2010 US Open – Wheelchair women's singles
# 2010 US Open – Wheelchair women's singles

Four-time defending champion Esther Vergeer defeated Daniela Di Toro in the final, 6–0, 6–0 to win the women's singles wheelchair tennis title at the 2010 US Open.

## Seeds

* Esther Vergeer (champion)
* Sharon Walraven (semifinals)

## Draw

### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Finals | Finals | Finals | Finals |
| - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Esther Vergeer | 7 | 7 | | | | | | | | |
| | Florence Alix-Gravellier | 5 | 5 | | | | | | | | |
| | Florence Alix-Gravellier | 5 | 5 | 1 | Esther Vergeer | 6 | 6 | | | | |
| | | | | | Jiske Griffioen | 1 | 0 | | | | |
| | Jiske Griffioen | 6 | 6 | | Jiske Griffioen | 1 | 0 | | | | |
| WC | Mackenzie Soldan | 1 | 1 | | | | | | | | |
| WC | Mackenzie Soldan | 1 | 1 | | | | | 1 | Esther Vergeer | 6 | 6 |
| | | | | | | | | | Daniela Di Toro | 0 | 0 |
| | Daniela Di Toro | 6 | 7 | | | | | | | | | Daniela Di Toro | 0 | 0 |
| | Aniek van Koot | 3 | $6^2$ | | | | | | | | |
| | Aniek van Koot | 3 | $6^2$ | | Daniela Di Toro | 6 | 6 | | | | |
| | | | | 2 | Sharon Walraven | 4 | 2 | | | | |
| | Annick Sevenans | 4 | 3 | 2 | Sharon Walraven | 4 | 2 | | | | |
| 2 | Sharon Walraven | 6 | 6 | | | | | | | | |
