HCN1
# HCN1

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.

## Function

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.

## Tissue distribution

HCN1 channel expression is found in the sinoatrial node, the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.

## Ligands

* Ketamine is an inhibitor of HCN1 in addition to its other targets.
* Propofol also inhibits HCN1.
* Isoflurane and Sevoflurane inhibit HCN1.

## Interactions

HCN1 has been shown to interact with HCN2.

## Epilepsy

De novo mutations in HCN1 cause epilepsy.

