JWH-359
# JWH-359

JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective $CB_2$ receptor agonist, with a $K_i$ of 13.0 nM and selectivity of around 220 times for $CB_2$ over $CB_1$ receptors. It is related to other dibenzopyran $CB_2$ agonists such as JWH-133 and L-759,656 but with a chiral side chain which has made it useful for mapping the shape of the $CB_2$ binding site. It was discovered by, and named after, John W. Huffman.

