Hesperetin
# Hesperetin

Hesperetin is the 4'-methoxy derivative of eriodictyol, a flavanone. Hesperetin's 7-O-glycoside, hesperidin, is a naturally occurring flavanon-glycoside, the main flavonoid in lemons and sweet oranges. Hesperetin (and naringenin, the parent flavanone of naringin) are not found to a significant extent in Citrus spp.

## Glycosides

A variety of glycosides of hesperetin are known, including:

* Hesperidin (hesperetin-7-O-rutinoside) is a water-insoluble flavonoid glycoside whose solubility is below 5 μg/ml in water. Hesperidin is found in citrus fruits and upon ingestion it releases its aglycone, hesperetin.
* Neohesperidin is the 7-O-neohesperidoside of hesperetin.
* Hesperetin-7-O-α-L-Rhamnopyranoside (CAS 66513-83-5) is found in the roots of clammy cherry (Cordia obliqua a.k.a. Cordia obliqua var. wallichii).

## Metabolism

Hesperidin 6-O-α-L-rhamnosyl-β-D-glucosidase is an enzyme that uses hesperidin and $H_2O$ to produce hesperetin and rutinose. It is found in the hyphomycetes species Stilbella fimetaria.

## Effects

Hesperetin was found to be affecting the slow inactivation phase of inward sodium current channels (INa) and therefore could be used as a template to develop drugs against lethal cardiac arrhythmias in LQT3. Hesperetin also inhibits TRPM3 channels.

