5-MeO-DET
# 5-MeO-DET

5-MeO-DET or 5-methoxy-N,N-diethyltryptamine is a hallucinogenic tryptamine.

## Pharmacology

5-MeO-DET inhibits serotonin reuptake with an $IC_{50}$ value of 2.4 μM and activates $5-HT_{2A}$ receptors with an $EC_{50}$ value of 8.11 nM.

## Effects

Low dosages (0.5–1 mg) are reported to produce a relaxing body high and mild entheogenic effects. Shulgin reports in TiHKAL that higher dosages (1–3 mg) can produce very unpleasant reactions.

