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This publication provides practical information to governments, health agencies and environmental and meteorological institutions in both industrialized and developing countries on how to assess vulnerability and adaptation to climate variability and change at the regional, national and local levels.Flexible methods and tools are described to achieve better understanding of the risk of climate change for current and future generations and to enable policy-makers to plan for measures, policies and strategies to cope with climate change. The methods will be further developed and adapted in pilot testing in countries in the next two years.