Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: The earliest sign manifested in the increase in Intracranial Pressure (ICP) is: 
 Options:  <1> Orthostatic hypotension. <2> Breathing difficulty <3> Hypertension maintained. <4> Changes in the level of consciousness <5> Frequent vomiting
