5F-CUMYL-PINACA
# 5F-CUMYL-PINACA

5F-CUMYL-PINACA (also known as SGT-25 and sometimes sold in e-cigarette form as C-Liquid) is an indazole-3-carboxamide based synthetic cannabinoid. 5F-CUMYL-PINACA acts as a potent agonist for the cannabinoid receptors, with the original patent claiming approximately 4x selectivity for $CB_1,$ having an $EC_{50}$ of <0.1 nM for human $CB_1$ receptors and 0.37 nM for human $CB_2$ receptors. In more recent assays using different techniques, 5F-CUMYL-PINACA was variously found to have an $EC_{50}$ of 0.43 nM at $CB_1$ and 11.3 nM at $CB_2,$ suggesting a somewhat higher $CB_1$ selectivity of 26 times, or alternatively 15.1 nM at $CB_1$ and 34.8 nM at $CB_2$ with only 2.3 times selectivity, however these figures cannot be directly compared due to the different assay techniques used in each case.

## Legal status

In the United States, 5F-CUMYL-PINACA was temporarily emergency scheduled by the DEA in 2019. and made a permanent Schedule I Controlled Substance on April 7, 2022. Sweden's public health agency suggested classifying 5F-CUMYL-PINACA as a hazardous substance on November 10, 2014.

