JWH-051
# JWH-051

JWH-051 is an analgesic drug which is a cannabinoid agonist. Its chemical structure is closely related to that of the potent cannabinoid agonist HU-210, with the only difference being the removal of the hydroxyl group at position 1 of the aromatic ring. It was discovered and named after John W. Huffman.

JWH-051 retains high affinity for the $CB_1$ receptor, but is a much stronger agonist for $CB_2,$ with a Ki value of 14nM at $CB_2$ vs 19nM at $CB_1.$ It was one of the first $CB_2-selective$ ligands developed, although its selectivity for $CB_2$ is modest compared to newer compounds such as HU-308.

It has similar effects to other cannabinoid agonists such as sedation and analgesia, but with a relatively strong antiinflammatory effect due to its strong activity at $CB_2.$

