Premios 40 Principales for Best Mexican Act
# Premios 40 Principales for Best Mexican Act

The Premios 40 Principales for Best Mexican Act was an honor presented annually at Los Premios 40 Principales between 2007 and 2011, later reemerging in 2014 as part of Los Premios 40 Principales América.

| Year | Winner | Other nominees |
| - | - | - |
| Los Premios 40 Principales España |||
| 2007 | Camila | Belinda Alejandro Fernández Belanova Aleks Syntek |
| 2008 | Belanova | Maná Julieta Venegas Café Tacuba Ximena Sariñana |
| 2009 | Zoé | Jotdog Paulina Rubio Gloria Trevi Ximena Sariñana |
| 2010 | Camila | Alejandro Fernández Belanova Panteon Rococo Moenia |
| 2011 | Zoé | Paty Cantú Belanova Maná Ximena Sariñana |
| Los Premios 40 Principales América |||
| 2014 | Zoé | Camila Molotov Café Tacuba Jenny and the Mexicats |
