Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: When comparing the characteristics of pragmatic or confirmatory clinical studies with explanatory or exploratory clinical studies, which of the following is an advantage of the former? 
 Options:  <1> Information about subgroups of patients representative of the usual clinical practice. <2> Very homogeneous sample, with little variability. <3> Greater capacity to detect differences in the effectiveness of interventions. <4> Greater internal validity <5> Smaller sample size
