Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Transcription factors: 
 Options:  <1> They bind to chromatin by interaction with histone H2A. <2> They bind to RNA and regulate the start of transcription. <3> They join the DNA. <4> They are organized into nucleosomes. <5> They regulate DNA methylation.
