JWH-307
# JWH-307

JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the $CB_1$ and $CB_2$ receptors. It is somewhat selective for the $CB_2$ subtype, with a $K_i$ of 7.7 nM at $CB_1$ vs 3.3 nM at $CB_2.$ It was discovered by, and named after, John W. Huffman. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany.

In the United States, $CB_1$ receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-307 are Schedule I Controlled Substances.

