Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The gradation of a tumor refers to: 
 Options:  <1> Determine the extent of the disease by considering tumor size and spread. <2> Measure the abnormal cell growth with respect to the size, shape and disposition of the tumor. <3> Obtain a sample of tissue to analyze it under a microscope and detect malignant cells. <4> Identify the type of tissue that caused the tumor and the degree to which the tumor cells retain the characteristics of the tissue of origin. <5> Select specific therapies to destroy tumor cells by interfering with their cellular functions.
