Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: All the following events occur during the formation of phosphoenolpyruvate from pyruvate EXCEPT: 
 Options:  <1> CO2 is consumed. <2> CO2 comes out. <3> CoA is needed. <4> ATP hydrolyzes. <5> GTP is hydrolyzed.
