HLA-A25
# HLA-A25

HLA-A25 (A25) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of $α^{25}$ subset of HLA-A α-chains. For A25, the alpha "A" chain are encoded by the HLA-A*25 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*2501. A25 and A*25 are almost synonymous in meaning. A25 is a split antigen of the broad antigen serotype A10. A25 is a sister serotype of A26, A34, A43, and A66.

A25 is more common in SW Asia to NW Europe. A25 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele..

## Serotype

A25 recognition of some HLA A*25 gene products :

| A*25 | A25 | A10 | Sample |
| - | - | - | - |
| allele | % | % | size (N) |
| *2501 | 95 | 2 | 1375 |

A25 reasonably good serotyping with no overt false recognition..

## A25 frequencies

A*2501 distribution is primarily located in Western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.

