WDR75
# WDR75

(See also: List of proteins in the human body)WDR75 is a human protein encoded by the WDR75 gene containing a WD40 superfamily domain. The WD40 domain is found throughout many eukaryotic cell types and is known to be involved in cellular regulator functions such as pre-mRNA processing and cytoskeleton assembly. The function of the WDR75 protein is not defined by the scientific community.

| Accession Numbers | Location | Identifiers | M.W. | pI |
| - | - | - | - | - |
| NM_032186, NP_115544.1 | 2q32.2 | FLJ12519, DKFZp781N2144 | 94.5 kDa | 5.56 |

## Protein sequence

The amino acid sequence is 830 residues long and contains an acidic tail.

## Secondary structure

The secondary structure is predicted to contain alternating sets of alpha helices and beta strands. No helix-turn-helix (HTH) regions were predicted.

## Homology

No known paralogs exist for the Human gene. No paralogs were found for the cow, mouse, or rat orthologs of WDR75. Conservation among mammalian orthologs to the human gene was strong, with minimum identity among orthologs at 76%. The following table summarizes some vertebrate and invertebrate orthologs. Conservation of specific amino acids from positions 340–390, 430- 450, and 515-530 all correlate to predicted alpha helices.

| Organism | Accession Number | % Identity to Human Gene |
| - | - | - |
| Bos Taurus | NP_001095532.1 | 91.7 |
| Mus musculus | NP_082875.1 | 84.9 |
| Pan troglodytes | XP_001164827.1 | 99.5 |
| Rattus norvegicus | NP_001041354.1 | 84.3 |
| Canis familiaris | XP_545565 | 90.7 |
| Xenopus Laevis | NP_001086564.1 | 61.0 |
| Gallus gallus | XP_001233408.1 | 60.8 |
| Schizosaccharomyces pombe | NP_594798 | 19.9 |
| Anopheles gambiae | XP_317524 | 22.7 |
