Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The active center of an enzyme: 
 Options:  <1> It is formed by functional groups that come from the central amino acid sequence of the enzyme. <2> It constitutes a large part of the total volume of the enzyme. <3> Increases the ΔG of a reaction, increasing the speed of it. <4> It has a high amount of water molecules together with amino acids. <5> It is the region that joins the substrates and contains the waste that participates in the formation and breaking of links.
