2021–22 UEFA Youth League
# 2021–22 UEFA Youth League

The 2021–22 UEFA Youth League was the eighth season of the UEFA Youth League, a European youth club football competition organised by UEFA.

Real Madrid, having won the title in 2019–20, were the title holders, since the 2020–21 edition was cancelled due to the COVID-19 pandemic in Europe and the title was not awarded. They were eliminated by city rivals Atlético Madrid in the round of 16.

Portuguese side Benfica won their first title, beating Red Bull Salzburg 6–0 in the final. This was a replay of the 2017 final, won by Salzburg by 2–1. It was also Benfica's first title in European football since the 1961–62 European Cup. In August, Benfica played the inaugural Under-20 Intercontinental Cup, beating the CONMEBOL champions, Peñarol, 1–0.

## Teams

A total of 64 teams from at least 32 of the 55 UEFA member associations may enter the tournament. They are split into two sections, each with 32 teams.

* UEFA Champions League Path: The youth teams of the 32 clubs which qualified for the 2021–22 UEFA Champions League group stage entered the UEFA Champions League Path. If there was a vacancy (youth teams not entering), it was filled by a team defined by UEFA.
* Domestic Champions Path: The youth domestic champions of the top 32 associations according to their 2021 UEFA country coefficients entered the Domestic Champions Path. If there was a vacancy (associations with no youth domestic competition, as well as youth domestic champions already included in the UEFA Champions League path), it was first filled by the title holders should they have not yet qualified, and then by the youth domestic champions of the next association in the UEFA ranking.

Akademia e Futbollit, Angers, Deportivo La Coruña, Daugavpils, Empoli, Hajduk Split, 1. FC Köln, Miercurea Ciuc, Pogoń Szczecin, St Patrick's Athletic, Trabzonspor, Žalgiris and Zvijezda 09 will make their tournament debuts. Lithuania will be represented for the first time.

Qualified teams for 2021–22 UEFA Youth League :

| Rank | Association | Teams | Teams |
| - | - | - | - |
| Rank | Association | UEFA Champions League Path | Domestic Champions Path |
| 1 | England | Manchester City (2020–21 U18 Premier League) Manchester United Liverpool Chelsea | |
| 2 | Spain | Atlético Madrid Real Madrid Barcelona Sevilla Villarreal | Deportivo La Coruña (2020–21 División de Honor Juvenil U-19) |
| 3 | Germany | Bayern Munich RB Leipzig Borussia Dortmund VfL Wolfsburg | 1. FC Köln (2019–20 U19 A-Junioren-Bundesliga) |
| 4 | Italy | Inter Milan Milan Atalanta Juventus | Empoli (2020–21 Campionato Primavera 1) |
| 5 | France | Lille Paris Saint-Germain | Angers (2019–20 Championnat National U19) |
| 6 | Portugal | Sporting CP Porto Benfica (2019–20 Campeonato Nacional Juniores S19) | |
| 7 | Russia | Zenit Saint Petersburg (2020–21 Russian Youth Football League U17) | |
| 8 | Belgium | Club Brugge | Genk (2019–20 Belgian U18 League) |
| 9 | Ukraine | Dynamo Kyiv Shakhtar Donetsk (2020–21 Ukrainian U19 League) | |
| 10 | Netherlands | Ajax | AZ (2019–20 Eredivisie U19) |
| 11 | Turkey | Beşiktaş | Trabzonspor (2020–21 U19 Elit) |
| 12 | Austria | Red Bull Salzburg (2020–21 Jugendliga U18) | |
| 13 | Denmark | | Midtjylland (2020–21 U19 Ligaen) |
| 14 | Scotland | | Rangers (2020–21 Scottish U18 League) |
| 15 | Czech Republic | | Sparta Prague (2020–21 Czech U19 League) |
| 16 | Cyprus | | APOEL (2020–21 Cypriot U19 League) |
| 17 | Switzerland | Young Boys (2020–21 Swiss U18 League) | |
| 18 | Greece | | PAOK (2020–21 Superleague K19) |
| 19 | Serbia | | Red Star Belgrade (2020–21 Serbian U19 League) |
| 20 | Croatia | | Hajduk Split (2020–21 1. HNL Juniori U19) |
| 21 | Sweden | Malmö | Hammarby IF (2020 P17 Allsvenskan) |
| 22 | Norway | | Rosenborg (2020 Norwegian U19 Cup) |
| 23 | Israel | | Maccabi Haifa (2020–21 Israeli U19 Noar Premier League) |
| 24 | Kazakhstan | | Kairat (2020 Kazakhstani U17 League) |
| 25 | Belarus | | Minsk (2020 Belarusian U18 League) |
| 26 | Azerbaijan | | Gabala (2020–21 Azerbaijani U19 League) |
| 27 | Bulgaria | | Septemvri Sofia (2020–21 U18 BFU Cup) |
| 28 | Romania | | Miercurea Ciuc (2020–21 Liga Elitelor U19) |
| 29 | Poland | | Pogoń Szczecin (2020–21 Polish U18 Central Junior League) |
| 30 | Slovakia | | Žilina (2020–21 Slovak U19 League) |
| 32 | Slovenia | | Domžale (2020–21 Slovenian U19 League) |
| 33 | Hungary | | MTK Budapest (2020–21 Hungarian U19 League) |
| 35 | Lithuania | | Žalgiris (2020 Lithuanian Elite Youth League U19 Division) |
| 37 | Latvia | | Daugavpils (2020 Latvian U18 League) |
| 38 | Albania | | Akademia e Futbollit (2020–21 Albanian U19 League) |
| 39 | North Macedonia | | Shkëndija (2020–21 Macedonian U19 League) |
| 40 | Bosnia and Herzegovina | | Zvijezda 09 (2020–21 Bosnia and Herzegovina U19 Junior League) |
| 41 | Moldova | Sheriff Tiraspol (2020–21 Divizia Națională U19) | |
| 42 | Republic of Ireland | | St Patrick's Athletic (2020 League of Ireland U19 Division) |
| Rank | Association |
| 31 | Liechtenstein |
| 34 | Luxembourg |
| 36 | Armenia |
| 43 | Finland |
| 44 | Georgia |
| 45 | Malta |
| Rank | Association |
| 46 | Iceland |
| 47 | Wales |
| 48 | Northern Ireland |
| 49 | Gibraltar |
| 50 | Montenegro |
| Rank | Association |
| 51 | Estonia |
| 52 | Kosovo |
| 53 | Faroe Islands |
| 54 | Andorra |
| 55 | San Marino |

### Notes

* $^{TH}$ Title holders.
* $^{YC}$ Teams playing in the UEFA Champions League Path which were also youth domestic champions.
* $^{PO}$ Teams playing in the UEFA Champions League Path after their senior team qualified for the Champions League group stage via play-offs.
* $^{V-LIE}$ Team playing in the Domestic Champions Path through the vacancy of Liechtenstein (no youth domestic competition).
* $^{V-YC}$ Teams playing in the Domestic Champions Path through the vacancies of teams which qualified for the Champions League group stage automatically.
* $^{V-PO}$ Teams playing in the Domestic Champions Path through the vacancies of teams which qualified for the Champions League group stage via play-offs.
* ^ Belgium (BEL): The 2020–21 Belgian U18 League was abandoned and 2020–21 Belgium Youth Cup was cancelled due to the COVID-19 pandemic in Belgium. Genk, which were originally selected to play in the 2020–21 UEFA Youth League (which was later cancelled) by the Royal Belgian Football Association in the Domestic Champions Path, were selected to play in the 2021–22 UEFA Youth League in the Domestic Champions Path.
* ^ France (FRA): The 2020–21 Championnat National U19 was abandoned due to the COVID-19 pandemic in France. Angers, which were originally selected to play in the 2020–21 UEFA Youth League (which was later cancelled) by the French Football Federation in the Domestic Champions Path, were selected to play in the 2021–22 UEFA Youth League in the Domestic Champions Path.
* ^ Germany (GER): The 2020–21 U19 A-Junioren-Bundesliga was abandoned due to the COVID-19 pandemic in Germany. 1. FC Köln, which were originally selected to play in the 2020–21 UEFA Youth League (which was later cancelled) by the German Football Association in the Domestic Champions Path, were selected to play in the 2021–22 UEFA Youth League in the Domestic Champions Path.
* ^ Netherlands (NED): The 2020–21 Eredivisie U19 was abandoned and the 2020–21 KNVB Youth Cup was not completed by the UEFA registration deadline due to the COVID-19 pandemic in the Netherlands. AZ, which were originally selected to play in the 2020–21 UEFA Youth League (which was later cancelled) by the Royal Dutch Football Association in the Domestic Champions Path, were selected to play in the 2021–22 UEFA Youth League in the Domestic Champions Path.
* ^ Portugal (POR): The 2020–21 Campeonato Nacional Juniores S19 was abandoned due to the COVID-19 pandemic in Portugal. Benfica, which were originally selected to play in the 2020–21 UEFA Youth League (which was later cancelled) by the Portuguese Football Federation in the Domestic Champions Path, would have been selected to play in the 2021–22 UEFA Youth League in the Domestic Champions Path, but since their senior team qualified for the Champions League group stage via play-offs, they qualified for the UEFA Champions League Path, so no team was selected to play in the 2021–22 UEFA Youth League in the Domestic Champions Path.

## Round and draw dates

The schedule of the competition is as follows (all draws were held at the UEFA headquarters in Nyon, Switzerland, unless stated otherwise).

* For the UEFA Champions League Path group stage, in principle the teams play their matches on Tuesdays and Wednesdays of the matchdays as scheduled for UEFA Champions League, and on the same day as the corresponding senior teams; however, matches could also be played on other dates, including Mondays and Thursdays.
* For the Domestic Champions Path first and second rounds, in principle matches are played on Wednesdays (first round on matchdays 2 and 3, second round on matchdays 4 and 5, as scheduled for UEFA Champions League); however, matches could also be played on other dates, including Mondays, Tuesdays and Thursdays.

Schedule for 2021–22 UEFA Youth League :

| Phase | Round | Draw date | First leg | Second leg |
| - | - | - | - | - |
| UEFA Champions League Path Group stage | Matchday 1 | 26 August 2021 (Istanbul) | 14–15 September 2021 | 14–15 September 2021 |
| UEFA Champions League Path Group stage | Matchday 2 | 26 August 2021 (Istanbul) | 28–29 September 2021 | 28–29 September 2021 |
| UEFA Champions League Path Group stage | Matchday 3 | 26 August 2021 (Istanbul) | 19–20 October 2021 | 19–20 October 2021 |
| UEFA Champions League Path Group stage | Matchday 4 | 26 August 2021 (Istanbul) | 2–3 November 2021 | 2–3 November 2021 |
| UEFA Champions League Path Group stage | Matchday 5 | 26 August 2021 (Istanbul) | 23–24 November 2021 | 23–24 November 2021 |
| UEFA Champions League Path Group stage | Matchday 6 | 26 August 2021 (Istanbul) | 7–8 December 2021 | 7–8 December 2021 |
| Domestic Champions Path | First round | 31 August 2021 | 29 September 2021 | 20 October 2021 |
| Domestic Champions Path | Second round | 31 August 2021 | 3 November 2021 | 24 November 2021 |
| Knockout phase | Play-offs | 14 December 2021 | 8–9 February 2022 | 8–9 February 2022 |
| Knockout phase | Round of 16 | 14 February 2022 | 1–2 March 2022 | 1–2 March 2022 |
| Knockout phase | Quarter-finals | 14 February 2022 | 15–16 March 2022 | 15–16 March 2022 |
| Knockout phase | Semi-finals | 14 February 2022 | 22 April 2022 at Colovray Stadium, Nyon | 22 April 2022 at Colovray Stadium, Nyon |
| Knockout phase | Final | 14 February 2022 | 25 April 2022 at Colovray Stadium, Nyon | 25 April 2022 at Colovray Stadium, Nyon |

## UEFA Champions League Path

For the UEFA Champions League Path, the 32 teams were drawn into eight groups of four. There was no separate draw held, with the group compositions identical to the draw for the 2021–22 UEFA Champions League group stage, which was held on 26 August 2021, 18:00 CEST (19:00 TRT), in Istanbul, Turkey.

In each group, teams played against each other home-and-away in a round-robin format. The group winners advance to the round of 16, while the eight runners-up advance to the play-offs, where they will join by the eight second round winners from the Domestic Champions Path.

### Group A

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | PSG | BRU | MCI | LPZ |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Paris Saint-Germain | 6 | 4 | 2 | 0 | 16 | 7 | +9 | 14 | Round of 16 | — | 3–2 | 1–1 | 3–0 |
| 2 | Club Brugge | 6 | 3 | 2 | 1 | 18 | 11 | +7 | 11 | Play-offs | 2–2 | — | 1–1 | 4–1 |
| 3 | Manchester City | 6 | 2 | 2 | 2 | 12 | 11 | +1 | 8 | | 1–3 | 3–5 | — | 5–1 |
| 4 | RB Leipzig | 6 | 0 | 0 | 6 | 4 | 21 | −17 | 0 | | 1–4 | 1–4 | 0–1 | — |

### Group B

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | LIV | ATM | POR | MIL |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Liverpool | 6 | 3 | 2 | 1 | 9 | 4 | +5 | 11 | Round of 16 | — | 2–0 | 4–0 | 1–0 |
| 2 | Atlético Madrid | 6 | 3 | 1 | 2 | 9 | 6 | +3 | 10 | Play-offs | 2–0 | — | 1–2 | 3–0 |
| 3 | Porto | 6 | 3 | 1 | 2 | 8 | 9 | −1 | 10 | | 1–1 | 1–2 | — | 3–1 |
| 4 | Milan | 6 | 0 | 2 | 4 | 3 | 10 | −7 | 2 | | 1–1 | 1–1 | 0–1 | — |

* 1 2 Head-to-head: Atlético Madrid 3 pts (0 GD, 3 GF), Porto 3 pts (0 GD, 3 GF). Goal difference in all group matches: Atlético Madrid +3, Porto –1.

### Group C

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | SPO | DOR | AJX | BES |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Sporting CP | 6 | 3 | 2 | 1 | 11 | 8 | +3 | 11 | Round of 16 | — | 3–2 | 1–1 | 1–2 |
| 2 | Borussia Dortmund | 6 | 3 | 1 | 2 | 16 | 9 | +7 | 10 | Play-offs | 0–0 | — | 0–1 | 6–2 |
| 3 | Ajax | 6 | 3 | 1 | 2 | 9 | 10 | −1 | 10 | | 2–3 | 1–5 | — | 3–1 |
| 4 | Beşiktaş | 6 | 1 | 0 | 5 | 8 | 17 | −9 | 3 | | 1–3 | 2–3 | 0–1 | — |

* 1 2 Head-to-head points: Borussia Dortmund 3, Ajax 3. Head-to-head goal difference: Borussia Dortmund +3, Ajax –3.

### Group D

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | RMA | INT | SHK | SHE |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Real Madrid | 6 | 4 | 1 | 1 | 11 | 6 | +5 | 13 | Round of 16 | — | 2–1 | 1–0 | 4–1 |
| 2 | Inter Milan | 6 | 4 | 1 | 1 | 10 | 6 | +4 | 13 | Play-offs | 1–1 | — | 1–0 | 2–1 |
| 3 | Shakhtar Donetsk | 6 | 3 | 0 | 3 | 14 | 5 | +9 | 9 | | 3–2 | 0–1 | — | 6–0 |
| 4 | Sheriff Tiraspol | 6 | 0 | 0 | 6 | 4 | 22 | −18 | 0 | | 0–1 | 2–4 | 0–5 | — |

* 1 2 Head-to-head points: Real Madrid 4, Inter Milan 1.

### Group E

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | BEN | DKV | BAR | BAY |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Benfica | 6 | 5 | 0 | 1 | 14 | 4 | +10 | 15 | Round of 16 | — | 1–0 | 4–0 | 4–0 |
| 2 | Dynamo Kyiv | 6 | 4 | 1 | 1 | 14 | 3 | +11 | 13 | Play-offs | 4–0 | — | 4–1 | 2–1 |
| 3 | Barcelona | 6 | 1 | 1 | 4 | 4 | 14 | −10 | 4 | | 0–3 | 0–0 | — | 2–0 |
| 4 | Bayern Munich | 6 | 1 | 0 | 5 | 4 | 15 | −11 | 3 | | 0–2 | 0–4 | 3–2 | — |

### Group F

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | MUN | VIL | ATA | YB |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Manchester United | 6 | 5 | 0 | 1 | 12 | 9 | +3 | 15 | Round of 16 | — | 1–4 | 4–2 | 2–1 |
| 2 | Villarreal | 6 | 3 | 2 | 1 | 15 | 9 | +6 | 11 | Play-offs | 1–2 | — | 2–0 | 3–3 |
| 3 | Atalanta | 6 | 2 | 1 | 3 | 11 | 12 | −1 | 7 | | 1–2 | 2–2 | — | 3–0 |
| 4 | Young Boys | 6 | 0 | 1 | 5 | 7 | 15 | −8 | 1 | | 0–1 | 1–3 | 2–3 | — |

### Group G

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | SLZ | SEV | LIL | WOL |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Red Bull Salzburg | 6 | 4 | 0 | 2 | 10 | 5 | +5 | 12 | Round of 16 | — | 2–0 | 3–1 | 3–0 |
| 2 | Sevilla | 6 | 3 | 2 | 1 | 8 | 3 | +5 | 11 | Play-offs | 2–0 | — | 0–0 | 2–0 |
| 3 | Lille | 6 | 3 | 1 | 2 | 7 | 6 | +1 | 10 | | 1–0 | 0–3 | — | 2–0 |
| 4 | VfL Wolfsburg | 6 | 0 | 1 | 5 | 2 | 13 | −11 | 1 | | 1–2 | 1–1 | 0–3 | — |

### Group H

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification | JUV | CHE | ZEN | MAL |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | Juventus | 6 | 5 | 1 | 0 | 18 | 7 | +11 | 16 | Round of 16 | — | 3–1 | 4–2 | 4–1 |
| 2 | Chelsea | 6 | 3 | 1 | 2 | 15 | 10 | +5 | 10 | Play-offs | 1–3 | — | 3–1 | 4–2 |
| 3 | Zenit Saint Petersburg | 6 | 2 | 1 | 3 | 10 | 13 | −3 | 7 | | 0–2 | 1–1 | — | 3–2 |
| 4 | Malmö | 6 | 0 | 1 | 5 | 8 | 21 | −13 | 1 | | 2–2 | 0–5 | 1–3 | — |

## Domestic Champions Path

For the Domestic Champions Path, the 32 teams were drawn into two rounds of two-legged home-and-away ties. The draw for both the first round and second round was held on 31 August 2021.

The eight second round winners advance to the play-offs, where they will join by the eight group runners-up from the UEFA Champions League Path (group stage).

### First round

| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
| - | - | - | - | - |
| Pogoń Szczecin | 3–4 | Deportivo La Coruña | 3–0 | 0–4 |
| MTK Budapest | 6–4 | Sparta Prague | 3–1 | 3–3 |
| PAOK | 1–7 | Žilina | 1–5 | 0–2 |
| Shkëndija | 1–5 | Hajduk Split | 0–2 | 1–3 |
| Daugavpils | 0–6 | Minsk | 0–4 | 0–2 |
| APOEL | 1–2 | Kairat | 1–1 | 0–1 |
| Žalgiris | 0–5 | Maccabi Haifa | 0–3 | 0–2 |
| 1. FC Köln | 3–7 | Genk | 2–4 | 1–3 |
| Septemvri Sofia | 4–1 | Akademia e Futbollit | 3–0 | 1–1 |
| Zvijezda 09 | 0–3 | Trabzonspor | 0–1 | 0–2 |
| Domžale | 2–3 | Empoli | 1–2 | 1–1 |
| Gabala | 0–11 | AZ | 0–4 | 0–7 |
| Miercurea Ciuc | 0–5 | Angers | 0–2 | 0–3 |
| Rangers | 5–1 | Hammarby IF | 3–0 | 2–1 |
| Rosenborg | 3–14 | Midtjylland | 2–4 | 1–10 |
| St Patrick's Athletic | 1–4 | Red Star Belgrade | 1–2 | 0–2 |

### Second round

| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
| - | - | - | - | - |
| Hajduk Split | 4–1 | Minsk | 3–0 | 1–1 |
| MTK Budapest | 1–3 | Genk | 1–2 | 0–1 |
| Deportivo La Coruña | 5–4 | Maccabi Haifa | 5–1 | 0–3 |
| Žilina | 3–3 (3–0 p) | Kairat | 3–2 | 0–1 |
| Red Star Belgrade | 1–6 | Empoli | 1–1 | 0–5 |
| Trabzonspor | 2–10 | Midtjylland | 2–5 | 0–5 |
| Angers | 1–1 (4–5 p) | AZ | 0–1 | 1–0 |
| Septemvri Sofia | 2–7 | Rangers | 2–4 | 0–3 |

Notes

* ↑ Order of legs reversed after original draw.

## Knockout phase

### Bracket

| Play-offs | Play-offs | Round of 16 | Round of 16 | Quarter-finals | Quarter-finals | | Semi-finals | Semi-finals | | Final | Final |
| - | - | - | - | - | - | - | - | - | - | - | - |
| 8 February | 8 February | | | | | | | | |
| Empoli | 3 | | | | | | | | |
| Empoli | 3 | 1 March | 1 March | | | | | | | |
| Borussia Dortmund | 5 | 1 March | 1 March | | | | | | |
| Borussia Dortmund | 5 | Manchester United | 2 (1) | | | | | | |
| | | Borussia Dortmund (p) | 2 (3) | | | | | | |
| | | | | 16 March | 16 March | | | | | |
| | | | | Borussia Dortmund | 0 | | | | |
| 9 February | 9 February | | | | Borussia Dortmund | 0 | | | | |
| 9 February | 9 February | | | Atlético Madrid | 1 | | | | |
| Hajduk Split | 0 (2) | | | Atlético Madrid | 1 | | | | |
| Hajduk Split | 0 (2) | 2 March | 2 March | | | | | | | |
| Atlético Madrid (p) | 0 (3) | 2 March | 2 March | | | | | | |
| Atlético Madrid (p) | 0 (3) | Real Madrid | 2 | | | | | | |
| | | Atlético Madrid | 3 | | | | | | |
| | | | | | | | 22 April – Nyon | 22 April – Nyon | | |
| | | | | | | | Atlético Madrid | 0 | |
| 8 February | 8 February | | | | | | | Atlético Madrid | 0 | |
| 8 February | 8 February | | | | | | Red Bull Salzburg | 5 | |
| Rangers | 0 | | | | | | Red Bull Salzburg | 5 | |
| Rangers | 0 | 1 March | 1 March | | | | | | | |
| Sevilla | 1 | 1 March | 1 March | | | | | | |
| Sevilla | 1 | Paris Saint-Germain | 2 | | | | | | |
| | | Sevilla | 0 | | | | | | |
| | | | | 16 March | 16 March | | | | | |
| | | | | Paris Saint-Germain | 1 | | | | |
| 8 February | 8 February | | | | Paris Saint-Germain | 1 | | | | |
| 8 February | 8 February | | | Red Bull Salzburg | 3 | | | | |
| Žilina | 3 | | | Red Bull Salzburg | 3 | | | | |
| Žilina | 3 | 2 March | 2 March | | | | | | | |
| Inter Milan | 1 | 2 March | 2 March | | | | | | |
| Inter Milan | 1 | Žilina | 1 (3) | | | | | | |
| | | Red Bull Salzburg (p) | 1 (4) | | | | | | |
| | | | | | | | | | | 25 April – Nyon | 25 April – Nyon |
| | | | | | | | | | | Red Bull Salzburg | 0 |
| 8 February | 8 February | | | | | | | | | | Red Bull Salzburg | 0 |
| 8 February | 8 February | | | | | | | | | Benfica | 6 |
| AZ (p) | 3 (4) | | | | | | | | | Benfica | 6 |
| AZ (p) | 3 (4) | 2 March | 2 March | | | | | | | | |
| Villarreal | 3 (3) | 2 March | 2 March | | | | | | | | |
| Villarreal | 3 (3) | AZ | 0 (4) | | | | | | | | |
| | | Juventus (p) | 0 (5) | | | | | | | | |
| | | | | 15 March | 15 March | | | | | | | |
| | | | | Juventus | 2 | | | | | | |
| 9 February | 9 February | | | | Juventus | 2 | | | | | | |
| 9 February | 9 February | | | Liverpool | 0 | | | | | | |
| Genk | 5 | | | Liverpool | 0 | | | | | | |
| Genk | 5 | 2 March | 2 March | | | | | | | | | |
| Chelsea | 1 | 2 March | 2 March | | | | | | | | |
| Chelsea | 1 | Liverpool (p) | 1 (4) | | | | | | | | |
| | | Genk | 1 (3) | | | | | | | | |
| | | | | | | | 22 April – Nyon | 22 April – Nyon | | | | |
| | | | | | | | Juventus | 2 (3) | | | |
| 9 February | 9 February | | | | | | | Juventus | 2 (3) | | | |
| 9 February | 9 February | | | | | | Benfica (p) | 2 (4) | |
| Deportivo La Coruña | 2 (2) | | | | | | Benfica (p) | 2 (4) | |
| Deportivo La Coruña | 2 (2) | 7 April | 7 April | | | | | | | |
| Dynamo Kyiv (p) | 2 (3) | 7 April | 7 April | | | | | | |
| Dynamo Kyiv (p) | 2 (3) | Dynamo Kyiv | 1 | | | | | | |
| | | Sporting CP | 2 | | | | | | |
| | | | | 13 April | 13 April | | | | | |
| | | | | Sporting CP | 0 | | | | |
| 9 February | 9 February | | | | Sporting CP | 0 | | | | |
| 9 February | 9 February | | | Benfica | 4 | | | | |
| Midtjylland | 3 | | | Benfica | 4 | | | | |
| Midtjylland | 3 | 2 March | 2 March | | | | | | | |
| Club Brugge | 2 | 2 March | 2 March | | | | | | |
| Club Brugge | 2 | Midtjylland | 2 | | | | | | |
| | | Benfica | 3 | | | | | | |

### Play-offs

The eight second round winners from the Domestic Champions Path were drawn against the eight group runners-up from the UEFA Champions League Path, with the teams from the Domestic Champions Path hosting the match. Teams from the same association could not be drawn against each other.

The draw was conducted on 14 December 2021 12:00 CET at the UEFA headquarters in Nyon. The play-offs were played over one leg on 8 and 9 February 2022.

| Team 1 | Score | Team 2 |
| - | - | - |
| Empoli | 3–5 | Borussia Dortmund |
| Genk | 5–1 | Chelsea |
| AZ | 3–3 (4–3 p) | Villarreal |
| Žilina | 3–1 | Inter Milan |
| Hajduk Split | 0–0 (2–3 p) | Atlético Madrid |
| Midtjylland | 3–2 | Club Brugge |
| Deportivo La Coruña | 2–2 (2–3 p) | Dynamo Kyiv |
| Rangers | 0–1 | Sevilla |

### Round of 16

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The round of 16 should have been played over one leg on 1 and 2 March 2022. The mechanism of the draws for each round was as follows:

* In the draw for the round of 16, the UEFA Champions League Path group winners were drawn against the play-off winners, with the first team drawn in each tie hosting the match. Teams from the same UEFA Champions League Path group could not be drawn against each other, but teams from the same association could be drawn against each other.
* In the draws for the quarter-finals onwards, there were no seedings, and teams from the same UEFA Champions League Path group or the same association could be drawn against each other (the identity of the quarter-final winners and onwards was not known at the time of the draws). The draws also decided the home team for each quarter-final, and which quarter-final and semi-final winners were designated as the "home" team for each semi-final and final (for administrative purposes as they were played at a neutral venue).

| Team 1 | Score | Team 2 |
| - | - | - |
| Liverpool | 1–1 (4–3 p) | Genk |
| Real Madrid | 2–3 | Atlético Madrid |
| AZ | 0–0 (4–5 p) | Juventus |
| Dynamo Kyiv | 1–2 | Sporting CP |
| Manchester United | 2–2 (1–3 p) | Borussia Dortmund |
| Žilina | 1–1 (3–4 p) | Red Bull Salzburg |
| Paris Saint-Germain | 2–0 | Sevilla |
| Midtjylland | 2–3 | Benfica |

### Quarter-finals

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The quarter-finals were played over one leg from 15 March to 13 April 2022.

| Team 1 | Score | Team 2 |
| - | - | - |
| Juventus | 2–0 | Liverpool |
| Paris Saint-Germain | 1–3 | Red Bull Salzburg |
| Sporting CP | 0–4 | Benfica |
| Borussia Dortmund | 0–1 | Atlético Madrid |

### Semi-finals

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The semi-finals were played over one leg on 22 April 2022 at Colovray Stadium, Nyon.

| Team 1 | Score | Team 2 |
| - | - | - |
| Juventus | 2–2 (3–4 p) | Benfica |
| Atlético Madrid | 0–5 | Red Bull Salzburg |

### Final

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The final was played on 25 April 2022 at Colovray Stadium, Nyon.

This was a replay of the 2017 UEFA Youth League Final, which Salzburg won 2–1. Benfica won 6–0 to win their first Youth League title, and their first title in European football since the 1961–62 European Cup.

## Top goalscorers

| Rank | Player | Team | Goals |
| - | - | - | - |
| 1 | Mads Hansen | Midtjylland | 7 |
| 1 | Aral Şimşir | Midtjylland | 7 |
| 1 | Roko Šimić | Red Bull Salzburg | 7 |
| 4 | Jamie Bynoe-Gittens | Borussia Dortmund | 6 |
| 4 | Filip Čuić | Hajduk Split | 6 |
| 6 | Samba Diallo | Dynamo Kyiv | 5 |
| 6 | Bradley Fink | Borussia Dortmund | 5 |
| 6 | Oscar Fraulo | Midtjylland | 5 |
| 6 | Djeidi Gassama | Paris Saint-Germain | 5 |
| 6 | Timotej Jambor | Žilina | 5 |
| 6 | James McAtee | Manchester City | 5 |
| 6 | Cisse Sandra | Club Brugge | 5 |
| 6 | Luís Semedo | Benfica | 5 |
| 6 | Zalán Vancsa | MTK Budapest | 5 |

## U-20 Intercontinental Cup

The UEFA champions, Benfica, played against the CONMEBOL champion, Peñarol, for the new U-20 Intercontinental Cup, a youth team equivalent to the former Intercontinental Cup, which featured the senior club champions of Europe and South America. Benfica won 1–0.

