2021–22 EHF Champions League group stage
# 2021–22 EHF Champions League group stage

The 2021–22 EHF Champions League group stage was played between 15 September 2021 and 10 March 2022 to determine the ten teams advancing to the knockout stage of the 2021–22 EHF Champions League.

## Draw

The draw was held on 2 July 2020 in Vienna, Austria.

### Seeding

The composition of the seeding pots for the group stage draw was announced on 30 June 2021. From each pot, two teams were drawn into Group A and the other two in Group B. Teams from the same national association were not drawn into the same group.

Seeding pots for Groups A and B :

| Pot 1 | Pot 2 | Pot 3 | Pot 4 |
| - | - | - | - |
| Barça THW Kiel Pick Szeged Paris Saint-Germain | Vardar 1961 Aalborg Håndbold Łomża Vive Kielce FC Porto | Meshkov Brest SG Flensburg-Handewitt Telekom Veszprém Montpellier Handball | Motor PPD Zagreb Dinamo București Elverum Håndball |

## Format

In each group, teams played against each other in a double round-robin format, with home and away matches.

## Tiebreakers

In the group stage, teams are ranked according to points (2 points for a win, 1 point for a draw, 0 points for a loss). After completion of the group stage, if two or more teams have the same number of points, the ranking is determined as follows:

* Highest number of points in matches between the teams directly involved;
* Superior goal difference in matches between the teams directly involved;
* Highest number of goals scored in matches between the teams directly involved (or in the away match in case of a two-team tie);
* Superior goal difference in all matches of the group;
* Highest number of plus goals in all matches of the group;

If the ranking of one of these teams is determined, the above criteria are consecutively followed until the ranking of all teams is determined. If no ranking can be determined, a decision shall be obtained by EHF through drawing of lots.

## Groups

The matchdays were 15–16 September, 22–23 September, 29–30 September, 13–14 October, 20–21 October, 27–28 October, 17–18 November, 24–25 November, 1–2 December, 8–9 December 2021, 16–17 February, 23–24 February, 2–3 March, 9–10 March 2022.

Times until 30 October 2021 are UTC+2, from 31 October 2021 on times are UTC+1.

Due to the COVID-19 pandemic, each local health department allows a different number of spectators.

### Group A

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification |
| - | - | - | - | - | - | - | - | - | - | - |
| 1 | Aalborg Håndbold | 14 | 11 | 0 | 3 | 453 | 410 | +43 | 22 | Quarterfinals |
| 2 | THW Kiel | 14 | 10 | 1 | 3 | 427 | 395 | +32 | 21 | Quarterfinals |
| 3 | Pick Szeged | 14 | 8 | 3 | 3 | 412 | 392 | +20 | 19 | Playoffs |
| 4 | Montpellier Handball | 14 | 7 | 3 | 4 | 424 | 409 | +15 | 17 | Playoffs |
| 5 | RK Vardar | 14 | 6 | 1 | 7 | 379 | 368 | +11 | 13 | Playoffs |
| 6 | Elverum Håndball | 14 | 3 | 2 | 9 | 417 | 449 | −32 | 8 | Playoffs |
| 7 | PPD Zagreb | 14 | 3 | 2 | 9 | 351 | 385 | −34 | 8 | |
| 8 | Meshkov Brest | 14 | 1 | 2 | 11 | 342 | 397 | −55 | 4 | |

* 1 2 Elverum 57–52 Zagreb

| 15 September 2021 18:45 | Meshkov Brest | 30–33 | THW Kiel | Universal Sports Complex Victoria, Brest Attendance: 1,650 Referees: Erdoğan, Özdeniz (TUR) |
| - | - | - | - | - |
| 15 September 2021 18:45 | three players 6 | (15–18) | Ekberg 11 | Universal Sports Complex Victoria, Brest Attendance: 1,650 Referees: Erdoğan, Özdeniz (TUR) |
| 15 September 2021 18:45 | 1× 2× | Report | 2× 3× | Universal Sports Complex Victoria, Brest Attendance: 1,650 Referees: Erdoğan, Özdeniz (TUR) |
| 15 September 2021 18:45 | Montpellier Handball | 29–29 | Pick Szeged | Sud de France Arena, Montpellier Attendance: 3,500 Referees: Santos, Fonseca (POR) |
| 15 September 2021 18:45 | six players 3 | (14–15) | Frimmel 8 | Sud de France Arena, Montpellier Attendance: 3,500 Referees: Santos, Fonseca (POR) |
| 15 September 2021 18:45 | 1× 3× | Report | 2× 1× | Sud de France Arena, Montpellier Attendance: 3,500 Referees: Santos, Fonseca (POR) |
| 15 September 2021 18:45 | Elverum Håndball | 27–27 | RK Vardar | Terningen Arena, Elverum Attendance: 940 Referees: Horáček, Novotný (CZE) |
| 15 September 2021 18:45 | Heldal, Máthé 6 | (13–13) | Toto 6 | Terningen Arena, Elverum Attendance: 940 Referees: Horáček, Novotný (CZE) |
| 15 September 2021 18:45 | 1× | Report | 1× 4× 1× | Terningen Arena, Elverum Attendance: 940 Referees: Horáček, Novotný (CZE) |
| 15 September 2021 20:45 | PPD Zagreb | 24–34 | Aalborg Håndbold | Arena Zagreb, Zagreb Attendance: 325 Referees: Marín, García (ESP) |
| 15 September 2021 20:45 | Klarica, Mandić 5 | (14–18) | Barthold 9 | Arena Zagreb, Zagreb Attendance: 325 Referees: Marín, García (ESP) |
| 15 September 2021 20:45 | 1× 6× | Report | 4× | Arena Zagreb, Zagreb Attendance: 325 Referees: Marín, García (ESP) |
| 22 September 2021 18:45 | Pick Szeged | 30–21 | PPD Zagreb | Újszegedi Sportcsarnok, Szeged Attendance: 2,500 Referees: Schulze, Tönnies (GER) |
| 22 September 2021 18:45 | Šoštarič 7 | (10–7) | Klis, Vistorop 4 | Újszegedi Sportcsarnok, Szeged Attendance: 2,500 Referees: Schulze, Tönnies (GER) |
| 22 September 2021 18:45 | 2× 5× | Report | 2× 2× | Újszegedi Sportcsarnok, Szeged Attendance: 2,500 Referees: Schulze, Tönnies (GER) |
| 22 September 2021 18:45 | Aalborg Håndbold | 36–28 | Montpellier Handball | Gigantium, Aalborg Attendance: 4,237 Referees: Mandák, Rudinský (SVK) |
| 22 September 2021 18:45 | Sandell 11 | (18–13) | Villeminot 7 | Gigantium, Aalborg Attendance: 4,237 Referees: Mandák, Rudinský (SVK) |
| 22 September 2021 18:45 | 1× 4× | Report | 7× | Gigantium, Aalborg Attendance: 4,237 Referees: Mandák, Rudinský (SVK) |
| 22 September 2021 20:45 | RK Vardar | 35–27 | Meshkov Brest | Jane Sandanski Arena, Skopje Attendance: 1,950 Referees: Brkic, Jusufhodzic (AUT) |
| 22 September 2021 20:45 | Nyokas 8 | (19–13) | Kašpárek 6 | Jane Sandanski Arena, Skopje Attendance: 1,950 Referees: Brkic, Jusufhodzic (AUT) |
| 22 September 2021 20:45 | 2× 7× | Report | 3× 5× | Jane Sandanski Arena, Skopje Attendance: 1,950 Referees: Brkic, Jusufhodzic (AUT) |
| 22 September 2021 20:45 | THW Kiel | 41–36 | Elverum Håndball | Sparkassen-Arena, Kiel Attendance: 4,622 Referees: Pichon, Reveret (FRA) |
| 22 September 2021 20:45 | Reinkind 7 | (20–20) | Johansson 7 | Sparkassen-Arena, Kiel Attendance: 4,622 Referees: Pichon, Reveret (FRA) |
| 22 September 2021 20:45 | 2× 1× | Report | 2× 4× | Sparkassen-Arena, Kiel Attendance: 4,622 Referees: Pichon, Reveret (FRA) |
| 29 September 2021 18:45 | RK Vardar | 30–28 | Aalborg Håndbold | Jane Sandanski Arena, Skopje Attendance: 2,000 Referees: Nikolić, Stojković (SRB) |
| 29 September 2021 18:45 | Nyokas 7 | (16–16) | three players 5 | Jane Sandanski Arena, Skopje Attendance: 2,000 Referees: Nikolić, Stojković (SRB) |
| 29 September 2021 18:45 | 2× 3× | Report | 2× 1× | Jane Sandanski Arena, Skopje Attendance: 2,000 Referees: Nikolić, Stojković (SRB) |
| 29 September 2021 20:45 | PPD Zagreb | 27–27 | Elverum Håndball | Arena Zagreb, Zagreb Attendance: 500 Referees: Lah, Sok (SLO) |
| 29 September 2021 20:45 | Čupić 7 | (14–11) | three players 5 | Arena Zagreb, Zagreb Attendance: 500 Referees: Lah, Sok (SLO) |
| 29 September 2021 20:45 | 2× 3× | Report | 2× 5× | Arena Zagreb, Zagreb Attendance: 500 Referees: Lah, Sok (SLO) |
| 30 September 2021 18:45 | Meshkov Brest | 25–28 | Pick Szeged | Universal Sports Complex Victoria, Brest Attendance: 1,350 Referees: Pavićević, Ražnatović (MNE) |
| 30 September 2021 18:45 | Skube, Vranješ 4 | (12–16) | Garciandia 7 | Universal Sports Complex Victoria, Brest Attendance: 1,350 Referees: Pavićević, Ražnatović (MNE) |
| 30 September 2021 18:45 | 1× 3× | Report | 1× 2× | Universal Sports Complex Victoria, Brest Attendance: 1,350 Referees: Pavićević, Ražnatović (MNE) |
| 30 September 2021 20:45 | Montpellier Handball | 37–30 | THW Kiel | Sud de France Arena, Montpellier Attendance: 4,000 Referees: Stark, Ştefan (ROU) |
| 30 September 2021 20:45 | Villeminot 8 | (18–14) | Ekberg 9 | Sud de France Arena, Montpellier Attendance: 4,000 Referees: Stark, Ştefan (ROU) |
| 30 September 2021 20:45 | 2× 2× | Report | 1× 3× | Sud de France Arena, Montpellier Attendance: 4,000 Referees: Stark, Ştefan (ROU) |
| 13 October 2021 18:45 | THW Kiel | 36–28 | PPD Zagreb | Sparkassen-Arena, Kiel Attendance: 5,413 Referees: Andorka, Hucker (HUN) |
| 13 October 2021 18:45 | Reinkind 8 | (18–15) | Čupić, Vistorop 6 | Sparkassen-Arena, Kiel Attendance: 5,413 Referees: Andorka, Hucker (HUN) |
| 13 October 2021 18:45 | 1× 4× | Report | 3× 3× | Sparkassen-Arena, Kiel Attendance: 5,413 Referees: Andorka, Hucker (HUN) |
| 13 October 2021 18:45 | Aalborg Håndbold | 34–33 | Meshkov Brest | Gigantium, Aalborg Attendance: 4,144 Referees: Kurtagic, Wetterwik (SWE) |
| 13 October 2021 18:45 | Claar 8 | (18–18) | Bonnefond 8 | Gigantium, Aalborg Attendance: 4,144 Referees: Kurtagic, Wetterwik (SWE) |
| 13 October 2021 18:45 | 3× | Report | 4× | Gigantium, Aalborg Attendance: 4,144 Referees: Kurtagic, Wetterwik (SWE) |
| 13 October 2021 20:45 | RK Vardar | 25–31 | Montpellier Handball | Jane Sandanski Arena, Skopje Attendance: 3,200 Referees: Marín, García (ESP) |
| 13 October 2021 20:45 | Dibirov 7 | (11–15) | Bos, Villeminot 7 | Jane Sandanski Arena, Skopje Attendance: 3,200 Referees: Marín, García (ESP) |
| 13 October 2021 20:45 | 1× 2× | Report | 2× 4× | Jane Sandanski Arena, Skopje Attendance: 3,200 Referees: Marín, García (ESP) |
| 14 October 2021 18:45 | Pick Szeged | 30–34 | Elverum Håndball | Újszegedi Sportcsarnok, Szeged Attendance: 2,800 Referees: Nikolić, Stojković (SRB) |
| 14 October 2021 18:45 | Bánhidi 6 | (15–19) | Grøndahl 9 | Újszegedi Sportcsarnok, Szeged Attendance: 2,800 Referees: Nikolić, Stojković (SRB) |
| 14 October 2021 18:45 | 1× 3× | Report | 2× 2× 1× | Újszegedi Sportcsarnok, Szeged Attendance: 2,800 Referees: Nikolić, Stojković (SRB) |
| 20 October 2021 18:45 | THW Kiel | 32–32 | Pick Szeged | Sparkassen-Arena, Kiel Attendance: 5,824 Referees: Mandák, Rudinský (SVK) |
| 20 October 2021 18:45 | Pekeler 8 | (17–14) | Šoštarič 5 | Sparkassen-Arena, Kiel Attendance: 5,824 Referees: Mandák, Rudinský (SVK) |
| 20 October 2021 18:45 | 1× 4× | Report | 1× 3× | Sparkassen-Arena, Kiel Attendance: 5,824 Referees: Mandák, Rudinský (SVK) |
| 20 October 2021 18:45 | Aalborg Håndbold | 33–29 | RK Vardar | Gigantium, Aalborg Attendance: 4,755 Referees: Bíró, Kiss (HUN) |
| 20 October 2021 18:45 | Pálmarsson 8 | (16–13) | Dibirov 9 | Gigantium, Aalborg Attendance: 4,755 Referees: Bíró, Kiss (HUN) |
| 20 October 2021 18:45 | 5× | Report | 1× 5× | Gigantium, Aalborg Attendance: 4,755 Referees: Bíró, Kiss (HUN) |
| 20 October 2021 18:45 | Elverum Håndball | 30–25 | PPD Zagreb | Terningen Arena, Elverum Attendance: 2,000 Referees: Stark, Ştefan (ROU) |
| 20 October 2021 18:45 | three players 5 | (17–14) | Ćavar 6 | Terningen Arena, Elverum Attendance: 2,000 Referees: Stark, Ştefan (ROU) |
| 20 October 2021 18:45 | 2× | Report | 5× | Terningen Arena, Elverum Attendance: 2,000 Referees: Stark, Ştefan (ROU) |
| 20 October 2021 20:45 | Montpellier Handball | 32–26 | Meshkov Brest | Sud de France Arena, Montpellier Attendance: 4,000 Referees: Mažeika, Gatelis (LTU) |
| 20 October 2021 20:45 | Bos 11 | (14–12) | Bonnefond 5 | Sud de France Arena, Montpellier Attendance: 4,000 Referees: Mažeika, Gatelis (LTU) |
| 20 October 2021 20:45 | 1× 4× | Report | 1× 2× | Sud de France Arena, Montpellier Attendance: 4,000 Referees: Mažeika, Gatelis (LTU) |
| 27 October 2021 18:45 | Pick Szeged | 31–28 | Aalborg Håndbold | Újszegedi Sportcsarnok, Szeged Attendance: 3,000 Referees: Lah, Sok (SLO) |
| 27 October 2021 18:45 | three players 5 | (17–13) | Barthold 8 | Újszegedi Sportcsarnok, Szeged Attendance: 3,000 Referees: Lah, Sok (SLO) |
| 27 October 2021 18:45 | 2× 5× 1× | Report | 2× 4× | Újszegedi Sportcsarnok, Szeged Attendance: 3,000 Referees: Lah, Sok (SLO) |
| 27 October 2021 20:45 | RK Vardar | 26–29 | THW Kiel | Jane Sandanski Arena, Skopje Attendance: 3,000 Referees: Brunner, Salah (SUI) |
| 27 October 2021 20:45 | Dibirov 10 | (13–10) | Duvnjak 7 | Jane Sandanski Arena, Skopje Attendance: 3,000 Referees: Brunner, Salah (SUI) |
| 27 October 2021 20:45 | 4× | Report | 1× 4× | Jane Sandanski Arena, Skopje Attendance: 3,000 Referees: Brunner, Salah (SUI) |
| 27 October 2021 20:45 | PPD Zagreb | 22–25 | Montpellier Handball | Arena Zagreb, Zagreb Attendance: 350 Referees: Horáček, Novotný (CZE) |
| 27 October 2021 20:45 | Čupić 7 | (13–12) | Bos 7 | Arena Zagreb, Zagreb Attendance: 350 Referees: Horáček, Novotný (CZE) |
| 27 October 2021 20:45 | 1× 2× | Report | 1× 3× | Arena Zagreb, Zagreb Attendance: 350 Referees: Horáček, Novotný (CZE) |
| 28 October 2021 18:45 | Meshkov Brest | 27–30 | Elverum Håndball | Universal Sports Complex Victoria, Brest Attendance: 920 Referees: Horváth, Marton (HUN) |
| 28 October 2021 18:45 | Vranješ 7 | (11–14) | Grøndahl 9 | Universal Sports Complex Victoria, Brest Attendance: 920 Referees: Horváth, Marton (HUN) |
| 28 October 2021 18:45 | 2× 6× | Report | 2× 4× | Universal Sports Complex Victoria, Brest Attendance: 920 Referees: Horváth, Marton (HUN) |
| 17 November 2021 18:45 | Meshkov Brest | 30–30 | PPD Zagreb | Universal Sports Complex Victoria, Brest Attendance: 1,220 Referees: Baďura, Ondogrecula (SVK) |
| 17 November 2021 18:45 | Kašpárek 6 | (13–15) | Čupić 7 | Universal Sports Complex Victoria, Brest Attendance: 1,220 Referees: Baďura, Ondogrecula (SVK) |
| 17 November 2021 18:45 | 2× 3× | Report | 1× 2× | Universal Sports Complex Victoria, Brest Attendance: 1,220 Referees: Baďura, Ondogrecula (SVK) |
| 17 November 2021 18:45 | Elverum Håndball | 30–37 | Montpellier Handball | Terningen Arena, Elverum Attendance: 2,430 Referees: Schulze, Tönnies (GER) |
| 17 November 2021 18:45 | Máthé 7 | (15–20) | Descat 9 | Terningen Arena, Elverum Attendance: 2,430 Referees: Schulze, Tönnies (GER) |
| 17 November 2021 18:45 | 1× 5× | Report | 3× | Terningen Arena, Elverum Attendance: 2,430 Referees: Schulze, Tönnies (GER) |
| 18 November 2021 18:45 | THW Kiel | 31–28 | Aalborg Håndbold | Sparkassen-Arena, Kiel Attendance: 6,233 Referees: Gubica, Milošević (CRO) |
| 18 November 2021 18:45 | Ekberg, Pekeler 7 | (17–14) | Juul 8 | Sparkassen-Arena, Kiel Attendance: 6,233 Referees: Gubica, Milošević (CRO) |
| 18 November 2021 18:45 | 6× | Report | 6× | Sparkassen-Arena, Kiel Attendance: 6,233 Referees: Gubica, Milošević (CRO) |
| 18 November 2021 18:45 | Pick Szeged | 34–31 | RK Vardar | Újszegedi Sportcsarnok, Szeged Attendance: 3,000 Referees: Elíasson, Pálsson (ISL) |
| 18 November 2021 18:45 | Frimmel 9 | (17–15) | Dibirov 7 | Újszegedi Sportcsarnok, Szeged Attendance: 3,000 Referees: Elíasson, Pálsson (ISL) |
| 18 November 2021 18:45 | 4× | Report | 1× 4× | Újszegedi Sportcsarnok, Szeged Attendance: 3,000 Referees: Elíasson, Pálsson (ISL) |
| 24 November 2021 18:45 | Aalborg Håndbold | 35–33 | THW Kiel | Gigantium, Aalborg Attendance: 5,020 Referees: Elíasson, Pálsson (ISL) |
| 24 November 2021 18:45 | Læsø 9 | (17–16) | Ekberg 7 | Gigantium, Aalborg Attendance: 5,020 Referees: Elíasson, Pálsson (ISL) |
| 24 November 2021 18:45 | 1× 4× | Report | 2× 3× | Gigantium, Aalborg Attendance: 5,020 Referees: Elíasson, Pálsson (ISL) |
| 24 November 2021 20:45 | PPD Zagreb | 31–24 | Meshkov Brest | Arena Zagreb, Zagreb Attendance: 340 Referees: Santos, Fonseca (POR) |
| 24 November 2021 20:45 | Čupić 8 | (14–14) | Malus 6 | Arena Zagreb, Zagreb Attendance: 340 Referees: Santos, Fonseca (POR) |
| 24 November 2021 20:45 | 1× 2× | Report | 1× 4× 1× | Arena Zagreb, Zagreb Attendance: 340 Referees: Santos, Fonseca (POR) |
| 24 November 2021 20:45 | Montpellier Handball | 39–32 | Elverum Håndball | Sud de France Arena, Montpellier Attendance: 2,900 Referees: Bíró, Kiss (HUN) |
| 24 November 2021 20:45 | Descat 11 | (19–16) | Grøndahl 8 | Sud de France Arena, Montpellier Attendance: 2,900 Referees: Bíró, Kiss (HUN) |
| 24 November 2021 20:45 | 2× | Report | 1× | Sud de France Arena, Montpellier Attendance: 2,900 Referees: Bíró, Kiss (HUN) |
| 25 November 2021 20:45 | RK Vardar | 27–30 | Pick Szeged | Jane Sandanski Arena, Skopje Attendance: 2,500 Referees: Stark, Ştefan (ROU) |
| 25 November 2021 20:45 | Dibirov, Gadža 5 | (9–16) | Šoštarić 7 | Jane Sandanski Arena, Skopje Attendance: 2,500 Referees: Stark, Ştefan (ROU) |
| 25 November 2021 20:45 | 1× 5× | Report | 3× | Jane Sandanski Arena, Skopje Attendance: 2,500 Referees: Stark, Ştefan (ROU) |
| 1 December 2021 18:45 | Elverum Håndball | 32–33 | Meshkov Brest | Terningen Arena, Elverum Attendance: 1,604 Referees: Brunner, Salah (SUI) |
| 1 December 2021 18:45 | Grøndahl 8 | (15–17) | Vailupau 8 | Terningen Arena, Elverum Attendance: 1,604 Referees: Brunner, Salah (SUI) |
| 1 December 2021 18:45 | 1× 4× | Report | 7× 1× | Terningen Arena, Elverum Attendance: 1,604 Referees: Brunner, Salah (SUI) |
| 1 December 2021 20:45 | Aalborg Håndbold | 34–30 | Pick Szeged | Gigantium, Aalborg Attendance: 450 Referees: Santos, Fonseca (POR) |
| 1 December 2021 20:45 | Læsø 9 | (16–14) | Šoštarič 7 | Gigantium, Aalborg Attendance: 450 Referees: Santos, Fonseca (POR) |
| 1 December 2021 20:45 | 1× 4× | Report | 1× 4× | Gigantium, Aalborg Attendance: 450 Referees: Santos, Fonseca (POR) |
| 1 December 2021 20:45 | Montpellier Handball | 24–23 | PPD Zagreb | Sud de France Arena, Montpellier Attendance: 2,800 Referees: Pavićević, Ražnatović (MNE) |
| 1 December 2021 20:45 | Wallinius 5 | (14–12) | Čupić 5 | Sud de France Arena, Montpellier Attendance: 2,800 Referees: Pavićević, Ražnatović (MNE) |
| 1 December 2021 20:45 | 1× 5× | Report | 1× 5× | Sud de France Arena, Montpellier Attendance: 2,800 Referees: Pavićević, Ražnatović (MNE) |
| 2 December 2021 20:45 | THW Kiel | 32–30 | RK Vardar | Sparkassen-Arena, Kiel Attendance: 4,711 Referees: Martins, Martins (POR) |
| 2 December 2021 20:45 | Sagosen 8 | (18–16) | Kuduz 9 | Sparkassen-Arena, Kiel Attendance: 4,711 Referees: Martins, Martins (POR) |
| 2 December 2021 20:45 | 1× | Report | 3× | Sparkassen-Arena, Kiel Attendance: 4,711 Referees: Martins, Martins (POR) |
| 8 December 2021 18:45 | Elverum Håndball | 28–34 | Aalborg Håndbold | Terningen Arena, Elverum Attendance: 1,513 Referees: Marín, García (ESP) |
| 8 December 2021 18:45 | Máthé 7 | (12–16) | Bjørnsen, Claar 6 | Terningen Arena, Elverum Attendance: 1,513 Referees: Marín, García (ESP) |
| 8 December 2021 18:45 | 2× 5× | Report | 2× | Terningen Arena, Elverum Attendance: 1,513 Referees: Marín, García (ESP) |
| 8 December 2021 18:45 | Meshkov Brest | 31–31 | Montpellier Handball | Universal Sports Complex Victoria, Brest Attendance: 1,120 Referees: Nikolić, Stojković (SRB) |
| 8 December 2021 18:45 | Vailupau 9 | (17–18) | Pellas 13 | Universal Sports Complex Victoria, Brest Attendance: 1,120 Referees: Nikolić, Stojković (SRB) |
| 8 December 2021 18:45 | 2× 5× | Report | 3× 5× | Universal Sports Complex Victoria, Brest Attendance: 1,120 Referees: Nikolić, Stojković (SRB) |
| 8 December 2021 20:45 | PPD Zagreb | 23–22 | RK Vardar | Arena Zagreb, Zagreb Attendance: 350 Referees: Mažeika, Gatelis (LTU) |
| 8 December 2021 20:45 | Čupić 5 | (14–12) | Dibirov, Toto 4 | Arena Zagreb, Zagreb Attendance: 350 Referees: Mažeika, Gatelis (LTU) |
| 8 December 2021 20:45 | 4× 3× | Report | 2× 4× 1× | Arena Zagreb, Zagreb Attendance: 350 Referees: Mažeika, Gatelis (LTU) |
| 9 December 2021 20:45 | Pick Szeged | 30–26 | THW Kiel | Pick Aréna, Szeged Attendance: 8,300 Referees: Nikolov, Nachevski (MKD) |
| 9 December 2021 20:45 | Bánhidi 6 | (19–13) | Ekberg, Reinkind 5 | Pick Aréna, Szeged Attendance: 8,300 Referees: Nikolov, Nachevski (MKD) |
| 9 December 2021 20:45 | 1× 3× | Report | 1× 3× | Pick Aréna, Szeged Attendance: 8,300 Referees: Nikolov, Nachevski (MKD) |
| 16 February 2022 18:45 | Meshkov Brest | 30–33 | Aalborg Håndbold | Universal Sports Complex Victoria, Brest Attendance: 1,150 Referees: Brkic, Jusufhodzic (AUT) |
| 16 February 2022 18:45 | Skube 8 | (15–17) | Claar 7 | Universal Sports Complex Victoria, Brest Attendance: 1,150 Referees: Brkic, Jusufhodzic (AUT) |
| 16 February 2022 18:45 | 1× 4× | Report | 1× 5× | Universal Sports Complex Victoria, Brest Attendance: 1,150 Referees: Brkic, Jusufhodzic (AUT) |
| 16 February 2022 18:45 | Montpellier Handball | 25–28 | RK Vardar | FDI Stadium, Montpellier Attendance: 2,800 Referees: Kurtagic, Wetterwik (SWE) |
| 16 February 2022 18:45 | Descat 7 | (10–14) | Nyokas 5 | FDI Stadium, Montpellier Attendance: 2,800 Referees: Kurtagic, Wetterwik (SWE) |
| 16 February 2022 18:45 | 1× 2× | Report | 1× 2× 1× | FDI Stadium, Montpellier Attendance: 2,800 Referees: Kurtagic, Wetterwik (SWE) |
| 17 February 2022 18:45 | Elverum Håndball | 30–31 | THW Kiel | Terningen Arena, Elverum Attendance: 8,532 Referees: Santos, Fonseca (POR) |
| 17 February 2022 18:45 | Johansson 8 | (15–14) | Sagosen 6 | Terningen Arena, Elverum Attendance: 8,532 Referees: Santos, Fonseca (POR) |
| 17 February 2022 18:45 | 1× 4× | Report | 7× | Terningen Arena, Elverum Attendance: 8,532 Referees: Santos, Fonseca (POR) |
| 17 February 2022 20:45 | PPD Zagreb | 26–24 | Pick Szeged | Arena Zagreb, Zagreb Attendance: 425 Referees: Erdoğan, Özdeniz (TUR) |
| 17 February 2022 20:45 | Obranović 7 | (14–10) | Martins 5 | Arena Zagreb, Zagreb Attendance: 425 Referees: Erdoğan, Özdeniz (TUR) |
| 17 February 2022 20:45 | 1× 2× | Report | 1× 1× | Arena Zagreb, Zagreb Attendance: 425 Referees: Erdoğan, Özdeniz (TUR) |
| 23 February 2022 18:45 | Aalborg Håndbold | 32–27 | Elverum Håndball | Gigantium, Aalborg Attendance: 4,384 Referees: Mažeika, Gatelis (LTU) |
| 23 February 2022 18:45 | Claar 6 | (14–13) | Heldal 8 | Gigantium, Aalborg Attendance: 4,384 Referees: Mažeika, Gatelis (LTU) |
| 23 February 2022 18:45 | 1× 2× | Report | 4× | Gigantium, Aalborg Attendance: 4,384 Referees: Mažeika, Gatelis (LTU) |
| 23 February 2022 20:45 | THW Kiel | 35–26 | Montpellier Handball | Sparkassen-Arena, Kiel Attendance: 3,435 Referees: Lah, Sok (SLO) |
| 23 February 2022 20:45 | Weinhold 5 | (19–13) | Descat 6 | Sparkassen-Arena, Kiel Attendance: 3,435 Referees: Lah, Sok (SLO) |
| 23 February 2022 20:45 | 3× | Report | 1× 1× | Sparkassen-Arena, Kiel Attendance: 3,435 Referees: Lah, Sok (SLO) |
| 23 February 2022 20:45 | RK Vardar | 20–19 | PPD Zagreb | Jane Sandanski Arena, Skopje Attendance: 2,200 Referees: Horáček, Novotný (CZE) |
| 23 February 2022 20:45 | Nyokas, Taleski 4 | (11–9) | Leimeter 4 | Jane Sandanski Arena, Skopje Attendance: 2,200 Referees: Horáček, Novotný (CZE) |
| 23 February 2022 20:45 | 4× | Report | 1× 3× | Jane Sandanski Arena, Skopje Attendance: 2,200 Referees: Horáček, Novotný (CZE) |
| 24 February 2022 20:45 | Pick Szeged | 28–26 | Meshkov Brest | Pick Aréna, Szeged Attendance: 3,400 Referees: Marín, García (ESP) |
| 24 February 2022 20:45 | Bánhidi 8 | (16–14) | Sretenović 7 | Pick Aréna, Szeged Attendance: 3,400 Referees: Marín, García (ESP) |
| 24 February 2022 20:45 | 5× | Report | 2× 2× | Pick Aréna, Szeged Attendance: 3,400 Referees: Marín, García (ESP) |
| 2 March 2022 18:45 | Elverum Håndball | 24–27 | Pick Szeged | Terningen Arena, Elverum Attendance: 1,655 Referees: Kurtagic, Wetterwik (SWE) |
| 2 March 2022 18:45 | Heldal 7 | (12–13) | Frimmel 7 | Terningen Arena, Elverum Attendance: 1,655 Referees: Kurtagic, Wetterwik (SWE) |
| 2 March 2022 18:45 | 1× 3× | Report | 5× | Terningen Arena, Elverum Attendance: 1,655 Referees: Kurtagic, Wetterwik (SWE) |
| 2 March 2022 20:45 | Montpellier Handball | 31–33 | Aalborg Håndbold | Sud de France Arena, Montpellier Attendance: 3,000 Referees: Brunner, Salah (SUI) |
| 2 March 2022 20:45 | Descat 8 | (14–20) | Claar 10 | Sud de France Arena, Montpellier Attendance: 3,000 Referees: Brunner, Salah (SUI) |
| 2 March 2022 20:45 | 1× 2× | Report | 1× | Sud de France Arena, Montpellier Attendance: 3,000 Referees: Brunner, Salah (SUI) |
| 3 March 2022 20:45 | PPD Zagreb | 27–28 | THW Kiel | Arena Zagreb, Zagreb Attendance: 1,721 Referees: Brkic, Jusufhodzic (AUT) |
| 3 March 2022 20:45 | Mandić 9 | (15–12) | Duvnjak, Reinkind 5 | Arena Zagreb, Zagreb Attendance: 1,721 Referees: Brkic, Jusufhodzic (AUT) |
| 3 March 2022 20:45 | 2× 5× | Report | 3× 4× | Arena Zagreb, Zagreb Attendance: 1,721 Referees: Brkic, Jusufhodzic (AUT) |
| 9 March 2022 18:45 | Aalborg Håndbold | 31–25 | PPD Zagreb | Gigantium, Aalborg Attendance: 4,877 Referees: Gasmi, Gasmi (FRA) |
| 9 March 2022 18:45 | Claar 6 | (16–13) | Čupić 11 | Gigantium, Aalborg Attendance: 4,877 Referees: Gasmi, Gasmi (FRA) |
| 9 March 2022 18:45 | 2× | Report | 4× | Gigantium, Aalborg Attendance: 4,877 Referees: Gasmi, Gasmi (FRA) |
| 9 March 2022 20:45 | RK Vardar | 39–30 | Elverum Håndball | Jane Sandanski Arena, Skopje Attendance: 2,200 Referees: Baumgart, Wild (GER) |
| 9 March 2022 20:45 | Dibirov 7 | (17–16) | Johansson 8 | Jane Sandanski Arena, Skopje Attendance: 2,200 Referees: Baumgart, Wild (GER) |
| 9 March 2022 20:45 | 5× | Report | 1× 3× | Jane Sandanski Arena, Skopje Attendance: 2,200 Referees: Baumgart, Wild (GER) |
| 10 March 2022 18:45 | Pick Szeged | 29–29 | Montpellier Handball | Pick Aréna, Szeged Attendance: 5,500 Referees: Gubica, Milošević (CRO) |
| 10 March 2022 18:45 | Šoštarič 6 | (17–16) | Pellas, Simonet 5 | Pick Aréna, Szeged Attendance: 5,500 Referees: Gubica, Milošević (CRO) |
| 10 March 2022 18:45 | 5× 1× | Report | 1× 5× | Pick Aréna, Szeged Attendance: 5,500 Referees: Gubica, Milošević (CRO) |
| Cancelled | THW Kiel | 10–0 | Meshkov Brest |
| Cancelled | Meshkov Brest | 0–10 | RK Vardar |

### Group B

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification |
| - | - | - | - | - | - | - | - | - | - | - |
| 1 | Łomża Vive Kielce | 14 | 10 | 0 | 4 | 449 | 415 | +34 | 20 | Quarterfinals |
| 2 | Barça | 14 | 9 | 2 | 3 | 420 | 369 | +51 | 20 | Quarterfinals |
| 3 | Paris Saint-Germain | 14 | 8 | 2 | 4 | 452 | 396 | +56 | 18 | Playoffs |
| 4 | Telekom Veszprém | 14 | 8 | 1 | 5 | 449 | 423 | +26 | 17 | Playoffs |
| 5 | FC Porto | 14 | 4 | 3 | 7 | 375 | 408 | −33 | 11 | Playoffs |
| 6 | SG Flensburg-Handewitt | 14 | 4 | 2 | 8 | 381 | 401 | −20 | 10 | Playoffs |
| 7 | Dinamo București | 14 | 4 | 0 | 10 | 415 | 470 | −55 | 8 | |
| 8 | Motor | 14 | 4 | 0 | 10 | 312 | 371 | −59 | 8 | |

* 1 2 Kielce 61–57 Barça
* 1 2 Dinamo 60–57 Motor

| 15 September 2021 18:45 | Telekom Veszprém | 34–31 | Paris Saint-Germain | Veszprém Aréna, Veszprém Attendance: 4,600 Referees: Gubica, Milošević (CRO) |
| - | - | - | - | - |
| 15 September 2021 18:45 | Omar 10 | (13–17) | Hansen 7 | Veszprém Aréna, Veszprém Attendance: 4,600 Referees: Gubica, Milošević (CRO) |
| 15 September 2021 18:45 | 1× 5× | Report | 3× | Veszprém Aréna, Veszprém Attendance: 4,600 Referees: Gubica, Milošević (CRO) |
| 15 September 2021 18:45 | Dinamo București | 32–29 | Łomża Vive Kielce | Dinamo Polyvalent Hall, Bucharest Attendance: 1,700 Referees: Hansen, Madsen (DEN) |
| 15 September 2021 18:45 | Nantes 11 | (16–12) | Moryto 7 | Dinamo Polyvalent Hall, Bucharest Attendance: 1,700 Referees: Hansen, Madsen (DEN) |
| 15 September 2021 18:45 | 5× 1× | Report | 4× | Dinamo Polyvalent Hall, Bucharest Attendance: 1,700 Referees: Hansen, Madsen (DEN) |
| 15 September 2021 18:45 | Motor | 30–27 | FC Porto | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,950 Referees: Pavićević, Ražnatović (MNE) |
| 15 September 2021 18:45 | Bokhan 8 | (15–10) | Areia 6 | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,950 Referees: Pavićević, Ražnatović (MNE) |
| 15 September 2021 18:45 | 1× 1× | Report | 3× 2× | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,950 Referees: Pavićević, Ražnatović (MNE) |
| 15 September 2021 20:45 | SG Flensburg-Handewitt | 21–25 | Barça | Flens-Arena, Flensburg Attendance: 2,066 Referees: Brunner, Salah (SUI) |
| 15 September 2021 20:45 | Wanne 6 | (10–13) | Mem 7 | Flens-Arena, Flensburg Attendance: 2,066 Referees: Brunner, Salah (SUI) |
| 15 September 2021 20:45 | 1× 1× | Report | 1× 3× | Flens-Arena, Flensburg Attendance: 2,066 Referees: Brunner, Salah (SUI) |
| 23 September 2021 18:45 | Barça | 36–25 | Motor | Palau Blaugrana, Barcelona Attendance: 487 Referees: Madsen, Mortensen (DEN) |
| 23 September 2021 18:45 | Mem 8 | (16–13) | Pukhouski 6 | Palau Blaugrana, Barcelona Attendance: 487 Referees: Madsen, Mortensen (DEN) |
| 23 September 2021 18:45 | 2× | Report | 1× 4× | Palau Blaugrana, Barcelona Attendance: 487 Referees: Madsen, Mortensen (DEN) |
| 23 September 2021 18:45 | Łomża Vive Kielce | 32–29 | Telekom Veszprém | Hala Legionów, Kielce Attendance: 4,100 Referees: Kurtagic, Wetterwik (SWE) |
| 23 September 2021 18:45 | A. Dujshebaev 7 | (17–12) | Nenadić 10 | Hala Legionów, Kielce Attendance: 4,100 Referees: Kurtagic, Wetterwik (SWE) |
| 23 September 2021 18:45 | 2× 4× 1× | Report | 5× | Hala Legionów, Kielce Attendance: 4,100 Referees: Kurtagic, Wetterwik (SWE) |
| 23 September 2021 20:45 | Paris Saint-Germain | 41–30 | Dinamo București | Stade Pierre de Coubertin, Paris Attendance: 2,421 Referees: Bíró, Kiss (HUN) |
| 23 September 2021 20:45 | Solé 6 | (21–11) | Sorhaindo 9 | Stade Pierre de Coubertin, Paris Attendance: 2,421 Referees: Bíró, Kiss (HUN) |
| 23 September 2021 20:45 | 2× | Report | 1× 5× | Stade Pierre de Coubertin, Paris Attendance: 2,421 Referees: Bíró, Kiss (HUN) |
| 23 September 2021 20:45 | FC Porto | 28–27 | SG Flensburg-Handewitt | Dragão Arena, Porto Attendance: 695 Referees: Nikolov, Nachevski (MKD) |
| 23 September 2021 20:45 | Salina 6 | (13–12) | Wanne 8 | Dragão Arena, Porto Attendance: 695 Referees: Nikolov, Nachevski (MKD) |
| 23 September 2021 20:45 | 1× 4× | Report | 1× 2× | Dragão Arena, Porto Attendance: 695 Referees: Nikolov, Nachevski (MKD) |
| 29 September 2021 18:45 | Motor | 25–26 | Łomża Vive Kielce | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,900 Referees: Mažeika, Gatelis (LTU) |
| 29 September 2021 18:45 | Malašinskas 9 | (13–14) | four players 4 | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,900 Referees: Mažeika, Gatelis (LTU) |
| 29 September 2021 18:45 | 7× 2× | Report | 1× 3× | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,900 Referees: Mažeika, Gatelis (LTU) |
| 29 September 2021 18:45 | Telekom Veszprém | 29–28 | Barça | Veszprém Aréna, Veszprém Attendance: 5,089 Referees: Horáček, Novotný (CZE) |
| 29 September 2021 18:45 | Marguč 8 | (16–12) | three players 5 | Veszprém Aréna, Veszprém Attendance: 5,089 Referees: Horáček, Novotný (CZE) |
| 29 September 2021 18:45 | 3× 6× | Report | 1× 3× | Veszprém Aréna, Veszprém Attendance: 5,089 Referees: Horáček, Novotný (CZE) |
| 29 September 2021 20:45 | SG Flensburg-Handewitt | 27–27 | Paris Saint-Germain | Flens-Arena, Flensburg Attendance: 2,400 Referees: Hansen, Madsen (DEN) |
| 29 September 2021 20:45 | Wanne 7 | (14–13) | Hansen 6 | Flens-Arena, Flensburg Attendance: 2,400 Referees: Hansen, Madsen (DEN) |
| 29 September 2021 20:45 | 2× 2× | Report | 3× 0× | Flens-Arena, Flensburg Attendance: 2,400 Referees: Hansen, Madsen (DEN) |
| 30 September 2021 18:45 | Dinamo București | 26–27 | FC Porto | Dinamo Polyvalent Hall, Bucharest Attendance: 1,250 Referees: Brunner, Salah (SUI) |
| 30 September 2021 18:45 | five players 3 | (14–15) | Alves, Iturriza | Dinamo Polyvalent Hall, Bucharest Attendance: 1,250 Referees: Brunner, Salah (SUI) |
| 30 September 2021 18:45 | 3× | Report | 4× 1× | Dinamo Polyvalent Hall, Bucharest Attendance: 1,250 Referees: Brunner, Salah (SUI) |
| 13 October 2021 20:45 | Łomża Vive Kielce | 37–29 | SG Flensburg-Handewitt | Hala Legionów, Kielce Attendance: 3,800 Referees: Lah, Sok (SLO) |
| 13 October 2021 20:45 | Sićko 9 | (21–16) | Mensing 9 | Hala Legionów, Kielce Attendance: 3,800 Referees: Lah, Sok (SLO) |
| 13 October 2021 20:45 | 3× | Report | 2× 3× | Hala Legionów, Kielce Attendance: 3,800 Referees: Lah, Sok (SLO) |
| 14 October 2021 20:45 | Paris Saint-Germain | 40–32 | Motor | Stade Pierre de Coubertin, Paris Attendance: 2,000 Referees: Pandžić, Mošorinski (SRB) |
| 14 October 2021 20:45 | Hansen 6 | (19–14) | Kozakevych 7 | Stade Pierre de Coubertin, Paris Attendance: 2,000 Referees: Pandžić, Mošorinski (SRB) |
| 14 October 2021 20:45 | 1× 4× | Report | 2× 5× | Stade Pierre de Coubertin, Paris Attendance: 2,000 Referees: Pandžić, Mošorinski (SRB) |
| 14 October 2021 20:45 | Barça | 36–32 | Dinamo București | Palau Blaugrana, Barcelona Attendance: 1,018 Referees: Bonaventura, Bonaventura (FRA) |
| 14 October 2021 20:45 | Mem 12 | (19–14) | Ghionea, Pascual Garcia 9 | Palau Blaugrana, Barcelona Attendance: 1,018 Referees: Bonaventura, Bonaventura (FRA) |
| 14 October 2021 20:45 | 2× | Report | 1× 4× | Palau Blaugrana, Barcelona Attendance: 1,018 Referees: Bonaventura, Bonaventura (FRA) |
| 14 October 2021 20:45 | FC Porto | 23–30 | Telekom Veszprém | Dragão Arena, Porto Attendance: 1,486 Referees: Baumgart, Wild (GER) |
| 14 October 2021 20:45 | Silva 6 | (10–16) | Nenadić 8 | Dragão Arena, Porto Attendance: 1,486 Referees: Baumgart, Wild (GER) |
| 14 October 2021 20:45 | 1× 1× | Report | 1× 2× | Dragão Arena, Porto Attendance: 1,486 Referees: Baumgart, Wild (GER) |
| 20 October 2021 18:45 | Łomża Vive Kielce | 39–33 | FC Porto | Hala Legionów, Kielce Attendance: 4,100 Referees: Gubica, Milošević (CRO) |
| 20 October 2021 18:45 | Guðjónsson 10 | (21–17) | Slišković 7 | Hala Legionów, Kielce Attendance: 4,100 Referees: Gubica, Milošević (CRO) |
| 20 October 2021 18:45 | 4× | Report | 1× 8× 1× | Hala Legionów, Kielce Attendance: 4,100 Referees: Gubica, Milošević (CRO) |
| 21 October 2021 18:45 | Telekom Veszprém | 28–23 | SG Flensburg-Handewitt | Veszprém Aréna, Veszprém Attendance: 5,000 Referees: Brkic, Jusufhodzic (AUT) |
| 21 October 2021 18:45 | Štrlek 7 | (14–8) | Einarsson 5 | Veszprém Aréna, Veszprém Attendance: 5,000 Referees: Brkic, Jusufhodzic (AUT) |
| 21 October 2021 18:45 | 1× | Report | 1× 4× 1× | Veszprém Aréna, Veszprém Attendance: 5,000 Referees: Brkic, Jusufhodzic (AUT) |
| 21 October 2021 18:45 | Motor | 28–27 | Dinamo București | Yunist Palace of Sports, Zaporizhzhia Attendance: 500 Referees: Nikolov, Nachevski (MKD) |
| 21 October 2021 18:45 | Denysov, Pukhouski 5 | (13–13) | Ghionea 8 | Yunist Palace of Sports, Zaporizhzhia Attendance: 500 Referees: Nikolov, Nachevski (MKD) |
| 21 October 2021 18:45 | 1× | Report | 2× 4× | Yunist Palace of Sports, Zaporizhzhia Attendance: 500 Referees: Nikolov, Nachevski (MKD) |
| 21 October 2021 20:45 | Barça | 30–27 | Paris Saint-Germain | Palau Blaugrana, Barcelona Attendance: 2,451 Referees: Schulze, Tönnies (GER) |
| 21 October 2021 20:45 | Mem 7 | (13–13) | Hansen 7 | Palau Blaugrana, Barcelona Attendance: 2,451 Referees: Schulze, Tönnies (GER) |
| 21 October 2021 20:45 | 1× 5× | Report | 1× 1× | Palau Blaugrana, Barcelona Attendance: 2,451 Referees: Schulze, Tönnies (GER) |
| 27 October 2021 18:45 | Łomża Vive Kielce | 38–33 | Paris Saint-Germain | Hala Legionów, Kielce Attendance: 4,000 Referees: Pavićević, Ražnatović (MNE) |
| 27 October 2021 18:45 | Nahi, Sićko 6 | (19–14) | Hansen 8 | Hala Legionów, Kielce Attendance: 4,000 Referees: Pavićević, Ražnatović (MNE) |
| 27 October 2021 18:45 | 6× | Report | 2× 5× | Hala Legionów, Kielce Attendance: 4,000 Referees: Pavićević, Ražnatović (MNE) |
| 28 October 2021 18:45 | Dinamo București | 31–29 | Telekom Veszprém | Dinamo Polyvalent Hall, Bucharest Attendance: 100 Referees: Nikolić, Stojković (SRB) |
| 28 October 2021 18:45 | Ghionea 8 | (14–13) | Nenadić 9 | Dinamo Polyvalent Hall, Bucharest Attendance: 100 Referees: Nikolić, Stojković (SRB) |
| 28 October 2021 18:45 | 1× 7× 1× | Report | 3× 4× 1× | Dinamo Polyvalent Hall, Bucharest Attendance: 100 Referees: Nikolić, Stojković (SRB) |
| 28 October 2021 20:45 | FC Porto | 33–33 | Barça | Dragão Arena, Porto Attendance: 1,792 Referees: Hansen, Madsen (DEN) |
| 28 October 2021 20:45 | Slišković 7 | (17–14) | Gómez 11 | Dragão Arena, Porto Attendance: 1,792 Referees: Hansen, Madsen (DEN) |
| 28 October 2021 20:45 | 5× | Report | 1× | Dragão Arena, Porto Attendance: 1,792 Referees: Hansen, Madsen (DEN) |
| 28 October 2021 20:45 | SG Flensburg-Handewitt | 34–27 | Motor | Flens-Arena, Flensburg Attendance: 1,234 Referees: Kurtagic, Wetterwik (SWE) |
| 28 October 2021 20:45 | Wanne 8 | (13–11) | Bokhan 7 | Flens-Arena, Flensburg Attendance: 1,234 Referees: Kurtagic, Wetterwik (SWE) |
| 28 October 2021 20:45 | 1× 5× | Report | 6× 1× | Flens-Arena, Flensburg Attendance: 1,234 Referees: Kurtagic, Wetterwik (SWE) |
| 17 November 2021 18:45 | Motor | 29–27 | Telekom Veszprém | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,100 Referees: Jurinović, Mrvica (CRO) |
| 17 November 2021 18:45 | Denysov, Horiha 6 | (14–12) | Mahé 6 | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,100 Referees: Jurinović, Mrvica (CRO) |
| 17 November 2021 18:45 | 1× 3× | Report | 1× 4× | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,100 Referees: Jurinović, Mrvica (CRO) |
| 17 November 2021 20:45 | SG Flensburg-Handewitt | 37–30 | Dinamo București | Flens-Arena, Flensburg Attendance: 1,277 Referees: Marín, García (ESP) |
| 17 November 2021 20:45 | Wanne 8 | (14–14) | Ghionea 8 | Flens-Arena, Flensburg Attendance: 1,277 Referees: Marín, García (ESP) |
| 17 November 2021 20:45 | 2× 3× | Report | 1× 1× | Flens-Arena, Flensburg Attendance: 1,277 Referees: Marín, García (ESP) |
| 18 November 2021 20:45 | Paris Saint-Germain | 33–19 | FC Porto | Stade Pierre de Coubertin, Paris Attendance: 2,383 Referees: Mažeika, Gatelis (LTU) |
| 18 November 2021 20:45 | Syprzak 8 | (18–4) | Iturriza 5 | Stade Pierre de Coubertin, Paris Attendance: 2,383 Referees: Mažeika, Gatelis (LTU) |
| 18 November 2021 20:45 | 2× | Report | 3× | Stade Pierre de Coubertin, Paris Attendance: 2,383 Referees: Mažeika, Gatelis (LTU) |
| 18 November 2021 20:45 | Barça | 30–32 | Łomża Vive Kielce | Palau Blaugrana, Barcelona Attendance: 2,480 Referees: Nikolov, Nachevski (MKD) |
| 18 November 2021 20:45 | Mem, N'Guessan 7 | (16–19) | Moryto 7 | Palau Blaugrana, Barcelona Attendance: 2,480 Referees: Nikolov, Nachevski (MKD) |
| 18 November 2021 20:45 | 1× 1× | Report | 1× 2× | Palau Blaugrana, Barcelona Attendance: 2,480 Referees: Nikolov, Nachevski (MKD) |
| 24 November 2021 18:45 | Łomża Vive Kielce | 29–27 | Barça | Hala Legionów, Kielce Attendance: 4,200 Referees: Brkic, Jusufhodzic (AUT) |
| 24 November 2021 18:45 | A. Dujshebaev 8 | (14–16) | Ariño 5 | Hala Legionów, Kielce Attendance: 4,200 Referees: Brkic, Jusufhodzic (AUT) |
| 24 November 2021 18:45 | 1× 2× | Report | 2× 4× | Hala Legionów, Kielce Attendance: 4,200 Referees: Brkic, Jusufhodzic (AUT) |
| 25 November 2021 18:45 | Telekom Veszprém | 36–29 | Motor | Veszprém Aréna, Veszprém Attendance: 4,000 Referees: Jørum, Kleven (NOR) |
| 25 November 2021 18:45 | Marguč 9 | (18–13) | Bokhan 8 | Veszprém Aréna, Veszprém Attendance: 4,000 Referees: Jørum, Kleven (NOR) |
| 25 November 2021 18:45 | 1× 3× | Report | 1× 5× | Veszprém Aréna, Veszprém Attendance: 4,000 Referees: Jørum, Kleven (NOR) |
| 25 November 2021 18:45 | Dinamo București | 20–28 | SG Flensburg-Handewitt | Dinamo Polyvalent Hall, Bucharest Attendance: 0 Referees: Horáček, Novotný (CZE) |
| 25 November 2021 18:45 | Shebib, Nantes 5 | (13–13) | Mensing 8 | Dinamo Polyvalent Hall, Bucharest Attendance: 0 Referees: Horáček, Novotný (CZE) |
| 25 November 2021 18:45 | 1× 2× | Report | 1× 4× | Dinamo Polyvalent Hall, Bucharest Attendance: 0 Referees: Horáček, Novotný (CZE) |
| 25 November 2021 20:45 | FC Porto | 30–39 | Paris Saint-Germain | Dragão Arena, Porto Attendance: 1,917 Referees: Mandák, Rudinský (SVK) |
| 25 November 2021 20:45 | Cruz, Slišković 5 | (15–23) | Syprzak 9 | Dragão Arena, Porto Attendance: 1,917 Referees: Mandák, Rudinský (SVK) |
| 25 November 2021 20:45 | 1× 5× | Report | 1× 3× | Dragão Arena, Porto Attendance: 1,917 Referees: Mandák, Rudinský (SVK) |
| 1 December 2021 18:45 | Motor | 31–22 | SG Flensburg-Handewitt | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,100 Referees: Bíró, Kiss (HUN) |
| 1 December 2021 18:45 | Malašinskas 9 | (15–14) | Jakobsen 8 | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,100 Referees: Bíró, Kiss (HUN) |
| 1 December 2021 18:45 | 3× | Report | 1× 1× | Yunist Palace of Sports, Zaporizhzhia Attendance: 1,100 Referees: Bíró, Kiss (HUN) |
| 2 December 2021 18:45 | Telekom Veszprém | 47–32 | Dinamo București | Veszprém Aréna, Veszprém Attendance: 4,300 Referees: Hansen, Madsen (DEN) |
| 2 December 2021 18:45 | Omar 8 | (22–15) | Humet, Nantes 6 | Veszprém Aréna, Veszprém Attendance: 4,300 Referees: Hansen, Madsen (DEN) |
| 2 December 2021 18:45 | 1× 4× | Report | 2× | Veszprém Aréna, Veszprém Attendance: 4,300 Referees: Hansen, Madsen (DEN) |
| 2 December 2021 20:45 | Barça | 38–31 | FC Porto | Palau Blaugrana, Barcelona Attendance: 1,140 Referees: Kurtagic, Wetterwik (SWE) |
| 2 December 2021 20:45 | Gómez 12 | (20–13) | Magalhães 9 | Palau Blaugrana, Barcelona Attendance: 1,140 Referees: Kurtagic, Wetterwik (SWE) |
| 2 December 2021 20:45 | 2× 1× | Report | 2× | Palau Blaugrana, Barcelona Attendance: 1,140 Referees: Kurtagic, Wetterwik (SWE) |
| 2 December 2021 20:45 | Paris Saint-Germain | 32–27 | Łomża Vive Kielce | Stade Pierre de Coubertin, Paris Attendance: 2,843 Referees: Horáček, Novotný (CZE) |
| 2 December 2021 20:45 | Hansen 7 | (16–14) | Nahi, Sićko 5 | Stade Pierre de Coubertin, Paris Attendance: 2,843 Referees: Horáček, Novotný (CZE) |
| 2 December 2021 20:45 | 1× 7× | Report | 6× 1× | Stade Pierre de Coubertin, Paris Attendance: 2,843 Referees: Horáček, Novotný (CZE) |
| 9 December 2021 18:45 | Dinamo București | 33–29 | Motor | Dinamo Polyvalent Hall, Bucharest Attendance: 2,000 Referees: Gubica, Milošević (CRO) |
| 9 December 2021 18:45 | Nantes 13 | (16–14) | Bokhan, Malašinskas 6 | Dinamo Polyvalent Hall, Bucharest Attendance: 2,000 Referees: Gubica, Milošević (CRO) |
| 9 December 2021 18:45 | 1× 5× | Report | 1× 5× | Dinamo Polyvalent Hall, Bucharest Attendance: 2,000 Referees: Gubica, Milošević (CRO) |
| 9 December 2021 18:45 | SG Flensburg-Handewitt | 30–27 | Telekom Veszprém | Flens-Arena, Flensburg Attendance: 1,703 Referees: Mandák, Rudinský (SVK) |
| 9 December 2021 18:45 | Mensah Larsen 7 | (16–12) | Marguč 6 | Flens-Arena, Flensburg Attendance: 1,703 Referees: Mandák, Rudinský (SVK) |
| 9 December 2021 18:45 | 1× 3× | Report | 5× | Flens-Arena, Flensburg Attendance: 1,703 Referees: Mandák, Rudinský (SVK) |
| 9 December 2021 20:45 | Paris Saint-Germain | 28–28 | Barça | Stade Pierre de Coubertin, Paris Attendance: 2,795 Referees: Lah, Sok (SLO) |
| 9 December 2021 20:45 | Solé 8 | (17–15) | Langaro 7 | Stade Pierre de Coubertin, Paris Attendance: 2,795 Referees: Lah, Sok (SLO) |
| 9 December 2021 20:45 | 3× | Report | 1× 3× 1× | Stade Pierre de Coubertin, Paris Attendance: 2,795 Referees: Lah, Sok (SLO) |
| 9 December 2021 20:45 | FC Porto | 29–27 | Łomża Vive Kielce | Dragão Arena, Porto Attendance: 608 Referees: Madsen, Mortensen (DEN) |
| 9 December 2021 20:45 | Cruz 7 | (14–14) | Karalek 7 | Dragão Arena, Porto Attendance: 608 Referees: Madsen, Mortensen (DEN) |
| 9 December 2021 20:45 | 1× 2× | Report | 2× | Dragão Arena, Porto Attendance: 608 Referees: Madsen, Mortensen (DEN) |
| 16 February 2022 18:45 | Telekom Veszprém | 28–28 | FC Porto | Veszprém Aréna, Veszprém Attendance: 4,800 Referees: Nikolić, Stojković (SRB) |
| 16 February 2022 18:45 | Mahé, Nenadić 6 | (15–15) | three players 4 | Veszprém Aréna, Veszprém Attendance: 4,800 Referees: Nikolić, Stojković (SRB) |
| 16 February 2022 18:45 | 2× 3× | Report | 3× 4× | Veszprém Aréna, Veszprém Attendance: 4,800 Referees: Nikolić, Stojković (SRB) |
| 16 February 2022 20:45 | SG Flensburg-Handewitt | 25–33 | Łomża Vive Kielce | Flens-Arena, Flensburg Attendance: 1,075 Referees: Elíasson, Pálsson (ISL) |
| 16 February 2022 20:45 | Jakobsen 6 | (12–14) | Karačić 6 | Flens-Arena, Flensburg Attendance: 1,075 Referees: Elíasson, Pálsson (ISL) |
| 16 February 2022 20:45 | 1× 3× | Report | 1× 2× | Flens-Arena, Flensburg Attendance: 1,075 Referees: Elíasson, Pálsson (ISL) |
| 17 February 2022 18:45 | Dinamo București | 30–35 | Barça | Dinamo Polyvalent Hall, Bucharest Attendance: 1,650 Referees: Pavićević, Ražnatović (MNE) |
| 17 February 2022 18:45 | Shebib 9 | (15–17) | Mem 9 | Dinamo Polyvalent Hall, Bucharest Attendance: 1,650 Referees: Pavićević, Ražnatović (MNE) |
| 17 February 2022 18:45 | 4× | Report | | Dinamo Polyvalent Hall, Bucharest Attendance: 1,650 Referees: Pavićević, Ražnatović (MNE) |
| 23 February 2022 18:45 | Łomża Vive Kielce | 33–27 | Motor | Hala Legionów, Kielce Attendance: 4,200 Referees: Hansen, Madsen (DEN) |
| 23 February 2022 18:45 | Tournat 8 | (19–13) | Horiha 5 | Hala Legionów, Kielce Attendance: 4,200 Referees: Hansen, Madsen (DEN) |
| 23 February 2022 18:45 | 2× | Report | 4× | Hala Legionów, Kielce Attendance: 4,200 Referees: Hansen, Madsen (DEN) |
| 24 February 2022 18:45 | Barça | 35–30 | Telekom Veszprém | Palau Blaugrana, Barcelona Attendance: 2,579 Referees: Gubica, Milošević (CRO) |
| 24 February 2022 18:45 | Mem 8 | (13–13) | Omar 7 | Palau Blaugrana, Barcelona Attendance: 2,579 Referees: Gubica, Milošević (CRO) |
| 24 February 2022 18:45 | 5× | Report | 6× | Palau Blaugrana, Barcelona Attendance: 2,579 Referees: Gubica, Milošević (CRO) |
| 24 February 2022 20:45 | Paris Saint-Germain | 33–30 | SG Flensburg-Handewitt | Stade Pierre de Coubertin, Paris Attendance: 2,911 Referees: Nikolov, Nachevski (MKD) |
| 24 February 2022 20:45 | Steins 7 | (17–13) | Semper 7 | Stade Pierre de Coubertin, Paris Attendance: 2,911 Referees: Nikolov, Nachevski (MKD) |
| 24 February 2022 20:45 | 1× 3× | Report | 1× 3× | Stade Pierre de Coubertin, Paris Attendance: 2,911 Referees: Nikolov, Nachevski (MKD) |
| 24 February 2022 20:45 | FC Porto | 31–32 | Dinamo București | Dragão Arena, Porto Attendance: 1,091 Referees: Jørum, Kleven (NOR) |
| 24 February 2022 20:45 | Magalhães 6 | (12–12) | Pascual García 6 | Dragão Arena, Porto Attendance: 1,091 Referees: Jørum, Kleven (NOR) |
| 24 February 2022 20:45 | 1× 2× | Report | 1× 2× | Dragão Arena, Porto Attendance: 1,091 Referees: Jørum, Kleven (NOR) |
| 2 March 2022 20:45 | SG Flensburg-Handewitt | 26–26 | FC Porto | Flens-Arena, Flensburg Attendance: 1,134 Referees: Pavićević, Ražnatović (MNE) |
| 2 March 2022 20:45 | Einarsson 8 | (14–13) | M'Bengue 6 | Flens-Arena, Flensburg Attendance: 1,134 Referees: Pavićević, Ražnatović (MNE) |
| 2 March 2022 20:45 | 1× | Report | 1× | Flens-Arena, Flensburg Attendance: 1,134 Referees: Pavićević, Ražnatović (MNE) |
| 3 March 2022 18:45 | Telekom Veszprém | 35–33 | Łomża Vive Kielce | Veszprém Aréna, Veszprém Attendance: 5,019 Referees: Nikolov, Nachevski (MKD) |
| 3 March 2022 18:45 | Mahé, Nenadić 6 | (18–16) | A. Dujshebaev, Nahi 6 | Veszprém Aréna, Veszprém Attendance: 5,019 Referees: Nikolov, Nachevski (MKD) |
| 3 March 2022 18:45 | 2× 4× | Report | 1× 3× | Veszprém Aréna, Veszprém Attendance: 5,019 Referees: Nikolov, Nachevski (MKD) |
| 3 March 2022 18:45 | Dinamo București | 31–39 | Paris Saint-Germain | Dinamo Polyvalent Hall, Bucharest Attendance: 3,000 Referees: Elíasson, Pálsson (ISL) |
| 3 March 2022 18:45 | Nantes 7 | (16–20) | Hansen 7 | Dinamo Polyvalent Hall, Bucharest Attendance: 3,000 Referees: Elíasson, Pálsson (ISL) |
| 3 March 2022 18:45 | 1× 5× | Report | 1× 3× | Dinamo Polyvalent Hall, Bucharest Attendance: 3,000 Referees: Elíasson, Pálsson (ISL) |
| 9 March 2022 18:45 | Łomża Vive Kielce | 34–29 | Dinamo București | Hala Legionów, Kielce Attendance: 4,200 Referees: Jurinović, Mrvica (CRO) |
| 9 March 2022 18:45 | Moryto 8 | (20–13) | Shebib 7 | Hala Legionów, Kielce Attendance: 4,200 Referees: Jurinović, Mrvica (CRO) |
| 9 March 2022 18:45 | 1× 3× | Report | 1× 5× 1× | Hala Legionów, Kielce Attendance: 4,200 Referees: Jurinović, Mrvica (CRO) |
| 10 March 2022 18:45 | Barça | 29–22 | SG Flensburg-Handewitt | Palau Blaugrana, Barcelona Attendance: 2,159 Referees: Hansen, Madsen (DEN) |
| 10 March 2022 18:45 | Gómez 9 | (15–11) | Wanne 6 | Palau Blaugrana, Barcelona Attendance: 2,159 Referees: Hansen, Madsen (DEN) |
| 10 March 2022 18:45 | 1× | Report | 1× 2× | Palau Blaugrana, Barcelona Attendance: 2,159 Referees: Hansen, Madsen (DEN) |
| 10 March 2022 20:45 | Paris Saint-Germain | 39–40 | Telekom Veszprém | Stade Pierre de Coubertin, Paris Attendance: 2,618 Referees: Santos, Fonseca (POR) |
| 10 March 2022 20:45 | N. Karabatić 8 | (19–20) | Nenadić 9 | Stade Pierre de Coubertin, Paris Attendance: 2,618 Referees: Santos, Fonseca (POR) |
| 10 March 2022 20:45 | 5× 1× | Report | 2× 9× 1× | Stade Pierre de Coubertin, Paris Attendance: 2,618 Referees: Santos, Fonseca (POR) |
| Cancelled | Motor | 0–10 | Paris Saint-Germain |
| Cancelled | Motor | 0–10 | Barça |
| Cancelled | FC Porto | 10–0 | Motor |
