Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: In patients with Chronic Obstructive Pulmonary Disease, which treatments listed below are contraindicated due to the effect they cause: 
 Options:  <1> Bronchodilators, both short and long acting. <2> Mucolytics and expectorants to reduce the viscosity of secretions. <3> Oxygen that in the long term reduces the mortality of the patient with COPD. <4> Respiratory depressants such as opioids and barbiturates. <5> Antibiotics for patients with repeated pulmonary infections.
