Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The standard free energy of activation of a reaction is: 
 Options:  <1> The difference in free energy between the basal state of the products and the substrates. <2> The difference of the enthalpy minus the entropy of the system. <3> The basal energy of the substrates in a catalyzed reaction. <4> The additional free energy that molecules must reach to reach the state of transition. <5> The energy released from a catalysed reaction.
