | | | | | |
| | M Zacarías | 6 | $6^4$ | 4 | Q | D Hewitt | 6 | 4 | 6 | | | | | | | | | |
| | F Di Lorenzo | 6 | 6 | | | F Di Lorenzo | 3 | 6 | 4 | | | | | | | | | |
| LL | S Schenck | 0 | 0 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 5 | R Anderson | 6 | 3 | 6 | | | | | | | | | | | | | | |
| | A Sutjiadi | 4 | 6 | 2 | 5 | R Anderson | 4 | 2 | | | | | | | | | | |
| Q | Z Hitt | 2 | 0 | | | C Alves | 6 | 6 | | | | | | | | | | |
| | C Alves | 6 | 6 | | | | | | | | C Alves | 4 | $7^7$ | 6 | | | | |
| Q | E Douglas | $7^7$ | 6 | | | | | | | Q | E Douglas | 6 | $6^5$ | 1 | | | | |
| Q | K Christian | $6^2$ | 2 | | Q | E Douglas | 7 | 5 | 6 | | | | | | | | | |
| WC | CS Martínez Solís | 0 | 1 | | 4 | A Hartono | 5 | 7 | 0 | | | | | | | | | |
| 4 | A Hartono | 6 | 6 | | | | | | | | | | | | | C Alves | 5 | 1 |
| 7 | V Grammatikopoulou | 6 | 2 | 6 | | | | | | | | | | | 2 | R Marino | 7 | 6 |
| | P Plipuech | 2 | 6 | 1 | 7 | V Grammatikopoulou | 2 | 1 | | | | | | | | | | |
| Q | MF Navarro | 4 | 2 | | | S Mendez | 6 | 6 | | | | | | | | | | |
| | S Mendez | 6 | 6 | | | | | | | | S Mendez | 5 | 1 | | | | | |
| | W Osuigwe | $7^8$ | 6 | | | | | | | 2 | R Marino | 7 | 6 | | | | | |
| Q | J Hinojosa Gómez | $6^6$ | 3 | | | W Osuigwe | 1 | 2 | | | | | | | | | | |
| SE | A Reami | 3 | 3 | | 2 | R Marino | 6 | 6 | | | | | | | | | | |
| 2 | R Marino | 6 | 6 | | | | | | | | | | | | | | | |
