Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The most frequent mechanism that induces the activation of the ABL protooncogene in chronic myeloid leukemia is: 
 Options:  <1> Point mutation <2> Gene amplification. <3> Methylation of the promoter. <4> Deletion <5> Translocation
