List of Ultratop 50 number-one singles of 2006
# List of Ultratop 50 number-one singles of 2006

These hits topped the Ultratop 50 in 2006.

| Issue Date | Artist | Song |
| - | - | - |
| January 7 | Kippensoep All Stars | Kippensoep voor iedereen (Chicken Soup For Everyone) |
| January 14 | Udo | Isn't it time |
| January 21 | Udo | Isn't it time |
| January 28 | Udo | Isn't it time |
| February 4 | Udo | Isn't it time |
| February 11 | Udo | Isn't it time |
| February 18 | Udo | Isn't it time |
| February 25 | Belle Perez | El mundo bailando |
| March 4 | Belle Perez | El mundo bailando |
| March 11 | Belle Perez | El mundo bailando |
| March 18 | Kate Ryan | Je t'adore (I Adore You) |
| March 25 | Kate Ryan | Je t'adore |
| April 1 | Kate Ryan | Je t'adore |
| April 8 | Kate Ryan | Je t'adore |
| April 15 | Kate Ryan | Je t'adore |
| April 22 | The Pussycat Dolls featuring will.i.am | Beep |
| April 29 | The Black Eyed Peas | Pump It |
| May 6 | Shakira featuring Wyclef Jean | Hips Don't Lie |
| May 13 | Shakira featuring Wyclef Jean | Hips Don't Lie |
| May 20 | Marco Borsato | Rood (Red) |
| May 27 | Marco Borsato | Rood |
| June 3 | Marco Borsato | Rood |
| June 10 | Marco Borsato | Rood |
| June 17 | Marco Borsato | Rood |
| June 24 | Marco Borsato | Rood |
| July 1 | Marco Borsato | Rood |
| July 8 | Laura Lynn | Jij bent de mooiste (You Are the Most Beautiful) |
| July 15 | Laura Lynn | Jij bent de mooiste |
| July 22 | Laura Lynn | Jij bent de mooiste |
| July 29 | Marco Borsato | Rood |
| August 5 | Marco Borsato | Rood |
| August 12 | Henkie | Lief klein konijntje (Cute Little Bunny) |
| August 19 | Henkie | Lief klein konijntje |
| August 26 | Henkie | Lief klein konijntje |
| September 2 | Henkie | Lief klein konijntje |
| September 9 | Henkie | Lief klein konijntje |
| September 16 | Henkie | Lief klein konijntje |
| September 23 | Bob Sinclar, Cutee-B, Dollarman & Big Ali | Rock This Party (Everybody Dance Now) |
| September 30 | Bob Sinclar, Cutee-B, Dollarman & Big Ali | Rock This Party (Everybody Dance Now) |
| October 7 | Bob Sinclar, Cutee-B, Dollarman & Big Ali | Rock This Party (Everybody Dance Now) |
| October 14 | Bob Sinclar, Cutee-B, Dollarman & Big Ali | Rock This Party (Everybody Dance Now) |
| October 21 | Scissor Sisters | I Don't Feel Like Dancin' |
| October 28 | Scissor Sisters | I Don't Feel Like Dancin' |
| November 4 | Scissor Sisters | I Don't Feel Like Dancin' |
| November 11 | Scissor Sisters | I Don't Feel Like Dancin' |
| November 18 | Scissor Sisters | I Don't Feel Like Dancin' |
| November 25 | Scissor Sisters | I Don't Feel Like Dancin' |
| December 2 | Scissor Sisters | I Don't Feel Like Dancin' |
| December 9 | Clouseau | Vonken en vuur (Sparks and Fire) |
| December 16 | Clouseau | Vonken en vuur |
| December 23 | Clouseau | Vonken en vuur |
| December 30 | Clouseau | Vonken en vuur |
