1,4-Dimethoxybenzene
# 1,4-Dimethoxybenzene

1,4-Dimethoxybenzene is an organic compound with the formula $C_6H_4(OCH_3)_2.$ It is one of three isomers of dimethoxybenzene. It is a white solid with an intensely sweet floral odor. It is produced by several plant species.

## Occurrence

It occurs naturally in willow (Salix), tea, hyacinth, zucchini (Cucurbita pepo). It appears to attract bees as it has a powerful response in their antenna. In a study in mice, Iranian scientists identified 1,4-dimethoxybenzene as the major psychoactive chemical in musk willow (Salix aegyptiaca) by its ability to cause somnolescence and depressed activity.

## Preparation

It is produced by the methylation of hydroquinone using dimethylsulfate and an alkali.

## Uses

1,4-Dimethoxybenzene is mainly used in perfumes and soaps.

It is an intermediate in synthesis of organic compounds, including pharmaceuticals such as methoxamine and butaxamine.

### Niche uses

It can be used as a developer in black and white film, and as a base in synthesizing catecholamines and phenethylamines.

