Cartazolate
# Cartazolate

Cartazolate (SQ-65,396) is a drug of the pyrazolopyridine class. It acts as a $GABA_A$ receptor positive allosteric modulator at the barbiturate binding site of the complex and has anxiolytic effects in animals. It is also known to act as an adenosine antagonist at the $A_1$ and $A_2$ subtypes and as a phosphodiesterase inhibitor. Cartazolate was tested in human clinical trials and was found to be efficacious for anxiety but was never marketed. It was developed by a team at E.R. Squibb and Sons in the 1970s.

