AP1G1
# AP1G1

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.

## Function

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.

## Interactions

AP1G1 has been shown to interact with:

* AP1B1,
* AP1GBP1,
* AP1M1,
* AP1S1,
* NECAP2,
* RABEP1, and
* Synaptophysin.
