Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Enzymatic regulation by reversible covalent modification: 
 Options:  <1> It involves the breaking of the peptide bond. <2> It requires the action of another enzyme. <3> It always involves phosphorylation reaction. <4> It never affects allosteric enzymes. <5> The enzyme never comes in two forms.
