List of ambassadors of the United States to Uzbekistan
# List of ambassadors of the United States to Uzbekistan

This is a list of United States ambassadors to Uzbekistan.

The United States recognized Uzbekistan on December 25, 1991, and established diplomatic relations on February 19, 1992.

The embassy was opened by interim ambassador Michael Mozur on March 16, 1992.

| Representative | From | To | Title | Appointed by |
| - | - | - | - | - |
| Michael Mozur | March 16, 1992 | April 27, 1992 | Chargé d'Affaires ad interim | George H. W. Bush |
| Henry Lee Clarke | September 9, 1992 | September 30, 1995 | Ambassador | George H. W. Bush |
| Stanley T. Escudero | October 12, 1995 | October 3, 1997 | Ambassador | Bill Clinton |
| Joseph A. Presel | December 3, 1997 | October 23, 2000 | Ambassador | Bill Clinton |
| John Edward Herbst | November 1, 2000 | July 12, 2003 | Ambassador | Bill Clinton |
| Jon Purnell | January 28, 2004 | April 28, 2007 | Ambassador | George W. Bush |
| Richard Norland | September 20, 2007 | July 24, 2010 | Ambassador | George W. Bush |
| George A. Krol | July 5, 2011 | December 8, 2014 | Ambassador | Barack Obama |
| Pamela L. Spratlen | January 27, 2015 | October 4, 2018 | Ambassador | Barack Obama |
| Daniel N. Rosenblum | May 24, 2019 | August 30, 2022 | Ambassador | Donald Trump |
| Jonathan Henick | November 24, 2022 | Incumbent | Ambassador | Joe Biden |
