Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The validation of an analytical method includes: 
 Options:  <1> Validate the analytical process as a whole, validate the range of concentrations in which it is applied and validate the method in each of the matrices to which it will be applied. <2> It only includes validating the range of concentrations in which it is applied. <3> It only includes validating the method in each of the matrices to which it will be applied. <4> It is only necessary to validate the treatment stages of the samples prior to the analytical measurement. <5> It is only necessary to validate the instrumentation by means of suitable calibrations.
