Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Serum disease is a hypersensitivity: 
 Options:  <1> Mediated by IgE. <2> Against molecules of the extracellular matrix. <3> Mediated by deposition of immune complexes in certain tissues. <4> With formation of granulomas. <5> With activation of mast cells associated with blood vessels.
