Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Regarding the stability of the drugs of a proteinaceous nature of biotechnological drugs, we can say: 
 Options:  <1> Which is strongly dependent on pH. <2> That is little affected by ionic strength. <3> That being generally so high does not usually give problems in the formulation. <4> That its maximum value occurs at the pH value of lower solubility. <5> That has a slight dependence on the temperature.
