Naphthylpiperazine
# Naphthylpiperazine

1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the $5-HT_{1A},$ $5-HT_{1B},$ $5-HT_{1D},$ $5-HT_{1E},$ and $5-HT_{1F}$ receptors, while antagonizing the $5-HT_{2A},$ $5-HT_{2B},$ and $5-HT_{2C}$ receptors. It has also been shown to possess high affinity for the $5-HT_3,$ $5-HT_{5A},$ $5-HT_6,$ and $5-HT_7$ receptors, and may bind to $5-HT_4$ and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the $5-HT_{2C}$ receptor.

