List of number-one dance airplay hits of 2022 (U.S.)
# List of number-one dance airplay hits of 2022 (U.S.)

These are the Billboard magazine Dance/Mix Show Airplay number-one hits of 2022.

Key :

| † | Indicates best charting dance/mix show airplay single of 2022 Note: Year-end most popular songs based radio airplay. |
| - | - |
| Issue date | Song | Artist(s) | Remixer(s) |
| January 1 | "Cold Heart" | Elton John and Dua Lipa | Pnau, PS1 |
| January 8 | "Cold Heart" | Elton John and Dua Lipa | Pnau, PS1 |
| January 15 | "Cold Heart" | Elton John and Dua Lipa | Pnau, PS1 |
| January 22 | "Cold Heart" | Elton John and Dua Lipa | Pnau, PS1 |
| January 29 | "Cold Heart" | Elton John and Dua Lipa | Pnau, PS1 |
| February 5 | "Tell It to My Heart" | Meduza featuring Hozier | Tiesto, Kream, James Hype |
| February 12 | "The Motto" | Tiësto and Ava Max | Juez, New Road & DVNIAR |
| February 19 | "The Motto" | Tiësto and Ava Max | Juez, New Road & DVNIAR |
| February 26 | "High" | The Chainsmokers | Don Diablo,Crankdat, Leondis, Baddies Only, Star Seed |
| March 5 | "High" | The Chainsmokers | Don Diablo,Crankdat, Leondis, Baddies Only, Star Seed |
| March 12 | "High" | The Chainsmokers | Don Diablo,Crankdat, Leondis, Baddies Only, Star Seed |
| March 19 | "High" | The Chainsmokers | Don Diablo,Crankdat, Leondis, Baddies Only, Star Seed |
| March 26 | "High" | The Chainsmokers | Don Diablo,Crankdat, Leondis, Baddies Only, Star Seed |
| April 2 | "High" | The Chainsmokers | Don Diablo,Crankdat, Leondis, Baddies Only, Star Seed |
| April 9 | "Don't Forget My Love" | Diplo and Miguel | John Summit, Burns, Joel Corry |
| April 16 | "Don't Forget My Love" | Diplo and Miguel | John Summit, Burns, Joel Corry |
| April 23 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| April 30 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| May 7 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| May 14 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| May 21 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| May 28 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| June 4 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| June 11 | "Escape" | Kx5 Featuring Hayla | John Summit, Spencer Brown |
| June 18 | "As It Was"† | Harry Styles | Thnked, Phrase, Minlee |
| June 25 | "As It Was"† | Harry Styles | Thnked, Phrase, Minlee |
| July 2 | "About Damn Time" | Lizzo | Purple Disco Machine, David Michael |
| July 9 | "About Damn Time" | Lizzo | Purple Disco Machine, David Michael |
| July 16 | "About Damn Time" | Lizzo | Purple Disco Machine, David Michael |
| July 23 | "About Damn Time" | Lizzo | Purple Disco Machine, David Michael |
| July 30 | "About Damn Time" | Lizzo | Purple Disco Machine, David Michael |
| August 6 | "Break My Soul" | Beyoncé | Terry Hunter,Essential Bounce |
| August 13 | "Break My Soul" | Beyoncé | Terry Hunter,Essential Bounce |
| August 20 | "Break My Soul" | Beyoncé | Terry Hunter,Essential Bounce |
| August 27 | "Break My Soul" | Beyoncé | Terry Hunter,Essential Bounce |
| September 3 | "Break My Soul" | Beyoncé | Terry Hunter,Essential Bounce |
| September 10 | "Deep Down" | Alok, Ella Eyre and Kenny Dope featuring Never Dull | Paul Mayson |
| September 17 | "Deep Down" | Alok, Ella Eyre and Kenny Dope featuring Never Dull | Paul Mayson |
| September 24 | "Deep Down" | Alok, Ella Eyre and Kenny Dope featuring Never Dull | Paul Mayson |
| October 1 | "Deep Down" | Alok, Ella Eyre and Kenny Dope featuring Never Dull | Paul Mayson |
| October 8 | "Hold Me Closer" | Elton John and Britney Spears | Purple Disco Machine,Joel Corry, MIB Project |
| October 15 | "Hold Me Closer" | Elton John and Britney Spears | Purple Disco Machine,Joel Corry, MIB Project |
| October 22 | "Hold Me Closer" | Elton John and Britney Spears | Purple Disco Machine,Joel Corry, MIB Project |
| October 29 | "I'm Good (Blue)" | David Guetta and Bebe Rexha | Oliver Heldens, Tiësto, R3hab |
| November 5 | "I'm Good (Blue)" | David Guetta and Bebe Rexha | Oliver Heldens, Tiësto, R3hab |
| November 12 | "I'm Good (Blue)" | David Guetta and Bebe Rexha | Oliver Heldens, Tiësto, R3hab |
| November 19 | "I'm Good (Blue)" | David Guetta and Bebe Rexha | Oliver Heldens, Tiësto, R3hab |
| November 26 | "I'm Good (Blue)" | David Guetta and Bebe Rexha | Oliver Heldens, Tiësto, R3hab |
| December 3 | "Unholy" | Sam Smith and Kim Petras | Acraze, Disclosure, Dxrk, Nova Twins |
| December 10 | "Unholy" | Sam Smith and Kim Petras | Acraze, Disclosure, Dxrk, Nova Twins |
| December 17 | "Unholy" | Sam Smith and Kim Petras | Acraze, Disclosure, Dxrk, Nova Twins |
| December 24 | "I'm Good (Blue)" | David Guetta and Bebe Rexha | Oliver Heldens, Tiësto, R3hab |
| December 31 | "I'm Good (Blue)" | David Guetta and Bebe Rexha | Oliver Heldens, Tiësto, R3hab |
