Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: What is the role of the helicase in replication ?: 
 Options:  <1> Join the single-stranded DNA to prevent the double helix from forming again. <2> Catalyze the union of nucleotides. <3> Correct the errors that occur in the replication. <4> Synthesize a primer to start replication. <5> Mechanically separate the strands of double-stranded DNA.
