Question: at what point can a person overdose on vitamin B6 and what are the effects of an overdose? i have cancer and the chemotherapy I'm on causes neuropathy. my oncologist has advised me to take 100mg ofvitamin B6, but this is not alleviating the symptoms.

Answer: High doses of Vitamin B6 (300 milligrams or more per day) for long periods of time (greater than 6 months) in a few people has caused peripheral neuropathy.\n\n100 mg/day is considered safe.  I do not know why your doctor is recommending B6 for the treatment of your chemotherapy induced peripheral neuropathy.  I just did a 'quick' search of Pubmed (where the world's medical research can be reviewed) and found several studies showing the supplement Acetyl-L-Carnitine may be effective for the treatment of chemotherapy induced peripheral neuropathies.  This might be a better 'bet' than B6.\n\nYou can read these studies by going to Pubmed (enter 'entrez pubmed' in your search engine).  In the search window of Pubmed enter: 'chemotherapy peripheral neuropathy Acetyl-L-Carnitine'.  You may want to share these studies with your doctor.\n\nBest wishes and good luck.
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