Neuronal calcium sensor
# Neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.

## Members of NCS family

* Highly evolutionarily conserved
* NCS1 (Frequenin)
* VILIP-1 (Visinin-like-protein-1)
* HPCAL4 (Visinin-like-protein-2)
* HPCAL1 (Visinin-like-protein-3)
* hippocalcin
* neurocalcin
* recoverin
* Guanylate cyclase activator proteins (GCAPs)
* Potassium Channel interacting proteins (KChIPs 1–4), including:

KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4

