List of best-selling singles in 2001 (Japan)
# List of best-selling singles in 2001 (Japan)

This is a list of the best-selling singles in 2001 in Japan, as reported by Oricon.

| Ranking | Single | Artist | Release | Sales |
| - | - | - | - | - |
| 1 | "Can You Keep a Secret?" | Hikaru Utada | February 16, 2001 (2001-02-16) | 1,484,000 |
| 2 | "M" | Ayumi Hamasaki | December 13, 2000 (2000-12-13) | 1,319,000 |
| 3 | "Pieces of a Dream" | Chemistry | March 7, 2001 (2001-03-07) | 1,131,000 |
| 4 | "Naminori Jonny" | Keisuke Kuwata | July 4, 2001 (2001-07-04) | 1,104,000 |
| 5 | "Ren'ai Revolution 21" | Morning Musume | December 13, 2000 (2000-12-13) | 986,000 |
| 6 | "Shiroi koibitotachi" | Keisuke Kuwata | October 24, 2001 (2001-10-24) | 957,000 |
| 7 | "Evolution" | Ayumi Hamasaki | January 31, 2001 (2001-01-31) | 955,000 |
| 8 | "Boku no Senaka ni wa Hane ga Aru" | KinKi Kids | February 7, 2001 (2001-02-07) | 919,000 |
| 9 | "Lifetime Respect" | Dōzan Miki | May 23, 2001 (2001-05-23) | 897,000 |
| 10 | "Agehachō" | Porno Graffitti | June 27, 2001 (2001-06-27) | 890,000 |
