Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The increase in standard free energy of ATP hydrolysis depends, among others, on the following structural characteristic: 
 Options:  <1> Its polar character. <2> Its amphipathic nature <3> Its stabilization by resonance. <4> Of the phosphoryl group number it contains. <5> Of the cation with which the soluble salt forms.
