List of highways numbered 381
# List of highways numbered 381

The following highways are numbered 381:

## Brazil

* BR-381

## Canada

* Newfoundland and Labrador Route 381
* Quebec Route 381
* Saskatchewan Highway 381

## Japan

* Japan National Route 381

## United States

* Interstate 381
* Georgia State Route 381 (former)
* Kentucky Route 381
* Maryland Route 381
* New York State Route 381 (former)
* North Carolina Highway 381
* Pennsylvania Route 381
* Puerto Rico Highway 381
* South Carolina Highway 381
* Tennessee State Route 381
* Virginia State Route 381

| Preceded by 380 | Lists of highways 381 | Succeeded by 382 |
| - | - | - |
