List of number-one dance airplay hits of 2016 (U.S.)
# List of number-one dance airplay hits of 2016 (U.S.)

These are the Billboard magazine Dance/Mix Show Airplay number-one hits of 2016.

Note that Billboard publishes charts with an issue date approximately 7–10 days in advance.

Key :

| † | Indicates best charting dance/mix show airplay single of 2016 Note: Year-end most popular songs based radio airplay. |
| - | - |
| Issue date | Song | Artist(s) | Remixer(s) |
| January 2 | "Sorry" | Justin Bieber | J Balvin, DJ Kue, Mayfair Media, Wide Awake, Zillamatic, Naffz |
| January 9 | "Sorry" | Justin Bieber | J Balvin, DJ Kue, Mayfair Media, Wide Awake, Zillamatic, Naffz |
| January 16 | "Sorry" | Justin Bieber | J Balvin, DJ Kue, Mayfair Media, Wide Awake, Zillamatic, Naffz |
| January 23 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| January 30 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| February 6 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| February 13 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| February 20 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| February 27 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| March 5 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| March 12 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| March 19 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| March 26 | "Roses" | The Chainsmokers featuring ROZES | The Him, King Arthur, Loosid, Zaxx, SAYMYNAME |
| April 2 | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Quintino |
| April 9 | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Quintino |
| April 16 | "I Took a Pill in Ibiza" | Mike Posner | SeeB |
| April 23 | "I Took a Pill in Ibiza" | Mike Posner | SeeB |
| April 30 | "Don't Let Me Down" | The Chainsmokers featuring Daya | W&W, Zomboy, Ephwurd, Hardwell & Sephyx, Illenium, Ricky Remedy, Riggi & Piros |
| May 7 | "Don't Let Me Down" | The Chainsmokers featuring Daya | W&W, Zomboy, Ephwurd, Hardwell & Sephyx, Illenium, Ricky Remedy, Riggi & Piros |
| May 14 | "Don't Let Me Down" | The Chainsmokers featuring Daya | W&W, Zomboy, Ephwurd, Hardwell & Sephyx, Illenium, Ricky Remedy, Riggi & Piros |
| May 21 | "I Took a Pill in Ibiza" | Mike Posner | |
| May 28 | "Don't Let Me Down" | The Chainsmokers featuring Daya | |
| June 4 | "Don't Let Me Down" | The Chainsmokers featuring Daya | |
| June 11 | "Don't Let Me Down" | The Chainsmokers featuring Daya | |
| June 18 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| June 25 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| July 2 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| July 9 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| July 16 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| July 23 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| July 30 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| August 6 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| August 13 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| August 20 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| August 27 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| September 3 | "This Is What You Came For"† | Calvin Harris featuring Rihanna | Dillon Francis, Grandtheft, R3hab & Henry Fong |
| September 10 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| September 17 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| September 24 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| October 1 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| October 8 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| October 15 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| October 22 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| October 29 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| November 5 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| November 12 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| November 19 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| November 26 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| December 3 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| December 10 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| December 17 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| December 24 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
| December 31 | "Closer" | The Chainsmokers featuring Halsey | R3hab, Shaun Frank, Wuki, Robotaki, Dave Aude |
