JWH-120
# JWH-120

JWH-120 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-propyl analog of JWH-122. It is a potent and selective ligand for the $CB_2$ receptor, but a weaker ligand for the $CB_1$ receptor. It has a binding affinity of $K_i$ = 6.1 ± 0.7 nM at the $CB_2$ subtype and 173 times selectivity over the $CB_1$ subtype.

In the United States, all $CB_1$ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-120 are Schedule I Controlled Substances.

