Zadik–Barak–Levin syndrome
# Zadik–Barak–Levin syndrome

Zadik–Barak–Levin syndrome (ZBLS) is a congenital disorder in humans. Presenting conditions include primary hypothyroidism, cleft palate, hypodontia, and ectodermal dysplasia. It is the result of an embryonic defect in the mesodermal-ectodermal midline development.

## Signs and symptoms

* anodontia/oligodontia—no teeth or fewer teeth than normal
* cleft palate
* depressed nasal bridge
* dry skin
* ectopic/agenesis/hypoplastic thyroid
* epibulbar dermoid
* frontal bossing
* hypertelorism
* hypothyroidy
* lordosis
* macroglossia
* microcephaly
* micrognatia/retrognatia—small or recessed jaw(s)
* polyhydramnios
* short stature/dwarfism
* sparse/absent scalp hair(generalized)
* squint/paresis of ocular muscles
* umbilical hernia
