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There are many determinants of health and well-being, and they can all interact with one another. Human biological and psychological factors come into play on a personal level, but ecological and global systems are also involved, as are economics and access to health care, which determine the social vulnerabilities to disease. Recently, our chief means of controlling infections--antibiotics and insecticides-- have themselves become a source of new, resistant microbes and disease carriers, and the growing number of people with malnutrition or depressed immune systems have helped select and disseminate these emerging organisms.