P-Hydroxynorephedrine
# P-Hydroxynorephedrine

p-Hydroxynorephedrine (PHN), or 4-hydroxynorephedrine, is the para-hydroxy analog of norephedrine and an active sympathomimetic metabolite of amphetamine in humans. When it occurs as a metabolite of amphetamine, it is produced from both p-hydroxyamphetamine and norephedrine.

## Amphetamine metabolism

* Metabolic pathways of amphetamine in humans
* 4-Hydroxyphenylacetone
* Phenylacetone
* Benzoic acid
* Hippuric acid
* Amphetamine
* Norephedrine
* 4-Hydroxyamphetamine
* 4-Hydroxynorephedrine
* Para- Hydroxylation
* Para- Hydroxylation
* Para- Hydroxylation
* CYP2D6
* CYP2D6
* unidentified
* Beta- Hydroxylation
* Beta- Hydroxylation
* DBH
* DBH
* Oxidative Deamination
* FMO3
* Oxidation
* unidentified
* Glycine Conjugation
* XM-ligase GLYAT
* In humans, para-hydroxynorephedrine is a metabolite of amphetamine. The aromatic ring hydroxylation of the substituted amphetamines in this image is mediated by CYP2D6 and dopamine β-hydroxylase.
