HLA-A74
# HLA-A74

HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of $α^{74}$ subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A*74 allele group and the β-chain are encoded by B2M locus. A74 and A*74 are almost synonymous in meaning. A74 is a split antigen of the broad antigen serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33.

A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.

## Serotype

A74 recognition of some HLA A*74 gene products :

| A*74 | A74 | A19 | Sample |
| - | - | - | - |
| allele | % | % | size (N) |
| *7401 | 40 | 11 | 119 |
| *7403 | 17 | 0 | 29 |

A74 has a poor serotyping rate.

## Disease associations

A significant association has been found between A74 and nasal polyposis.

## Sources

* Madrigal JA, Belich MP, Hildebrand WH, et al. (November 1992). "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion" (PDF). J. Immunol. 149 (10): 3411–5. PMID 1431115.
