Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: As is known, estrogenic treatment can give rise to various adverse effects. Which of the following is NOT an adverse effect due to this pharmacological action? 
 Options:  <1> Edema. <2> Breast pain <3> Ovarian cancer. <4> Sickness. <5> Headaches
