2,5-Dimethoxy-4-ethoxyamphetamine
# 2,5-Dimethoxy-4-ethoxyamphetamine

2,5-Dimethoxy-4-ethoxyamphetamine (MEM) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized by Alexander Shulgin. In his book PiHKAL, he lists the active dose range as 20–50 mg, and the duration as 10–14 hours. According to Shulgin, MEM produces color enhancement, visual phenomena, and pattern movement, among other effects.

MEM possesses affinity $(K_i)$ for the $5-HT_{2A}$ (3,948 nM), $5-HT_{2B}$ (64.5 nM), $5-HT_7$ (7,156 nM), and $σ_1$ (5,077 nM) receptors. It behaves as a partial agonist at the $5-HT_{2A}$ receptor. MEM is relatively selective for these sites and displays low/negligible (> 10,000 nM) affinity for a wide array of other targets.

