Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Which of the following changes is the most potent stimulus for glucagon secretion? 
 Options:  <1> Gastric filling <2> Hyperglycemia <3> Hypernatremia <4> Pass from chyme to duodenum. <5> Hypoglycemia
