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Michael Döring’s (d. 1641) gout and arthritis* pains were sometimes so severe that he could not leave his house on foot to visit patients throughout the city of Breslau (a.k.a. Wroclaw). Desperate to find a cure, or at least some respite from his miserable condition, he spent his adult life searching for a recipe that he could use to make a medicine.[caption id="attachment_5528" align="alignleft" width="174"] Fig. 1: Line engraving of Daniel Sennert by S. Furck, 1650. Image from Wellcome Images, used under Creative Commons 2.0 Licence.[/caption]We know this because Döring was a tireless writer of letters, and a large number of the epistles he exchanged with his brother in law, the Wittenberg professor of medicine Daniel Sennert (1572-1637; see Fig. 1), were saved for posterity and published in the 1666 Lyon edition of Sennert’s complete works (see fig. 2), nearly a quarter century after both Döring and Sennert had died. Sennert is remembered by historians for his experimentalist atomism and his philosophy of generation, but Döring has been largely forgotten, save the occasional mention that he and Sennert were the first to accurately describe the symptoms of scarlet fever.Nevertheless, over the two decades from which letters have survived, the two physicians candidly discussed a variety of topics, including medical observations, noteworthy case histories, questions about religion and natural philosophy, and even the movements of troops during the Thirty Years’ War. Among such issues, however, the search to find a cure for gout and arthritis was paramount, for Sennert also suffered from a similar affliction, although apparently less so than Döring.[caption id="attachment_5529" align="aligncenter" width="270"] Fig. 2: Title page of 'Tomus Quintus' of Sennert's 1666 complete works, which contained his letters with Döring. Image from Google Books, used under Creative Commons Licence.[/caption]Like most academically trained physicians of their day, Sennert and Döring understood pathology and therapy in a Galenic framework; that is, diseases were caused by an imbalance of the body’s four humors, and treatment involved the balancing of these humors through diet, bloodletting, and the administration of purgatives. Even so, Sennert and Döring also promoted the use of new chymical drugs made from minerals and metals, and they believed that diseases could have causes besides the humors. In the case of gout and arthritis, one of the causes lay in the excess consumption of tartar, which they believed was found throughout the vegetable world, but in especially large amounts in wine. The iconoclastic Paracelsus von Hohenheim (1493-1541) had popularized this understanding of tartar in the sixteenth century, but Sennert and Döring were hardly alone among learned physicians who had adopted such ideas.So, what is one to do with a gouty body riddled with tartar? In short, you have to expel the tartar, and Döring wrote that this could be done by combating the weakness of the “natural faculty,” that is, the body’s ability to rid itself of excrements and disease-causing agents like tartar. The medicines that he and Sennert hoped might accomplish this, which they discussed in letters, most often included gold in their ingredients, and were thought to work against almost all maladies.Sennert noted in a letter from 1619 that he wanted to synthesize the famous ‘potable gold’ of the Englishman Francis Anthony (1550-1623), but had not yet had success. Döring responded that they ought to attempt to create a similar compound called the “Golden Fleece,” for he had found a recipe for the substance which promised that the drug had freed one Johann Weidner from excruciating gout pains. As Döring put it, “if that Golden Fleece carries away the feebleness of the natural faculties, it would not undeservedly be had for a panacea.”In short, the recipe and protocol called for the dissolution of twelve sheets of gold leaf in a preparation of May dew over the course of nine months, and in 1621, Döring wrote to Sennert that he and an apothecary had acquired enough gold to begin the synthesis.In May of 1622 Döring reported to Sennert that the Golden Fleece had apparently failed, for the gold had not gone into solution. Sennert consoled him, writing, “What has happened to you in the production of the Golden Fleece has happened to many others in chymical labors: when you make a trial, what was predicted from most certain things does not succeed.”What is especially striking about this episode is that the interpretation of and experimentation upon recipes was done collaboratively through the undoubtedly tedious process of sending letters between Breslau and Wittenberg – a 350 km trip. It is similarly notable that physicians - working during a period in which recipes for universal remedies and promises of their effectiveness were ubiquitous - actually tested recipes for the synthesis of medicines, occasionally found them wanting, and reported failures to one another. Such experimentalism and candid communication represent archetypal values and ideals that would later be codified as hallmarks of modern science and medicine.---* Physicians often believed that gout and arthritis were the same disease or at least had the same root cause.