Cirazoline
# Cirazoline

Cirazoline is a full agonist at the $α_{1A}$ adrenergic receptor, a partial agonist at both the $α_{1B}$ and $α_{1D}$ adrenergic receptors, and a nonselective antagonist to the $α_2$ adrenergic receptor. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.

Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of $α_1$ adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain. Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats. However, in preliminary studies, through stimulation of $α_2$ adrenoceptors, working memory is comparatively improved.

