P21-activated kinases
# P21-activated kinases

p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.

Members include:

* PAK1, regulating cell motility and morphology
* PAK2, possibly playing a role in apoptosis
* PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
* PAK4, a mediator of filopodia formation
* PAK5, a mediator of filopodia formation
* PAK6, involved in cytoskeleton rearrangement
