A-412997
# A-412997

A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the $D_4$ subtype, with significantly improved selectivity over older $D_4-preferring$ compounds such as PD-168,077 and CP-226,269. In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability. Also unlike other dopamine agonists, selective $D_4$ agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.

