List of highways numbered 280
# List of highways numbered 280

Route 280, or Highway 280, may refer to:

## Australia

* McIvor Highway

## Canada

* Manitoba Provincial Road 280
* New Brunswick Route 280

## Japan

* Japan National Route 280

## United States

* Interstate 280 (multiple highways)
* U.S. Route 280
* Arizona State Route 280 (former)
* Arkansas Highway 280
   * Arkansas Highway 280 Spur
* Florida State Road 280 (former)
* Georgia State Route 280
* Kentucky Route 280
* Maryland Route 280 (former)
* Minnesota State Highway 280
* Montana Secondary Highway 280
* New York State Route 280
* North Carolina Highway 280
* Pennsylvania Route 280 (former)
* South Carolina Highway 280
* Tennessee State Route 280
* Texas State Highway 280 (former proposed)
   * Texas State Highway Spur 280
   * Farm to Market Road 280 (Texas)
* Utah State Route 280

| Preceded by 279 | Lists of highways 280 | Succeeded by 281 |
| - | - | - |
