Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: In general, allosteric enzymes: 
 Options:  <1> They link the effectors in the active center. <2> They form covalent bonds with their negative effectors. <3> They originate hyperbolic curves of speed before the concentration of substrate. <4> They change their conformation when they link effectors. <5> They are irreversibly modified when they are inhibited.
