Rnd2
# Rnd2

Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND2.

## Function

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

## Clinical significance

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.

## Interactions

Rnd2 has been shown to interact with:

* ARHGAP5,
* RACGAP1, and
* UBXD5.
