Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Observe that the liquids coming from the synthesis of chloroquine had an antibacterial activity gave rise to the discovery of the quinolones. This group of antibiotics has various characteristics such as: 
 Options:  <1> Fluoroquinolones have a smaller spectrum of activity than first-generation quinolones. <2> The second generation quinolones are very effective against anaerobes. <3> Fluoroquinolones are not effective against enterobacteria. <4> Fluoroquinolones are effective against Gram-positive but less than Gram-negative. <5> The third and fourth generation fluoroquinolones are not effective against streptococci or staphylococci.
