Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: Topoisomerases: 
 Options:  <1> They modify the degree of DNA supercoiling. <2> They are a type of DNA polymerases. <3> They bind to the single-stranded DNA to prevent the double helix from forming. <4> They exhibit exonuclease activity. <5> They synthesize dNTPs.
