2010 US Open – Wheelchair men's singles
# 2010 US Open – Wheelchair men's singles

Two-time defending champion Shingo Kunieda won the men's singles wheelchair tennis title at the 2010 US Open after Nicolas Peifer withdrew before the final. It was his third US Open singles title and eleventh major singles title overall.

## Seeds

* Shingo Kunieda (champion)
* Maikel Scheffers (semifinals)

## Draw

### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Finals | Finals | Finals |
| - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Shingo Kunieda | 6 | 6 | | | | | | | | |
| | Ronald Vink | 0 | 0 | | | | | | | | |
| | Ronald Vink | 0 | 0 | | 1 | Shingo Kunieda | 6 | 6 | | | |
| | | | | | | Stéphane Houdet | 2 | 1 | | | |
| WC | Jon Rydberg | 1 | 4 | | | Stéphane Houdet | 2 | 1 | | | |
| | Stéphane Houdet | 6 | 6 | | | | | | | | |
| | Stéphane Houdet | 6 | 6 | | | | | | 1 | Shingo Kunieda | |
| | | | | | | | | | | Nicolas Peifer | w/o |
| | Robin Ammerlaan | 0 | 4 | | | | | | | | | Nicolas Peifer | w/o |
| | Nicolas Peifer | 6 | 6 | | | | | | | | |
| | Nicolas Peifer | 6 | 6 | | | Nicolas Peifer | 7 | 7 | | | |
| | | | | | 2 | Maikel Scheffers | 5 | $6^3$ | | | |
| | Stefan Olsson | 6 | 4 | 2 | 2 | Maikel Scheffers | 5 | $6^3$ | | | |
| 2 | Maikel Scheffers | 4 | 6 | 6 | | | | | | | |
