Missouri Route 22
# Missouri Route 22

Route 22 is a highway in central Missouri. Its eastern terminus is at U.S. Route 54 in Mexico; its western terminus is at U.S. Route 63 south of Clark on the Randolph/Boone county line. Route 22 was one of the original 1922 state highways and originally had an eastern terminus at Route 9 (now U.S. Route 61) in Louisiana. This section was replaced by U.S. Route 54 in 1926.

## Route description

Route 22 begins at a junction of US Route 63 east of Sturgeon. Route 22 passes north of Sturgeon. Strugeon can be accessed by taking Route V. Route 22 picks up a concurrent with Route 151 for a little bit before passing through Centralia where it met the terminus of Route 151 and Route 124. Next, it passes through Thompson. Then, it passes through Mexico. Through Mexico, it will pick a concurrency with US Route 54 Business Route and Route 15. After leaving Mexico, Route 22 along with US Route 54 Business Route and Route 15 ends at a junction of US Route 54.

## Major intersections

| County | Location | mi | km | Destinations | Notes |
| - | - | - | - | - | - |
| Boone | ​ | 0.000– 0.173 | 0.000– 0.278 | US 63 / Route F – Moberly, Columbia | Western terminus; Partial cloverleaf interchange |
| Audrain–Boone county line | ​ | 1.799 | 2.895 | Route Y | Southern terminus of Route Y |
| Audrain–Boone county line | ​ | 2.721 | 4.379 | Route V – Sturgeon | Northern terminus of Route V |
| Audrain | ​ | 5.289 | 8.512 | Route 151 north – Madison | Western end of Route 151 concurrency |
| Audrain–Boone county line | ​ | 5.600 | 9.012 | Route 151 south | Eastern end of Route 151 concurrency |
| Boone | Centralia | 10.254 | 16.502 | Route 124 south / Route 151 north (Switzler Street) – Hallsville | Northern terminus of Route 124; Southern terminus of Route 151 |
| Boone | Centralia | 10.593 | 17.048 | Route 124 Bus. (Allen Street) | Northern terminus of Route 124 Business |
| Audrain | ​ | 17.743 | 28.555 | Route E – Paris | Southern terminus of Route E |
| Audrain | ​ | 21.664 | 34.865 | Route NN | Southern terminus of Route NN |
| Audrain | Mexico | 24.602 | 39.593 | Route 15 north (Western Street) / W. Monroe Street | Western end of Route 15 concurrency |
| Audrain | Mexico | | | Route FF (W. Liberty Street) | |
| Audrain | Mexico | 25.474 | 40.996 | US 54 Bus. (Boulevard Street) / Clark Street | Western end of US 54 Business concurrency |
| Audrain | ​ | 28.627 | 46.071 | Route D | Eastern terminus of Route D |
| Audrain | ​ | 28.665– 28.797 | 46.132– 46.344 | US 54 / US 54 Bus. / Route 15 – Bowling Green, Jefferson City | Eastern end of US 54 Business and Route 15 concurrency |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus ||||||
