Non-noradrenergic, non-cholinergic transmitter
# Non-noradrenergic, non-cholinergic transmitter

A non-noradrenergic, non-cholinergic transmitter (NANC) is a neurotransmitter of the enteric nervous system (ENS) that is neither acetylcholine, norepinephrine, nor epinephrine.

## Comparison table

This table compares different NANCs in the PNS:

| Neurotransmitter | Type | Location | Function |
| - | - | - | - |
| ATP | non-peptide | postganglionic sympathetic neurons (e.g. in blood vessels & vas deferens) | Fast depolarization/contraction (vasoconstriction) |
| GABA | non-peptide | ENSs | peristalsis |
| 5-HT | non-peptide | ENSs | peristalsis |
| dopamine | non-peptide | some SNSs (e.g. kidney) | vasodilation |
| NO | non-peptide | gastric nerves & Pelvic Nerve | erection gastric emptying |
| NPY | peptide | postganglionic sympathetic neurons (e.g. blood vessels) | enhance vasoconstrictor action of noradrenaline noradrenaline release inhibitor |
| VIP | peptide | parasympathetic nerves to salivary glands NANC innervation to smooth muscle of airways parasympathetic ganglia in sphincters, gallbladder and small intestine | vasodilation acetylcholine cotransmitter bronchodilation relaxation of intestinal smooth muscle and sphincters |
| GnRH | peptide | sympathetic ganglia | slow depolarization acetylcholine cotransmitter |
| substance P | peptide | sympathetic ganglia ENSs | slow depolarization acetylcholine cotransmitter |
| CGRP | peptide | non-myelinated sensory neurons | vasodilation increase vascular permeability neurogenic inflammation |
