ZK-93423
# ZK-93423

ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil. It is a nonbenzodiazepine $GABA_A$ agonist which is not subtype selective and stimulates $α_1,$ $α_2,$ $α_3,$ and $α_5-subunit$ containing $GABA_A$ receptors equally. It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs. ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the $GABA_A$ receptor.

