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The Panel "Thinking Transregional Studies" was the first panel of the conference "Areas and Disciplines: Lessons from Internationalization Initiatives in the Humanities and Social Sciences in Germany" organized by the Forum Transregionale Studien and the Max Weber Stiftung. The panelists Engseng Ho, Dhruv Raina, Dominic Sachsenmaier and Birgit Schäbler and their host Sebastian Conrad stressed the need for reconfigurations in the systematic disciplines with a view to contemporary knowledge production and problematized the relationship between systematic disciplines and area studies.