JWH-302
# JWH-302

JWH-302 (1-pentyl-3-(3-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with moderate affinity at both the $CB_1$ and $CB_2$ receptors. It is a positional isomer of the more common drug JWH-250, though it is slightly less potent with a $K_i$ of 17 nM at $CB_1,$ compared to 11 nM for JWH-250. Because of their identical molecular weight and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GC-MS testing.

In the United States, $CB_1$ receptor agonists of the 3-phenylacetylindole class such as JWH-302 are Schedule I Controlled Substances.

