WDR5
# WDR5

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

## Interactions

WDR5 has been shown to interact with Host cell factor C1 and MLL. It also interacts with the long non-coding RNA HOTTIP and to the lncRNA NeST. WDR5 is a key determinant for MYC recruitment to chromatin

