O-methylated flavonoid
# O-methylated flavonoid

The O-methylated flavonoids or methoxyflavonoids are flavonoids with methylations on hydroxyl groups (methoxy bonds). O-methylation has an effect on the solubility of flavonoids.

## Enzymes

O-methylated flavonoids formation implies the presence of specific O-methyltransferase (OMT) enzymes which accept a variety of substrates. Those enzymes mediate the O-methylation on a specific hydroxyl group, like on 4' (example in Catharanthus roseus) or 3' (example in rice) positions. Those positions can be ortho, meta, para and there can be a special 3-O-methyltransferase for the 3-OH position. Calamondin orange (Citrus mitis) exhibits all of those activities.

### Plant enzymes

* Apigenin 4'-O-methyltransferase
* 8-hydroxyquercetin 8-O-methyltransferase
* Isoflavone 4'-O-methyltransferase
* Isoflavone 7-O-methyltransferase
* Isoliquiritigenin 2'-O-methyltransferase
* Isoorientin 3'-O-methyltransferase
* Kaempferol 4'-O-methyltransferase
* Luteolin O-methyltransferase
* Methylquercetagetin 6-O-methyltransferase
* 3-methylquercetin 7-O-methyltransferase
* Myricetin O-methyltransferase
* Quercetin 3-O-methyltransferase
* Vitexin 2"-O-rhamnoside 7-O-methyltransferase

### Animal enzyme

* Catechol-O-methyl transferase

## O-methylated anthocyanidins

* 5-Desoxy-malvidin
* Capensinidin
* Europinidin
* Hirsutidin
* Malvidin
* Peonidin
* Petunidin
* Pulchellidin
* Rosinidin

## O-methylated flavanols

* Meciadanol (3-O'methyl catechin)

## O-methylated flavanones

* Hesperetin
* Homoeriodictyol
* Isosakuranetin
* Sakuranetin
* Sterubin

## O-methylated flavanonols

* Dihydrokaempferide

## O-methylated flavonols

of kaempferol

* Kaempferide

of myricetin

* Annulatin
* Combretol
* Europetin
* Laricitrin (3'-O-Dimethylmyricetin)
* 5-O-methylmyricetin
* Syringetin (3',5'-O-Dimethylmyricetin)

of quercetin

* Ayanin
* Azaleatin
* Isorhamnetin
* Ombuin
* Pachypodol
* Retusin (quercetin-3,7,3',4'-tetramethyl ether)
* Rhamnazin
* Rhamnetin
* Tamarixetin

other

* Eupatolitin
* Natsudaidain

## O-methylated flavones

* Acacetin
* Chrysoeriol
* Diosmetin
* Nepetin
* Nobiletin
* Oroxylin-A
* Sinensetin
* Tangeritin
* Thevetiaflavone
* Wogonin

## O-methylated isoflavones

* Biochanin A
* Calycosin
* Formononetin
* Glycitein
* Irigenin
* 5-O-methylgenistein
* Pratensein
* Prunetin
* Psi-tectorigenin
* Retusin
* Tectorigenin
