1925 U.S. National Championships – Women's singles
# 1925 U.S. National Championships – Women's singles

First-seeded Helen Wills defeated Kathleen McKane Godfree 3–6, 6–0, 6–2 in the final to win the women's singles tennis title at the 1925 U.S. National Championships. The event was held at the West Side Tennis Club, Forest Hills, New York City. It was Wills's third consecutive U.S. National singles title.

## Draw

### Final eight

| Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Finals | Finals | Finals | Finals |
| - | - | - | - | - | - | - | - | - | - | - | - |
| Elizabeth Ryan | 6 | 5 | 2 | | | | | | | | |
| Kathleen McKane Godfree | 3 | 7 | 6 | | | | | | | | |
| Kathleen McKane Godfree | 3 | 7 | 6 | Kathleen McKane Godfree | 4 | 7 | 8 | | | | |
| | | | | Molla Bjurstedt Mallory | 6 | 5 | 6 | | | | |
| Molla Bjurstedt Mallory | 6 | 6 | | Molla Bjurstedt Mallory | 6 | 5 | 6 | | | | |
| Penelope Anderson | 2 | 1 | | | | | | | | | |
| Penelope Anderson | 2 | 1 | | | | | | Kathleen McKane Godfree | 6 | 0 | 2 |
| | | | | | | | | Helen Wills | 3 | 6 | 6 |
| Helen Wills | 4 | 6 | 6 | | | | | | | | | Helen Wills | 3 | 6 | 6 |
| Joan Fry | 6 | 0 | 3 | | | | | | | | |
| Joan Fry | 6 | 0 | 3 | Helen Wills | 3 | 6 | 6 | | | | |
| | | | | Eleanor Goss | 6 | 0 | 2 | | | | |
| Eleanor Goss | 6 | 11 | | Eleanor Goss | 6 | 0 | 2 | | | | |
| Dorothea Douglass Lambert Chambers | 2 | 9 | | | | | | | | | |
