List of NUTS-2 regions in EU with GDP over 100 billion EUR
# List of NUTS-2 regions in EU with GDP over 100 billion EUR

This is a list of NUTS-2 regions in EU which have a Gross domestic product over €100 billion.

| Rank | Region | Largest city | Country | Region GDP (billions EUR) 2018 |
| - | - | - | - | - |
| 1 | Île-de-France | Paris | France | 733.875 |
| 2 | Lombardy | Milan | Italy | 388.124 |
| 3 | Upper Bavaria | Munich | Germany | 273.696 |
| 4 | Catalonia | Barcelona | Spain | 228.682 |
| 5 | Rhône-Alpes | Lyon | France | 227.320 |
| 6 | Community of Madrid | Madrid | Spain | 220.025 |
| 7 | Düsseldorf | Düsseldorf | Germany | 215.672 |
| 8 | Stuttgart | Stuttgart | Germany | 213.362 |
| 9 | Darmstadt | Frankfurt | Germany | 207.713 |
| 10 | Lazio | Rome | Italy | 197.548 |
| 11 | Cologne | Cologne | Germany | 190.785 |
| 12 | Eastern and Midland Ireland | Dublin | Ireland | 175.305 |
| 13 | North Holland | Amsterdam | Netherlands | 166.941 |
| 14 | South Holland | Rotterdam | Netherlands | 163.805 |
| 15 | Veneto | Venice | Italy | 162.866 |
| 16 | Provence-Alpes-Côte d'Azur | Marseille | France | 162.582 |
| 17 | Emilia-Romagna | Bologna | Italy | 161.505 |
| 18 | Andalusia | Seville | Spain | 160.622 |
| 19 | Berlin | Berlin | Germany | 145.698 |
| 20 | Stockholm County | Stockholm | Sweden | 145.659 |
| 21 | Piedmont | Turin | Italy | 137.338 |
| 22 | Southern Ireland | Cork | Ireland | 126.936 |
| 23 | Arnsberg | Arnsberg | Germany | 124.763 |
| 24 | Karlsruhe | Karlsruhe | Germany | 123.302 |
| 25 | Capital Region of Denmark | Copenhagen | Denmark | 122.244 |
| 26 | Pays de la Loire | Nantes | France | 119.149 |
| 27 | Hamburg | Hamburg | Germany | 119.046 |
| 28 | Tuscany | Florence | Italy | 117.537 |
| 29 | North Brabant | Eindhoven | Netherlands | 116.090 |
| 30 | Nord-Pas-de-Calais | Lille | France | 113.565 |
| 31 | Valencian Community | Valencia | Spain | 110.979 |
| 32 | Lisbon | Lisbon | Portugal | 110.210 |
| 32 | Campania | Naples | Italy | 108.053 |
| 33 | Aquitaine | Bordeaux | France | 106.776 |
