1925 U.S. National Championships – Men's singles
# 1925 U.S. National Championships – Men's singles

Five-time defending champion Bill Tilden defeated Bill Johnston in the final, 4–6, 11–9, 6–3, 4–6, 6–3 to win the men's singles tennis title at the 1925 U.S. National Championships. It was Tilden's sixth U.S. Championships title and his eight major title overall.

## Draw

### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Final eight

| Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final | Final |
| - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Bill Johnston | 6 | 6 | 6 | 6 | | | | | | | | | | | |
| Manuel Alonso | 3 | 8 | 1 | 2 | | | | | | | | | | | |
| Manuel Alonso | 3 | 8 | 1 | 2 | Bill Johnston | 7 | 6 | 6 | | | | | | | |
| | | | | | R. Norris Williams | 5 | 3 | 2 | | | | | | | |
| Howard Kinsey | 5 | 4 | 3 | | R. Norris Williams | 5 | 3 | 2 | | | | | | | |
| R. Norris Williams | 7 | 6 | 6 | | | | | | | | | | | | |
| R. Norris Williams | 7 | 6 | 6 | | | | | | | Bill Johnston | 6 | 9 | 3 | 6 | 3 |
| | | | | | | | | | | Bill Tilden | 4 | 11 | 6 | 4 | 6 |
| Bill Tilden | 6 | 6 | 6 | | | | | | | | | | | | | Bill Tilden | 4 | 11 | 6 | 4 | 6 |
| Wallace Johnson | 4 | 0 | 4 | | | | | | | | | | | | |
| Wallace Johnson | 4 | 0 | 4 | | Bill Tilden | 6 | 6 | 6 | 6 | | | | | | |
| | | | | | Vincent Richards | 8 | 4 | 4 | 1 | | | | | | |
| Vincent Richards | 6 | 6 | 6 | | Vincent Richards | 8 | 4 | 4 | 1 | | | | | | |
| René Lacoste | 4 | 4 | 3 | | | | | | | | | | | | |
