Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: What would be the pathophysiological mechanism that would explain the jaundice that can be observed in choledocholithiasis? 
 Options:  <1> Increase in bilirubin production. <2> Defect in the uptake of bilirubin by the hepatocyte. <3> Disorder in bilirubin conjugation. <4> Defect in the elimination of bilirubin by the hepatocyte. <5> Disorder in the conduction of bilirubin to the duodenum.
