JWH-424
# JWH-424

JWH-424 is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the $CB_1$ and $CB_2$ receptors, but with moderate selectivity for $CB_2,$ having a $K_i$ of 5.44nM at $CB_2$ vs 20.9 nM at $CB_1.$ The heavier 8-iodo analogue is even more $CB_2$ selective, with its 2-methyl derivative having 40 times selectivity for $CB_2.$ However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall.

In the United States, all $CB_1$ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-424 are Schedule I Controlled Substances.

