Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: In disorders related to substance use, what is physical dependence? 
 Options:  <1> In a physical process of short duration. <2> In an intense sense of dissatisfaction for not being able to consume the substances. <3> In the action of consuming drugs producing a state of intoxication with psychoactive effect. <4> In a series of physical and psychic changes that take place after the administration of a substance. <5> In a state of physical adaptation manifested by intense physical disturbances when the administration of the drug is interrupted.
