DPA-713
# DPA-713

DPA-713 or N,N-diethyl-2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO).

The binding affinity of DPA-713 for TSPO is reported as $K_i$ = 4.7 ± 0.2 nM.

DPA-713 has been radiolabelled with carbon-11 as a potential radiotracer for imaging the TSPO using positron emission tomography (PET). Radiation dosimetry and biodistribution of $[^{11}C]DPA-713$ have been assessed in healthy volunteers, indicating that $[^{11}C]DPA-713$ is a suitable radiotracer for imaging the TSPO in humans.

