N-myc-interactor
# N-myc-interactor

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.

## Function

NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.

## Interactions

NMI (gene) has been shown to interact with BRCA1, IFI35, Myc, and STAT5A, and TUBA3C.

