Estradiol cypionate/testosterone enanthate
# Estradiol cypionate/testosterone enanthate

Estradiol cypionate/testosterone enanthate (EC/TE), sold under the brand name Supligol, is an injectable combination medication of estradiol cypionate (EC), an estrogen, and testosterone enanthate (TE), an androgen/anabolic steroid, which is used in menopausal hormone therapy for women, to treat prostatic hypertrophy in men, to treat osteoporosis, and to suppress lactation in women, among other uses. It contains 4 mg EC and 80 mg TE (57.5 mg free testosterone) in oil solution in each ampoule and is administered by intramuscular injection once every 3 to 6 weeks for hormone therapy in women. The medication was marketed by 1976 and remains available today in Paraguay.

vte Androgen replacement therapy formulations and dosages used in women :

| Route | Medication | Major brand names | Form | Dosage |
| - | - | - | - | - |
| Oral | Testosterone undecanoate | Andriol, Jatenzo | Capsule | 40–80 mg 1x/1–2 days |
| Oral | Methyltestosterone | Metandren, Estratest | Tablet | 0.5–10 mg/day |
| Oral | Fluoxymesterone | Halotestin | Tablet | 1–2.5 mg 1x/1–2 days |
| Oral | $Normethandrone^a$ | Ginecoside | Tablet | 5 mg/day |
| Oral | Tibolone | Livial | Tablet | 1.25–2.5 mg/day |
| Oral | Prasterone $(DHEA)^b$ | – | Tablet | 10–100 mg/day |
| Sublingual | Methyltestosterone | Metandren | Tablet | 0.25 mg/day |
| Transdermal | Testosterone | Intrinsa | Patch | 150–300 μg/day |
| Transdermal | Testosterone | AndroGel | Gel, cream | 1–10 mg/day |
| Vaginal | Prasterone (DHEA) | Intrarosa | Insert | 6.5 mg/day |
| Injection | Testosterone $propionate^a$ | Testoviron | Oil solution | 25 mg 1x/1–2 weeks |
| Injection | Testosterone enanthate | Delatestryl, Primodian Depot | Oil solution | 25–100 mg 1x/4–6 weeks |
| Injection | Testosterone cypionate | Depo-Testosterone, Depo-Testadiol | Oil solution | 25–100 mg 1x/4–6 weeks |
| Injection | Testosterone $isobutyrate^a$ | Femandren M, Folivirin | Aqueous suspension | 25–50 mg 1x/4–6 weeks |
| Injection | Mixed testosterone esters | $Climacteron^a$ | Oil solution | 150 mg 1x/4–8 weeks |
| Injection | Mixed testosterone esters | Omnadren, Sustanon | Oil solution | 50–100 mg 1x/4–6 weeks |
| Injection | Nandrolone decanoate | Deca-Durabolin | Oil solution | 25–50 mg 1x/6–12 weeks |
| Injection | Prasterone $enanthate^a$ | Gynodian Depot | Oil solution | 200 mg 1x/4–6 weeks |
| Implant | Testosterone | Testopel | Pellet | 50–100 mg 1x/3–6 months |
| Notes: Premenopausal women produce about 230 ± 70 μg testosterone per day (6.4 ± 2.0 mg testosterone per 4 weeks), with a range of 130 to 330 μg per day (3.6–9.2 mg per 4 weeks). Footnotes: $^a$ = Mostly discontinued or unavailable. $^b$ = Over-the-counter. Sources: See template. |||||
