Patricia Donoho Hughes (August 18, 1930 – January 20, 2010) was a First Lady of Maryland, married to former Maryland Governor Harry Hughes. She was educated at Sorbonne (1949) and Bryn Mawr College (1951) before getting married on June 30, 1951. She later continued her education at the University of Delaware (1966). Mrs. Hughes was a teacher and educator by profession.
Particia Donoho Hughes was the First Lady of Maryland in 2010.