CRZ1
# CRZ1

CRZ1, short for Calcineurin-Responsive Zinc Finger 1, is a transcription factor that regulates calcineurin dependent-genes in Candida albicans.

## Mechanism of action

The cytoplasmic protein Crz1 is dephosphorylated by the calcineurin and is then targeted to the nucleus. The nuclear protein activates the transcription of genes involved in cell-wall maintenance and ion homeostasis.

## Structure

The protein Crz1 possesses a Zinc-Finger motif that binds to a specific motif called CDRE (Calcineurin-Dependent Response Element) present on the promoter of the targeted genes. It also possesses a nuclear localization signal (NLS) at the N-terminal part

