CGS-15943
# CGS-15943

CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors $A_1$ and $A_{2A},$ having a $K_i$ of 3.3nM at $A_{2A}$ and 21nM at $A_1.$ It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative, instead being a triazoloquinazoline. Consequently, CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor, and so has more a specific pharmacological effects profile. It produces similar effects to caffeine in animal studies, though with higher potency.

