List of target antigens in pemphigus
# List of target antigens in pemphigus

Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

Target antigens for the different pemphigus variants :

| Pemphigus variant | Antibody isotype | Antigen | Molecular weight (KDa) |
| - | - | - | - |
| Mucosal pemphigus vulgaris | IgG | Desmoglein 3 | 130 |
| Mucocutaneous pemphigus vulgaris | IgG | Desmoglein 3 Desmoglein 1 | 130 160 |
| Pemphigus foliaceus | IgG | Desmoglein 1 | 160 |
| Paraneoplastic pemphigus | IgG | Desmoglein 3 Desmoglein 1 BPAG1 Plectin Desmoplakin I Desmoplakin II Envoplakin Periplakin Alpha-2-macroglobulin-like-1 | 130 160 230 500 250 210 210 190 170 |
| Drug-induced pemphigus | IgG | Desmoglein 3 Desmoglein 1 | 130 160 |
| Subcorneal pustular dermatosis type of IgA pemphigus | IgA1 | Desmocollin 1 | 110/100 |
| Intraepidermal neutrophilic type of IgA pemphigus | IgA1 | Unknown | |
| Pemphigus erythematosus (Senear–Usher syndrome) | IgG | Desmoglein 1 | 160 |
| Fogo selvagem | IgG | Desmoglein 1 | 160 |
| Pemphigus vegetans | IgG | Desmoglein 3 | 130 |
| Pemphigus vegetans of Hallopeau | IgG | Desmoglein 3 | 130 |
| Pemphigus vegetans of Neumann | IgG | Desmoglein 3 | 130 |
| Pemphigus herpetiformis | IgG | Desmoglein 3 Desmoglein 1 | 130 160 |

## Footnotes

* ↑ Notably not BPAG2
* ↑ Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome
* ↑ Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
* 1 2 Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.
