Triazolobenzodiazepine
# Triazolobenzodiazepine

Triazolobenzodiazepines (TBZD) are a class of benzodiazepine (BZD) derivative pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional triazole ring fused to the diazepine ring. The triazole and diazepine rings share a nitrogen atom.

Examples include:

* Adinazolam
* Alprazolam
* Bromazolam
* Clonazolam
* Estazolam
* Flualprazolam
* Flubromazolam
* Flunitrazolam
* Nitrazolam
* Pyrazolam
* Triazolam
* Zapizolam

## Synthesis

Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2-thiones with hydrazine and acetic acid in n-butanol under reflux.

