Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: In the alcaptonuria the defective enzyme can be: 
 Options:  <1> Dihydrobiopterin reductase. <2> Tyrosine aminotransferase. <3> p-hydroxyphenylpyruvate dioxygenase. <4> Homogentisic 1,2-dioxygenase. <5> Fumarilacetoacetasa.
