Repulsive guidance molecule
# Repulsive guidance molecule

Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin). RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth.

## Family members

| RGM domain family, member AIdentifiersSymbolRGMAAlt. symbolsRGMNCBI gene56963HGNC30308OMIM607362RefSeqNM_020211UniProtQ96B86Other dataLocusChr. 15 q26.1Search forStructuresSwiss-modelDomainsInterPro | RGM domain family, member BIdentifiersSymbolRGMBAlt. symbolsDRAGONNCBI gene285704HGNC26896OMIM612687RefSeqNM_173670UniProtQ6NW40Other dataLocusChr. 5 q21.1Search forStructuresSwiss-modelDomainsInterPro | hemochromatosis type 2IdentifiersSymbolHFE2Alt. symbolsRGMC, HJV, hemojuvelinNCBI gene148738HGNC4887OMIM608374RefSeqNM_145277UniProtQ6ZVN8Other dataLocusChr. 1 q21.2Search forStructuresSwiss-modelDomainsInterPro |
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