List of 2016 box office number-one films in Italy
# List of 2016 box office number-one films in Italy

The following is a list of 2016 box office number-one films in Italy.

| # | Date | Film | Gross |
| - | - | - | - |
| 1 | 3 January 2016 | Quo vado? | US$24.2 million |
| 2 | 10 January 2016 | Quo vado? | US$14.3 million |
| 3 | 17 January 2016 | Quo vado? | US$6.46 million |
| 4 | 24 January 2016 | The Revenant | US$4.18 million |
| 5 | 31 January 2016 | L'abbiamo fatta grossa | US$3.6 million |
| 6 | 7 February 2016 | The Hateful Eight | US$3.8 million |
| 7 | 14 February 2016 | Perfetti sconosciuti | US$3.7 million |
| 8 | 21 February 2016 | Perfetti sconosciuti | US$3.4 million |
| 9 | 28 February 2016 | Zootopia | US$3.4 million |
| 10 | 6 March 2016 | Zootopia | US$2.2 million |
| 11 | 13 March 2016 | The Divergent Series: Allegiant | US$1.6 million |
| 12 | 20 March 2016 | Kung Fu Panda 3 | US$2.6 million |
| 13 | 27 March 2016 | Batman v Superman: Dawn of Justice | US$4.6 million |
| 14 | 3 April 2016 | Batman v Superman: Dawn of Justice | US$1.9 million |
| 15 | 10 April 2016 | The Huntsman: Winter's War | US$1.5 million |
| 16 | 17 April 2016 | The Jungle Book | US$3.4 million |
| 17 | 24 April 2016 | The Jungle Book | US$3.04 million |
| 18 | 1 May 2016 | The Jungle Book | US$1.75 million |
| 19 | 8 May 2016 | Captain America: Civil War | US$5.4 million |
| 20 | 15 May 2016 | Captain America: Civil War | US$2.6 million |
| 21 | 22 May 2016 | X-Men: Apocalypse | US$2 million |
| 22 | 29 May 2016 | Alice Through the Looking Glass | US$2.1 million |
| 23 | 5 June 2016 | Alice Through the Looking Glass | US$2 million |
| 24 | 12 June 2016 | Now You See Me 2 | US$1.06 million |
| 25 | 19 June 2016 | The Angry Birds Movie | US$1.4 million |
| 26 | 26 June 2016 | The Conjuring 2 | US$1 million |
| 27 | 3 July 2016 | The Conjuring 2 | US$404 thousands |
| 28 | 10 July 2016 | Teenage Mutant Ninja Turtles: Out of the Shadows | US$750 thousands |
| 29 | 17 July 2016 | The Legend of Tarzan | US$1.5 million |
| 30 | 24 July 2016 | Star Trek Beyond | US$959,882 |
| 31 | 31 July 2016 | Ghostbusters | US$903,484 |
| 32 | 7 August 2016 | Lights Out | US$604,411 |
| 33 | 14 August 2016 | Suicide Squad | US$2.15 million |
| 34 | 21 August 2016 | Suicide Squad | US$2.97 million |
| 35 | 28 August 2016 | Ice Age: Collision Course | US$4.5 million |
| 36 | 4 September 2016 | Me Before You | US$2.1 million |
| 37 | 11 September 2016 | Me Before You | US$1.48 million |
| 38 | 18 September 2016 | Finding Dory | US$6.4 million |
| 39 | 25 September 2016 | Finding Dory | US$3.5 million |
| 40 | 2 October 2016 | Finding Dory | US$2.46 million |
| 41 | 9 October 2016 | The Secret Life of Pets | US$5.1 million |
| 42 | 16 October 2016 | Inferno | US$5.07 million |
| 43 | 23 October 2016 | Inferno | US$3.08 million |
| 44 | 30 October 2016 | Doctor Strange | US$2.67 million |
| 45 | 6 November 2016 | The Girl on the Train | US$1.8 million |
| 46 | 13 November 2016 | The Girl on the Train | US$1.25 million |
| 47 | 20 November 2016 | Fantastic Beasts and Where to Find Them | US$6.28 million |
| 48 | 27 November 2016 | Fantastic Beasts and Where to Find Them | US$3.39 million |
| 49 | 4 December 2016 | Sully | US$2.3 million |
| 50 | 11 December 2016 | Sully | US$2 million |
| 51 | 18 December 2016 | Rogue One: A Star Wars Story | US$3.29 million |
| 52 | 25 December 2016 | Moana | US$1.7 million |
