Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The acetylation of the stories affects the transcription: 
 Options:  <1> Blocking the incorporation of other components of the transcription machinery. <2> Preventing the remodeling of chromatin. <3> Facilitating the action of helicases. <4> Decreasing the sensitivity of nuclear receptors. <5> Reducing the affinity of histones for DNA.
