Phenylpiperidines
# Phenylpiperidines

Phenylpiperidines are chemical compounds with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated with phenylpiperidines including morphine-like activity or other central nervous system effects.

"Phenyl"piperidines :

| Compound | N | 4-position | 3-position | 4'-position | Type of pharmacology |
| - | - | - | - | - | - |
| MPPP | Me | Ph | H | –OCOEt | Opioid analgesic |
| Prodine | Me | Ph | Me | –OCOEt | Opioid analgesic |
| PEPAP | $CH_2CH_2Ph$ | Ph | H | –OCOMe | Opioid analgesic |
| Pethidine | Me | Ph | H | $–CO_2Et$ | mu-Agonist with serotonin reuptake inhibitor properties |
| Budipine | t-Bu | Ph | H | Ph | Antiparkinson agent |
| Ketobemidone | Me | 3-HO–Ph | H | –COEt | Opioid and NMDA antagonist |
| Paroxetine | H | 4-F–Ph | $–CH_2OAr$ | H | Selective serotonin reuptake inhibitor (and norepinephrine transporter) |
| Femoxetine | Me | Ph | $–CH_2O(4-MeOPh)$ | H | Selective serotonin reuptake inhibitor |
| CPCA | Me | 4-Cl–Ph | $–CO_2Me$ | H | Monoamine reuptake inhibitor |

Methylphenidate is a benzylpiperidine.

