PSEN2
# PSEN2

Presenilin-2 is a protein that (in humans) is encoded by the PSEN2 gene.

## Function

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.

In melanocytic cells PSEN2 gene expression may be regulated by MITF.

## Interactions

PSEN2 has been shown to interact with:

* BCL2-like 1,
* CAPN1,
* CIB1,
* Calsenilin,
* FHL2,
* FLNB,
* KCNIP4,
* Nicastrin, and
* UBQLN1.
