2021 Uruguay Open – Doubles
# 2021 Uruguay Open – Doubles

Facundo Bagnis and Andrés Molteni were the defending champions but chose not to defend their title.

Rafael Matos and Felipe Meligeni Alves won the title after defeating Ignacio Carou and Luciano Darderi 6–4, 6–4 in the final.

## Seeds

* Rafael Matos / Felipe Meligeni Alves (champions)
* Marcelo Tomás Barrios Vera / Alejandro Tabilo (withdrew)
* Tomás Martín Etcheverry / Renzo Olivo (semifinals, withdrew)
* Francisco Cerúndolo / Martín Cuevas (semifinals)

## Draw

### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

| First round | First round | First round | First round | First round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 1 | R Matos F Meligeni Alves | 6 | 6 | | | | | | | | | | | | | | |
| | R Cid Subervi GA Olivieri | 2 | 1 | | 1 | R Matos F Meligeni Alves | 6 | 6 | | | | | | | | | |
| WC | D Acosta R Arús | 3 | 6 | [4] | | H Casanova S Rodríguez Taverna | 4 | 1 | | | | | | | | | |
| | H Casanova S Rodríguez Taverna | 6 | 1 | [10] | | | | | | 1 | R Matos F Meligeni Alves | 6 | 6 | | | | |
| 4 | F Cerúndolo M Cuevas | 6 | 6 | | | | | | | 4 | F Cerúndolo M Cuevas | 2 | 3 | | | | |
| | Gilbert Klier Júnior M Pucinelli de Almeida | 3 | 2 | | 4 | F Cerúndolo M Cuevas | 1 | 6 | [12] | | | | | | | | |
| | A Collarini G Durán | 1 | 6 | [10] | | A Collarini G Durán | 6 | 2 | [10] | | | | | | | | |
| | P Cachin C Ugo Carabelli | 6 | 4 | [8] | | | | | | | | | | 1 | R Matos F Meligeni Alves | 6 | 6 |
| | G Andreozzi JP Ficovich | 4 | 6 | [10] | | | | | | | | | | | I Carou L Darderi | 4 | 4 |
| WC | F Llanes F Roncadelli | 6 | 3 | [4] | | G Andreozzi JP Ficovich | 1 | 1 | | | | | | | | | |
| | N Álvarez Varona T Skatov | 2 | 5 | | 3 | TM Etcheverry R Olivo | 6 | 6 | | | | | | | | | |
| 3 | TM Etcheverry R Olivo | 6 | 7 | | | | | | | 3 | TM Etcheverry R Olivo | | | | | | |
| WC | JM Fumeaux Mateo Núñez | 1 | 0 | | | | | | | | I Carou L Darderi | w/o | | | | | |
| | I Carou L Darderi | 6 | 6 | | | I Carou L Darderi | 6 | 5 | [10] | | | | | | | | |
| | T Lipovšek Puches JI Londero | 4 | 4 | | Alt | F Comesaña M Navone | 2 | 7 | [8] | | | | | | | | |
| Alt | F Comesaña M Navone | 6 | 6 | | | | | | | | | | | | | | |
