Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The pyruvate carboxylase activity depends on the positive allosteric effector: 
 Options:  <1> Succinate <2> AMP. <3> Isocitrate. <4> Citrate. <5> Acetyl CoA
