A-796,260
# A-796,260

A-796,260 is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid $CB_2$ receptor agonist. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids with the 3-tetramethylcyclopropylmethanone group, imparts significant selectivity for $CB_2,$ and A-796,260 was found to be a highly selective $CB_2$ agonist with little affinity for $CB_1,$ having a $CB_2$ $K_i$ of 4.6 nM vs 945 nM at $CB_1.$ It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects.

## Legal Status

As of October 2015 A-796,260 is a controlled substance in China.

