List of number-one hits of 2000 (Italy)
# List of number-one hits of 2000 (Italy)

This is a list of the number-one hits and albums of 2000 on Italian Charts.

| Issue date | Song | Artist | Album | Artist |
| - | - | - | - | - |
| 7 January | "Move Your Body" | Eiffel 65 | No Man's Land | Hevia |
| 14 January | "Move Your Body" | Eiffel 65 | Io non so parlar d'amore | Adriano Celentano |
| 21 January | "Move Your Body" | Eiffel 65 | Io non so parlar d'amore | Adriano Celentano |
| 28 January | "Cartoon Heroes" | Aqua | No Man's Land | Hevia |
| 4 February | "Go Let It Out" | Oasis | Stagioni | Francesco Guccini |
| 11 February | "Go Let It Out" | Oasis | Io non so parlar d'amore | Adriano Celentano |
| 18 February | "Pure Shores" | All Saints | No Man's Land | Hevia |
| 25 February | "American Pie" | Madonna | Standing on the Shoulder of Giants | Oasis |
| 3 March | "American Pie" | Madonna | No Man's Land | Hevia |
| 10 March | "American Pie" | Madonna | Supernatural | Santana |
| 17 March | "American Pie" | Madonna | Supernatural | Santana |
| 24 March | "Tutti gli zeri del mondo" | Renato Zero | Supernatural | Santana |
| 31 March | "Tutti gli zeri del mondo" | Renato Zero | Supernatural | Santana |
| 7 April | "Io ci sarò" | Piero Pelù | Supernatural | Santana |
| 14 April | "Io ci sarò" | Piero Pelù | Supernatural | Santana |
| 21 April | "American Pie" | Madonna | Né buoni né cattivi | Piero Pelù |
| 28 April | "The Bad Touch" | Bloodhound Gang | Supernatural | Santana |
| 5 May | "Oops!... I Did It Again" | Britney Spears | Supernatural | Santana |
| 12 May | "It's My Life" | Bon Jovi | Supernatural | Santana |
| 19 May | "It's My Life" | Bon Jovi | Supernatural | Santana |
| 26 May | "It's My Life" | Bon Jovi | Supernatural | Santana |
| 2 June | "It's My Life" | Bon Jovi | Crush | Bon Jovi |
| 9 June | "Vamos a bailar (Esta vida nueva)" | Paola & Chiara | Supernatural | Santana |
| 16 June | "It's My Life" | Bon Jovi | ...Squérez? | Lùnapop |
| 23 June | "It's My Life" | Bon Jovi | ...Squérez? | Lùnapop |
| 30 June | "Vamos a bailar (Esta vida nueva)" | Paola & Chiara | ...Squérez? | Lùnapop |
| 7 July | "Vamos a bailar (Esta vida nueva)" | Paola & Chiara | ...Squérez? | Lùnapop |
| 14 July | "Vamos a bailar (Esta vida nueva)" | Paola & Chiara | ...Squérez? | Lùnapop |
| 21 July | "Freestyler" | Bomfunk MC's | ...Squérez? | Lùnapop |
| 28 July | "Freestyler" | Bomfunk MC's | ...Squérez? | Lùnapop |
| 4 August | "Freestyler" | Bomfunk MC's | ...Squérez? | Lùnapop |
| 11 August | "Freestyler" | Bomfunk MC's | ...Squérez? | Lùnapop |
| 18 August | "Music" | Madonna | ...Squérez? | Lùnapop |
| 25 August | "Music" | Madonna | ...Squérez? | Lùnapop |
| 1 September | "Music" | Madonna | ...Squérez? | Lùnapop |
| 8 September | "Music" | Madonna | ...Squérez? | Lùnapop |
| 15 September | "Music" | Madonna | Music | Madonna |
| 22 September | "Music" | Madonna | Sailing to Philadelphia | Mark Knopfler |
| 29 September | "Fuoco nel fuoco" | Eros Ramazzotti | Cento di queste vite | Pooh |
| 6 October | "Beautiful Day" | U2 | Cento di queste vite | Pooh |
| 13 October | "Beautiful Day" | U2 | Sailing to Philadelphia | Mark Knopfler |
| 20 October | "Beautiful Day" | U2 | Greatest Hits | Lenny Kravitz |
| 27 October | "She Bangs" | Ricky Martin | All That You Can't Leave Behind | U2 |
| 3 November | "Beautiful Day" | U2 | All That You Can't Leave Behind | U2 |
| 10 November | "Shape of My Heart" | Backstreet Boys | Esco di rado e parlo ancora meno | Adriano Celentano |
| 17 November | "Again" | Lenny Kravitz | 1 | The Beatles |
| 24 November | "Again" | Lenny Kravitz | 1 | The Beatles |
| 1 December | "Again" | Lenny Kravitz | 1 | The Beatles |
| 8 December | "Don't Tell Me" | Madonna | 1 | The Beatles |
| 15 December | "Goodnight Moon" | Shivaree | 1 | The Beatles |
| 22 December | "Goodnight Moon" | Shivaree | 1 | The Beatles |
| 29 December | "Goodnight Moon" | Shivaree | 1 | The Beatles |
