Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Of all the groups of drugs listed below, those that less frequently provoke an anaphylactic reaction in the patient are: 
 Options:  <1> The NSAIDs. <2> Opioid analgesics. <3> Contrast media containing iodine, used for radiological examinations. <4> The benzodiazepines. <5> Antibiotics, especially penicillins, cephalosporins and sulfonamides.
