Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: T-independent antigens: 
 Options:  <1> They are mostly proteins. <2> They induce maturation of the affinity of the specific antibodies. <3> Induce isotype change of specific antibodies. <4> They are usually polymeric antigens. <5> They induce intense secondary responses.
