Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: When carrying out the validation of an analytical method it is necessary to take into account the following basic aspects: 
 Options:  <1> Validate the analytical process as a whole, the range of concentrations in which it is applied, as well as the method in a single matrix to ensure selectivity. <2> Validate the previous stages of treatment of the sample, the range of concentrations in which it is applied and the method in a single matrix to ensure the selectivity. <3> Validate the final measurement method, validate the range of low concentrations (traces) in which it is applied and the method in a single matrix to ensure sensitivity. <4> All that is required is to validate the instrumentation by means of suitable calibrations. <5> Validate the analytical process as a whole, the concentration interval in which it is applied and the method in each of the matrices to which it will be applied.
