Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: All of the following statements that describe restriction endonucleases are true EXCEPT: 
 Options:  <1> They do not provide single chain ends in complementary pieces of DNA. <2> They are limited by the methylation of the recognition sequences. <3> They recognize palidromic sequences. <4> They break both chains in the DNA duplex. <5> They are specific to short symmetric sequences.
